# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 49 2.373623e-52 6.374388787142857e-50 2.278304 431 0.03489596 587 0.029095871625212946 1.205469 141 248 0.01592141 GO Biological Process regulation of megakaryocyte differentiation 99 2.091913e-30 2.780553855252525e-28 2.719209 176 0.01424986 376 0.005019119078989362 1.450702 52 76 0.005871725 GO Biological Process gene silencing 111 2.841095e-29 3.3681053247747746e-27 2.157052 266 0.02153672 618 0.03483877189320388 1.236817 105 180 0.01185637 GO Biological Process cellular response to unfolded protein 156 1.034868e-24 8.72937693076923e-23 2.242358 204 0.01651688 688 0.045803973434593026 1.279164 73 121 0.008242999 GO Biological Process response to unfolded protein 165 2.139732e-23 1.7064686901818184e-21 2.007522 249 0.02016031 576 0.028074680809027776 1.258903 95 160 0.01072719 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 174 6.542425e-23 4.947802906609195e-21 2.411553 162 0.01311635 242 0.00024725407555785124 1.437463 80 118 0.009033424 GO Biological Process cotranslational protein targeting to membrane 182 2.970814e-22 2.1479638146153847e-20 2.542626 142 0.01149704 250 0.000358719182512 1.471199 68 98 0.00767841 GO Biological Process viral gene expression 197 2.075515e-21 1.3863808063451775e-19 2.278436 169 0.0136831 257 0.0006031942233463035 1.402375 84 127 0.009485095 GO Biological Process multi-organism metabolic process 207 1.839765e-20 1.1695394992753623e-18 2.064949 201 0.01627399 208 0.00008405444105288461 1.413505 98 147 0.01106594 GO Biological Process viral transcription 212 9.710933e-20 6.027649403160377e-18 2.269693 156 0.01263056 288 0.001294974905451389 1.407251 75 113 0.008468835 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 249 5.350734e-17 2.827723241204819e-15 2.351613 123 0.009958708 287 0.0012976740972473868 1.451915 63 92 0.007113821 GO Biological Process regulation of gene silencing by miRNA 286 2.143001e-15 9.860052503146854e-14 2.000875 159 0.01287345 679 0.04466193669955817 1.300158 65 106 0.007339657 GO Biological Process protein targeting to ER 296 3.596425e-15 1.5988296140202703e-13 2.175391 128 0.01036353 387 0.00576977606614987 1.385515 66 101 0.007452575 GO Biological Process establishment of protein localization to endoplasmic reticulum 330 2.067061e-14 8.242562333030304e-13 2.055715 138 0.01117318 345 0.0035800096963188406 1.393312 69 105 0.007791328 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 342 4.518498e-14 1.738564771403509e-12 3.093096 62 0.005019836 595 0.030635899161344536 1.678537 19 24 0.002145438 GO Biological Process protein peptidyl-prolyl isomerization 412 2.571283e-12 8.21250315461165e-11 2.270718 92 0.00744879 579 0.028296872692573402 1.51447 30 42 0.003387534 GO Biological Process multi-organism transport 439 1.303127e-11 3.9061157615034167e-10 2.070229 106 0.008582301 664 0.04071937606927711 1.373688 46 71 0.005194219 GO Biological Process regulation of transforming growth factor beta production 477 7.178766e-11 1.980406326918239e-9 2.191376 86 0.006962999 703 0.04832576299857753 1.590193 21 28 0.002371274 GO Biological Process low-density lipoprotein particle clearance 485 9.169435e-11 2.4878473229896908e-9 2.745214 55 0.004453081 515 0.02060615335708738 1.696206 20 25 0.002258356 GO Biological Process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 548 5.276252e-10 1.2669744537956205e-8 2.230472 75 0.006072383 661 0.040401593942511346 1.531297 26 36 0.002935863 GO Cellular Component ficolin-1-rich granule lumen 61 1.177341e-20 3.3351561442622954e-19 2.133285 188 0.01522144 99 0.03334209163636363 1.282414 75 124 0.008468835 GO Cellular Component