# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 52 6.810526e-78 1.7234559929615384e-75 2.268137 656 0.03474024 248 0.00000971081139516129 1.325031 163 248 0.01750054 GO Biological Process platelet activation 105 3.193541e-55 4.0022672399047623e-53 2.118821 538 0.02849124 205 0.0000018992275576585364 1.458381 102 141 0.01095126 GO Biological Process regulation of regulatory T cell differentiation 155 3.528184e-45 2.995314403612903e-43 3.420481 189 0.010009 604 0.008568156053642384 1.693438 21 25 0.00225467 GO Biological Process gene silencing 211 2.575659e-36 1.6063079043127963e-34 2.036767 384 0.02033575 448 0.0021447880535491073 1.287998 115 180 0.012347 GO Biological Process positive regulation of leukocyte migration 247 4.595993e-33 2.448529226194332e-31 2.00528 362 0.01917068 771 0.023231813415045398 1.278437 78 123 0.00837449 GO Biological Process positive regulation of leukocyte chemotaxis 250 2.511648e-32 1.3220310412800001e-30 2.182348 289 0.01530477 833 0.03401530412965186 1.313796 58 89 0.006227185 GO Biological Process positive regulation of gene expression, epigenetic 282 3.946484e-30 1.8415525870921984e-28 2.623481 186 0.00985013 605 0.008678732432066115 1.385998 55 80 0.005905089 GO Biological Process positive regulation of regulatory T cell differentiation 292 1.568672e-29 7.069231112328768e-28 3.733775 108 0.00571943 880 0.04366088909659091 1.847998 11 12 0.001181018 GO Biological Process homotypic cell-cell adhesion 326 1.8378e-27 7.418285337423312e-26 2.280574 221 0.01170365 581 0.007257711689156626 1.48347 39 53 0.004187245 GO Biological Process positive regulation of leukocyte mediated immunity 346 2.417663e-26 9.194805611849711e-25 2.004639 285 0.01509294 497 0.004055495244869216 1.379367 65 95 0.006978742 GO Biological Process cellular response to hydrogen peroxide 368 1.086897e-25 3.886542832336957e-24 2.167686 230 0.01218027 761 0.021925003590013144 1.398192 43 62 0.004616706 GO Biological Process regulation of megakaryocyte differentiation 376 2.818633e-25 9.864465863563829e-24 2.203016 218 0.01154478 373 0.0005531951875067025 1.485472 56 76 0.006012454 GO Biological Process platelet-derived growth factor receptor signaling pathway 381 3.467184e-25 1.1974980119685037e-23 2.299708 198 0.01048562 825 0.03125155632969697 1.527271 25 33 0.002684131 GO Biological Process organelle transport along microtubule 404 6.612892e-24 2.153936777920792e-22 2.145455 218 0.01154478 677 0.014243017816543573 1.405089 46 66 0.004938802 GO Biological Process macrophage differentiation 422 1.639788e-22 5.113263102369668e-21 3.021248 108 0.00571943 900 0.04704031070333334 1.631998 17 21 0.001825209 GO Biological Process positive regulation of mRNA metabolic process 540 5.231761e-19 1.2749026481296297e-17 2.167898 166 0.008790976 764 0.022494156503926704 1.43446 37 52 0.003972514 GO Biological Process positive regulation of mRNA catabolic process 578 5.593634e-18 1.2734711039100348e-16 2.503986 116 0.006143092 798 0.029520303662907272 1.612798 20 25 0.002147305 GO Biological Process gene silencing by miRNA 671 3.49235e-16 6.848857473919523e-15 2.218421 132 0.006990415 418 0.0013253659801674641 1.603634 35 44 0.003757784 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 718 2.121416e-15 3.8879823320334263e-14 2.571229 93 0.004925065 809 0.030721889510506795 1.763998 14 16 0.001503114 GO Biological Process actin polymerization or depolymerization 731 3.135953e-15 5.64514439493844e-14 2.056904 147 0.00778478 842 0.035608019576009495 1.453393 31 43 0.003328323 GO Cellular Component platelet dense tubular network membrane 91 5.598046e-20 1.06301357010989e-18 4.244901 61 0.003230419 117 0.02679795692307692 2.015997 9 9 0.0009662873 GO Cellular Component podosome 96 1.949772e-19 3.5095895999999996e-18 2.476857 129 0.006831542 127 0.04848193814173228 1.529377 22 29 0.002362036 GO