# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process SRP-dependent cotranslational protein targeting to membrane 87 1.186466e-9 1.7945639188505748e-7 3.545269 33 0.01501365 300 0.025236540744000002 1.958712 25 92 0.009596929 GO Biological Process protein targeting to ER 96 5.764411e-9 7.901446286354167e-7 3.246988 34 0.01546861 362 0.039703901872928174 1.855541 26 101 0.009980806 GO Biological Process mammary gland epithelium development 111 1.328021e-8 0.0000015743629134234235 2.478298 50 0.02274795 90 0.00003444226425222222 3.0701 23 54 0.008829175 GO Biological Process negative regulation of cell growth 115 1.589141e-8 0.0000018183918625217394 2.015872 77 0.03503185 272 0.016981699175735297 1.744626 38 157 0.01458733 GO Biological Process platelet-derived growth factor receptor signaling pathway 163 7.36251e-7 0.000059437588398773004 2.893669 29 0.01319381 257 0.013241456239688717 2.839539 13 33 0.004990403 GO Biological Process positive regulation of protein dephosphorylation 182 0.000001974908 0.00014279018885714288 2.873731 27 0.01228389 138 0.0007919977769927536 3.203583 16 36 0.006142035 GO Biological Process positive regulation of phosphoprotein phosphatase activity 226 0.000008914565 0.0005190564638716815 3.199632 20 0.009099181 142 0.0008646906783239436 4.505038 10 16 0.003838772 GO Biological Process collecting duct development 231 0.00001320787 0.0007523911745887447 3.879074 15 0.006824386 281 0.019163564090035588 4.204702 7 12 0.00268714 GO Biological Process regulation of protein dephosphorylation 276 0.00004193733 0.0019994685705434783 2.157268 34 0.01546861 230 0.008485163494782608 2.293474 21 66 0.00806142 GO Biological Process regulation of phosphoprotein phosphatase activity 306 0.00007800863 0.0033546260201633995 2.319642 27 0.01228389 237 0.009411672148523207 2.703023 15 40 0.005758157 GO Biological Process apoptotic cell clearance 324 0.0001090028 0.004427061250617283 3.207668 15 0.006824386 295 0.024392677715593218 2.936618 11 27 0.004222649 GO Biological Process positive regulation of dephosphorylation 339 0.0001409856 0.005472653423008849 2.130766 30 0.01364877 187 0.0027322812795721927 2.703023 18 48 0.006909789 GO Biological Process positive regulation of pri-miRNA transcription from RNA polymerase II promoter 346 0.0001514992 0.005761786048554913 3.266477 14 0.006369427 155 0.0015237290011612902 3.964434 11 20 0.004222649 GO Biological Process regulation of pri-miRNA transcription from RNA polymerase II promoter 356 0.0001694623 0.0062639168699438206 2.505102 21 0.00955414 113 0.0001714303281415929 3.728308 15 29 0.005758157 GO Biological Process negative regulation of peptidyl-threonine phosphorylation 436 0.0004850342 0.014638910637155963 2.779578 15 0.006824386 271 0.017041905278228783 3.844299 8 15 0.003071017 GO Biological Process positive regulation of phosphatase activity 503 0.0009350291 0.024461327886481116 2.103394 23 0.01046406 238 0.009576064162605043 3.089169 12 28 0.004606526 GO Biological Process cellular response to vascular endothelial growth factor stimulus 521 0.001025457 0.02590017017850288 2.222713 20 0.009099181 366 0.04000389930327869 2.734092 11 29 0.004222649 GO Cellular Component cytosolic ribosome 44 0.000005712568 0.0002243481250909091 2.350703 35 0.01592357 28 0.032443601142857145 1.866373 29 112 0.01113244 GO Molecular Function phosphatase binding 6 2.475636e-11 1.742022532e-8 2.258287 83 0.0377616 32 0.0052585379425 1.870446 41 158 0.01573896 GO Molecular Function protein phosphatase binding 11 6.072146e-9 0.0000023306000374545456 2.293015 61 0.0277525 