# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of cytokine production 25 1.12772e-7 0.000059358669920000004 2.295549 49 0.07596899 53 0.03064852758679245 1.935053 36 386 0.03977901 GO Biological Process regulation of T cell activation 71 0.00001311633 0.0024309547390140847 2.078179 41 0.06356589 16 0.0050120155463125 2.290371 34 308 0.03756906 GO Biological Process regulation of T cell differentiation 75 0.00001790102 0.0031407936290666666 2.626496 25 0.03875969 25 0.017975351908 2.964009 18 126 0.0198895 GO Biological Process positive regulation of immune effector process 100 0.00009467039 0.0124576766201 2.469889 23 0.03565891 63 0.04310861246507936 2.440949 20 170 0.02209945 GO Molecular Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 13 9.90505e-7 0.0003216855469230769 2.563622 34 0.05271318 6 0.014681413919999999 2.964009 19 133 0.02099448 GO Molecular Function phosphoprotein binding 46 0.0004242885 0.038942305369565215 2.803058 15 0.02325581 13 0.023618530529230772 3.50292 13 77 0.01436464 Mouse Phenotype Single KO abnormal B cell differentiation 37 0.000005166185 0.0012785609741891892 2.188742 40 0.0620155 6 0.042994419511666666 2.333116 28 249 0.03093923 Mouse Phenotype Single KO increased IgG1 level 71 0.00003424514 0.004416658408169014 3.546309 15 0.02325581 7 0.04585807286 3.746179 13 72 0.01436464 Mouse Phenotype Single KO abnormal noradrenaline level 125 0.0002269879 0.0166282256024 2.978073 15 0.02325581 1 0.00550692823 5.288723 13 51 0.01436464 Mouse Phenotype abnormal hemopoiesis 1 1.556348e-13 1.4880243228000002e-9 2.007205 121 0.1875969 2 0.00242364322665 1.735894 84 1004 0.09281768 Mouse Phenotype abnormal lymphopoiesis 7 2.424001e-10 3.310839080142857e-7 2.074498 85 0.1317829 1 0.0022880496027 1.976006 62 651 0.06850829 Mouse Phenotype abnormal CD4-positive, alpha beta T cell morphology 14 2.681982e-9 0.000001831602135857143 2.1354 71 0.1100775 48 0.02721002835625 1.753883 47 556 0.0519337 Mouse Phenotype increased litter size 17 5.497041e-9 0.0000030916005294705885 13.76555 10 0.01550388 64 0.0357574677421875 7.980025 5 13 0.005524862 Mouse Phenotype abnormal CD4-positive, alpha beta T cell number 24 6.602289e-8 0.000026301868803750003 2.102136 61 0.09457364 41 0.025514134807317068 1.824472 43 489 0.04751381 Mouse Phenotype impaired natural killer cell mediated cytotoxicity 30 1.464424e-7 0.000046671192880000004 4.621051 18 0.02790698 49 0.027378450330612248 3.741455 11 61 0.0121547 Mouse Phenotype abnormal B cell differentiation 31 1.505569e-7 0.00004643466196451613 2.207686 52 0.08062016 8 0.006027324912375 2.218724 37 346 0.04088398 Mouse Phenotype abnormal natural killer cell mediated cytotoxicity 40 4.866984e-7 0.00011633308505999999 4.248359 18 0.02790698 61 0.034288708342622945 3.566074 11 64 0.0121547 Mouse Phenotype abnormal NK cell morphology 61 0.000005108063 0.0008006260711967213 2.642925 28 0.04341085 26 0.020292472329230767 2.609038 21 167 0.02320442 Mouse Phenotype epidermal hyperplasia 89 0.00001803995 0.0019379771005617978 3.022076 20 0.03100775 57 0.03129694385263158 2.908607 15 107 0.01657459 Mouse Phenotype abnormal fourth pharyngeal arch artery morphology 94 0.00002476723 0.002519143468404255 4.126824 13 0.02015504 16 0.016506247839375 6.147575 8 27 0.008839779 Mouse Phenotype abnormal NK cell number 106 0.00004208861 0.003796313209528302 2.489927 25 0.03875969 66 0.03782640159545454 2.463833 19 160 0.02099448 Mouse Phenotype abnormal heart ventricle wall thickness 107 0.00004256116 0.0038030584183177565 2.134869 34 0.05271318 31 0.022871275213548387 2.434722 23 196 0.02541436 Mouse Phenotype increased interleukin-12 secretion 113 0.00005020206 0.00424762739522124 4.926649 10 0.01550388 70 0.04275315882 4.486068 8 37 0.008839779 Mouse Phenotype abnormal fourth pharyngeal arch morphology 125 0.00007532737 0.005761639876560001 3.692869 13 0.02015504 34 0.023247894886764705 5.35434 8 31 0.008839779 Mouse Phenotype abnormal double-negative T cell morphology 138 0.0001443194 0.009998824517391305 2.142367 29 0.04496124 14 0.017108555839285715 2.60768 23 183 0.02541436 Mouse Phenotype decreased tumor incidence 150 0.0001952544 0.012445515456 2.072474 30 0.04651163 76 0.04556948723684211 2.189016 23 218 0.02541436 Mouse Phenotype abnormal noradrenaline level 162 0.0002558648 0.01510076143703704 2.823504 16 0.0248062 3 0.0022966611953999998 4.841215 14 60 0.01546961 Mouse Phenotype mesangial cell hyperplasia 194 0.0004912069 0.02420839778814433 4.046561 9 0.01395349 65 0.037661455624615384 4.610681 8 36 0.008839779