# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA processing	25	7.256066e-32	3.8193028997600003e-29	2.037706	329	0.04342661	72	2.721074676805555e-9	1.484137	196	396	0.0312999	
GO Biological Process	viral gene expression	28	4.340094e-31	2.039689176642857e-28	3.143028	143	0.0188754	94	3.551791886489362e-8	1.818026	77	127	0.01229639	
GO Biological Process	protein folding	30	5.900619e-31	2.5882081807000002e-28	2.28492	247	0.03260296	184	0.00004309373684673913	1.472745	111	226	0.01772597	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	31	1.315734e-30	5.585078614838711e-28	3.251987	134	0.01768743	151	0.000001550084012781457	1.753397	69	118	0.01101884	
GO Biological Process	response to endoplasmic reticulum stress	34	1.03183e-28	3.993485579411765e-26	2.099536	275	0.03629884	101	6.352680531881188e-8	1.573017	128	244	0.02044075	
GO Biological Process	cotranslational protein targeting to membrane	35	1.098304e-28	4.129309238857143e-26	3.415404	117	0.01544351	147	0.0000012513770366666667	1.835855	60	98	0.009581603	
GO Biological Process	multi-organism metabolic process	39	3.896494e-28	1.3147170396410257e-25	2.713254	162	0.02138332	85	1.6703864307058822e-8	1.77466	87	147	0.01389332	
GO Biological Process	viral transcription	42	1.153758e-27	3.6148336957142863e-25	3.083528	130	0.01715945	100	5.5918499391000005e-8	1.857517	70	113	0.01117854	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	49	4.05386e-26	1.0886682395918368e-23	3.366253	108	0.01425554	162	0.000004568771496358025	1.825212	56	92	0.00894283	
GO Biological Process	protein targeting to ER	50	8.789876e-26	2.31331956568e-23	3.186305	115	0.01517951	140	6.5425034715e-7	1.840702	62	101	0.00990099	
GO Biological Process	RNA catabolic process	53	5.965529e-25	1.481139549264151e-22	2.136033	228	0.03009504	131	4.29551748259542e-7	1.542829	124	241	0.01980198	
GO Biological Process	nuclear-transcribed mRNA catabolic process	54	2.102788e-24	5.1241828318518525e-22	2.298037	190	0.0250792	172	0.000014906538151744187	1.52957	101	198	0.01612903	
GO Biological Process	mRNA catabolic process	56	2.993765e-24	7.034813149107143e-22	2.220229	203	0.02679514	146	9.87445050890411e-7	1.562631	111	213	0.01772597	
GO Biological Process	rRNA processing	57	3.051554e-24	7.044806857192982e-22	2.171821	213	0.0281151	166	0.000009453187786746989	1.475483	124	252	0.01980198	
GO Biological Process	translational initiation	58	3.132551e-24	7.107110105e-22	2.608189	148	0.01953537	169	0.000010760231095857987	1.63558	78	143	0.01245608	
GO Biological Process	protein localization to endoplasmic reticulum	61	7.143618e-24	1.5410306436393443e-21	2.725481	135	0.01781943	114	1.7929749278070175e-7	1.789465	74	124	0.01181731	
GO Biological Process	rRNA metabolic process	65	5.620084e-23	1.1377643900923077e-20	2.113695	214	0.0282471	177	0.000030436655483050845	1.447183	125	259	0.01996167	
GO Biological Process	protein targeting to membrane	66	1.039246e-22	2.072036077878788e-20	2.538279	145	0.01913939	126	2.9846544075396825e-7	1.745432	78	134	0.01245608	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	72	2.83795e-22	5.1867477847222224e-20	2.841396	117	0.01544351	136	5.795065885514706e-7	1.827695	64	105	0.01022038	
