# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA processing	16	6.122752e-54	5.0355808479999997e-51	2.003362	597	0.0426947	83	2.7767376651807224e-17	1.405987	298	396	0.02965174	
GO Biological Process	rRNA processing	19	7.862119e-53	5.445138101105263e-50	2.320242	420	0.03003647	103	3.2888889159223304e-14	1.460582	197	252	0.01960199	
GO Biological Process	rRNA metabolic process	21	1.0702e-51	6.706077047619048e-49	2.2797	426	0.03046557	107	6.485270491682244e-14	1.449961	201	259	0.02	
GO Biological Process	endoplasmic reticulum unfolded protein response	26	2.513403e-45	1.2720719260384615e-42	2.790812	256	0.01830795	437	0.0012664730494965676	1.343907	82	114	0.008159204	
GO Biological Process	cellular response to topologically incorrect protein	27	1.299797e-44	6.334825452962964e-42	2.561382	292	0.0208825	464	0.0018042129068534484	1.303818	97	139	0.009651741	
GO Biological Process	mitochondrial transport	34	3.701006e-41	1.432398175117647e-38	2.033009	437	0.03125223	207	1.5927717170048307e-8	1.368045	175	239	0.01741294	
GO Biological Process	mRNA catabolic process	38	8.314785e-40	2.8793225214473685e-37	2.162889	365	0.02610313	166	5.71654704879518e-10	1.421005	162	213	0.0161194	
GO Biological Process	cellular response to unfolded protein	39	1.070756e-39	3.6128405651282053e-37	2.543771	262	0.01873704	497	0.0032417898136820928	1.312483	85	121	0.008457711	
GO Biological Process	nuclear-transcribed mRNA catabolic process	40	1.353939e-39	4.45412082525e-37	2.228035	340	0.02431524	175	1.9352911222285717e-9	1.424859	151	198	0.01502488	
GO Biological Process	response to topologically incorrect protein	41	3.576621e-39	1.1479208716829268e-36	2.222694	338	0.02417221	431	0.001046166756937355	1.276711	123	180	0.01223881	
GO Biological Process	IRE1-mediated unfolded protein response	42	3.655908e-39	1.1454307945714287e-36	3.677842	148	0.01058428	555	0.008962936322702703	1.417375	44	58	0.004378109	
GO Biological Process	multi-organism metabolic process	43	5.455289e-39	1.6694453011860463e-36	2.46822	272	0.01945219	106	5.604405685849057e-14	1.58874	125	147	0.01243781	
GO Biological Process	viral gene expression	45	8.73754e-39	2.5550508635555557e-36	2.715105	228	0.01630551	120	9.665312914583333e-13	1.603552	109	127	0.01084577	
GO Biological Process	cotranslational protein targeting to membrane	46	1.46235e-38	4.183274706521739e-36	3.02085	191	0.01365944	137	3.759448498613139e-11	1.63958	86	98	0.008557214	
GO Biological Process	RNA catabolic process	50	5.658497e-38	1.48920324046e-35	2.035434	401	0.02867768	149	1.0041968498657719e-10	1.410959	182	241	0.01810945	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	52	9.879628e-38	2.5001158625384616e-35	2.787529	212	0.01516127	204	1.3508100529411763e-8	1.52002	96	118	0.009552239	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	54	2.71959e-37	6.627237927777777e-35	2.220068	322	0.02302796	313	0.000022233589341214056	1.362093	113	155	0.01124378	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	60	7.861276e-36	1.7241088480666665e-33	2.506325	242	0.01730673	414	0.000787361136594203	1.3558	82	113	0.008159204	
GO Biological Process	protein targeting to ER	62	1.116576e-35	2.369842513548387e-33	2.86723	191	0.01365944	155	2.5070450392903223e-10	1.609378	87	101	0.008656716	
GO Biological Process	viral transcription	64	4.632988e-35	9.525857670625e-33	2.685904	209	0.01494672	126	4.99471254484127e-12	1.620346	98	113	0.009751244	
GO Cellular Component	ribosomal subunit	32	2.999516e-41	1.61973864e-39	2.430511	297	0.02124008	38	2.2358614736842105e-15	1.545183	153	185	0.01522388	
