# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mitochondrial transport	14	3.899747e-56	3.6654836266428567e-53	2.161336	521	0.03322492	159	8.599365119496856e-9	1.428452	163	239	0.01818182	
GO Biological Process	nuclear-transcribed mRNA catabolic process	27	1.176397e-42	5.733410415925926e-40	2.202982	377	0.02404183	141	4.905729329219858e-10	1.502101	142	198	0.01583938	
GO Biological Process	mRNA catabolic process	31	1.352218e-40	5.739947310322581e-38	2.103057	398	0.02538103	158	7.509711375696202e-9	1.455318	148	213	0.01650864	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	35	3.29934e-38	1.240457573142857e-35	2.685008	229	0.01460366	261	0.000003435513906781609	1.508735	85	118	0.009481316	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	36	3.446964e-38	1.259961091e-35	2.465811	267	0.01702698	888	0.04384639556644144	1.278929	69	113	0.007696598	
GO Biological Process	regulation of DNA-templated transcription in response to stress	43	8.38737e-37	2.566730275116279e-34	2.335001	286	0.01823863	737	0.018590060327001355	1.302449	74	119	0.008254322	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	51	1.978648e-33	5.105299810196079e-31	2.071891	337	0.02149098	437	0.0010864910528375286	1.337764	99	155	0.01104294	
GO Biological Process	cotranslational protein targeting to membrane	71	9.844327e-30	1.824528154830986e-27	2.609121	185	0.01179772	382	0.00039363012746073295	1.453312	68	98	0.007585053	
GO Biological Process	mitochondrial membrane organization	85	8.168161e-28	1.2645274188117646e-25	2.029858	292	0.01862126	229	8.863684041048035e-7	1.520186	90	124	0.01003904	
GO Biological Process	multi-organism metabolic process	88	4.694585e-27	7.020005001704546e-25	2.103851	260	0.01658058	264	0.00000406108173219697	1.453312	102	147	0.01137758	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	89	6.573313e-27	9.718901771573033e-25	2.5534	173	0.01103246	363	0.00023908449347382919	1.563044	50	67	0.005577245	
GO Biological Process	regulation of membrane permeability	91	7.575402e-27	1.0954364276703295e-24	2.253368	221	0.01409349	213	4.415936140985915e-7	1.654897	64	81	0.007138873	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	95	3.277191e-26	4.5394269862105265e-24	2.204287	226	0.01441235	851	0.03642091116216216	1.31462	59	94	0.006581149	
GO Biological Process	cellular response to epidermal growth factor stimulus	97	4.118779e-26	5.5875270990721655e-24	2.517287	172	0.01096869	733	0.018611798773533424	1.5433	28	38	0.003123257	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	102	9.149053e-26	1.1803175335980394e-23	2.529872	168	0.0107136	450	0.0013203863417333333	1.434262	63	92	0.007027328	
GO Biological Process	protein targeting to ER	104	1.387917e-25	1.756115365673077e-23	2.422894	181	0.01154263	410	0.0007227301522439025	1.430881	69	101	0.007696598	
GO Biological Process	regulation of mitochondrial membrane permeability	105	1.69576e-25	2.1251910323809522e-23	2.307236	199	0.01269052	207	3.5992814650241544e-7	1.692798	59	73	0.006581149	
GO Biological Process	mitochondrial transmembrane transport	107	2.651611e-25	3.260985901775701e-23	2.436051	177	0.01128755	634	0.010332502839905363	1.387907	55	83	0.006134969	
GO Biological Process	translational elongation	108	2.976393e-25	3.626514396944444e-23	2.312689	196	0.0124992	249	0.0000018422420318875502	1.533457	82	112	0.009146682	
GO Biological Process	viral gene expression	116	2.361713e-24	2.6791190833620693e-22	2.208725	208	0.01326446	300	0.000029938602350666667	1.451292	88	127	0.009815951	
