# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	15	2.662946e-42	2.3361137609333334e-39	2.835359	232	0.01860018	402	0.0023131692178855723	1.395042	73	114	0.00846966	
GO Biological Process	cellular response to topologically incorrect protein	17	2.153601e-39	1.6670138564117646e-36	2.546951	259	0.02076485	458	0.005891287173144105	1.332212	85	139	0.009861933	
GO Biological Process	rRNA processing	19	9.048e-37	6.266454315789474e-34	2.136646	345	0.02765975	132	7.592591472121212e-10	1.461018	169	252	0.01960784	
GO Biological Process	cellular response to unfolded protein	20	9.802498e-36	6.4495535591e-33	2.546959	234	0.01876052	475	0.007242270349473684	1.350346	75	121	0.008701706	
GO Biological Process	rRNA metabolic process	22	1.568657e-35	9.382707937727272e-33	2.093741	349	0.02798044	131	7.288012704122138e-10	1.455176	173	259	0.02007193	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	24	4.135075e-35	2.2672271635416668e-32	2.589144	223	0.01787862	460	0.005987488032608695	1.368829	71	113	0.008237615	
GO Biological Process	regulation of DNA-templated transcription in response to stress	25	6.428018e-33	3.38345155448e-30	2.422345	236	0.01892087	395	0.0019249344990379747	1.391349	76	119	0.008817728	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	27	5.052162e-32	2.4622740651111113e-29	2.726997	185	0.01483204	173	5.267566715895954e-8	1.606226	87	118	0.01009398	
GO Biological Process	response to topologically incorrect protein	29	7.589006e-32	3.443576894965517e-29	2.152659	292	0.02341057	448	0.004968494738616071	1.295032	107	180	0.01241443	
GO Biological Process	mRNA catabolic process	31	1.659364e-31	7.043732540645162e-29	2.07929	313	0.0250942	143	3.967468866923078e-9	1.483057	145	213	0.0168233	
GO Biological Process	cotranslational protein targeting to membrane	32	4.423464e-31	1.81901133675e-28	2.8901	163	0.01306823	197	5.105766812588833e-7	1.622804	73	98	0.00846966	
GO Biological Process	macromolecular complex disassembly	44	4.185439e-29	1.2517316318409091e-26	2.04173	301	0.02413213	204	0.0000010115903844117646	1.437165	126	191	0.01461887	
GO Biological Process	response to unfolded protein	48	5.858278e-28	1.6060225042083331e-25	2.115622	265	0.02124589	463	0.006356365423326134	1.307135	96	160	0.01113818	
GO Biological Process	nuclear-transcribed mRNA catabolic process	50	1.199484e-27	3.1568019911999994e-25	2.056982	280	0.02244849	175	8.069685315428572e-8	1.463375	133	198	0.01543102	
GO Biological Process	translational elongation	53	3.50164e-27	8.693977501886791e-25	2.566316	173	0.01386996	218	0.0000022095771871559633	1.556114	80	112	0.009281819	
GO Biological Process	protein targeting to ER	55	6.435177e-27	1.5396453480545455e-24	2.675813	159	0.01274753	195	4.079171906410257e-7	1.617742	75	101	0.008701706	
GO Biological Process	protein complex disassembly	56	1.063822e-26	2.4997917317857143e-24	2.106322	255	0.02044416	236	0.000005219516234830508	1.452373	106	159	0.01229841	
GO Biological Process	mitochondrial translational termination	63	1.121998e-24	2.3435510606349206e-22	2.828814	132	0.01058286	312	0.00017219437201923077	1.527495	61	87	0.007077387	
GO Biological Process	mitochondrial translation	65	1.647093e-24	3.334476428769231e-22	2.547492	157	0.01258719	242	0.000006372729696694215	1.547388	76	107	0.008817728	
GO Biological Process	cellular protein complex disassembly	69	2.878862e-24	5.4902818924637685e-22	2.232565	202	0.01619498	293	0.00008778795556996587	1.452373	84	126	0.00974591	
GO Cellular Component	ribosomal subunit	28	3.023197e-36	1.8657444342857143e-34	2.412828	263	0.02108554	35	8.3503872e-11	1.554431	132	185	0.015315	
