# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process adherens junction assembly 309 2.010244e-10 8.560776956634305e-9 2.143665 86 0.007856751 521 0.0026688674633397313 1.748737 26 34 0.003166484 GO Biological Process negative regulation of cyclin-dependent protein serine/threonine kinase activity 376 1.975513e-9 6.913770097606384e-8 2.56334 53 0.004841951 826 0.030098998092009683 1.715108 18 24 0.002192181 GO Biological Process gene silencing by miRNA 392 3.345436e-9 1.1230253143877551e-7 2.145445 74 0.00676046 604 0.006622467185099339 1.611162 31 44 0.003775423 GO Biological Process negative regulation of cyclin-dependent protein kinase activity 406 5.215404e-9 1.6903818038423643e-7 2.417939 56 0.005116024 663 0.011923713264555052 1.759085 20 26 0.002435757 GO Biological Process posttranscriptional gene silencing 408 5.833286e-9 1.8813777076960786e-7 2.018368 83 0.007582679 559 0.004176442967620752 1.583176 36 52 0.004384362 GO Biological Process posttranscriptional gene silencing by RNA 415 6.933997e-9 2.1986618439277108e-7 2.019919 82 0.007491321 599 0.006257798697662771 1.56938 35 51 0.004262575 GO Biological Process endoplasmic reticulum organization 492 6.685009e-8 0.0000017879681591666667 2.080931 66 0.0060296 681 0.013556593098237885 1.600767 28 40 0.00341006 GO Biological Process protein localization to membrane raft 569 2.520245e-7 0.000005828454122144113 3.308312 26 0.002375297 660 0.011628817647727272 2.28681 9 9 0.001096091 GO Biological Process regulation of transforming growth factor beta2 production 579 3.202651e-7 0.0000072787019877374785 2.693443 35 0.003197515 763 0.0230156601310616 2.28681 8 8 0.0009743028 GO Biological Process membrane raft assembly 647 8.338717e-7 0.000016959687326584236 3.184066 25 0.002283939 948 0.04911702244092827 2.058129 9 10 0.001096091 GO Biological Process nuclear-transcribed mRNA catabolic process, deadenylation-independent decay 1078 0.00004051001 0.0004945002055565862 2.875054 20 0.001827151 763 0.0230156601310616 2.28681 8 8 0.0009743028 GO Biological Process cellular response to dopamine 1172 0.0000718004 0.0008061616583617747 2.223145 30 0.002740727 791 0.026303194045512006 1.960123 12 14 0.001461454 GO Biological Process protein repair 1210 0.00009813487 0.0010672369870495866 2.431816 24 0.002192582 918 0.043766704990196074 2.28681 7 7 0.0008525149 GO Biological Process positive regulation of protein homooligomerization 2155 0.004385359 0.026778161986542925 2.038777 18 0.001644436 948 0.04911702244092827 2.058129 9 10 0.001096091 GO Cellular Component cytoplasmic stress granule 86 1.095291e-9 2.200770753488372e-8 2.178608 76 0.006943176 80 0.0033351717600000005 1.648631 31 43 0.003775423 GO Cellular Component Sin3 complex 96 6.447839e-9 1.1606110200000001e-7 3.061206 37 0.00338023 120 0.0450960048 1.934993 11 13 0.001339666 GO Cellular Component nuclear lamina 142 8.416687e-7 0.000010242278264788732 2.715129 32 0.002923442 96 0.010498545 2.28681 9 9 0.001096091 GO Cellular Component nucleotide-activated protein kinase complex 290 0.001782492 0.010621193710344829 2.356506 16 0.001461721 124 0.049310514580645164 2.058129 9 10 0.001096091 GO Molecular Function inositol-1,4,5-trisphosphate 3-kinase activity 160 0.000002131157 0.000056235905337499995 3.01667 25 0.002283939 120 0.046952862000000005 2.28681 8 8 0.0009743028 Mouse Phenotype Single KO increased squamous cell carcinoma incidence 38 4.890063e-22 1.1783764971315789e-19 3.764982 78 0.007125891 675 0.03185089484444444 1.671131 19 26 0.002313969 Mouse Phenotype Single KO abnormal liver sinusoid morphology 85 1.655982e-15 1.7839796675294115e-13 2.175933 131 0.01196784 786 0.04920654916539441 1.385946 40 66 0.004871514 Mouse Phenotype Single KO abnormal Mullerian duct morphology 125 1.137901e-12 8.3358075656e-11 2.281945 94 0.008587612 534 0.014490614685580525 1.633436 25 35 0.003044696 Mouse Phenotype Single KO abnormal interventricular septum thickness 139 4.931905e-12 3.249025473741007e-10 2.241952 92 0.008404897 470 0.009681160318085106 1.595449 30 43 0.003653635 Mouse Phenotype Single KO abnormal white fat cell number 326 6.371781e-8 0.0000017897668287423314 2.341969 51 0.004659236 338 0.0025529978789644967 2.03272 16 18 0.001948606 Mouse Phenotype Single KO abnormal renal fat pad morphology 439 7.98643e-7 0.00001665871059453303 2.205405 48 0.004385164 448 0.008010210432366072 2.000959 14 16 0.00170503 Mouse Phenotype Single KO abnormal iris stroma morphology 473 0.000001592146 0.00003082300406342494 2.111776 50 0.004567879 749 0.04326023538317757 2.058129 9 10 0.001096091 Mouse Phenotype Single