# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	20	1.483355e-57	9.7597342225e-55	2.686647	350	0.01855189	685	0.011278797896496351	1.25885	83	113	0.007575758	
GO Biological Process	regulation of DNA-templated transcription in response to stress	27	2.046622e-54	9.974629221481481e-52	2.517613	371	0.01966501	593	0.006129928201686341	1.267389	88	119	0.008032129	
GO Biological Process	nuclear-transcribed mRNA catabolic process	32	1.118258e-49	4.5984865693749995e-47	2.185627	450	0.02385243	160	8.873368655625e-9	1.367622	158	198	0.01442132	
GO Biological Process	mRNA catabolic process	33	1.713886e-49	6.834250264848485e-47	2.116942	482	0.02554861	176	3.212165732272727e-8	1.343727	167	213	0.01524279	
GO Biological Process	liver regeneration	56	5.644722e-39	1.3264088713928571e-36	3.234894	175	0.009275946	517	0.002653355816441006	1.517986	31	35	0.0028295	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	74	3.290806e-36	5.851853534324324e-34	2.465611	253	0.01341037	264	0.0000041454199563636365	1.394323	96	118	0.008762322	
GO Biological Process	endoplasmic reticulum unfolded protein response	80	1.568601e-34	2.5801525698749996e-32	2.278559	282	0.01494752	577	0.004968849802946274	1.277875	85	114	0.007758306	
GO Biological Process	cellular response to topologically incorrect protein	105	1.882196e-30	2.358839729904762e-28	2.047965	315	0.0166967	787	0.018513977299872936	1.22066	99	139	0.009036145	
GO Biological Process	cellular response to epidermal growth factor stimulus	107	2.918413e-30	3.589102492242991e-28	2.493745	205	0.01086611	865	0.03243685893641619	1.398145	31	38	0.0028295	
GO Biological Process	cellular response to unfolded protein	110	4.704583e-30	5.62796433609091e-28	2.101261	292	0.01547758	623	0.007367692417014447	1.260604	89	121	0.008123403	
GO Biological Process	response to epidermal growth factor	115	2.774022e-29	3.1742048259130433e-27	2.400999	213	0.01129015	839	0.02635826120738975	1.387407	34	42	0.003103322	
GO Biological Process	multi-organism metabolic process	123	1.059753e-28	1.1337633924390244e-26	2.031152	302	0.01600763	202	2.7700913184653467e-7	1.387407	119	147	0.01086163	
GO Biological Process	protein targeting to ER	136	8.071035e-28	7.809319820955882e-26	2.347643	211	0.01118414	286	0.000012324972457692308	1.408416	83	101	0.007575758	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	144	3.750915e-27	3.4276590614583335e-25	2.404489	196	0.01038906	592	0.00613543265168919	1.355736	53	67	0.004837532	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	146	4.014571e-27	3.6183383417123293e-25	2.107788	260	0.01378141	629	0.0076840484683624805	1.294508	71	94	0.006480467	
GO Biological Process	cotranslational protein targeting to membrane	159	5.158705e-26	4.269396169496856e-24	2.332757	199	0.01054808	282	0.000010670922411347517	1.416554	81	98	0.007393209	
GO Biological Process	viral gene expression	178	3.974716e-24	2.9383869575280897e-22	2.082976	236	0.01250928	200	2.38188624585e-7	1.416967	105	127	0.00958379	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	179	4.120756e-24	3.0293311845810055e-22	2.145501	220	0.01166119	256	0.000003336039352617187	1.420052	87	105	0.007940854	
GO Biological Process	translational elongation	188	9.94738e-24	6.962636884042553e-22	2.138019	218	0.01155518	167	2.4793005853892214e-8	1.469019	96	112	0.008762322	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	191	1.369029e-23	9.431964717801049e-22	2.303037	184	0.009752995	324	0.0000757246433117284	1.397165	75	92	0.006845564	
GO Cellular Component	nuclear ubiquitin ligase complex	60	2.400001e-21	6.91200288e-20	2.963876	105	0.005565568	105	0.0046779115885714284	1.456777	34	40	0.003103322	
GO Cellular Component	mitochondrial ribosome	61	2.84888e-21	8.070269901639344e-20	2.444227	146	0.007738789	53	0.0000011762877464150943	1.471899	73	85	0.006663016	
GO Cellular Component	DNA-directed RNA polymerase III complex	98	9.204464e-14	1.6229912032653062e-12	4.095552	42	0.002226227	141	0.044520571914893614	1.53345	17	19	0.001551661	
