# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 51 5.78263e-87 1.4920319249019607e-84 2.197007 788 0.03365077 478 0.0004843244279079498 1.202011 185 248 0.01587574 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 89 8.752263e-58 1.2940565035617977e-55 2.492276 403 0.01720972 844 0.016377342156398106 1.226333 86 113 0.007380074 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 95 1.2775e-53 1.7695392105263157e-51 4.394294 167 0.007131571 880 0.01882474203068182 1.477066 22 24 0.001887926 GO Biological Process regulation of DNA-templated transcription in response to stress 103 5.217074e-51 6.665191919029126e-49 2.29075 419 0.01789298 867 0.01751602534140715 1.218664 90 119 0.007723333 GO Biological Process histone H2A ubiquitination 137 2.590328e-37 2.4880384052554745e-35 3.559007 147 0.006277491 721 0.007251977828016643 1.538102 21 22 0.001802111 GO Biological Process histone H2A monoubiquitination 139 3.910788e-37 3.7023064238848917e-35 3.769692 136 0.005807747 691 0.005696611082344428 1.611345 17 17 0.001458852 GO Biological Process endoplasmic reticulum unfolded protein response 140 9.531536e-37 8.958963015999999e-35 2.174234 334 0.01426314 391 0.00005838052611253197 1.328653 94 114 0.008066592 GO Biological Process histone monoubiquitination 144 3.779283e-36 3.4535822914583333e-34 3.219019 163 0.006960755 669 0.004914082011061286 1.496249 26 28 0.002231185 GO Biological Process histone ubiquitination 164 3.470162e-33 2.7843818145121955e-31 2.692996 197 0.008412692 583 0.002569970756946827 1.446079 35 39 0.003003518 GO Biological Process cellular response to unfolded protein 168 3.034357e-32 2.376732366845238e-30 2.017553 348 0.014861 352 0.000024462622121875 1.33169 100 121 0.008581481 GO Biological Process positive regulation of mRNA catabolic process 182 3.935102e-30 2.845165231758242e-28 2.837274 163 0.006960755 808 0.013741184777475247 1.482437 23 25 0.001973741 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 183 4.388279e-30 3.155484336666667e-28 2.044309 313 0.01336636 951 0.026812438009463726 1.234221 72 94 0.006178666 GO Biological Process erythrocyte homeostasis 193 1.290946e-28 8.801843737823835e-27 2.009214 310 0.01323825 604 0.0030749990415562915 1.318373 63 77 0.005406333 GO Biological Process positive regulation of mRNA metabolic process 195 1.530699e-28 1.0329470841538462e-26 2.327356 221 0.009437588 569 0.002140047707469244 1.394433 45 52 0.003861667 GO Biological Process gene silencing by miRNA 198 4.125773e-28 2.741972066010101e-26 2.520709 186 0.007942947 888 0.019144848311936937 1.354994 37 44 0.003175148 GO Biological Process negative regulation of histone methylation 207 3.880242e-27 2.4666717139130436e-25 2.85937 144 0.006149379 1053 0.04264257052896486 1.51656 16 17 0.001373037 GO Biological Process posttranscriptional gene silencing by RNA 215 3.341428e-26 2.045109351255814e-24 2.325925 202 0.008626212 742 0.008202187365363881 1.358585 43 51 0.003690037 GO Biological Process posttranscriptional gene silencing 217 6.383938e-26 3.871255306082949e-24 2.307504 203 0.008668916 698 0.006337308416475645 1.363446 44 52 0.003775852 GO Biological Process IRE1-mediated unfolded protein response 230 1.150984e-24 6.58512976347826e-23 2.478089 167 0.007131571 1081 0.046322674555041625 1.277963 46 58 0.003947481 GO Biological Process definitive hemopoiesis 283 4.467748e-21 2.0774238845229682e-19 2.622017 127 0.00542341 1053 0.04264257052896486 1.51656 16 17 0.001373037 GO Cellular Component PcG protein complex 30 1.472341e-52 8.48068416e-51 2.903477 281 0.01199983 82 0.00016235388175609754 