GO Cellular Component	ribosome	33	5.084493e-30	2.662425425454545e-28	2.031044	315	0.02525455	40	4.637213279999999e-9	1.449296	157	236	0.01821557	
GO Cellular Component	mitochondrial ribosome	36	1.487917e-27	7.1420016e-26	3.165248	125	0.01002165	64	0.000031334472	1.563436	61	85	0.007077387	
GO Cellular Component	large ribosomal subunit	40	1.290184e-24	5.57359488e-23	2.494494	164	0.0131484	53	9.188926913207547e-7	1.553407	82	115	0.009513865	
GO Cellular Component	mitochondrial large ribosomal subunit	43	3.083293e-22	1.2390535590697674e-20	3.578643	84	0.006734547	96	0.0018442944000000001	1.580523	37	51	0.004292841	
GO Cellular Component	catalytic step 2 spliceosome	47	1.806958e-20	6.64345409361702e-19	2.291926	159	0.01274753	81	0.0006728919466666666	1.452373	64	96	0.007425455	
GO Cellular Component	very-low-density lipoprotein particle	56	1.486323e-17	4.586368114285715e-16	4.037166	56	0.004489698	107	0.005962853203738318	1.851775	17	20	0.001972387	
GO Cellular Component	small ribosomal subunit	59	5.54722e-15	1.6246773152542372e-13	2.372324	105	0.008418183	70	0.0001289902134857143	1.573404	52	72	0.006033183	
GO Cellular Component	endopeptidase complex	67	2.256037e-13	5.818555128358209e-12	2.261135	102	0.008177664	125	0.012987392256	1.420799	45	69	0.005221023	
GO Cellular Component	proteasome complex	69	1.133509e-12	2.8387007999999993e-11	2.218052	100	0.008017317	134	0.017503195701492537	1.409656	44	68	0.005105001	
GO Cellular Component	protein-lipid complex	82	1.735648e-10	3.6575606634146342e-9	2.196794	82	0.0065742	144	0.024676896	1.504243	29	42	0.003364659	
GO Cellular Component	plasma lipoprotein particle	85	2.86276e-10	5.819822682352941e-9	2.209295	79	0.006333681	167	0.049440925508982034	1.470527	27	40	0.003132614	
GO Cellular Component	cytosolic small ribosomal subunit	86	3.503533e-10	7.039657004651163e-9	2.327334	70	0.005612122	105	0.004600470857142856	1.584407	32	44	0.003712728	
GO Cellular Component	spliceosomal snRNP complex	89	5.489186e-10	1.065765551460674e-8	2.201894	77	0.006173334	128	0.0139961385	1.44066	41	62	0.004756932	
GO Cellular Component	Bcl-2 family protein complex	101	5.99828e-9	1.0262403801980199e-7	4.019052	26	0.002084503	164	0.04517956097560976	2.178559	7	7	0.0008121592	
GO Cellular Component	endoribonuclease complex	108	9.83403e-9	1.5734447999999998e-7	2.544078	49	0.003928486	154	0.039141298285714284	1.577577	21	29	0.002436478	
GO Cellular Component	exon-exon junction complex	159	0.000001132056	0.00001230309916981132	2.544938	35	0.002806061	129	0.014805155720930233	1.763595	17	21	0.001972387	
GO Cellular Component	pronucleus	199	0.000008153089	0.00007079667232160805	2.556423	29	0.002325022	137	0.01749410802919708	1.888084	13	15	0.001508296	
GO Cellular Component	U1 snRNP	284	0.0003665312	0.0022301616676056336	2.073168	28	0.002244849	155	0.03889686750967742	1.719915	15	19	0.001740341	
GO Molecular Function	structural constituent of ribosome	9	2.375447e-28	1.1143485815555555e-25	2.279464	228	0.01827948	12	9.02678377e-9	1.559956	116	162	0.01345864	
GO Molecular Function	unfolded protein binding	11	4.986373e-24	1.913860618727273e-21	2.544766	154	0.01234667	68	0.003183823859411765	1.418119	69	106	0.008005569	
GO Molecular Function	rRNA binding	14	2.416252e-20	7.286725674285714e-18	3.357577	83	0.006654373	88	0.017713784818181817	1.488682	41	60	0.004756932	
GO Molecular Function	NF-kappaB binding	15	3.595046e-17	1.0118856141333334e-14	3.253187	72	0.005772469	73	0.00522884405260274	1.789531	23	28	0.002668523	
GO Molecular Function	endoribonuclease activity	54	4.681276e-11	3.6600643096296297e-9	2.211078	86	0.006894893	75	0.005388682148	1.556114	40	56	0.00464091	
