# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Cellular Component immunoglobulin complex 1 0.00001101174 0.01902828672 6.742858 9 0.006844106 5 0.0476888256 7.509598 5 7 0.002799552 Mouse Phenotype Single KO absent cochlear outer hair cells 2 8.751035e-18 4.0066613747500004e-14 13.39618 22 0.01673004 345 0.034393134617391304 5.256719 5 10 0.002799552 Mouse Phenotype Single KO absent cochlear hair cells 19 9.492533e-11 4.574901299e-8 5.092841 25 0.01901141 211 0.012654500960663506 4.205375 8 20 0.004479283 Mouse Phenotype Single KO abnormal crista ampullaris morphology 22 2.201594e-10 9.163634662727274e-8 4.234881 29 0.02205323 316 0.031115196221518985 3.262791 9 29 0.005039194 Mouse Phenotype Single KO abnormal circulating aldosterone level 25 5.579241e-10 2.04356439348e-7 4.664998 25 0.01901141 332 0.03239175666566265 3.003839 10 35 0.005599104 Mouse Phenotype Single KO abnormal cochlear inner hair cell number 26 5.692847e-10 2.0049769222692306e-7 4.188229 28 0.02129278 181 0.007879072351933702 3.754799 10 28 0.005599104 Mouse Phenotype Single KO abnormal semicircular canal ampulla morphology 27 7.169619e-10 2.4315630067777775e-7 3.795207 31 0.02357414 253 0.01945557025375494 3.285449 10 32 0.005599104 Mouse Phenotype Single KO abnormal semicircular canal morphology 33 1.281308e-7 0.00003555435562424242 2.441981 44 0.03346008 24 0.0000014648811549166667 4.057818 22 57 0.01231803 Mouse Phenotype Single KO abnormal inner ear canal morphology 36 2.645096e-7 0.00006728095575555556 2.376673 44 0.03346008 30 0.000005111767052 3.791732 22 61 0.01231803 Mouse Phenotype Single KO abnormal cochlear outer hair cell number 39 7.467384e-7 0.0001753303468923077 2.713083 32 0.0243346 203 0.011404633013793103 2.971189 13 46 0.007278835 Mouse Phenotype Single KO abnormal neurotransmitter secretion 50 0.000008972979 0.00164331137406 2.632755 27 0.02053232 248 0.017951910804435485 2.676148 14 55 0.007838746 Mouse Phenotype Single KO abnormal cochlear hair cell number 55 0.00001375275 0.0022897078500000003 2.277566 34 0.02585551 220 0.01306319306 2.672908 15 59 0.008398656 Mouse Phenotype Single KO abnormal vestibular labyrinth morphology 80 0.000147892 0.01692808805 2.0111 34 0.02585551 270 0.02218477242740741 2.35169 17 76 0.009518477 Mouse Phenotype Single KO abnormal palatine bone morphology 87 0.0001995965 0.02100810517816092 2.409802 22 0.01673004 202 0.010638593533663367 3.154031 12 40 0.006718925 Mouse Phenotype Single KO abnormal hippocampus layer morphology 97 0.0002675304 0.025255421369072165 2.176348 26 0.01977186 237 0.015370097910548521 2.448335 17 73 0.009518477 Mouse Phenotype Single KO abnormal maxillary shelf morphology 107 0.0004045207 0.034618654671962616 2.715884 16 0.0121673 241 0.016411912519502074 4.005119 8 21 0.004479283 Mouse Phenotype absent cochlear inner hair cells 3 6.475094e-17 2.0636124578e-13 13.19522 21 0.01596958 532 0.040534578372180455 6.007679 4 7 0.002239642 Mouse Phenotype decreased cochlear inner hair cell number 8 1.224256e-12 1.463138952e-9 6.275323 25 0.01901141 501 0.03380441358083832 3.679703 7 20 0.003919373 Mouse Phenotype abnormal cochlear inner hair cell number 12 7.246322e-12 5.773507053499999e-9 4.213917 34 0.02585551 91 0.00011025135817582419 4.329063 14 34 0.007838746 Mouse Phenotype absent cochlear outer hair cells 14 8.048643e-12 5.49664826592857e-9 6.017163 24 0.01825095 490 0.033664281000000004 4.205375 6 15 0.003359462 Mouse Phenotype abnormal crista ampullaris morphology 24 2.303097e-9 9.174962673749999e-7 3.60829 31 0.02357414 418 0.02095245116267943 3.092188 10 34 0.005599104 Mouse Phenotype abnormal semicircular canal ampulla morphology 25 9.614703e-9 0.0000036770470153200002 3.167377 34 0.02585551 269 0.006386943485130111 3.234904 12 39 0.006718925 Mouse Phenotype abnormal semicircular canal morphology 30 4.322577e-8 0.000013776052899 2.398222 49 0.03726236 20 6.1768505865e-8 4.079842 26 67 0.01455767 Mouse Phenotype absent cochlear hair cells 31 5.638841e-8 0.000017391277032580646 3.45795 27 0.02053232 339 0.012279316395575222 3.639267 9 26 0.005039194 Mouse Phenotype abnormal inner ear canal morphology 32 8.746452e-8 0.00002613275861625 2.341482 49 0.03726236 25 2.21006989548e-7 3.849991 26 71 0.01455767 Mouse Phenotype abnormal cochlear outer hair cell number 37 3.865135e-7 0.00009987717766216216 2.609392 36 0.02737643 175 0.0014539816993714284 3.115093 16 54 0.008958567 Mouse Phenotype decreased cochlear outer hair cell number 38 6.182644e-7 0.0001555585770631579 2.911441 29 0.02205323 541 0.04106986753974122 2.766694 10 38 0.005599104 Mouse Phenotype abnormal cochlear hair cell number 49 0.000009212317 0.0017975298538163264 2.151985 40 0.03041825 137 0.0007081972276642336 2.880394 20 73 0.01119821 Mouse Phenotype abnormal utricle morphology 53 0.00002279025 0.004111275099056603 2.445394 28 0.02129278 516 0.03868369482558139 2.523225 12 50 0.006718925 Mouse Phenotype decreased cochlear hair cell number 55 0.00002714609 0.004718977572545455 2.264103 32 0.0243346 479 0.03206326260751566 2.484994 13 55 0.007278835 Mouse Phenotype abnormal vestibular saccule morphology 73 0.00007806568 0.010224465294246575 2.200873 30 0.02281369 479 0.03206326260751566 2.484994 13 55 0.007278835 Mouse Phenotype abnormal otolith organ morphology 79 0.0001499149 0.01814349821392405 2.034199 33 0.02509506 299 0.007897254895986623 2.628359 16 64 0.008958567 Mouse Phenotype abnormal transitional stage T1 B cell morphology 108 0.000543495 0.048114404583333326 3.391257 11 0.008365019 363 0.01576047882644628 3.504479 9 27 0.005039194