KO thin interventricular septum 492 0.000002422726 0.00004509126419105691 2.245114 42 0.003837018 649 0.027297750688751923 1.805377 15 19 0.001826818 Mouse Phenotype Single KO persistent right dorsal aorta 496 0.000002623332 0.00004843115145967742 2.024484 53 0.004841951 614 0.023580169820846906 1.960123 12 14 0.001461454 Mouse Phenotype Single KO subcutaneous edema 501 0.000002742492 0.00005012574699401198 2.036743 52 0.004750594 739 0.04065668348579161 1.600767 21 30 0.002557545 Mouse Phenotype Single KO abnormal habituation 512 0.000003108939 0.000055602645357421874 2.3006 39 0.003562945 728 0.03939103670192307 1.934993 11 13 0.001339666 Mouse Phenotype Single KO abnormal ilium morphology 601 0.00001000947 0.00015250701628951747 2.017909 47 0.004293806 749 0.04326023538317757 2.058129 9 10 0.001096091 Mouse Phenotype Single KO abnormal cervical rib 651 0.00001729615 0.0002432885492319508 2.451729 29 0.00264937 627 0.024681065102073366 2.078919 10 11 0.001217878 Mouse Phenotype Single KO increased white fat cell number 779 0.00006026282 0.0007083782320154045 2.32107 28 0.002558012 718 0.03893968337465181 2.28681 7 7 0.0008525149 Mouse Phenotype Single KO increased sternebra number 1661 0.006347222 0.03499187950270921 2.35136 12 0.001096291 718 0.03893968337465181 2.28681 7 7 0.0008525149 Mouse Phenotype abnormal liver sinusoid morphology 54 7.826661e-25 1.3857538114999998e-22 2.336063 188 0.01717522 580 0.001519609020362069 1.495222 51 78 0.00621118 Mouse Phenotype increased squamous cell carcinoma incidence 109 3.778234e-17 3.3141004838532107e-15 2.381584 121 0.01105427 530 0.001030943868792453 1.627154 37 52 0.00450615 Mouse Phenotype enlarged liver sinusoidal spaces 123 2.54561e-16 1.9787461146341463e-14 2.4426 109 0.009957976 1130 0.02980912503982301 1.505948 27 41 0.003288272 Mouse Phenotype abnormal pulmonary valve cusp morphology 236 8.874505e-11 3.595302640042373e-9 2.267538 79 0.007217248 1211 0.03698420600660611 1.609237 19 27 0.002313969 Mouse Phenotype increased fibroblast apoptosis 284 6.679006e-10 2.248520294577465e-8 2.166478 79 0.007217248 880 0.012191383206818182 1.52454 32 48 0.003897211 Mouse Phenotype transmission ratio distortion 315 2.534547e-9 7.692953608571428e-8 2.028235 86 0.007856751 1083 0.025857137421052633 1.545142 25 37 0.003044696 Mouse Phenotype abnormal sebaceous gland number 357 8.877126e-9 2.3774286186554621e-7 3.603517 29 0.00264937 1337 0.04995102616155572 2.28681 6 6 0.0007307271 Mouse Phenotype abnormal pancreatic epsilon cell morphology 370 1.197664e-8 3.094828514594594e-7 2.684418 44 0.004019733 1337 0.04995102616155572 2.28681 6 6 0.0007307271 Mouse Phenotype abnormal axon radial sorting 384 1.672368e-8 4.1639350125e-7 3.117614 34 0.003106158 1337 0.04995102616155572 2.28681 6 6 0.0007307271 Mouse Phenotype increased rhabdomyosarcoma incidence 393 2.181273e-8 5.306654237404581e-7 2.357205 54 0.004933309 722 0.005189611482132963 2.000959 14 16 0.00170503 Mouse Phenotype double ureter 438 6.317766e-8 0.0000013790904275342463 2.171456 60 0.005481454 1296 0.047276068659722226 1.748737 13 17 0.001583242 Mouse Phenotype decreased integument system tumor incidence 461 1.058758e-7 0.0000021958319388286335 2.153487 59 0.005390097 914 0.013817601134573304 1.883256 14 17 0.00170503 Mouse Phenotype decreased abdominal adipose tissue amount 513 2.514066e-7 0.000004685572129824562 2.491045 41 0.003745661 1176 0.03246579826785714 1.646503 18 25 0.002192181 Mouse Phenotype absent sternum 523 2.87774e-7 0.000005260816852772466 2.006924 65 0.005938242 1134 0.029833743074074076 2.058129 9 10 0.001096091 Mouse Phenotype decreased gland tumor incidence 530 3.178369e-7 0.00000573365773754717 2.05245 61 0.005572812 867 0.011512006411764704 1.829448 16 20 0.001948606 Mouse Phenotype persistent right dorsal aorta 569 5.449118e-7 0.00000915624203831283 2.005232 62 0.00566417 648 0.002844955225 2.017774 15 17 0.001826818 Mouse Phenotype abnormal intestinal enteroendocrine cell morphology 589 6.855448e-7 0.000011128172891001699 2.454958 39 0.003562945 1278 0.04588653821830986 1.905675 10 12 0.001217878 Mouse Phenotype increased salivary adenocarcinoma incidence 626 0.0000014786 0.00002258289872204473 5.950411 12 0.001096291 1337 0.04995102616155572 2.28681 6 6 0.0007307271 Mouse Phenotype decreased mammary gland tumor incidence 662 0.000002336269 0.0000337417944244713 2.032934 53 0.004841951 1047 0.022993419664756445 1.858033 13 16 0.001583242 Mouse Phenotype subcutaneous edema 674 0.000002742492 0.00003890351040356084 2.036743 52 0.004750594 1116 0.028110093913978496 1.600767 21 30 0.002557545