# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	62	1.204984e-46	2.5574813638709673e-44	2.469462	329	0.01343131	278	5.468624793525179e-7	1.319687	107	118	0.008293288	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	100	5.592022e-32	7.3585417498e-30	2.352206	244	0.009961217	348	0.000007830815022988505	1.328803	84	92	0.006510619	
GO Biological Process	cotranslational protein targeting to membrane	104	3.019661e-31	3.820742221057692e-29	2.284227	253	0.01032864	300	0.0000015749980782000001	1.336551	90	98	0.006975663	
GO Biological Process	protein targeting to ER	108	1.749935e-30	2.1321661726851852e-28	2.228053	260	0.01061441	286	6.79776456013986e-7	1.34008	93	101	0.007208185	
GO Biological Process	viral gene expression	113	1.114308e-29	1.2976264576991152e-27	2.059763	303	0.01236987	255	2.0675431120784313e-7	1.317842	115	127	0.008913347	
GO Biological Process	protein localization to endoplasmic reticulum	115	2.163484e-29	2.475590083130435e-27	2.004366	321	0.01310472	244	1.128512604180328e-7	1.326252	113	124	0.008758332	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	119	3.12331e-28	3.4537509487394954e-26	2.088109	278	0.01134925	256	2.2979171042187498e-7	1.344472	97	105	0.007518214	
GO Biological Process	viral transcription	122	5.128241e-28	5.531354370409836e-26	2.068789	282	0.01151255	245	1.1647277966938775e-7	1.339442	104	113	0.008060766	
GO Biological Process	mitochondrial transmembrane transport	158	4.943917e-23	4.117531886265823e-21	2.052888	233	0.009512145	812	0.014613328790640394	1.227408	70	83	0.005425515	
GO Biological Process	snRNA metabolic process	185	6.163907e-20	4.384370389891891e-18	2.033335	204	0.00832823	489	0.00046850426333333334	1.286128	76	86	0.00589056	
GO Biological Process	mRNA transcription from RNA polymerase II promoter	308	6.865361e-15	2.933158616850649e-13	3.163901	64	0.002612778	798	0.013152351242105263	1.455356	19	19	0.00147264	
GO Biological Process	nucleobase-containing small molecule interconversion	520	2.882991e-10	7.2956304940384615e-9	2.026268	97	0.003959992	643	0.003840733497356143	1.406844	29	30	0.002247714	
GO Biological Process	mitochondrion transport along microtubule	581	1.242405e-9	2.8139083296041305e-8	2.13782	79	0.003225148	839	0.01821390672943981	1.455356	18	18	0.001395133	
GO Biological Process	establishment of mitochondrion localization	625	4.888721e-9	1.029290874224e-7	2.028784	83	0.003388447	756	0.009534873891931217	1.455356	20	20	0.001550147	
GO Biological Process	positive regulation by host of viral transcription	709	2.657045e-8	4.931460529619182e-7	2.08472	70	0.002857726	942	0.0343874983195329	1.455356	16	16	0.001240118	
GO Cellular Component	mitochondrial ribosome	56	1.661302e-19	5.126303314285715e-18	2.179104	169	0.006899367	100	0.0012675783743999998	1.267016	74	85	0.005735545	
GO Cellular Component	mitochondrial large ribosomal subunit	110	4.197149e-11	6.59333952e-10	2.104284	97	0.003959992	163	0.03532591744785276	1.255601	44	51	0.003410324	
GO Cellular Component	INO80-type complex	143	4.17191e-9	5.0413010349650356e-8	2.560234	51	0.002082058	154	0.022878394597402596	1.392079	22	23	0.001705162	
GO Molecular Function	rRNA binding	13	6.196098e-25	2.0123019812307696e-22	2.801433	136	0.005552154	118	0.012575842410169492	1.285564	53	60	0.00410789	
GO Molecular Function	snRNA binding	64	5.06309e-12	3.340057184375e-10	2.370859	82	0.003347622	100	0.004390909554	1.378758	36	38	0.002790265	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	3	5.993352e-30	1.8293708088e-26	2.392541	220	0.008981425	511	0.020236808722113506	1.261308	52	60	0.004030383	
Mouse Phenotype Single KO	increased squamous cell carcinoma incidence	37	1.376252e-15	3.40603772e-13	2.372679	110	0.004490712	289	0.0018206660315224913	1.455356	26	26	0.002015191	
Mouse Phenotype Single KO	abnormal stapedial artery morphology	102	4.704738e-12	4.223655477058823e-10	2.419516	79	0.003225148	544	0.028460662974264708	1.455356	17	17	0.001317625	
Mouse Phenotype Single KO	absent stapedial artery	124	4.766257e-11	3.5197270442741934e-9	2.360325	75	0.003061849	588	0.03833579607312925	1.455356	16	16	0.001240118	
Mouse Phenotype	abnormal cellular replicative senescence	8	1.887317e-34	2.255579729625e-31	2.194022	306	0.01249235	474	0.0018876310539240506	1.264773	73	84	0.005658038	
Mouse Phenotype	early cellular replicative senescence	9	6.075703e-34	6.454421820333333e-31	2.269034	280	0.0114309	612	0.0068550104730392145	1.255992	63	73	0.004882964	
Mouse Phenotype	abnormal pulmonary valve cusp morphology	78	1.060089e-15	1.299424478076923e-13	2.026575	158	0.006450296	630	0.007975904574285713	1.401454	26	27	0.002015191	
Mouse Phenotype	decreased cellular sensitivity to ultraviolet irradiation	144	1.276675e-12	8.476590052083334e-11	2.857093	62	0.002531129	920	0.037245291195652175	1.455356	15	15	0.00116261	
Mouse Phenotype	abnormal stapedial artery morphology	164	1.603116e-11	9.34597077804878e-10	2.173035	94	0.003837518	636	0.008234932895754717	1.455356	20	20	0.001550147	
Mouse Phenotype	absent stapedial artery	189	1.308278e-10	6.6182253746031746e-9	2.123563	90	0.003674219	685	0.011132588328175182	1.455356	19	19	0.00147264