# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process production of molecular mediator of immune response 23 6.463307e-22 3.6978546440434787e-19 3.848258 75 0.02172654 310 0.04071338992612903 1.918165 23 68 0.006946542 GO Biological Process regulation of gene expression, epigenetic 34 1.876717e-20 7.263446765588236e-18 2.496546 132 0.0382387 291 0.03435607792714777 1.463509 64 248 0.01932951 GO Biological Process mitochondrial transport 38 1.635467e-19 5.663450066578947e-17 2.449801 130 0.03765933 170 0.0061509864537058825 1.566077 66 239 0.01993355 GO Biological Process regulation of chromatin organization 52 5.947563e-17 1.5050765676346155e-14 2.350057 121 0.03505214 295 0.036523794770508475 1.589352 44 157 0.01328904 GO Biological Process mitochondrial membrane organization 58 2.985597e-16 6.773701883275863e-14 2.747293 87 0.02520278 234 0.015349827288888888 1.737917 38 124 0.0114769 GO Biological Process erythrocyte homeostasis 133 2.483569e-12 2.457239433909774e-10 2.769909 63 0.01825029 163 0.0055210304050306745 2.062217 28 77 0.00845666 GO Biological Process erythrocyte differentiation 140 3.776517e-12 3.549656228785714e-10 2.854136 59 0.01709154 159 0.005087609547735849 2.136935 26 69 0.007852613 GO Biological Process thymus development 148 1.324285e-11 1.1774504266891893e-9 2.566836 67 0.01940904 328 0.04327726303353659 2.142414 17 45 0.0051344 GO Biological Process myeloid cell homeostasis 179 1.413256e-10 1.0389405421229051e-8 2.336373 72 0.02085747 191 0.008157870378534032 1.910264 32 95 0.009664754 GO Biological Process platelet-derived growth factor receptor signaling pathway 192 4.012195e-10 2.7498163544270832e-8 2.922574 46 0.01332561 217 0.012194008688018433 2.577771 15 33 0.004530353 GO Biological Process face development 215 1.543796e-9 9.448749564651162e-8 2.522477 55 0.01593279 151 0.004228816327019868 2.38186 21 50 0.006342495 GO Biological Process cytokine production 216 1.589388e-9 9.682757727777778e-8 2.021626 88 0.02549247 176 0.007149900032784092 1.774923 41 131 0.01238297 GO Biological Process neurotrophin TRK receptor signaling pathway 247 7.08455e-9 3.774315524291498e-7 4.852842 21 0.00608343 236 0.016292314023728813 3.402658 9 15 0.002718212 GO Biological Process macromolecular complex disassembly 248 7.231958e-9 3.8373119081451613e-7 2.009768 82 0.02375435 214 0.010900724978971963 1.603347 54 191 0.01630927 GO Biological Process fatty acid biosynthetic process 271 1.944775e-8 9.443282001845018e-7 2.176207 64 0.01853998 252 0.020304263894444445 1.768966 34 109 0.0102688 GO Biological Process face morphogenesis 285 3.074237e-8 0.0000014194345502807017 2.777452 39 0.0112978 136 0.0027844085997794123 2.835548 16 32 0.004832377 GO Biological Process cellular response to dexamethasone stimulus 291 3.929691e-8 0.0000017770035693814435 2.890278 36 0.01042874 190 0.007889146012105264 2.592501 16 35 0.004832377 GO Biological Process regulation of pro-B cell differentiation 300 5.087906e-8 0.0000022317251684666664 7.35195 13 0.003765933 301 0.038059421587375415 4.725914 5 6 0.001510118 GO Biological Process head morphogenesis 331 1.210107e-7 0.000004810815109667674 2.557627 41 0.01187717 134 0.0023181797853731342 2.686309 