GO Cellular Component	ribosomal subunit	38	8.732891e-34	3.9711672757894735e-32	2.189218	300	0.01913143	49	8.919946579591836e-8	1.449153	128	185	0.01427775	
GO Cellular Component	mitochondrial ribosome	43	6.45918e-26	2.5956890790697672e-24	2.81983	140	0.008928002	70	0.00004913138468571429	1.527737	62	85	0.006915784	
GO Cellular Component	large ribosomal subunit	45	1.631948e-23	6.26668032e-22	2.27454	188	0.01198903	52	3.071341218461538e-7	1.548093	85	115	0.009481316	
GO Cellular Component	mitochondrial large ribosomal subunit	48	2.67746e-21	9.638856e-20	3.185401	94	0.005994516	77	0.00015544268883116883	1.642728	40	51	0.004461796	
GO Cellular Component	PcG protein complex	54	1.205285e-18	3.856912e-17	2.268229	147	0.009374402	153	0.02549799529411765	1.457029	32	46	0.003569437	
GO Cellular Component	DNA-directed RNA polymerase III complex	59	4.083348e-17	1.1959364989830507e-15	5.044727	43	0.002742172	143	0.014285388083916084	1.763771	16	19	0.001784718	
GO Cellular Component	MLL1 complex	67	7.245925e-16	1.8687997611940298e-14	3.092583	71	0.004527772	126	0.0069219894857142856	1.661138	23	29	0.002565533	
GO Cellular Component	chylomicron	79	2.757654e-14	6.031931787341772e-13	4.000835	45	0.002869715	168	0.041116330285714285	1.795267	12	14	0.001338539	
GO Cellular Component	very-low-density lipoprotein particle	95	5.588932e-13	1.016597315368421e-11	3.153904	55	0.003507429	161	0.03521645754037267	1.675583	16	20	0.001784718	
GO Cellular Component	spliceosomal snRNP complex	116	3.576193e-11	5.3272944e-10	2.138113	94	0.005994516	156	0.02936383753846154	1.385058	41	62	0.004573341	
GO Cellular Component	pre-autophagosomal structure	188	1.057964e-7	9.72426485106383e-7	2.006946	70	0.004464001	147	0.01854948048979592	1.570859	24	32	0.002677078	
GO Cellular Component	BLOC complex	276	0.00002793608	0.00017490415304347826	2.060529	40	0.002550858	157	0.030796680152866237	1.639157	18	23	0.002007808	
GO Cellular Component	telomerase holoenzyme complex	304	0.00006372604	0.00036223222736842106	2.144802	33	0.002104458	139	0.013682403453237409	1.713664	18	22	0.002007808	
GO Molecular Function	unfolded protein binding	9	9.85806e-31	4.624525480000001e-28	2.576204	196	0.0124992	70	0.0012355206517142858	1.422665	72	106	0.008031233	
GO Molecular Function	structural constituent of ribosome	12	2.429209e-26	8.546766998333333e-24	2.075561	261	0.01664435	32	0.0000013694109775	1.460963	113	162	0.01260457	
GO Molecular Function	ribonucleoprotein complex binding	14	1.012309e-23	3.052834712857143e-21	2.144928	216	0.01377463	82	0.002730804531463415	1.384177	76	115	0.008477412	
GO Molecular Function	ribonuclease activity	18	1.963356e-20	4.605160573333333e-18	2.124352	188	0.01198903	69	0.0011936615846376813	1.438632	68	99	0.007585053	
GO Molecular Function	endoribonuclease activity	57	4.622043e-12	3.423555358947368e-10	2.126847	104	0.00663223	106	0.010977602284905661	1.496056	40	56	0.004461796	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	85	2.035577e-9	1.0110830698823529e-7	2.199738	72	0.004591544	116	0.018370373317241378	1.661138	23	29	0.002565533	
GO Molecular Function	RNA cap binding	413	0.0001960383	0.0020040525486682806	2.039728	32	0.002040686	119	0.02243481038151261	1.848069	15	17	0.001673173	
Human Phenotype	Increased serum lactate	14	1.14555e-19	5.4601822499999995e-17	2.131159	179	0.01141509	115	0.009901008625217391	1.382356	66	100	0.007361963	
Human Phenotype	Abnormality of the mitochondrion	18	1.086817e-18	4.029072133888889e-16	2.242779	151	0.009629488	97	0.00611744729628866	1.474985	50	71	0.005577245	
