# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	12	4.904046e-27	5.3776951095e-24	2.726341	153	0.03290323	95	9.02264703536842e-8	1.884817	83	213	0.02138073	
GO Biological Process	nuclear-transcribed mRNA catabolic process	14	1.081194e-26	1.0162451318571428e-23	2.817906	143	0.03075269	90	6.607271338444444e-8	1.92989	79	198	0.02035033	
GO Biological Process	RNA catabolic process	18	1.948006e-23	1.4241006085555555e-20	2.442194	160	0.0344086	113	4.406861761504425e-7	1.786256	89	241	0.02292633	
GO Biological Process	succinate transmembrane transport	20	3.431196e-23	2.2575554082e-20	41.15525	18	0.003870968	537	0.04471293424394786	4.83694	4	4	0.001030397	
GO Biological Process	ncRNA processing	30	2.923728e-21	1.2824445584e-18	2.068647	205	0.04408602	225	0.00018474908487111112	1.465739	120	396	0.0309119	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	32	1.546047e-20	6.357635147812501e-18	3.020933	97	0.02086022	222	0.00015013962584234234	1.926215	45	113	0.01159196	
GO Biological Process	translation	33	1.675694e-20	6.6819567715151515e-18	2.027456	207	0.04451613	85	2.745778613647059e-8	1.677326	129	372	0.03323029	
GO Biological Process	tumor necrosis factor-mediated signaling pathway	34	4.965058e-20	1.921623477117647e-17	2.947896	98	0.02107527	187	0.00003864977037219251	1.927218	51	128	0.01313756	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	35	1.353292e-19	5.087991265142857e-17	3.247532	83	0.01784946	294	0.0017393051477210884	1.797801	42	113	0.01081917	
GO Biological Process	regulation of cellular amino acid metabolic process	38	5.118283e-19	1.772407526236842e-16	4.50409	54	0.0116129	273	0.0009217638492673994	2.176623	27	60	0.006955178	
GO Biological Process	rRNA metabolic process	39	3.581991e-18	1.2086005017692307e-15	2.269001	141	0.03032258	179	0.000027524746462569832	1.643439	88	259	0.02266873	
GO Biological Process	rRNA processing	40	3.592027e-18	1.1816870823249999e-15	2.292506	138	0.02967742	182	0.00002952172484505495	1.650702	86	252	0.02215353	
GO Biological Process	regulation of hematopoietic stem cell differentiation	43	7.860763e-18	2.4055762864418604e-15	3.275152	74	0.01591398	299	0.0019726612889966557	1.831463	39	103	0.01004637	
GO Biological Process	ribosome biogenesis	44	1.330738e-17	3.979813941363636e-15	2.040553	173	0.0372043	139	0.0000022955761897122306	1.63228	109	323	0.02807831	
GO Biological Process	regulation of DNA-templated transcription in response to stress	45	1.464364e-17	4.282125750222222e-15	2.698162	98	0.02107527	233	0.0002890941373004292	1.869741	46	119	0.01184956	
GO Biological Process	viral gene expression	46	2.121534e-17	6.068970849130435e-15	2.972195	83	0.01784946	162	0.000012434856980864197	1.980479	52	127	0.01339516	
GO Biological Process	viral transcription	47	2.93003e-17	8.203460589361702e-15	3.052943	79	0.01698925	144	0.0000036901710594444445	2.097434	49	113	0.01262236	
GO Biological Process	negative regulation of G2/M transition of mitotic cell cycle	49	6.714521e-17	1.803191466102041e-14	3.11299	75	0.01612903	151	0.0000057397640794701985	2.228253	41	89	0.01056157	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	52	2.618985e-16	6.627543002884616e-14	3.005001	76	0.01634409	207	0.00009668870850724638	1.926578	47	118	0.01210716	
GO Biological Process	negative regulation of mitotic cell cycle phase transition	53	2.973548e-16	7.382814741886792e-14	2.119364	145	0.0311828	114	4.469794867982457e-7	1.87158	77	199	0.01983514	
GO Cellular Component	intracellular ribonucleoprotein complex	15	4.139637e-44	4.7688618239999994e-42	2.004491	465	0.1	19	1.633997709473684e-14	1.580622	266	814	0.06852138	