18 38 0.005436424 GO Biological Process regulation of megakaryocyte differentiation 339 1.673885e-7 0.000006497537674041298 2.432282 44 0.01274623 308 0.03996217831136363 1.865492 25 76 0.007550589 GO Cellular Component mitochondrial proton-transporting ATP synthase complex 94 9.717776e-7 0.00001786416694468085 4.842242 15 0.004345307 38 0.03838686972631579 2.712263 11 23 0.003322259 GO Cellular Component proton-transporting ATP synthase complex 98 0.000001441009 0.000025408811755102042 4.687097 15 0.004345307 47 0.048227413787234046 2.599252 11 24 0.003322259 GO Molecular Function cAMP response element binding 133 0.0004740854 0.015049538036090226 3.059549 13 0.003765933 50 0.043276859484 3.489905 8 13 0.002416188 Mouse Phenotype Single KO abnormal platelet physiology 29 5.917601e-24 1.868533529551724e-21 3.133174 108 0.03128621 191 0.04818192864921466 1.701329 33 110 0.009966777 Mouse Phenotype Single KO abnormal T cell activation 56 1.459008e-18 2.385738617142857e-16 2.053135 179 0.051854 148 0.02463053572297297 1.452115 74 289 0.02234974 Mouse Phenotype Single KO abnormal liver sinusoid morphology 60 1.914558e-18 2.921934601e-16 3.581524 68 0.01969873 167 0.032757714443113775 1.976291 23 66 0.006946542 Mouse Phenotype Single KO cortical renal glomerulopathies 63 6.936562e-18 1.0082237814920633e-15 2.535954 111 0.03215527 119 0.012797792420168068 1.735186 41 134 0.01238297 Mouse Phenotype Single KO abnormal erythropoiesis 73 1.520301e-16 1.907040583150685e-14 2.495491 105 0.03041715 24 0.00003242797407166667 2.216883 43 110 0.01298701 Mouse Phenotype Single KO abnormal T cell proliferation 76 2.63867e-16 3.1792501565789476e-14 2.019534 162 0.04692932 170 0.03644696072352941 1.455799 67 261 0.02023558 Mouse Phenotype Single KO decreased circulating alanine transaminase level 132 8.931099e-12 6.195611632045454e-10 2.548989 69 0.01998841 139 0.019612568004316544 1.96598 26 75 0.007852613 Mouse Phenotype Single KO decreased erythroid progenitor cell number 138 1.377164e-11 9.138181701449276e-10 2.680248 62 0.0179606 104 0.006064232054807692 2.335157 21 51 0.006342495 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 151 4.283029e-11 2.597330897549669e-9 2.046784 102 0.02954809 152 0.02647332677697368 1.587907 49 175 0.01479915 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 207 3.703611e-9 1.638355841884058e-7 2.618257 49 0.01419467 123 0.01308014914390244 2.054745 25 69 0.007550589 Mouse Phenotype Single KO abnormal erythroid progenitor cell morphology 214 7.793626e-9 3.33487071411215e-7 2.047241 78 0.0225956 57 0.0005021250588947368 2.20172 33 85 0.009966777 Mouse Phenotype Single KO extramedullary hematopoiesis 230 2.12312e-8 8.452786886956522e-7 2.155933 65 0.01882966 109 0.007448739807614678 1.840619 37 114 0.01117487 Mouse Phenotype Single KO abnormal interleukin-1 beta secretion 278 1.631259e-7 0.000005373179375179856 2.406533 45 0.01303592 168 0.032783869597619045 1.944376 24 70 0.007248565 Mouse Phenotype Single KO increased body temperature 365 0.000002536338 0.00006363081387945205 2.838168 27 0.007821553 128 0.01438555399921875 2.577771 15 33 0.004530353 Mouse Phenotype abnormal platelet aggregation 12 6.803439e-33 5.42064002325e-30 