GO Biological Process	response to topologically incorrect protein	77	2.565003e-21	4.383490191818182e-19	2.196857	181	0.02389124	191	0.00008731189406806282	1.51594	91	180	0.0145321	
GO Cellular Component	ribosomal subunit	23	3.371944e-31	2.533356187826087e-29	2.71878	180	0.02375924	30	1.808201088e-8	1.66947	103	185	0.01644842	
GO Cellular Component	ribosome	32	7.854499e-24	4.24142946e-22	2.186789	206	0.02719113	34	4.3569090635294117e-7	1.537399	121	236	0.0193229	
GO Cellular Component	large ribosomal subunit	34	2.643253e-23	1.343394465882353e-21	2.929918	117	0.01544351	31	2.2123082322580648e-8	1.851287	71	115	0.01133823	
GO Cellular Component	ficolin-1-rich granule lumen	35	4.470811e-21	2.2073032594285715e-19	2.515892	136	0.01795143	120	0.0329671584	1.378372	57	124	0.009102523	
GO Cellular Component	cytosolic ribosome	46	1.187895e-17	4.462353391304348e-16	2.396749	123	0.01623548	44	0.00005154254836363637	1.659919	62	112	0.00990099	
GO Cellular Component	cytosolic large ribosomal subunit	49	9.435267e-17	3.327375791020408e-15	3.044653	77	0.01016367	36	0.0000031067923199999997	2.015427	41	61	0.006547429	
GO Cellular Component	mitochondrial ribosome	61	4.901114e-14	1.3883811462295083e-12	2.876588	69	0.009107709	78	0.007544120123076922	1.552197	44	85	0.007026509	
GO Cellular Component	mitochondrial nucleoid	68	1.915009e-12	4.866375811764706e-11	3.167498	52	0.00686378	82	0.00931503687804878	1.784859	25	42	0.003992335	
GO Cellular Component	clathrin coat	72	1.218597e-11	2.9246327999999997e-10	2.381056	78	0.01029567	131	0.04522351438167939	1.591074	26	49	0.004152028	
GO Cellular Component	methyltransferase complex	76	6.178419e-11	1.4047773726315788e-9	2.121375	93	0.01227561	65	0.0027364235815384615	1.581659	48	91	0.007665283	
GO Cellular Component	mitochondrial large ribosomal subunit	99	1.666965e-8	2.909611636363636e-7	2.805627	40	0.005279831	83	0.00969716958072289	1.705065	29	51	0.004631108	
GO Cellular Component	histone methyltransferase complex	100	1.737651e-8	3.002660928e-7	2.034626	76	0.01003168	93	0.017559521651612904	1.564468	36	69	0.005748962	
GO Cellular Component	intrinsic component of mitochondrial membrane	102	1.911275e-8	3.237924705882353e-7	2.183115	64	0.00844773	85	0.010533654211764706	1.614611	35	65	0.005589269	
GO Cellular Component	host cell	106	5.299391e-8	8.63900721509434e-7	2.093221	66	0.008711721	104	0.025098369230769232	1.543378	35	68	0.005589269	
GO Cellular Component	integral component of mitochondrial membrane	112	1.589971e-7	0.000002453098114285714	2.09529	61	0.008051742	92	0.016031335930434785	1.592986	34	64	0.005429575	
GO Cellular Component	cytoplasmic stress granule	118	2.520475e-7	0.0000036910006779661018	2.195113	53	0.006995776	76	0.005446753768421053	1.813084	26	43	0.004152028	
GO Cellular Component	endoribonuclease complex	129	7.152868e-7	0.000009581516204651163	2.735365	32	0.004223865	103	0.023872185786407766	1.861177	18	29	0.002874481	
GO Cellular Component	endopeptidase complex	137	0.00000104122	0.000013133052262773722	2.043833	56	0.007391763	117	0.030907421538461537	1.52101	35	69	0.005589269	
GO Cellular Component	TOR complex	215	0.0002094378	0.0016832954344186046	2.410291	22	0.002903907	113	0.027649009274336285	2.198946	11	15	0.001756627	