GO Cellular Component	ribonucleoprotein complex	16	5.663721e-44	6.11681868e-42	2.001939	465	0.1	20	2.59823808e-14	1.574818	266	817	0.06852138	
GO Cellular Component	ribosome	22	5.641017e-22	4.430762443636364e-20	2.490515	144	0.03096774	30	6.506444159999999e-8	1.8241	89	236	0.02292633	
GO Cellular Component	ribosomal subunit	23	1.983497e-21	1.4902099200000001e-19	2.805391	114	0.02451613	32	1.95351102e-7	1.90863	73	185	0.01880474	
GO Cellular Component	large ribosomal subunit	25	5.149527e-17	3.5593530624e-15	3.100774	76	0.01634409	33	0.0000013893046690909092	2.103017	50	115	0.01287996	
GO Cellular Component	endopeptidase complex	32	1.0702e-14	5.779080000000001e-13	3.389372	57	0.01225806	44	0.00005822511709090909	2.243218	32	69	0.008243174	
GO Cellular Component	mitochondrial ribosome	33	3.240546e-14	1.6968677236363636e-12	3.531986	52	0.0111828	62	0.006579164903225807	1.820966	32	85	0.008243174	
GO Cellular Component	mitochondrial large ribosomal subunit	34	4.946095e-14	2.513780047058823e-12	4.456784	39	0.008387097	56	0.0023076174857142857	2.181365	23	51	0.005924781	
GO Cellular Component	peptidase complex	35	5.172981e-14	2.5539746194285715e-12	2.921891	67	0.0144086	36	0.0000230061024	2.143644	39	88	0.01004637	
GO Cellular Component	proteasome complex	38	1.219022e-13	5.543342147368421e-12	3.272294	55	0.01182796	46	0.00012701036660869565	2.205075	31	68	0.007985574	
GO Cellular Component	catalytic step 2 spliceosome	41	1.320981e-12	5.567451629268293e-11	2.667906	69	0.01483871	64	0.0069041106	1.763468	35	96	0.009015971	
GO Cellular Component	nuclear chromosome, telomeric region	44	2.046019e-11	8.035274618181817e-10	2.430344	73	0.01569892	73	0.010805858630136988	1.612313	44	132	0.01133436	
GO Cellular Component	chromosome, telomeric region	46	3.237649e-11	1.2162298852173912e-9	2.221041	86	0.01849462	85	0.0333188894117647	1.477149	51	167	0.01313756	
GO Cellular Component	cytosolic ribosome	52	8.768559e-10	2.9138596061538463e-8	2.254046	71	0.01526882	47	0.000182712138893617	1.900226	44	112	0.01133436	
GO Cellular Component	methyltransferase complex	66	5.505955e-8	0.0000014415591272727272	2.192671	59	0.01268817	71	0.0103045970028169	1.754055	33	91	0.008500773	
GO Cellular Component	endoplasmic reticulum chaperone complex	69	6.567055e-8	0.000001644618991304348	7.191379	13	0.002795699	95	0.04369217077894737	3.078053	7	11	0.001803194	
GO Cellular Component	U1 snRNP	70	8.850809e-8	0.0000021848854217142855	4.170746	21	0.004516129	70	0.010286381622857143	2.800334	11	19	0.002833591	
GO Cellular Component	cytosolic large ribosomal subunit	78	3.807414e-7	0.000008434886400000001	2.512457	39	0.008387097	58	0.0025163356468965513	2.061646	26	61	0.006697579	
GO Cellular Component	proton-transporting ATP synthase complex, catalytic core F(1)	80	5.820986e-7	0.00001257332976	21.04972	6	0.001290323	88	0.03676581163636364	4.030783	5	6	0.001287996	
GO Cellular Component	tethering complex	83	7.320875e-7	0.000015241532530120483	2.022312	59	0.01268817	93	0.04121491819354838	1.722746	26	73	0.006697579	
GO Molecular Function	ribonucleoprotein complex binding	4	1.065073e-23	1.1241845515e-20	3.31524	99	0.02129032	27	0.0006904002044444445	1.892716	45	115	0.01159196	
GO Molecular Function	structural constituent of ribosome	9	2.018119e-16	9.467220464444444e-14	2.601283	97	0.02086022	14	0.00014195763291428572	1.821317	61	162	0.01571355	
GO Molecular Function	RNA polymerase binding	62	0.000009985827	0.0006800026063548388	2.133221	41	0.008817204	34	0.0017959394588235294	2.321731	24	50	0.00618238	
GO Molecular Function	DNA helicase activity	78	0.00005736249	0.003104928625384615	2.154342	33	0.007096774	55	0.02780447228727273	2.072974	21	49	0.005409583	
