# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 27 1.353586e-56 6.596977101481481e-54 2.455512 401 0.0376102 191 0.00021671770675392668 1.380142 128 248 0.01822842 GO Biological Process gene silencing 72 6.84484e-30 1.2509895772222221e-27 2.273306 242 0.02269743 479 0.02818355610020877 1.307301 88 180 0.01253204 GO Biological Process nucleosome organization 115 1.568951e-24 1.7952892355652173e-22 2.097013 235 0.02204089 382 0.0128933535486911 1.344831 86 171 0.01224722 GO Biological Process mitochondrial membrane organization 129 6.68887e-23 6.823165917054263e-21 2.136801 209 0.01960233 353 0.008612710882719546 1.423271 66 124 0.009399032 GO Biological Process chromatin assembly or disassembly 131 8.815413e-23 8.855116005114503e-21 2.012553 240 0.02250985 383 0.013187434434464752 1.337012 89 178 0.01267445 GO Biological Process regulation of megakaryocyte differentiation 139 1.938371e-21 1.8350376970503597e-19 2.505656 140 0.01313074 494 0.030195589700404854 1.47775 42 76 0.005981202 GO Biological Process cellular response to topologically incorrect protein 183 5.47085e-18 3.933929789617486e-16 2.047732 178 0.0166948 379 0.012592805380738785 1.385106 72 139 0.01025349 GO Biological Process endoplasmic reticulum unfolded protein response 196 5.198146e-17 3.4899185313265303e-15 2.144587 150 0.01406866 427 0.019624898075644027 1.407381 60 114 0.008544574 GO Biological Process hepatocyte apoptotic process 251 1.329789e-14 6.971591016334661e-13 4.085024 45 0.004220597 528 0.038300714996212126 2.228354 10 12 0.001424096 GO Biological Process interleukin-12-mediated signaling pathway 256 2.378188e-14 1.22244437078125e-12 2.36005 101 0.009472894 402 0.017215949160447764 1.595032 34 57 0.004841925 GO Biological Process positive regulation of histone methylation 271 5.226975e-14 2.5380724732472323e-12 2.483132 89 0.008347402 564 0.04611461891666667 1.701652 21 33 0.002990601 GO Biological Process regulation of membrane permeability 272 5.391737e-14 2.6084509993749996e-12 2.039453 136 0.01275558 515 0.03580814304271845 1.452557 44 81 0.006266021 GO Biological Process response to interleukin-12 290 1.865869e-13 8.466541438275861e-12 2.237258 105 0.009848059 373 0.011299982560321716 1.613635 35 58 0.004984335 GO Biological Process regulation of mitochondrial membrane permeability 329 1.260698e-12 5.042408809118541e-11 2.046234 120 0.01125492 552 0.043513427894927535 1.465219 40 73 0.005696383 GO Biological Process regulation of transforming growth factor beta production 372 1.035399e-11 3.6625847959677415e-10 2.361413 80 0.007503283 481 0.028472081792099792 1.814517 19 28 0.002705782 GO Biological Process posttranscriptional gene silencing by RNA 424 1.014051e-10 3.147145544575472e-9 2.17488 86 0.008066029 524 0.03789287236832061 1.572956 30 51 0.004272287 GO Biological Process negative regulation of G0 to G1 transition 440 1.60518e-10 4.800582640909091e-9 2.250894 78 0.007315701 377 0.012416106386206896 1.759227 25 38 0.003560239 GO Biological Process regulation of G0 to G1 transition 508 1.468731e-9 3.804533706496063e-8 2.127176 79 0.007409492 485 0.029391833872164947 1.655348 26 42 0.003702649 GO Biological Process actin polymerization or depolymerization 564 5.357264e-9 1.249933279716312e-7 2.03209 82 0.007690865 343 0.00792446872973761 1.741225 28 43 0.003987468 GO Biological Process regulation of gene expression by genetic imprinting 565 5.379954e-9 1.2530055696637168e-7 2.977227 39 0.00365785 412 0.018406873078640775 2.079797 14 18 0.001993734 GO Cellular Component methyltransferase complex 51 2.960367e-18 1.0030419952941176e-16 2.285361 141 0.01322454 69 0.005583658852173913 1.498629 51 91 0.007262888 GO Cellular Component histone methyltransferase complex 55 7.432286e-17 2.3350891287272723e-15 2.339793 123 0.0115363 52 0.0020916110769230766 