# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	15	2.561086e-32	2.2467553782666666e-29	2.0322	340	0.02630764	111	5.386935394864866e-10	1.422134	180	252	0.01908599	
GO Biological Process	rRNA metabolic process	16	4.546864e-32	3.739511461e-29	2.009097	347	0.02684927	113	6.702409718053097e-10	1.414446	184	259	0.01951013	
GO Biological Process	nuclear-transcribed mRNA catabolic process	17	8.102648e-32	6.271926178352941e-29	2.127001	300	0.02321263	181	0.0000013175794082872928	1.387658	138	198	0.01463259	
GO Biological Process	mRNA catabolic process	18	1.664083e-31	1.2165371220555556e-28	2.058021	321	0.02483751	168	6.077325928690475e-7	1.383409	148	213	0.01569293	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	23	3.303528e-30	1.8900489109565215e-27	2.631835	185	0.01431445	180	0.0000012352843107222221	1.501677	89	118	0.009436963	
GO Biological Process	viral gene expression	42	1.754304e-23	5.496401508571428e-21	2.319144	180	0.01392758	189	0.000002373518768465608	1.473644	94	127	0.00996713	
GO Biological Process	protein targeting to ER	43	2.558014e-23	7.828117726976745e-21	2.501228	154	0.01191582	166	4.779355141686746e-7	1.557307	79	101	0.00837663	
GO Biological Process	protein-lipid complex assembly	49	8.499409e-23	2.2825249598163267e-20	3.689965	83	0.00642216	472	0.008234414313347458	1.647714	24	29	0.002544799	
GO Biological Process	cotranslational protein targeting to membrane	53	3.787196e-22	9.402964559245282e-20	2.498343	146	0.01129681	204	0.000005021604699901961	1.523715	75	98	0.007952497	
GO Biological Process	translational termination	54	4.49663e-22	1.0957621142592592e-19	2.50265	145	0.01121944	277	0.00011835598894945847	1.467043	70	95	0.007422331	
GO Biological Process	translational elongation	55	4.771149e-22	1.141519085290909e-19	2.347912	164	0.01268957	237	0.00003061427469198312	1.457687	82	112	0.00869473	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	57	5.925257e-21	1.367902751982456e-18	2.503148	137	0.01060043	206	0.0000060808601361650485	1.536523	71	92	0.007528364	
GO Biological Process	multi-organism metabolic process	58	6.644051e-21	1.5073977087758621e-18	2.05194	209	0.01617146	210	0.00000785090378142857	1.422134	105	147	0.0111335	
GO Biological Process	protein localization to endoplasmic reticulum	59	8.589074e-21	1.9156546570508475e-18	2.165726	183	0.0141597	149	1.1734427855704698e-7	1.525353	95	124	0.01007316	
GO Biological Process	plasma lipoprotein particle assembly	62	1.250079e-20	2.6531918646774194e-18	3.836264	71	0.005493655	470	0.008047918409574467	1.684681	22	26	0.002332732	
GO Biological Process	mitochondrial translational elongation	65	1.796899e-20	3.637752914e-18	2.607157	124	0.009594553	333	0.0006301928084684686	1.452249	62	85	0.006574064	
GO Biological Process	mitochondrial translational termination	71	2.436405e-20	4.5155849852112674e-18	2.585321	125	0.009671928	341	0.0007728763068035191	1.441749	63	87	0.006680098	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	76	5.643386e-20	9.77122583868421e-18	2.263529	159	0.01230269	193	0.0000027869296101036273	1.516943	80	105	0.008482664	
GO Biological Process	cellular protein complex disassembly	80	1.437518e-19	2.3645374202500002e-17	2.058657	193	0.01493346	324	0.000544761480617284	1.374729	87	126	0.009224897	
GO Biological Process	viral transcription	83	2.053866e-19	3.2562436980722896e-17	2.22468	160	0.01238007	211	0.000008156646687203791	1.480026	84	113	0.008906797	
GO Cellular Component	ribosomal subunit	31	2.820153e-31	1.5720078658064514e-29	2.266651	256	0.01980811	38	8.920640842105262e-9	1.452883	135	185	0.01431449	