Human Phenotype	Abnormal CNS myelination	5	3.300942e-10	4.4054371932e-7	2.19587	79	0.01698925	4	0.016237017193	1.818689	47	125	0.01210716	
Human Phenotype	Leukodystrophy	20	6.050373e-7	0.00020187069514500004	2.573647	36	0.007741935	32	0.034718764021875	2.128253	22	50	0.005667182	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	18	1.212934e-9	6.170464798888888e-7	2.749809	48	0.01032258	39	0.0013373596576410256	2.257239	28	60	0.007212777	
Mouse Phenotype Single KO	early cellular replicative senescence	30	4.319548e-8	0.000013184700345333333	2.663587	41	0.008817204	45	0.0018909432907555552	2.325452	25	52	0.006439979	
Mouse Phenotype Single KO	endometrium hyperplasia	46	9.808709e-7	0.00019525727894130433	3.727904	20	0.004301075	57	0.003487216934736842	3.720723	10	13	0.002575992	
Mouse Phenotype Single KO	abnormal memory T cell physiology	57	0.000001952673	0.0003136952045789473	3.559176	20	0.004301075	128	0.04638808145078125	2.845259	10	17	0.002575992	
Mouse Phenotype Single KO	skin fibrosis	72	0.000005068995	0.0006446776002083333	3.784548	17	0.003655914	106	0.03358687391320755	3.762064	7	9	0.001803194	
Mouse Phenotype Single KO	increased fibroblast apoptosis	74	0.000005653326	0.0006995608943513514	2.510702	31	0.006666667	68	0.007203146670882353	2.487569	18	35	0.004636785	
Mouse Phenotype Single KO	spontaneous chromosome breakage	155	0.0001473112	0.008702765538064516	2.605358	20	0.004301075	119	0.039534447189915965	2.515209	13	25	0.003348789	
Mouse Phenotype Single KO	decreased platelet dense granule number	184	0.0003928414	0.019550264672826084	2.84092	15	0.003225806	115	0.03929611888434783	3.109461	9	14	0.002318393	
Mouse Phenotype	decreased interscapular fat pad weight	7	2.168629e-12	2.962037409857143e-9	4.706412	32	0.00688172	198	0.02383045931363636	3.109461	9	14	0.002318393	
Mouse Phenotype	early cellular replicative senescence	9	8.763496e-12	9.309753917333333e-9	2.689354	63	0.01354839	43	0.00003904543414883721	2.319081	35	73	0.009015971	
Mouse Phenotype	abnormal cellular replicative senescence	18	6.562346e-11	3.485699450333333e-8	2.492803	66	0.01419355	58	0.00018509139900000003	2.130557	37	84	0.00953117	
Mouse Phenotype	increased fibroblast apoptosis	20	8.215448e-11	3.9273949164e-8	3.034083	47	0.01010753	39	0.00001640153022076923	2.720779	27	48	0.006955178	
Mouse Phenotype	increased hepatocyte apoptosis	32	5.384237e-9	0.00000160870906115625	2.274704	63	0.01354839	133	0.009300811403007519	1.962816	28	69	0.007212777	
Mouse Phenotype	abnormal fibroblast apoptosis	42	5.994743e-8	0.000013646604243571427	2.170636	60	0.01290323	44	0.00003840944875909091	2.349371	34	70	0.008758372	
Mouse Phenotype	decreased tumor latency	65	0.000001573503	0.00023145018743076922	2.232867	44	0.009462366	62	0.0003455707792741936	2.523621	24	46	0.00618238	
Mouse Phenotype	endometrium hyperplasia	106	0.0000183066	0.001651220779245283	2.947636	21	0.004516129	190	0.02096846560894737	2.800334	11	19	0.002833591	
Mouse Phenotype	colon polyps	184	0.0001136078	0.005903283564130435	3.05859	16	0.00344086	247	0.03899471268825911	2.902164	9	15	0.002318393	
Mouse Phenotype	abnormal nucleotide metabolism	189	0.0001268275	0.006415860992063492	3.520566	13	0.002795699	198	0.02383045931363636	3.109461	9	14	0.002318393	
Mouse Phenotype	decreased platelet dense granule number	224	0.0002737598	0.011684899320535713	2.823698	16	0.00344086	176	0.017802918807954548	3.023087	10	16	0.002575992	
Mouse Phenotype	spontaneous chromosome breakage	300	0.0009154803	0.029176357161	2.151072	22	0.004731183	233	0.033964262504291846	2.335074	14	29	0.003606388