41 0.023245734741463416 1.930731 30 112 0.01151631 GO Molecular Function retinoic acid-responsive element binding 55 0.00003449108 0.0026476607229090907 4.691013 11 0.00500455 45 0.03468724833333334 7.208061 4 4 0.001535509 Human Phenotype Lipodystrophy 69 0.0004338155 0.04195435987681159 2.937157 14 0.006369427 2 0.027574107206499998 3.93167 12 22 0.004606526 Mouse Phenotype Single KO abnormal circulating interleukin-6 level 25 2.369744e-10 8.679898323200001e-8 2.777832 51 0.02320291 193 0.010710378297409326 1.930731 30 112 0.01151631 Mouse Phenotype Single KO abnormal body temperature 28 5.054703e-10 1.653068406107143e-7 2.572365 56 0.02547771 157 0.00534547048955414 2.049351 29 102 0.01113244 Mouse Phenotype Single KO abnormal tumor necrosis factor level 30 6.041385e-10 1.8440320814999998e-7 2.443439 61 0.0277525 199 0.012222459900502514 1.814979 35 139 0.0134357 Mouse Phenotype Single KO abnormal circulating free fatty acids level 32 1.214138e-9 3.4743317706250004e-7 2.197074 73 0.03321201 239 0.018830834106694557 1.703724 39 165 0.01497121 Mouse Phenotype Single KO abnormal free fatty acids level 34 1.56602e-9 4.2176603352941175e-7 2.183497 73 0.03321201 285 0.02924724273017544 1.653614 39 170 0.01497121 Mouse Phenotype Single KO abnormal mesangial cell morphology 39 2.748811e-9 6.454067263333333e-7 4.1645 26 0.01182894 317 0.04040394816719243 2.544022 12 34 0.004606526 Mouse Phenotype Single KO abnormal axon extension 49 5.000259e-9 9.34436156387755e-7 2.477553 53 0.02411283 316 0.040334382683544306 2.149773 17 57 0.006525912 Mouse Phenotype Single KO increased circulating interleukin-6 level 68 2.159592e-8 0.000002908144697647059 2.90492 37 0.01683348 291 0.031510653030927836 2.059446 20 70 0.007677543 Mouse Phenotype Single KO abnormal cell chemotaxis 87 1.337324e-7 0.000014075719388505746 2.34097 48 0.02183803 148 0.00478301169554054 2.013062 31 111 0.01190019 Mouse Phenotype Single KO increased susceptibility to endotoxin shock 94 1.883657e-7 0.000018349624626595747 3.349908 26 0.01182894 138 0.003971365685072464 2.485538 20 58 0.007677543 Mouse Phenotype Single KO abnormal transitional stage T1 B cell morphology 97 2.168533e-7 0.000020471398640206187 5.464618 15 0.006824386 60 0.0003021057599833333 4.66404 11 17 0.004222649 Mouse Phenotype Single KO abnormal transitional stage T2 B cell morphology 106 3.541648e-7 0.00003059516107169811 5.253007 15 0.006824386 84 0.0010171855048333332 4.505038 10 16 0.003838772 Mouse Phenotype Single KO abnormal adrenal medulla morphology 119 6.666032e-7 0.00005129483615462185 4.410006 17 0.007734304 70 0.0005820081932285715 4.404926 11 18 0.004222649 Mouse Phenotype Single KO decreased circulating leptin level 122 7.510267e-7 0.00005637009419590164 2.15996 50 0.02274795 104 0.0020116502621153843 2.162418 30 100 0.01151631 Mouse Phenotype Single KO decreased transitional stage T1 B cell number 125 9.397508e-7 0.00006884238460480001 7.873237 10 0.004549591 96 0.0014444995806249998 5.242226 8 11 0.003071017 Mouse Phenotype Single KO abnormal mammary gland physiology 126 9.928146e-7 0.00007215240708095239 2.346867 41 0.01865332 325 0.041066552864615385 1.965835 21 77 0.00806142 Mouse Phenotype Single KO increased acute inflammation 141 0.000001723193 0.00011190977518439716 2.24246 43 0.01956324 319 0.040335034912225703 1.743886 30 124 0.01151631 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 145 0.000002005015 0.0001266201541724138 2.433046 36 0.01637853 284 0.029069480097535214 1.853502 27 105 0.01036468 Mouse Phenotype Single KO increased circulating tumor necrosis