GO Cellular Component	mitochondrial ribosome	39	5.933864e-22	2.629158203076923e-20	2.834847	116	0.008975549	84	0.002190248228571429	1.405403	60	85	0.006361998	
GO Cellular Component	large ribosomal subunit	41	4.462997e-20	1.8809899551219513e-18	2.290009	156	0.01207057	58	0.000014172349903448276	1.454286	84	115	0.008906797	
GO Cellular Component	mitochondrial large ribosomal subunit	45	4.13185e-17	1.5866303999999998e-15	3.124832	76	0.005880532	97	0.006115864082474227	1.483481	38	51	0.004029265	
GO Cellular Component	catalytic step 2 spliceosome	47	5.041149e-17	1.8534266961702125e-15	2.128477	153	0.01183844	129	0.021719071255813956	1.306585	63	96	0.006680098	
GO Cellular Component	small ribosomal subunit	57	1.12239e-13	3.402613894736842e-12	2.267734	104	0.008047044	77	0.0009629827574025974	1.465588	53	72	0.005619765	
GO Cellular Component	endopeptidase complex	62	1.719989e-12	4.793775793548387e-11	2.18223	102	0.007892293	133	0.025513309353383456	1.35618	47	69	0.004983565	
GO Cellular Component	proteasome complex	65	8.059566e-12	2.142604622769231e-10	2.14065	100	0.007737543	145	0.03227261660689655	1.346844	46	68	0.004877532	
GO Cellular Component	cytosolic small ribosomal subunit	94	7.48738e-9	1.3764034723404256e-7	2.181944	68	0.005261529	134	0.02565363008955224	1.447991	32	44	0.003393065	
GO Cellular Component	nuclear telomere cap complex	293	0.001447727	0.008538130566552901	2.036408	23	0.001779635	132	0.023457521454545455	1.837834	12	13	0.0012724	
GO Molecular Function	structural constituent of ribosome	7	5.507274e-25	3.3216729754285714e-22	2.161324	224	0.0173321	12	0.0000011335222081666666	1.450225	118	162	0.01251193	
GO Molecular Function	unfolded protein binding	11	1.683888e-19	6.463068305454545e-17	2.32838	146	0.01129681	100	0.029823000508000002	1.314803	70	106	0.007422331	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	21	3.542542e-12	7.122196344761905e-10	2.594856	70	0.00541628	89	0.014011352159550563	1.647714	24	29	0.002544799	
GO Molecular Function	5'-3' RNA polymerase activity	24	6.572562e-12	1.1562231985000001e-9	2.643752	66	0.005106778	116	0.04883423615517241	1.460057	33	45	0.003499099	
GO Molecular Function	nucleoside-triphosphate diphosphatase activity	196	0.00005442055	0.0011722630719387757	2.730655	21	0.001624884	109	0.03947980579816514	1.990987	10	10	0.001060333	
GO Molecular Function	fatty-acyl-CoA binding	211	0.00008634477	0.0017277138338388624	2.234136	29	0.002243887	79	0.007813821073417722	1.87387	16	17	0.001696533	
Human Phenotype	Increased serum lactate	4	1.153239e-21	1.9238909617499998e-18	2.340209	162	0.01253482	17	0.000003713481321764706	1.55297	78	100	0.008270597	
Human Phenotype	Increased CSF lactate	40	3.089931e-9	5.15477739075e-7	2.150242	74	0.005725781	111	0.028747019484684687	1.441749	42	58	0.004453398	
Human Phenotype	Abnormal CSF metabolite level	44	3.947692e-9	5.98703379909091e-7	2.078857	79	0.006112659	114	0.02926884333859649	1.422134	45	63	0.004771498	
Human Phenotype	Weight loss	199	0.00006151439	0.002062741328994975	2.070376	36	0.002785515	95	0.018041073630526316	1.990987	12	12	0.0012724	
Mouse Phenotype Single KO	extramedullary hematopoiesis	1	1.366778e-30	1.2515586146e-26	2.250243	254	0.01965336	269	0.036214981855018584	1.292395	74	114	0.007846464	
Mouse Phenotype Single KO	decreased circulating VLDL cholesterol level	158	4.475025e-7	0.000025935318939873418	2.058731	59	0.00456515	231	0.01813326222597403	1.719489	19	22	0.002014633	
Mouse Phenotype	abnormal kidney inner medulla morphology	258	0.000002905813	0.00010768402361627907	2.082886	49	0.003791396	453	0.04285124117218543	1.990987	9	9	0.0009542997