GO Molecular Function	insulin-like growth factor I binding	121	5.32859e-8	0.0000018592815685950415	2.576696	43	0.003447446	72	0.0051092075616666665	2.178559	12	12	0.001392273	
Human Phenotype	Progressive external ophthalmoplegia	12	1.457157e-17	8.1030072175e-15	4.649788	48	0.003848312	201	0.046046189925373134	1.888084	13	15	0.001508296	
Human Phenotype	Increased serum lactate	15	3.062096e-14	1.3622244405333333e-11	2.050625	137	0.01098372	95	0.002726223243473684	1.437849	66	100	0.007657501	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	251	0.00001448615	0.00038512382051792825	2.523497	28	0.002244849	201	0.046046189925373134	1.888084	13	15	0.001508296	
Human Phenotype	Global brain atrophy	397	0.0002678908	0.004502859718891688	2.149476	27	0.002164676	201	0.046046189925373134	1.888084	13	15	0.001508296	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	8	2.122026e-24	2.42892401025e-21	2.203898	209	0.01675619	217	0.04235403667281107	1.358671	58	93	0.006729319	
Mouse Phenotype Single KO	absent hypoglossal nerve	54	6.315374e-14	1.0709236984814814e-11	3.978282	44	0.00352762	96	0.00080182125875	2.178559	15	15	0.001740341	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	122	9.618938e-10	7.219722562786885e-8	2.648476	52	0.004169005	198	0.028351070945454544	1.782457	18	22	0.002088409	
Mouse Phenotype Single KO	thin hypoglossal nerve	172	2.025145e-8	0.000001078154230523256	2.830166	39	0.003126754	156	0.009230637541666666	2.033322	14	15	0.001624318	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	178	2.616358e-8	0.0000013459545059550563	2.681206	42	0.003367273	164	0.010661132170121951	1.936497	16	18	0.001856364	
Mouse Phenotype Single KO	abnormal infrahyoid muscle connection	193	5.084275e-8	0.0000024122645686528498	3.403278	28	0.002244849	212	0.03898626440849057	2.178559	9	9	0.001044205	
Mouse Phenotype	decreased circulating free fatty acid level	6	1.296749e-28	2.0663695314999997e-25	2.120859	270	0.02164676	348	0.025558742688793105	1.31812	72	119	0.008353637	
Mouse Phenotype	dry eyes	36	6.572277e-19	1.7454872332499998e-16	3.284291	79	0.006333681	329	0.020962091461094227	1.906239	14	16	0.001624318	
Mouse Phenotype	absent hypoglossal nerve	68	6.315374e-14	8.879601590294117e-12	3.978282	44	0.00352762	152	0.0005287560086842105	2.178559	15	15	0.001740341	
Mouse Phenotype	absent hypoglossal canal	135	9.506076e-11	6.7324142693333335e-9	5.125944	25	0.002004329	403	0.046674548166253105	2.178559	8	8	0.0009281819	
Mouse Phenotype	absent segment of posterior cerebral artery	168	9.618938e-10	5.4742063225e-8	2.648476	52	0.004169005	309	0.018968207137864075	1.782457	18	22	0.002088409	
Mouse Phenotype	thin hypoglossal nerve	223	2.025145e-8	8.682695670403587e-7	2.830166	39	0.003126754	224	0.006712099439732143	2.033322	14	15	0.001624318	
Mouse Phenotype	abnormal hypoglossal nerve topology	231	2.616358e-8	0.0000010829003825974025	2.681206	42	0.003367273	241	0.007574958135684647	1.936497	16	18	0.001856364	
Mouse Phenotype	abnormal infrahyoid muscle connection	253	5.084275e-8	0.0000019213736472332015	3.403278	28	0.002244849	344	0.025086446412209307	2.178559	9	9	0.001044205	
Mouse Phenotype	abnormal stapedial artery morphology	270	9.005749e-8	0.000003189035784777778	2.315344	51	0.004088832	405	0.046600007103703704	1.742847	16	20	0.001856364	
Mouse Phenotype	abnormal pharyngeal muscle morphology	311	3.665272e-7	0.000011268059675884244	2.942529	30	0.002405195	372	0.03395077687903226	1.997012	11	12	0.00127625	
Mouse Phenotype	abnormal lipoprotein lipase activity	621	0.0001491707	0.002296652274879227	2.316048	25	0.002004329	281	0.014088878645551601	2.178559	10	10	0.001160227