factor level 158 0.000002762335 0.00016009304806962027 2.888689 26 0.01182894 323 0.04073793375851393 2.092663 18 62 0.006909789 Mouse Phenotype Single KO abnormal epididymal fat pad morphology 162 0.000003077581 0.000173959316154321 2.051379 50 0.02274795 256 0.0240237758109375 1.912343 26 98 0.009980806 Mouse Phenotype abnormal body temperature 29 3.320656e-12 1.0947859315862069e-9 2.537647 72 0.03275705 192 0.0018543430028125 1.965835 36 132 0.01381958 Mouse Phenotype abnormal brown adipose tissue morphology 54 1.320013e-10 2.3371563505555554e-8 2.191621 82 0.03730664 478 0.0323446629790795 1.667171 34 147 0.01305182 Mouse Phenotype abnormal tumor necrosis factor level 55 1.712982e-10 2.9777856185454543e-8 2.24385 77 0.03503185 216 0.0028479930556944448 1.755331 47 193 0.01804223 Mouse Phenotype decreased neurotransmitter release 56 2.093412e-10 3.5741271664285714e-8 3.628269 35 0.01592357 214 0.0026542171470560747 2.922187 15 37 0.005758157 Mouse Phenotype hydroureter 57 2.211989e-10 3.710320496315789e-8 2.891093 48 0.02183803 356 0.014431972305337078 2.790217 12 31 0.004606526 Mouse Phenotype abnormal hypodermis fat layer morphology 65 6.357209e-10 9.350965422923078e-8 2.399435 63 0.02866242 284 0.006853402230633803 1.856622 34 132 0.01305182 Mouse Phenotype decreased fatty acid level 78 6.285773e-9 7.704907135e-7 2.238845 64 0.02911738 557 0.04143191547576301 1.617193 35 156 0.0134357 Mouse Phenotype abnormal B cell activation 84 7.139411e-9 8.126179591785714e-7 2.003544 82 0.03730664 81 0.00003385669317407407 1.969031 56 205 0.02149712 Mouse Phenotype decreased circulating free fatty acid level 86 9.292074e-9 0.0000010330409245813953 2.40705 54 0.02456779 600 0.04884289435499999 1.696014 28 119 0.01074856 Mouse Phenotype abnormal transitional stage B cell morphology 87 9.598727e-9 0.0000010548669982413792 2.657116 45 0.02047316 104 0.00008766035026442307 2.485538 30 87 0.01151631 Mouse Phenotype extramedullary hematopoiesis 96 2.420921e-8 0.0000024110860084375 2.074441 70 0.03184713 245 0.00404774105755102 1.771124 43 175 0.01650672 Mouse Phenotype abnormal mammary gland epithelium physiology 99 2.940041e-8 0.0000028393668687878787 3.583836 27 0.01228389 485 0.03246249287010309 2.772331 10 26 0.003838772 Mouse Phenotype increased susceptibility to endotoxin shock 101 3.031639e-8 0.000002869851532574257 3.089014 33 0.01501365 184 0.0014625196694021737 2.369774 24 73 0.009213052 Mouse Phenotype abnormal spleen marginal zone morphology 104 3.396262e-8 0.000003122275094423077 2.166672 62 0.02820746 139 0.0004182126534604317 1.957745 44 162 0.0168906 Mouse Phenotype decreased transitional stage B cell number 106 3.70804e-8 0.000003344582116981132 2.944702 35 0.01592357 234 0.003690045886153846 2.365145 21 64 0.00806142 Mouse Phenotype increased Purkinje cell number 115 5.852854e-8 0.000004866011921217391 8.098723 12 0.005459509 324 0.010909942013888889 7.208061 4 4 0.001535509 Mouse Phenotype thin lung-associated mesenchyme 116 5.883485e-8 0.000004849310352155173 16.09419 8 0.003639672 572 0.04458830852622378 7.208061 3 3 0.001151631 Mouse Phenotype abnormal hypodermis morphology 118 6.806663e-8 0.000005515127537542373 2.080528 65 0.02957234 350 0.01400666831657143 1.741545 36 149 0.01381958 Mouse Phenotype abnormal marginal zone B cell morphology 121 8.384468e-8 0.000006625115582479338 2.246131 54 0.02456779 253 0.00450955713201581 1.866836 36 139 0.01381958 Mouse Phenotype abnormal mesangial cell morphology 124 9.41967e-8 0.000007263021360483871 3.131671 30 0.01364877 396 0.019902687037121215 2.30658 16 50 0.006142035