1.627667 42 69 0.005981202 GO Cellular Component podosome 119 9.736123e-9 1.4137832389915966e-7 2.210329 65 0.006096417 61 0.0038354546360655738 1.936363 21 29 0.002990601 GO Cellular Component AP-2 adaptor complex 186 0.00001331574 0.00012370752 2.179908 38 0.003564059 84 0.013837431085714285 2.262636 11 13 0.001566505 GO Cellular Component clathrin coat of coated pit 194 0.00001676537 0.00014933278020618556 2.08714 41 0.003845432 105 0.047277207771428575 1.93124 13 18 0.001851324 GO Cellular Component clathrin coat of endocytic vesicle 212 0.00004885941 0.00039825028528301884 2.04811 38 0.003564059 101 0.03544976601980198 2.101019 11 14 0.001566505 GO Molecular Function histone-lysine N-methyltransferase activity 48 2.722355e-11 2.3945380854166665e-9 2.074678 102 0.009566685 85 0.010426844915294118 1.706824 30 47 0.004272287 GO Molecular Function RNA polymerase II core binding 95 4.455323e-9 1.980039337473684e-7 2.346256 60 0.005627462 86 0.01304251403255814 1.910017 20 28 0.002848191 Mouse Phenotype Single KO abnormal T cell activation 13 6.214561e-51 4.377441159769231e-48 2.023919 545 0.05111611 88 0.00000890096507715909 1.406407 152 289 0.02164625 Mouse Phenotype Single KO abnormal erythropoiesis 14 6.328463e-51 4.139266835071428e-48 2.562377 333 0.03123241 52 3.6926676686538465e-7 1.750271 72 110 0.01025349 Mouse Phenotype Single KO decreased erythroid progenitor cell number 28 3.492813e-40 1.1422745943214286e-37 2.925241 209 0.01960233 112 0.000028878496307142855 1.939979 37 51 0.005269154 Mouse Phenotype Single KO decreased T cell proliferation 42 9.61504e-34 2.0963076495238096e-31 2.115419 322 0.03020071 248 0.0035001111256451616 1.40832 79 150 0.01125036 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 43 6.548903e-33 1.3946117388604651e-30 2.091991 322 0.03020071 250 0.003708823082 1.375213 90 175 0.01281686 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 44 1.055943e-32 2.1975613752272726e-30 2.268912 267 0.02504221 90 0.00000919446535677778 1.76171 56 85 0.007974936 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 45 1.768812e-32 3.599335885333334e-30 3.76418 118 0.01106734 265 0.0046785393611320746 1.936363 21 29 0.002990601 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 51 2.331115e-30 4.185494128431372e-28 3.446612 123 0.0115363 279 0.005857782131182795 1.833617 24 35 0.00341783 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 79 3.006807e-25 3.4852318606329113e-23 2.43647 176 0.01650722 198 0.001001206956060606 1.765865 35 53 0.004984335 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 81 4.158669e-25 4.701349633703703e-23 2.629613 152 0.01425624 322 0.0115020934810559 1.550159 40 69 0.005696383 Mouse Phenotype Single KO abnormal erythrocyte physiology 96 6.234375e-22 5.9466845703125e-20 3.096009 101 0.009472894 373 0.015331484086327077 1.663837 28 45 0.003987468 Mouse Phenotype Single KO extramedullary hematopoiesis 100 3.251641e-21 2.9775276637e-19 2.115535 197 0.01847683 439 0.02523078896810934 1.383925 59 114 0.008402165 Mouse Phenotype Single KO decreased circulating alanine transaminase level 104 6.060746e-21 5.336370300192308e-19 2.176819 182 0.01706997 393 0.01842115088015267 1.497454 42 75 0.005981202 Mouse Phenotype Single KO abnormal platelet physiology 106 9.907021e-21 8.558357669528303e-19 2.019442 215 0.02016507 455 0.028112815136263736 1.385631 57 110 0.008117345 Mouse Phenotype Single KO embryo tumor 110 2.948661e-20 2.4546262524545452e-18 6.546314 41 0.003845432 510 0.04117920854901961 2.376911 8 9 0.001139277 Mouse Phenotype Single KO increased spleen red pulp amount 132 3.657669e-18 2.537369320681818e-16 2.527296 115 0.01078597 474 0.03301821014345992 1.604415 27 45 0.003845058 Mouse Phenotype Single KO abnormal iron level 146 4.739575e-17 2.972622484589041e-15 