1.471228 42 46 0.003604222 GO Cellular Component ficolin-1-rich granule lumen 41 4.918001e-37 2.0727574946341466e-35 2.124664 355 0.01515993 76 0.00013509699536842106 1.299472 100 124 0.008581481 GO Cellular Component cytoplasmic stress granule 57 3.720999e-27 1.1280502231578947e-25 2.478914 185 0.007900243 122 0.007262081468852459 1.386506 37 43 0.003175148 GO Cellular Component histone methyltransferase complex 60 1.151555e-25 3.3164784e-24 2.113341 244 0.01041978 63 0.000027393240685714286 1.424522 61 69 0.005234704 GO Cellular Component nuclear transcriptional repressor complex 103 1.711601e-13 2.8715014834951458e-12 2.100282 122 0.00520989 139 0.012170582469064748 1.444654 26 29 0.002231185 GO Cellular Component ESC/E(Z) complex 124 2.070375e-11 2.885167741935484e-10 2.114374 99 0.004227698 159 0.02423839516981132 1.521826 17 18 0.001458852 GO Cellular Component MLL1 complex 135 1.048089e-10 1.3415539199999999e-9 2.275098 78 0.003330913 139 0.012170582469064748 1.444654 26 29 0.002231185 GO Molecular Function SUMO transferase activity 58 1.971897e-14 1.4354050231034481e-12 2.727007 78 0.003330913 153 0.04011901690196078 1.526537 18 19 0.001544667 GO Molecular Function mitogen-activated protein kinase binding 75 2.232473e-12 1.2567334674666667e-10 2.155705 104 0.004441218 129 0.012299432213953488 1.491986 25 27 0.00214537 Human Phenotype Exotropia 25 1.756895e-19 4.689504134e-17 2.24493 158 0.006747235 173 0.04855834097687861 1.477066 22 24 0.001887926 Mouse Phenotype Single KO extramedullary hematopoiesis 47 1.768575e-45 3.4457109095744678e-43 2.131807 436 0.01861895 729 0.04027910566941015 1.201441 85 114 0.007294259 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 48 1.896993e-45 3.618909354375e-43 2.972697 233 0.009950036 506 0.009092616879644268 1.427191 31 35 0.002660259 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 53 3.389966e-43 5.856965785283019e-41 3.064631 211 0.009010548 569 0.015755180150790863 1.444654 26 29 0.002231185 Mouse Phenotype Single KO decreased erythroid progenitor cell number 57 7.217003e-40 1.159405201245614e-37 2.217696 348 0.014861 209 0.000046507044784689 1.484965 47 51 0.004033296 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 58 2.919148e-38 4.608730730344827e-36 2.180881 346 0.01477559 219 0.00012428114551598174 1.459331 48 53 0.004119111 Mouse Phenotype Single KO pale liver 92 1.992928e-29 1.983613227826087e-27 2.095393 288 0.01229876 402 0.0037867156218905477 1.309218 65 80 0.005577963 Mouse Phenotype Single KO abnormal mesangial cell morphology 120 7.766808e-25 5.926721738e-23 2.49571 166 0.007088867 535 0.01237079549084112 1.421775 30 34 0.002574444 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 134 2.051566e-23 1.4019544673134329e-21 2.295418 184 0.007857539 754 0.04419181559018568 1.350046 31 37 0.002660259 Mouse Phenotype Single KO abnormal vascular branching morphogenesis 171 3.036106e-20 1.625825885497076e-18 2.027047 209 0.00892514 400 0.0037931911015 1.500217 27 29 0.002317 Mouse Phenotype Single KO abnormal erythrocyte osmotic lysis 291 1.630656e-14 5.131242952577319e-13 2.344461 104 0.004441218 569 0.015755180150790863 1.444654 26 29 0.002231185 Mouse Phenotype Single KO abnormal erythrocyte physiology 292 1.673113e-14 5.246813609931507e-13 2.023747 145 0.006192083 557 0.015451666470736085 1.360691 38 45 0.003260963 Mouse Phenotype Single KO hemolysis 313 3.689883e-14 1.0794970808626199e-12 2.252362 110 0.004697442 498 0.008406896438353415 1.455408 28 31 0.002402815 Mouse Phenotype Single KO subcutaneous edema 352 7.037113e-13 1.8306489699147728e-11 