Human Phenotype	Abnormality of mitochondrial metabolism	20	4.161924e-18	1.3886259426e-15	2.234541	147	0.009374402	121	0.010879151831404959	1.457029	48	69	0.005354155	
Human Phenotype	Leukodystrophy	76	1.331356e-10	1.1689656036842107e-8	2.056352	97	0.00618583	186	0.04278228918817204	1.466135	35	50	0.003904071	
Human Phenotype	Abnormality of monocarboxylic acid metabolism	81	1.533572e-10	1.2633982661728395e-8	2.831916	51	0.003252344	178	0.03811808792696628	1.933365	12	13	0.001338539	
Human Phenotype	CNS hypomyelination	181	4.70299e-7	0.00001733870291160221	2.188076	51	0.003252344	185	0.0427264975945946	1.605767	23	30	0.002565533	
Human Phenotype	Abnormality of aromatic amino acid family metabolism	471	0.0001751419	0.002481362842250531	2.140528	29	0.001849372	151	0.02712972228476821	2.094479	10	10	0.001115449	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	73	2.620611e-15	3.287251359863014e-13	2.957418	73	0.004655315	259	0.03891230027027027	1.713664	18	22	0.002007808	
Mouse Phenotype Single KO	increased hepatocyte apoptosis	91	5.806755e-14	5.843126981868132e-12	2.13384	122	0.007780116	230	0.021215741823478265	1.545925	31	42	0.003457892	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	163	7.989069e-11	4.488092321042945e-9	2.620924	60	0.003826287	210	0.015557520615714285	1.745399	20	24	0.002230898	
Mouse Phenotype	decreased circulating free fatty acid level	11	2.271445e-33	1.9742986950000003e-30	2.080604	333	0.02123589	344	0.015237840970639533	1.320049	75	119	0.008365867	
Mouse Phenotype	abnormal cellular replicative senescence	44	2.23454e-20	4.85555385e-18	2.116825	189	0.0120528	272	0.005321663145220588	1.421253	57	84	0.006358059	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	58	6.439495e-19	1.0615174430172414e-16	3.123153	85	0.005420573	233	0.0025439551801287557	1.745399	25	30	0.002788622	
Mouse Phenotype	pancytopenia	67	3.819483e-18	5.450459248208955e-16	2.659513	105	0.006696002	480	0.03844053830625	1.588915	22	29	0.002453988	
Mouse Phenotype	early cellular replicative senescence	72	8.166594e-18	1.0844556282500001e-15	2.101332	166	0.01058606	300	0.008511071533	1.434574	50	73	0.005577245	
Mouse Phenotype	absent segment of posterior cerebral artery	105	2.620611e-15	2.386253502e-13	2.957418	73	0.004655315	406	0.025918552241379306	1.713664	18	22	0.002007808	
Mouse Phenotype	absent hypoglossal nerve	130	5.696105e-14	4.189266146538462e-12	3.59592	50	0.003188572	498	0.041839991933734944	1.815215	13	15	0.001450084	
Mouse Phenotype	abnormal cerebral artery morphology	177	8.001091e-12	4.3219452571186443e-10	2.455494	75	0.004782858	458	0.03473383959170306	1.658129	19	24	0.002119353	
Mouse Phenotype	abnormal hair medulla	286	5.710095e-9	1.9088887515734268e-7	2.685105	46	0.002933486	395	0.02461139368860759	1.933365	12	13	0.001338539	
Mouse Phenotype	dry eyes	304	1.226627e-8	3.8578226141447366e-7	2.182507	66	0.004208915	417	0.027014846244604315	1.832669	14	16	0.001561629	
Mouse Phenotype	increased liver adenoma incidence	312	1.617382e-8	4.956342724999999e-7	2.227783	62	0.003953829	374	0.021697012490374333	1.645662	22	28	0.002453988	
Mouse Phenotype	abnormal hypoglossal nerve topology	387	1.210211e-7	0.000002989877873643411	2.38658	47	0.002997258	494	0.0408050706194332	1.745399	15	18	0.001673173	
Mouse Phenotype	decreased type II pneumocyte number	640	0.00001394162	0.00020827473253124998	2.063626	43	0.002742172	482	0.039230707101659754	1.919939	11	12	0.001226994