2.000097 178 0.0166948 387 0.01745831975762274 1.393189 62 119 0.008829393 Mouse Phenotype Single KO poikilocytosis 147 4.925211e-17 3.0680378997959186e-15 3.567201 63 0.005908835 498 0.03634282748393574 1.701652 21 33 0.002990601 Mouse Phenotype Single KO decreased mean corpuscular volume 152 8.582379e-17 5.1703187173026315e-15 2.090389 157 0.01472519 542 0.048574252610701106 1.396435 47 90 0.00669325 Mouse Phenotype Single KO abnormal erythroblast morphology 153 1.189374e-16 7.118364521568628e-15 2.546998 103 0.009660476 365 0.014722918125753425 1.811436 21 31 0.002990601 Mouse Phenotype abnormal erythropoiesis 10 3.127129e-59 2.9898480369e-56 2.503761 405 0.03798537 66 2.3402372781818183e-8 1.686968 94 149 0.0133865 Mouse Phenotype decreased erythroid progenitor cell number 24 1.761315e-46 7.01663863125e-44 2.771057 265 0.02485462 134 0.0000027644254430597012 1.829596 52 76 0.007405298 Mouse Phenotype abnormal erythroid progenitor cell morphology 41 8.223983e-41 1.917792718609756e-38 2.291817 329 0.03085725 116 9.775413667241379e-7 1.68531 75 119 0.01068072 Mouse Phenotype abnormal mean corpuscular hemoglobin 52 3.468693e-36 6.377725725576923e-34 2.100344 352 0.03301444 265 0.0005553584420377358 1.409676 97 184 0.01381373 Mouse Phenotype abnormal embryonic erythropoiesis 65 7.51669e-31 1.1056472783076923e-28 3.469751 124 0.01163009 380 0.0038204925702631583 1.897695 22 31 0.003133011 Mouse Phenotype abnormal platelet physiology 71 7.888554e-30 1.0622882365352111e-27 2.181477 264 0.02476083 389 0.004322048821079691 1.418043 70 132 0.00996867 Mouse Phenotype abnormal embryonic erythrocyte morphology 73 3.010927e-29 3.94348945849315e-27 3.18287 132 0.01238042 328 0.0015788041405792686 1.851248 27 39 0.003845058 Mouse Phenotype abnormal proerythroblast morphology 81 6.597103e-28 7.787024911481481e-26 2.329433 214 0.02007128 400 0.00502382505975 1.542706 45 78 0.006408431 Mouse Phenotype decreased mean corpuscular hemoglobin 90 9.623921e-27 1.0223812075666667e-24 2.501427 178 0.0166948 329 0.0016178290155319148 1.597469 46 77 0.00655084 Mouse Phenotype microcytic anemia 91 4.435022e-26 4.65969729032967e-24 4.036949 86 0.008066029 372 0.0034798724491935484 1.936363 21 29 0.002990601 Mouse Phenotype abnormal iron level 105 9.61815e-24 8.758012585714287e-22 2.137827 217 0.02035265 512 0.014376067123242188 1.366724 69 135 0.00982626 Mouse Phenotype abnormal iron homeostasis 110 2.082616e-23 1.8101719614545455e-21 2.087329 226 0.02119677 523 0.01576627729502868 1.356112 71 140 0.01011108 Mouse Phenotype poikilocytosis 114 4.613803e-23 3.869523726578947e-21 3.689624 84 0.007878447 494 0.012387750293927125 1.714118 25 39 0.003560239 Mouse Phenotype abnormal embryonic hematopoiesis 115 9.134777e-23 7.594574164956523e-21 2.245509 186 0.01744513 341 0.0019113653050733138 1.665786 38 61 0.005411564 Mouse Phenotype microcytosis 117 1.80348e-22 1.4737668615384615e-20 4.498023 65 0.006096417 395 0.004854761134177215 2.005518 18 24 0.002563372 Mouse Phenotype abnormal reticulocyte cell number 123 9.153908e-22 7.115488974634145e-20 2.113378 203 0.01903958 334 0.0017190051096107786 1.496472 61 109 0.008686984 Mouse Phenotype decreased mean corpuscular volume 124 1.006752e-21 7.762545058064515e-20 2.139028 197 0.01847683 447 0.009082877276510068 1.437919 57 106 0.008117345 Mouse Phenotype embryo tumor 137 2.948661e-20 2.057821008832117e-18 6.546314 41 0.003845432 656 0.03342677176829268 2.376911 8 9 0.001139277 Mouse Phenotype decreased circulating alanine transaminase level 138 3.273437e-20 2.2679225476086958e-18 2.105689 189 0.01772651 518 0.015186085147297298 1.461385 47 86 0.00669325 Mouse Phenotype abnormal circulating tumor necrosis factor level 139 3.83314e-20 2.636593635971223e-18 2.021053 208 0.01950853 740 0.04537502016891892 1.300382 71 146 0.01011108