2.105498 115 0.004910962 718 0.03809396172980502 1.396499 26 30 0.002231185 Mouse Phenotype Single KO microcytosis 518 6.4794e-10 1.1454028146718147e-8 2.343003 67 0.002861169 770 0.04874573162077922 1.457883 19 21 0.001630481 Mouse Phenotype Single KO athymia 851 0.000001062901 0.000011437114520564043 2.002875 59 0.002519537 732 0.04074242023770492 1.611345 12 12 0.001029778 Mouse Phenotype abnormal embryonic erythrocyte morphology 71 1.158447e-45 1.5599875728169014e-43 2.810557 256 0.01093223 600 0.0018143702545 1.446079 35 39 0.003003518 Mouse Phenotype decreased erythroid progenitor cell number 77 8.40128e-43 1.0431771179220778e-40 2.075838 436 0.01861895 309 0.000011414113638834951 1.420528 67 76 0.005749592 Mouse Phenotype abnormal embryonic erythropoiesis 80 1.124785e-40 1.3442586731250001e-38 2.841116 223 0.009522996 710 0.006156824802676056 1.455408 28 31 0.002402815 Mouse Phenotype abnormal embryonic hematopoiesis 100 7.624315e-35 7.2896075715e-33 2.033812 370 0.01580049 275 0.000004543766163272727 1.479267 56 61 0.004805629 Mouse Phenotype enlarged liver sinusoidal spaces 172 2.347838e-25 1.305097623139535e-23 2.231155 213 0.009095956 820 0.011660105890243903 1.375538 35 41 0.003003518 Mouse Phenotype abnormal mesangial cell morphology 213 2.331659e-21 1.0466193285915493e-19 2.067444 211 0.009010548 950 0.019396883782105263 1.321303 41 50 0.003518407 Mouse Phenotype pancytopenia 224 1.440548e-20 6.148696173214285e-19 2.425445 143 0.006106675 814 0.011499033493120394 1.444654 26 29 0.002231185 Mouse Phenotype abnormal erythrocyte osmotic lysis 241 1.45538e-19 5.7738125228215766e-18 2.551477 123 0.005252594 774 0.008928130975193798 1.421775 30 34 0.002574444 Mouse Phenotype lymph node hyperplasia 252 3.907446e-19 1.4825036192857143e-17 2.020975 198 0.008455396 1096 0.03417472150456205 1.318373 36 44 0.003089333 Mouse Phenotype hemolysis 257 4.902052e-19 1.8236777887937745e-17 2.448509 129 0.005508818 680 0.004895454152647059 1.432306 32 36 0.002746074 Mouse Phenotype abnormal erythrocyte physiology 279 5.821467e-18 1.9949478848387098e-16 2.060578 176 0.007515907 704 0.005805227336931818 1.34767 46 55 0.003947481 Mouse Phenotype decreased classified tumor incidence 283 1.015723e-17 3.431564524028268e-16 2.371169 127 0.00542341 1193 0.04748606491533948 1.381153 24 28 0.002059555 Mouse Phenotype decreased inguinal fat pad weight 295 4.139015e-17 1.341461776779661e-15 2.059547 167 0.007131571 1100 0.03448657045909091 1.367202 28 33 0.002402815 Mouse Phenotype absent spleen germinal center 321 3.105142e-16 9.248679957009346e-15 2.611116 96 0.004099586 774 0.008928130975193798 1.421775 30 34 0.002574444 Mouse Phenotype microcytic anemia 376 1.379034e-14 3.506634062234043e-13 2.308267 108 0.004612034 814 0.011499033493120394 1.444654 26 29 0.002231185 Mouse Phenotype microcytosis 414 1.860073e-13 4.295690326811594e-12 2.552118 81 0.003459025 866 0.013898702047344112 1.477066 22 24 0.001887926 Mouse Phenotype subcutaneous edema 437 7.037113e-13 1.539630146292906e-11 2.105498 115 0.004910962 1037 0.027539238867888137 1.396499 26 30 0.002231185 Mouse Phenotype polyploidy 470 2.845342e-12 5.788152098297873e-11 2.050423 116 0.004953666 1037 0.027539238867888137 1.396499 26 30 0.002231185 Mouse Phenotype abnormal spongiotrophoblast cell morphology 574 1.353574e-10 2.254620385714286e-9 2.102306 92 0.00392877 1154 0.043129207034662054 1.510636 15 16 0.001287222 Mouse Phenotype abnormal cellular hemoglobin content 579 1.570678e-10 2.5936532569948186e-9 2.980899 47 0.002007089 1163 0.04315911033018057 1.611345 11 11 0.0009439629