4.102991 107 0.03099652 191 0.011597533046073298 1.870255 31 94 0.00936273 Mouse Phenotype abnormal platelet activation 13 7.558039e-33 5.5586469906923074e-30 4.064211 108 0.03128621 206 0.015919891144660192 1.814751 32 100 0.009664754 Mouse Phenotype abnormal platelet physiology 34 1.185397e-24 3.333406093235294e-22 3.011595 118 0.03418308 131 0.003779631894732824 1.80444 42 132 0.01268499 Mouse Phenotype decreased erythrocyte cell number 67 1.034044e-18 1.4755962214925373e-16 2.1122 169 0.04895713 302 0.04910488443377484 1.448462 59 231 0.01781939 Mouse Phenotype abnormal erythropoiesis 71 2.334435e-18 3.143596202112676e-16 2.405892 126 0.03650058 38 0.000010911526474736842 2.055297 54 149 0.01630927 Mouse Phenotype cortical renal glomerulopathies 81 8.616633e-17 1.0170818285555555e-14 2.225298 134 0.03881808 141 0.005315838020212766 1.641633 55 190 0.0166113 Mouse Phenotype abnormal liver sinusoid morphology 86 2.846392e-16 3.1644597572093027e-14 2.994504 76 0.02201622 113 0.0026860986459292034 2.108485 29 78 0.008758683 Mouse Phenotype abnormal third pharyngeal arch artery morphology 106 2.23567e-14 2.0165321575471698e-12 4.173873 43 0.01245655 298 0.048683200308724826 2.700522 10 21 0.003020236 Mouse Phenotype extramedullary hematopoiesis 119 7.123536e-13 5.723372075294118e-11 2.113382 112 0.03244496 109 0.002424638899541284 1.717532 53 175 0.01600725 Mouse Phenotype abnormal mean corpuscular hemoglobin 132 2.944269e-12 2.1325875688636365e-10 2.064114 112 0.03244496 158 0.007289947834177215 1.633522 53 184 0.01600725 Mouse Phenotype decreased circulating alanine transaminase level 152 2.849105e-11 1.7921245332236843e-9 2.443198 71 0.02056779 283 0.04480274464664311 1.78046 27 86 0.008154636 Mouse Phenotype enlarged liver sinusoidal spaces 158 3.848474e-11 2.328813918607595e-9 3.197592 45 0.01303592 262 0.03643238026030534 2.213111 16 41 0.004832377 Mouse Phenotype abnormal liver vasculature morphology 166 7.057865e-11 4.065075136445783e-9 2.107645 93 0.0269409 172 0.009289462041279069 1.806721 36 113 0.01087285 Mouse Phenotype heart hemorrhage 195 7.718553e-10 3.7844659093846155e-8 2.414042 62 0.0179606 188 0.011595687598404255 2.025392 25 70 0.007550589 Mouse Phenotype decreased erythroid progenitor cell number 233 1.134071e-8 4.653584906008584e-7 2.163926 67 0.01940904 257 0.0347974306307393 1.865492 25 76 0.007550589 Mouse Phenotype decreased mean corpuscular hemoglobin 244 2.375615e-8 9.308711071721311e-7 2.343848 54 0.01564311 137 0.004772738142919708 2.062217 28 77 0.00845666 Mouse Phenotype abnormal circulating interleukin-10 level 271 7.252187e-8 0.000002558603686605166 3.337131 28 0.00811124 301 0.048943330754152824 2.268439 14 35 0.00422833 Mouse Phenotype increased bleeding time 287 1.47364e-7 0.0000049092237073170725 2.06676 63 0.01825029 294 0.04767247933673469 1.731177 29 95 0.008758683 Mouse Phenotype abnormal vascular branching morphogenesis 299 2.307236e-7 0.0000073777536441471575 2.196762 53 0.01535342 159 0.0073011644452830185 2.43047 18 42 0.005436424 Mouse Phenotype increased circulating interferon-gamma level 331 7.207369e-7 0.000020818626890936554 2.901171 29 0.008400927 255 0.033907932774117654 2.072131 19 52 0.005738448