GO Cellular Component	axon cytoplasm	114	1.87542e-12	2.8427418947368422e-11	2.094145	112	0.005936606	89	0.00125352634247191	1.499623	35	40	0.003194597	
GO Cellular Component	mitochondrial large ribosomal subunit	128	7.369731e-12	9.94913685e-11	2.337805	83	0.004399449	90	0.001248633984	1.445015	43	51	0.00392479	
GO Cellular Component	mitochondrial small ribosomal subunit	169	7.568155e-9	7.738326532544379e-8	2.461228	53	0.002809287	129	0.02514581581395349	1.469019	24	28	0.002190581	
GO Molecular Function	unfolded protein binding	13	1.353176e-27	4.394699286153846e-25	2.327007	213	0.01129015	101	0.006976018960396038	1.293476	80	106	0.007301935	
GO Molecular Function	rRNA binding	18	5.668388e-24	1.3295518964444445e-21	3.048905	114	0.006042616	89	0.005068174188764044	1.399649	49	60	0.004472435	
GO Molecular Function	endoribonuclease activity	61	3.423448e-12	2.369474992786885e-10	2.022757	119	0.006307643	79	0.0020118556825316457	1.438414	47	56	0.004289887	
GO Molecular Function	sugar transmembrane transporter activity	148	6.472724e-9	1.8464757248648647e-7	2.015064	83	0.004399449	131	0.041715164824427484	1.428213	30	36	0.002738226	
GO Molecular Function	cAMP response element binding	188	8.058949e-8	0.000001809834185	2.282343	53	0.002809287	127	0.030113518056692913	1.713855	13	13	0.001186564	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	32	1.534175e-29	4.3901376484375e-27	2.070583	297	0.01574261	284	0.015505838286619718	1.289999	70	93	0.006389193	
Mouse Phenotype Single KO	prenatal lethality prior to heart atrial septation	155	9.696517e-17	5.728452010903226e-15	2.024075	170	0.009010919	193	0.0030819036427979277	1.418363	48	58	0.004381161	
Mouse Phenotype Single KO	abnormal rostral-caudal body axis extension	177	1.695948e-15	8.773895952542374e-14	2.628952	90	0.004770487	312	0.026585547449358975	1.713855	13	13	0.001186564	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	211	5.902909e-14	2.5617506025118482e-12	2.005038	142	0.007526768	204	0.004795637606862745	1.399649	49	60	0.004472435	
Mouse Phenotype Single KO	spontaneous chromosome breakage	294	1.940252e-11	6.043159035374149e-10	2.408085	75	0.003975405	348	0.037318037839080456	1.508193	22	25	0.002008032	
Mouse Phenotype Single KO	increased hepatocyte proliferation	455	2.362168e-8	4.753927994725274e-7	2.331582	55	0.002915297	355	0.040063087335211266	1.713855	12	12	0.00109529	
Mouse Phenotype Single KO	increased pancreas tumor incidence	719	0.00000580129	0.00007388374482614742	2.51094	31	0.001643168	312	0.026585547449358975	1.713855	13	13	0.001186564	
Mouse Phenotype	extramedullary hematopoiesis	8	1.842032e-55	2.2014584939999997e-52	2.040509	591	0.0313262	567	0.020337410507936506	1.194802	122	175	0.01113545	
Mouse Phenotype	decreased circulating free fatty acid level	36	4.653602e-36	1.2359191311666666e-33	2.020174	389	0.0206191	352	0.0035169350803977277	1.281791	89	119	0.008123403	
Mouse Phenotype	early cellular replicative senescence	167	1.494953e-19	8.558829720359282e-18	2.051706	195	0.01033605	246	0.0004735586619512195	1.408648	60	73	0.005476451	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	220	9.696517e-17	4.214018138045454e-15	2.024075	170	0.009010919	306	0.002029574710392157	1.418363	48	58	0.004381161	
Mouse Phenotype	increased liver adenoma incidence	354	2.545487e-12	6.874972092372883e-11	2.419135	81	0.004293438	443	0.008455368549887134	1.530228	25	28	0.002281855	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	524	4.644146e-9	8.473793875190841e-8	2.168336	71	0.003763384	369	0.004225309053658537	1.54247	27	30	0.002464403	
Mouse Phenotype	tachypnea	526	4.76133e-9	8.654577211026616e-8	2.404181	57	0.003021308	517	0.015667721659381045	1.618641	17	18	0.001551661	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	1054	0.0000442013	0.0004009569537950664	2.016734	40	0.002120216	469	0.010590552535394456	1.623653	18	19	0.001642935