GO Cellular Component	Sin3-type complex	233	0.0004179789	0.0030998606832618025	2.240248	23	0.003035903	89	0.015386257617977529	2.248922	12	16	0.001916321	
GO Molecular Function	ribonucleoprotein complex binding	13	2.211743e-26	7.183060727692307e-24	2.856982	139	0.01834741	38	0.001123466422631579	1.590542	61	115	0.009741297	
GO Molecular Function	structural constituent of ribosome	14	4.581842e-26	1.3817526374285715e-23	2.617134	159	0.02098733	10	3.7938984883999994e-8	1.739907	94	162	0.01501118	
GO Molecular Function	unfolded protein binding	28	1.816002e-15	2.7382715871428573e-13	2.557325	94	0.0124076	29	0.000679715357724138	1.640723	58	106	0.009262217	
GO Molecular Function	histone methyltransferase activity	38	6.635961e-12	7.372901932105263e-10	2.184278	96	0.01267159	40	0.0012697781105	1.829632	36	59	0.005748962	
GO Molecular Function	snRNA binding	49	1.047837e-8	9.028505742857143e-7	3.178398	34	0.004487856	39	0.0011205870015384616	2.051648	26	38	0.004152028	
GO Molecular Function	histone-lysine N-methyltransferase activity	59	1.073962e-7	0.00000768519926101695	2.003767	70	0.009239704	61	0.004343610903278688	1.850177	29	47	0.004631108	
GO Molecular Function	endoribonuclease activity	77	6.71949e-7	0.000036843749064935065	2.158772	51	0.006731785	63	0.004989339117777778	1.76701	33	56	0.005269882	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning, complete penetrance	3	1.596223e-34	4.872204670333334e-31	3.151396	159	0.02098733	27	0.0035451562903703704	1.742408	43	74	0.006866816	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning	5	1.616734e-30	2.9608866476e-27	2.836714	164	0.02164731	49	0.0434793421510204	1.548708	47	91	0.007505589	
Mouse Phenotype Single KO	abnormal chromosome number	25	1.162416e-14	4.2576973248e-12	2.448946	96	0.01267159	33	0.01239186009181818	1.726445	38	66	0.006068349	
Mouse Phenotype Single KO	increased B cell derived lymphoma incidence	97	3.16256e-7	0.000029855218474226802	2.024923	63	0.008315734	38	0.02606696682894737	1.811632	29	48	0.004631108	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	116	0.000001834888	0.000144845426	2.712428	30	0.003959873	46	0.0382881641	2.123982	17	24	0.002714788	
Mouse Phenotype	embryonic lethality between somite formation and embryo turning, complete penetrance	10	2.252594e-29	2.1537051233999996e-26	2.62886	179	0.02362724	23	0.0002374079023434783	1.76582	53	90	0.00846375	
Mouse Phenotype	abnormal pre-B cell morphology	11	1.057332e-28	9.190137501818181e-26	2.193489	249	0.03286695	69	0.03906843533043478	1.442917	64	133	0.01022038	
Mouse Phenotype	embryonic lethality between somite formation and embryo turning	20	9.438511e-22	4.51208018355e-19	2.170424	190	0.0250792	53	0.01736021617754717	1.512096	59	117	0.00942191	
Mouse Phenotype	abnormal chromosome number	50	7.077166e-13	1.35329568252e-10	2.166271	107	0.01412355	51	0.014982679407058825	1.628849	44	81	0.007026509	
Mouse Phenotype	increased B cell derived lymphoma incidence	69	5.141581e-11	7.12444289e-9	2.048223	102	0.01346357	49	0.01179930814897959	1.653054	43	78	0.006866816	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	135	1.485319e-7	0.00001051935922888889	2.737856	36	0.004751848	31	0.0026782957890967743	2.198946	22	30	0.003513255