GO Cellular Component	ribosome	33	2.862283e-36	1.4987954618181817e-34	2.082034	362	0.02588858	40	5.07927456e-15	1.480436	187	236	0.01860697	
GO Cellular Component	large ribosomal subunit	36	2.606441e-33	1.25109168e-31	2.686423	198	0.01416005	45	9.60521856e-11	1.57592	97	115	0.009651741	
GO Cellular Component	mitochondrial ribosome	39	1.055491e-25	4.6766370461538464e-24	2.936376	130	0.009297004	48	8.287614e-9	1.60459	73	85	0.007263682	
GO Cellular Component	outer mitochondrial membrane protein complex	42	2.105612e-23	8.663089371428572e-22	5.944058	52	0.003718801	156	0.013118477538461537	1.743801	14	15	0.001393035	
GO Cellular Component	mitochondrial large ribosomal subunit	47	2.360499e-21	8.678600578723404e-20	3.3442	88	0.006293356	63	0.0000034312100571428574	1.648551	45	51	0.004477612	
GO Cellular Component	endopeptidase complex	50	1.169224e-17	4.0408381440000004e-16	2.412441	122	0.00872488	69	0.000009403230052173913	1.543426	57	69	0.005671642	
GO Cellular Component	proteasome complex	52	2.738265e-17	9.099465230769231e-16	2.394019	121	0.008653365	70	0.000014407037074285713	1.538648	56	68	0.005572139	
GO Cellular Component	cytosolic large ribosomal subunit	57	3.439703e-16	1.0427731200000001e-14	2.399411	112	0.008009726	71	0.000018144172799999998	1.56207	51	61	0.005074627	
GO Cellular Component	methyltransferase complex	58	5.663687e-16	1.6873881268965518e-14	2.014474	163	0.01165701	72	0.000025423944	1.45773	71	91	0.007064677	
GO Cellular Component	peptidase complex	60	8.395971e-16	2.418039648e-14	2.102857	145	0.01036973	73	0.000025465488657534244	1.464963	69	88	0.006865672	
GO Cellular Component	catalytic step 2 spliceosome	61	1.614245e-15	4.572812065573771e-14	2.018709	157	0.01122792	54	9.549510399999999e-8	1.537503	79	96	0.007860697	
GO Cellular Component	spliceosomal snRNP complex	77	1.078421e-12	2.4201447896103895e-11	2.321227	91	0.006507902	84	0.00015861279085714285	1.50674	50	62	0.004975124	
GO Cellular Component	small ribosomal subunit	80	4.82021e-12	1.04116536e-10	2.116141	105	0.007509118	81	0.00011457504	1.479117	57	72	0.005671642	
GO Cellular Component	small nuclear ribonucleoprotein complex	85	1.223931e-11	2.4881797270588235e-10	2.124518	100	0.007151541	75	0.00003410452224	1.516349	56	69	0.005572139	
GO Cellular Component	MLL1 complex	93	7.144519e-11	1.3274977238709677e-9	2.735422	56	0.004004863	194	0.03309072791752577	1.481801	23	29	0.002288557	
GO Cellular Component	proteasome regulatory particle, base subcomplex	108	1.147309e-9	1.8356944e-8	4.709902	24	0.00171637	138	0.006899483269565217	1.868358	12	12	0.00119403	
GO Cellular Component	proteasome accessory complex	125	7.541524e-9	1.0425402777599999e-7	2.767016	43	0.003075163	66	0.000007895986036363638	1.868358	24	24	0.00238806	
GO Cellular Component	mitochondrial nucleoid	158	1.354151e-7	0.0000014809955240506328	2.079185	63	0.004505471	143	0.008347948665734265	1.467996	33	42	0.003283582	
GO Cellular Component	mitochondrial small ribosomal subunit	170	3.020227e-7	0.000003069971915294118	2.506198	40	0.002860616	168	0.01603848342857143	1.534723	23	28	0.002288557	
GO Molecular Function	structural constituent of ribosome	7	9.695739e-40	5.847915722571429e-37	2.470291	277	0.01980977	9	2.2051693644444445e-14	1.580031	137	162	0.01363184	
GO Molecular Function	ribonucleoprotein complex binding	9	8.371494e-27	3.927160852e-24	2.316305	208	0.01487521	41	0.000028117521136585368	1.4297	88	115	0.008756219	
GO Molecular Function	unfolded protein binding	10	4.790518e-26	2.0225566996e-23	2.520541	171	0.01222914	93	0.009509664578494623	1.321952	75	106	0.007462687	
