# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of interleukin-2 secretion	91	1.645848e-21	2.379968552967033e-19	6.50006	44	0.004962219	575	0.03623448508869565	2.511637	7	7	0.0009363296	
GO Biological Process	multi-organism metabolic process	152	4.385163e-15	3.7963394682236844e-13	2.060636	144	0.01623999	620	0.04751757348387097	1.298534	76	147	0.01016586	
GO Biological Process	coronary artery morphogenesis	160	2.619262e-14	2.154179291125e-12	3.612829	51	0.005751663	364	0.009062541843131868	2.511637	9	9	0.001203852	
GO Biological Process	head morphogenesis	175	1.955959e-13	1.4707693989142857e-11	2.33141	96	0.01082666	390	0.011318494533333336	1.718489	26	38	0.003477796	
GO Biological Process	negative regulation of cAMP-dependent protein kinase activity	236	2.220177e-11	1.2379368280932204e-9	4.178889	33	0.003721665	448	0.01850589823236607	2.511637	8	8	0.001070091	
GO Biological Process	regulation of cAMP-dependent protein kinase activity	346	3.144083e-9	1.1957511039595377e-7	2.703325	47	0.005300553	367	0.009417713436512262	2.176752	13	15	0.001738898	
GO Biological Process	unsaturated fatty acid biosynthetic process	347	3.314955e-9	1.257103540201729e-7	2.243038	67	0.007556107	544	0.030123103851102936	1.545623	32	52	0.004280364	
GO Biological Process	face morphogenesis	350	4.29607e-9	1.6151995751428572e-7	2.107122	76	0.008571106	492	0.02332024072113821	1.726751	22	32	0.00294275	
GO Biological Process	positive regulation of antigen receptor-mediated signaling pathway	742	0.00001512332	0.00026820453892183286	2.220035	36	0.004059998	201	0.0003020645831293533	2.260474	18	20	0.002407705	
GO Biological Process	Golgi ribbon formation	771	0.00002205022	0.0003763409143709468	2.751423	23	0.002593887	461	0.019990484859436008	2.283307	10	11	0.001337614	
GO Biological Process	megakaryocyte development	776	0.00002318498	0.0003931587007989691	2.174004	36	0.004059998	495	0.023570214713131313	2.040705	13	16	0.001738898	
GO Biological Process	positive regulation of T cell receptor signaling pathway	888	0.00005912599	0.0008761699351463965	2.794873	20	0.002255554	546	0.03017838304578754	2.125232	11	13	0.001471375	
GO Biological Process	neuronal action potential propagation	1261	0.0006147916	0.006415577053449644	3.347323	11	0.001240555	575	0.03623448508869565	2.511637	7	7	0.0009363296	
GO Biological Process	embryonic retina morphogenesis in camera-type eye	1663	0.002953495	0.023370439389657244	2.120028	18	0.002029999	448	0.01850589823236607	2.511637	8	8	0.001070091	
GO Biological Process	establishment of blood-brain barrier	1879	0.005263549	0.0368616505007983	2.001259	18	0.002029999	448	0.01850589823236607	2.511637	8	8	0.001070091	
GO Molecular Function	phosphotyrosine binding	17	4.680621e-12	1.1624459918823529e-9	2.315862	86	0.009698884	52	0.0006280376829615384	1.937549	27	35	0.003611557	
GO Molecular Function	protein phosphorylated amino acid binding	26	3.479429e-11	5.650057399230769e-9	2.126936	95	0.01071388	46	0.00020566353252173913	1.883728	33	44	0.004414125	
GO Molecular Function	glycosphingolipid binding	62	1.490109e-8	0.0000010147161609677419	5.452398	18	0.002029999	86	0.030930367090697675	2.511637	8	8	0.001070091	
Mouse Phenotype Single KO	abnormal CD4-positive, alpha-beta T cell physiology	34	3.74211e-26	1.0078382726470589e-23	2.149068	237	0.02672832	187	0.010700835922459892	1.365387	81	149	0.01083467	
Mouse Phenotype Single KO	abnormal embryonic erythrocyte morphology	89	7.019326e-16	7.222018896853932e-14	2.796581	83	0.00936055	333	0.04737042593093093	1.650504	23	35	0.003076512	
Mouse Phenotype Single KO	decreased circulating alanine transaminase level	97	3.000736e-15	2.8327566548453606e-13	2.070977	144	0.01623999	212	0.013732973186320755	1.506982	45	75	0.006019262	
Mouse Phenotype Single KO	abnormal somite size	239	3.578218e-9	1.3709515575732216e-7	2.002524	87	0.009811661	233	0.01926788429699571	1.750535	23	33	0.003076512	
Mouse Phenotype Single KO	increased circulating tumor necrosis factor level	265	1.199324e-8	4.144230138867925e-7	2.065569	75	0.008458329	235	0.01966963345276596	1.539391	38	62	0.005082932	
Mouse Phenotype Single KO	abnormal bone marrow morphology	273	1.885528e-8	6.3244615003663e-7	2.031184	76	0.008571106	262	0.024210919267938932	1.635485	28	43	0.003745318	
Mouse Phenotype Single KO	abnormal T-helper 17 cell morphology	466	0.000002965124	0.000058265322892703866	2.433039	35	0.00394722	305	0.03620999045573771	1.953496	14	18	0.001872659	
Mouse Phenotype Single KO	multiple persisting craniopharyngeal ducts	724	0.0001552628	0.001963731297790055	2.12396	30	0.003383331	196	0.012271164885714286	2.176752	13	15	0.001738898	
Mouse Phenotype Single KO	decreased T-helper 17 cell number	1033	0.002156609	0.019117200980638915	3.272727	9	0.001014999	329	0.04406810424924012	2.511637	7	7	0.0009363296	
Mouse Phenotype	abnormal platelet physiology	25	7.443578e-32	2.84672197032e-29	2.364752	238	0.0268411	486	0.02734213860493827	1.331929	70	132	0.009363296	
Mouse Phenotype	decreased circulating alanine transaminase level	85	1.035638e-17	1.1649099903529411e-15	2.130059	159	0.01793166	254	0.003183052260590551	1.518664	52	86	0.006955591	
Mouse Phenotype	abnormal embryonic erythrocyte morphology	116	6.217443e-15	5.124566596810345e-13	2.580459	89	0.01003722	402	0.014890527344029852	1.674425	26	39	0.003477796	
Mouse Phenotype	thymus hyperplasia	129	5.773077e-14	4.278789860232558e-12	2.572494	83	0.00936055	460	0.022164518047826088	1.652393	25	38	0.003344034	
Mouse Phenotype	microcytosis	236	5.251675e-10	2.1275959608050848e-8	3.245151	39	0.004398331	543	0.036346238342541436	1.779076	17	24	0.002273943	
Mouse Phenotype	lymph node hyperplasia	271	2.97989e-9	1.0513183870848709e-7	2.102543	78	0.008796662	474	0.023895399848101264	1.598315	28	44	0.003745318	
Mouse Phenotype	increased circulating interleukin-1 beta level	503	0.000002250636	0.00004277998170178926	2.102169	49	0.005526108	449	0.021515252452115812	1.674425	24	36	0.003210273	
Mouse Phenotype	multiple persisting craniopharyngeal ducts	773	0.0001552628	0.0019203979699870634	2.12396	30	0.003383331	323	0.007774803915789474	2.176752	13	15	0.001738898