cAMP-dependent protein kinase complex 79 3.353405e-16 7.335042835443039e-15 5.546913 37 0.002995709 107 0.039475287925233644 2.120257 8 8 0.0009033424 GO Cellular Component other organism cell 111 1.959915e-11 3.051110918918919e-10 2.017381 111 0.008987127 93 0.02968681703225807 1.375302 48 74 0.005420054 GO Cellular Component AP-type membrane coat adaptor complex 142 5.781264e-9 7.035228304225353e-8 2.049293 80 0.006477208 94 0.0323309535319149 1.474962 32 46 0.003613369 GO Cellular Component NuA4 histone acetyltransferase complex 163 3.848215e-8 4.0795800736196315e-7 2.607887 43 0.003481499 95 0.0328572288 1.766881 15 18 0.001693767 GO Cellular Component clathrin adaptor complex 164 4.258129e-8 4.4866139707317076e-7 2.165739 62 0.005019836 118 0.048191196203389824 1.554855 22 30 0.002484192 GO Cellular Component clathrin coat of endocytic vesicle 203 0.000001294529 0.00001101943897536946 2.186775 47 0.00380536 122 0.04981814085245902 1.817364 12 14 0.001355014 GO Molecular Function clathrin adaptor activity 123 1.273398e-8 4.370964517073171e-7 3.092229 35 0.002833779 76 0.014223423581578947 2.120257 11 11 0.001242096 GO Molecular Function mRNA 5'-UTR binding 156 1.366197e-7 0.0000036974895730769237 2.518744 42 0.003400534 86 0.045088480802325574 1.734756 18 22 0.00203252 Mouse Phenotype Single KO abnormal erythropoiesis 26 2.32783e-39 8.198438196153847e-37 2.2319 336 0.02720427 84 0.0002820491174761905 1.464905 76 110 0.008581752 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 42 1.638496e-33 3.5723113980952383e-31 3.579878 130 0.01052546 213 0.01738959440140845 1.681583 23 29 0.002597109 Mouse Phenotype Single KO decreased erythroid progenitor cell number 45 2.915772e-33 5.933272045333333e-31 2.573544 213 0.01724557 135 0.004386858912518519 1.5798 38 51 0.004290876 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 47 5.28589e-33 1.0298488240425531e-30 3.362317 139 0.01125415 200 0.013165110470000001 1.635627 27 35 0.00304878 Mouse Phenotype Single KO abnormal platelet physiology 55 2.691661e-30 4.481370868545454e-28 2.181131 269 0.02177961 146 0.0050717367874657535 1.387805 72 110 0.008130081 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 60 1.296685e-28 1.9789574241666665e-26 2.425945 203 0.01643592 196 0.011808731713775509 1.520185 38 53 0.004290876 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 72 2.334479e-25 2.969003361527778e-23 2.002652 273 0.02210347 207 0.016684376928019322 1.396875 56 85 0.006323397 Mouse Phenotype Single KO abnormal megakaryocyte progenitor cell morphology 82 2.540289e-22 2.836759313780487e-20 2.006711 237 0.01918873 289 0.042445705086505185 1.349255 56 88 0.006323397 Mouse Phenotype Single KO increased respiratory quotient 99 1.642299e-19 1.5190436306060605e-17 2.615172 117 0.009472917 290 0.043113682068965514 1.471199 34 49 0.003839205 Mouse Phenotype Single KO abnormal vascular branching morphogenesis 160 9.824089e-15 5.6224489358125e-13 2.206622 120 0.009715812 149 0.005259790018456376 1.754696 24 29 0.002710027 Mouse Phenotype Single KO increased mean platelet volume 241 8.379526e-12 3.183872181825727e-10 2.129749 101 0.008177476 141 0.004704041820567375 1.627174 33 43 0.003726287 Mouse Phenotype Single KO abnormal erythrocyte physiology 245 1.154218e-11 4.3139486636734693e-10 2.275704 86 0.006962999 264 0.03379331884469697 1.507739 32 45 0.003613369 Mouse Phenotype Single KO increased compact bone thickness 280 5.684502e-11 1.8590351719285712e-9 2.168656 89 0.007205894 288 0.04051823062847222 1.590193 24 32 0.002710027 Mouse Phenotype Single KO increased metastatic potential 302 1.398456e-10 4.2402852953642385e-9 2.3311 73 0.005910453 