Molecular Function S100 protein binding 25 3.564286e-26 6.019366196799999e-24 4.652483 74 0.003918869 78 0.005932256420512821 2.015997 13 13 0.001395748 GO Molecular Function ribonucleoprotein complex binding 36 6.368187e-24 7.468468198333333e-22 2.036848 247 0.01308055 109 0.03802234815779817 1.297251 74 115 0.007945029 GO Molecular Function nucleosomal DNA binding 59 3.169545e-19 2.268104913559322e-17 2.481648 127 0.006725626 87 0.010495358183908047 1.533911 35 46 0.003757784 GO Molecular Function O-methyltransferase activity 198 1.585587e-8 3.3809839969696974e-7 2.36055 55 0.002912673 105 0.026347740822857145 1.727998 18 21 0.001932575 GO Molecular Function death receptor binding 343 0.000002753897 0.00003389782254810496 2.105962 48 0.002541969 110 0.0403998958 1.778821 15 17 0.001610479 Human Phenotype Leukocytosis 50 6.692784e-13 8.932189526400001e-11 2.26176 98 0.005189853 49 0.031538450097959185 1.668412 24 29 0.002576766 Mouse Phenotype Single KO abnormal T cell activation 32 1.462622e-88 4.185384266875e-86 2.023446 965 0.05110417 149 0.000008048720300671142 1.304469 187 289 0.0200773 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 45 1.260444e-76 2.5648634906666666e-74 2.085728 777 0.04114812 503 0.016001416944532804 1.19724 155 261 0.01664161 Mouse Phenotype Single KO abnormal erythropoiesis 55 1.98003e-68 3.2965699472727273e-66 2.34183 539 0.02854419 154 0.000013165976222727271 1.484507 81 110 0.008696586 Mouse Phenotype Single KO decreased T cell proliferation 56 9.63024e-67 1.5747162085714284e-64 2.207116 595 0.03150982 220 0.00015099426825454547 1.370878 102 150 0.01095126 Mouse Phenotype Single KO decreased erythroid progenitor cell number 73 4.294944e-55 5.387507151780822e-53 2.671159 338 0.0178997 187 0.00006167450062032087 1.660233 42 51 0.004509341 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 86 1.151633e-49 1.2262213233720932e-47 2.01026 548 0.02902081 170 0.00003127808200117647 1.370878 119 175 0.01277647 Mouse Phenotype Single KO abnormal platelet activation 98 8.430288e-47 7.877157879183674e-45 2.459209 332 0.01758195 321 0.0019262676610591902 1.423057 60 85 0.006441915 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 104 5.581077e-45 4.9140309700961536e-43 2.470036 316 0.01673463 167 0.000024401694231137728 1.673658 44 53 0.004724071 Mouse Phenotype Single KO decreased platelet aggregation 107 3.236661e-44 2.7699163342990656e-42 2.791708 250 0.01323942 429 0.008986833483916084 1.444798 43 60 0.004616706 Mouse Phenotype Single KO abnormal platelet aggregation 112 2.231627e-43 1.8245543249107143e-41 2.426193 315 0.01668167 307 0.0016298263922801303 1.447383 56 78 0.006012454 Mouse Phenotype Single KO abnormal platelet physiology 117 3.685697e-42 2.884609181965812e-40 2.131997 402 0.02128899 224 0.00017893734579464284 1.429525 78 110 0.00837449 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 129 5.550707e-40 3.9401413952713177e-38 3.069423 194 0.01027379 388 0.004989724821649485 1.612798 28 35 0.003006227 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 136 4.073018e-38 2.7423989577941176e-36 3.170069 176 0.009320553 513 0.017823531088109162 1.598895 23 29 0.002469401 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 137 5.714894e-38 3.819801777956204e-36 2.005628 418 0.02213631 278 0.0008641339026258994 1.446775 61 85 0.006549281 Mouse Phenotype Single KO increased interleukin-1 beta secretion 148 7.329398e-35 4.534817397702703e-33 3.201561 158 0.008367315 584 0.030721546842465752 1.527271 25 33 0.002684131 Mouse Phenotype Single KO increased mean corpuscular hemoglobin 170 2.456871e-32 1.3233863380588237e-30 2.020432 347 0.01837632 223 0.00017634772339013453 1.439998 75 105 0.008052394 Mouse Phenotype Single KO abnormal vascular branching morphogenesis 252 2.640644e-24 9.595387741269842e-23 2.297266 191 0.01011492 671 0.0486262355976155 