GO Molecular Function	rRNA binding	14	1.43114e-22	4.3159093428571425e-20	3.355841	93	0.006650933	68	0.0011011801773529411	1.494687	48	60	0.004776119	
GO Molecular Function	protein transporter activity	17	1.580221e-20	3.924525330588236e-18	2.11372	191	0.01365944	44	0.00004603893333636364	1.459655	75	96	0.007462687	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	30	3.752113e-13	5.2804736953333335e-11	2.603907	76	0.005435171	94	0.009689260934042552	1.610654	25	29	0.002487562	
GO Molecular Function	signal sequence binding	31	4.628608e-13	6.303865476129032e-11	2.110256	116	0.008295788	76	0.003014995752105263	1.536206	37	45	0.003681592	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	40	1.711411e-11	1.8063943105e-9	2.562318	67	0.004791533	101	0.019318316966336634	1.477306	34	43	0.003383085	
GO Molecular Function	snRNA binding	52	1.542155e-10	1.2521112326923077e-8	2.735034	54	0.003861832	98	0.012718951634693878	1.524187	31	38	0.003084577	
GO Molecular Function	phosphate transmembrane transporter activity	151	0.000004677974	0.00013079739223841058	2.06276	48	0.00343274	102	0.019529635033333333	1.634813	21	24	0.002089552	
Human Phenotype	Exercise intolerance	3	5.993222e-19	1.3330923468666667e-15	2.569898	117	0.008367303	126	0.005636820796825396	1.414614	53	70	0.005273632	
Human Phenotype	Abnormal CSF metabolite level	4	1.099883e-18	1.83487981475e-15	2.651066	109	0.00779518	36	0.0000020829194880555556	1.631106	55	63	0.005472637	
Human Phenotype	Increased serum lactate	7	3.411083e-18	3.2517366941428573e-15	2.149622	161	0.01151398	34	0.0000015850734101764708	1.51337	81	100	0.008059701	
Human Phenotype	Increased CSF lactate	19	6.294662e-16	2.2107515540000004e-13	2.578241	96	0.00686548	39	0.000003892721926410256	1.642867	51	58	0.005074627	
Human Phenotype	Abnormality of mitochondrial metabolism	44	5.696028e-12	8.638544282727272e-10	2.011529	118	0.008438819	23	2.3166349463043477e-8	1.678815	62	69	0.006169154	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	107	4.462738e-8	0.0000027831636143925234	3.182448	31	0.002216978	236	0.04829631818220339	1.660763	16	18	0.00159204	
Human Phenotype	Glycosuria	123	1.967168e-7	0.000010672286230894308	2.113124	59	0.004219409	105	0.002297161184285714	1.67508	26	29	0.002587065	
Human Phenotype	Progressive macrocephaly	147	6.43292e-7	0.000029201955891156465	2.462072	39	0.002789101	115	0.004040956424521739	1.712662	22	24	0.002189055	
Human Phenotype	Abnormality of renal resorption	163	0.0000013152	0.000053842512883435575	2.707132	31	0.002216978	165	0.015400786558181818	1.758455	16	17	0.00159204	
Human Phenotype	Increased muscle lipid content	172	0.000001893466	0.00007345987568604652	2.709529	30	0.002145462	209	0.03236181502392344	1.671689	17	19	0.001691542	
Human Phenotype	Abnormal mitochondria in muscle tissue	175	0.00000206199	0.0000786266244	2.40531	37	0.00264607	131	0.00610822988091603	1.705892	21	23	0.002089552	
Human Phenotype	Renal Fanconi syndrome	193	0.000003960401	0.00013693137758031087	2.909323	25	0.001787885	140	0.0075148799792857145	1.868358	14	14	0.001393035	
Human Phenotype	Increased intramyocellular lipid droplets	211	0.00000723501	0.00022881147739336493	2.624627	28	0.002002432	165	0.015400786558181818	1.758455	16	17	0.00159204	
Human Phenotype	Acute necrotizing encephalopathy	242	0.00001839771	0.0005073054497107438	2.290734	33	0.002360009	189	0.02112696867883598	1.681522	18	20	0.001791045	
Human Phenotype	Increased hepatocellular lipid droplets	301	0.00007352527	0.00163001371	2.601217	22	0.001573339	186	0.019767879941935483	1.868358	12	12	0.00119403