125 0.00328370899072 1.734756 27 33 0.00304878 Mouse Phenotype Single KO hemolysis 519 1.634902e-7 0.000002884546746435453 2.174016 56 0.004534046 233 0.02265316431630901 1.64149 24 31 0.002710027 Mouse Phenotype Single KO abnormal erythrocyte osmotic lysis 565 5.207181e-7 0.000008439319719823008 2.179761 51 0.00412922 298 0.04856817489261745 1.608471 22 29 0.002484192 Mouse Phenotype abnormal platelet activation 40 2.916834e-43 6.9719624685e-41 2.703051 257 0.02080803 420 0.023081801971428572 1.335762 63 100 0.007113821 Mouse Phenotype abnormal platelet aggregation 42 7.899771e-43 1.7983264412142856e-40 2.711477 253 0.02048417 346 0.0108041704066474 1.375912 61 94 0.006887986 Mouse Phenotype abnormal platelet physiology 43 2.723414e-42 6.055479361395348e-40 2.339683 328 0.02655655 141 0.00013146734385106383 1.429568 89 132 0.01004968 Mouse Phenotype abnormal erythropoiesis 49 2.224756e-38 4.340998391020408e-36 2.070647 388 0.03141446 193 0.0007576582249740933 1.366072 96 149 0.01084011 Mouse Phenotype decreased platelet aggregation 50 1.246819e-37 2.3841672917999999e-35 2.949087 193 0.01562627 467 0.029875402059957173 1.384057 47 72 0.005307136 Mouse Phenotype abnormal embryonic erythropoiesis 57 1.486874e-34 2.494035493684211e-32 3.430058 142 0.01149704 285 0.004579407009473685 1.709885 25 31 0.002822945 Mouse Phenotype abnormal embryonic erythrocyte morphology 59 3.783988e-34 6.131984621694916e-32 3.205548 154 0.01246863 218 0.0015634502448165137 1.685333 31 39 0.003500452 Mouse Phenotype decreased erythroid progenitor cell number 65 1.610552e-32 2.3689981033846155e-30 2.310873 256 0.02072707 289 0.0047445817380622835 1.450702 52 76 0.005871725 Mouse Phenotype abnormal megakaryocyte progenitor cell morphology 75 2.806671e-29 3.5779441908e-27 2.041296 303 0.02453243 463 0.02875977710151188 1.29284 75 123 0.008468835 Mouse Phenotype abnormal embryonic hematopoiesis 76 3.24475e-29 4.081980888157895e-27 2.334459 224 0.01813618 246 0.0025595830831707314 1.529366 44 61 0.004968383 Mouse Phenotype decreased mean corpuscular volume 98 3.862215e-24 3.7680242464285716e-22 2.118338 226 0.01829811 449 0.026037860979955457 1.32016 66 106 0.007452575 Mouse Phenotype increased respiratory quotient 114 1.207729e-21 1.0129032428947369e-19 2.571429 135 0.01093029 308 0.006183291161688312 1.51447 40 56 0.004516712 Mouse Phenotype decreased mean corpuscular hemoglobin 151 7.96431e-18 5.042832311920529e-16 2.074438 171 0.01384503 452 0.026295161402654865 1.376791 50 77 0.00564589 Mouse Phenotype microcytic anemia 162 2.783701e-17 1.6428990901851854e-15 3.120198 77 0.006234313 474 0.031881578088607594 1.608471 22 29 0.002484192 Mouse Phenotype increased B cell derived lymphoma incidence 188 7.257868e-16 3.6910891461702126e-14 2.007717 163 0.01319731 503 0.03587517196222664 1.359139 50 78 0.00564589 Mouse Phenotype abnormal erythrocyte physiology 256 2.085753e-13 7.789798606640625e-12 2.264153 102 0.008258441 406 0.019417168793349752 1.464905 38 55 0.004290876 Mouse Phenotype increased compact bone thickness 283 2.30833e-12 7.798566477031802e-11 2.230742 96 0.00777265 332 0.008280689945783133 1.635627 27 35 0.00304878 Mouse Phenotype decreased cellular sensitivity to ultraviolet irradiation 301 1.044739e-11 3.318521454817276e-10 3.655678 40 0.003238604 314 0.006857797764649682 1.978907 14 15 0.001580849 Mouse Phenotype hemolysis 319 3.252256e-11 9.747592356112853e-10 2.483078 69 0.005586592 301 0.005474949417607974 1.649089 28 36 0.003161698 Mouse Phenotype abnormal erythrocyte osmotic lysis 344 9.532387e-11 2.649393956598837e-9 2.517072 64 0.005181767 368 0.012370450486141304 1.621373 26 34 0.002935863