1.529377 22 29 0.002362036 Mouse Phenotype Single KO abnormal platelet volume 289 1.409946e-22 4.4674309764705885e-21 2.208621 192 0.01016788 533 0.022323494671669792 1.414735 40 57 0.00429461 Mouse Phenotype Single KO abnormal liver sinusoid morphology 300 3.810368e-22 1.1630513258666665e-20 2.079757 216 0.01143886 566 0.02773511311837456 1.374544 45 66 0.004831437 Mouse Phenotype Single KO abnormal lymph node cortex morphology 344 3.443219e-20 9.165568715988372e-19 2.1433 182 0.009638299 502 0.015637974372111556 1.469998 35 48 0.003757784 Mouse Phenotype decreased inflammatory response 41 9.2251e-92 2.1512483195121954e-89 2.169964 850 0.04501403 500 0.0021570170538000003 1.214939 182 302 0.01954048 Mouse Phenotype abnormal erythropoiesis 57 2.431255e-74 4.078110360526316e-72 2.240993 642 0.03399883 179 5.217031758100558e-7 1.46126 108 149 0.01159545 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 69 3.877619e-68 5.373031196956522e-66 2.122619 663 0.03511095 820 0.02271579334390244 1.220798 109 180 0.01170281 Mouse Phenotype abnormal platelet physiology 77 2.581083e-62 3.204900592597403e-60 2.323505 498 0.02637293 266 0.00003113128814548872 1.420362 93 132 0.009984969 Mouse Phenotype decreased erythroid progenitor cell number 81 2.289353e-61 2.7022844485185186e-59 2.503417 424 0.02245406 187 0.0000016373928296791442 1.618103 61 76 0.006549281 Mouse Phenotype abnormal interleukin-6 secretion 92 1.622332e-55 1.6859908969565217e-53 2.041368 591 0.03129799 784 0.019506586346938776 1.217998 116 192 0.01245437 Mouse Phenotype abnormal tumor necrosis factor level 93 1.116375e-54 1.1477055241935485e-52 2.021651 596 0.03156278 528 0.0028807962994318185 1.263915 121 193 0.0129912 Mouse Phenotype extramedullary hematopoiesis 100 1.895139e-53 1.8119423979e-51 2.017974 585 0.03098025 321 0.00016642951840186915 1.336318 116 175 0.01245437 Mouse Phenotype abnormal platelet activation 108 1.728588e-50 1.5302805433333334e-48 2.462835 358 0.01895885 525 0.0026559256045714285 1.370878 68 100 0.007300837 Mouse Phenotype abnormal platelet aggregation 110 3.064513e-50 2.663618981181818e-48 2.474522 353 0.01869406 426 0.0008743002585211268 1.415488 66 94 0.007086107 Mouse Phenotype decreased platelet aggregation 116 4.538615e-49 3.7408360357758616e-47 2.788468 279 0.01477519 627 0.00762886523875598 1.399998 50 72 0.005368263 Mouse Phenotype abnormal circulating tumor necrosis factor level 117 6.010876e-49 4.911964567179487e-47 2.260369 412 0.02181857 601 0.006338042579700499 1.284163 93 146 0.009984969 Mouse Phenotype skin inflammation 131 1.567154e-45 1.1437831598473282e-43 2.054619 475 0.0251549 459 0.0012959325179084968 1.321296 97 148 0.01041443 Mouse Phenotype abnormal embryonic hematopoiesis 139 1.707859e-43 1.174736683381295e-41 2.331286 342 0.01811153 259 0.000025951385384942084 1.619408 49 61 0.005260898 Mouse Phenotype abnormal T-helper 2 physiology 140 3.400543e-43 2.3223279730714284e-41 2.483128 300 0.01588731 981 0.041096715862385315 1.334116 45 68 0.004831437 Mouse Phenotype abnormal embryonic erythrocyte morphology 142 4.65555e-43 3.134627714788732e-41 2.981651 219 0.01159773 401 0.0006720298148379053 1.654152 32 39 0.003435688 Mouse Phenotype abnormal circulating interleukin-6 level 150 2.345382e-41 1.4949464868e-39 2.017409 450 0.02383096 962 0.038485151875259874 1.225944 90 148 0.009662873 Mouse Phenotype increased circulating tumor necrosis factor level 158 3.510423e-40 2.124250272341772e-38 2.421602 292 0.01546364 509 0.002377069344400786 1.378284 67 98 0.007193472 Mouse Phenotype abnormal embryonic erythropoiesis 164 2.066689e-39 1.2048544834756098e-37 3.04931 193 0.01022083 593 0.005997771694097808 1.625804 25 31 0.002684131 Mouse Phenotype increased body temperature 183 5.526246e-37 2.887237049508197e-35 3.001083 185 0.009797172 873 0.028208980295532645 1.497598 26 35 0.002791497