# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to topologically incorrect protein	4	8.600325e-38	2.829291916875e-34	2.840562	205	0.02315861	174	0.00000359962705591954	1.515627	93	139	0.01121969	
GO Biological Process	endoplasmic reticulum unfolded protein response	5	6.074272e-37	1.59862690496e-33	3.065276	178	0.02010845	207	0.000023431271392270534	1.530065	77	114	0.00928942	
GO Biological Process	response to topologically incorrect protein	7	1.252074e-36	2.353720252285714e-33	2.524225	243	0.02745142	162	9.958853042592591e-7	1.472439	117	180	0.01411509	
GO Biological Process	cellular response to unfolded protein	10	2.859786e-33	3.7631923974e-30	2.80664	183	0.02067329	204	0.00002139512134264706	1.516435	81	121	0.009771987	
GO Biological Process	response to unfolded protein	12	1.514177e-32	1.6604212619166664e-29	2.486074	221	0.02496611	170	0.0000024720141332941175	1.486597	105	160	0.01266739	
GO Biological Process	viral gene expression	13	5.135089e-32	5.197895088538461e-29	2.990941	159	0.01796204	114	2.891047305877193e-9	1.658835	93	127	0.01121969	
GO Biological Process	viral transcription	20	1.161858e-28	7.644444711000001e-26	2.943548	145	0.01638048	132	2.2586625984848485e-8	1.663887	83	113	0.01001327	
GO Biological Process	multi-organism metabolic process	21	1.451473e-28	9.09520628904762e-26	2.580159	180	0.02033439	111	2.0084036372072074e-9	1.618065	105	147	0.01266739	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	33	2.683057e-26	1.0698893049393939e-23	2.8663	138	0.0155897	180	0.000004533482388722223	1.554988	81	118	0.009771987	
GO Biological Process	translational initiation	37	1.546026e-25	5.498420576756757e-23	2.518793	167	0.01886579	145	9.636961886896553e-8	1.568279	99	143	0.01194354	
GO Biological Process	nuclear-transcribed mRNA catabolic process	38	2.604855e-25	9.020338669736842e-23	2.215214	214	0.02417533	168	0.0000017919800876190477	1.441549	126	198	0.01520087	
GO Biological Process	protein targeting to ER	40	1.052881e-24	3.46371526975e-22	2.940423	124	0.01400813	160	7.271711101374999e-7	1.63729	73	101	0.008806852	
GO Biological Process	mRNA catabolic process	41	3.601314e-24	1.1558461201463414e-21	2.115479	226	0.02553095	161	8.673129593167702e-7	1.435748	135	213	0.01628664	
GO Biological Process	RNA catabolic process	42	3.868496e-24	1.2120366396190476e-21	2.020562	252	0.02846814	152	1.8459895376315788e-7	1.428731	152	241	0.01833756	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	43	4.312223e-24	1.319640522255814e-21	2.535786	155	0.01751017	521	0.039372485715930904	1.323091	66	113	0.00796236	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	45	5.79722e-24	1.6952359551111112e-21	3.04107	114	0.01287845	167	0.0000017173416917964073	1.649723	67	92	0.008083002	
GO Biological Process	cotranslational protein targeting to membrane	46	1.123951e-23	3.215232871521739e-21	2.948063	118	0.01333032	155	2.9316239946451613e-7	1.664296	72	98	0.008686211	
GO Biological Process	protein localization to endoplasmic reticulum	50	3.560862e-22	9.371476611599999e-20	2.505394	145	0.01638048	156	3.233446350512821e-7	1.589358	87	124	0.01049584	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	52	7.80136e-22	1.9741941584615384e-19	2.660446	128	0.01446001	157	3.3085137282165603e-7	1.639639	76	105	0.009168778	
GO Biological Process	regulation of DNA-templated transcription in response to stress	54	2.099714e-21	5.11669194925926e-19	2.328517	161	0.01818798	473	0.024301075835729383	1.332524	70	119	0.008444927	
GO Cellular Component	ribosomal subunit	23	5.912942e-33	4.442419033043479e-31	2.624196	203	0.02293267	28	3.0650801142857143e-12	1.616316	132	185	0.01592472	
GO Cellular Component	ribosome	25	3.030554e-25	2.0947189248e-23	2.125955	234	0.0264347	32	9.1045836e-10	1.487797	155	236	0.01869948	
GO Cellular Component	large ribosomal subunit	26	2.831301e-24	1.8817262030769231e-22	2.807627	131	0.01479892	35	3.935851282285714e-9	1.674346	85	115	0.01025455	
GO Cellular Component	cytosolic ribosome	33	1.961845e-17	1.027293381818182e-15	2.268062	136	0.01536376	36	5.088504e-9	1.678743	83	112	0.01001327	
GO Cellular Component	cytosolic large ribosomal subunit	37	1.575739e-15	7.359127005405405e-14	2.774978	82	0.009263443	41	3.1336685736585363e-7	1.81966	49	61	0.005911449	
GO Cellular Component	mitochondrial ribosome	42	5.091174e-14	2.0946544457142855e-12	2.711695	76	0.00858563	73	0.0010046244032876712	1.492427	56	85	0.006755942	
GO Cellular Component	methyltransferase complex	49	5.994703e-12	2.1140503640816328e-10	2.088896	107	0.01208766	68	0.000560524574117647	1.493599	60	91	0.007238509	
GO Cellular Component	other organism cell	50	7.521507e-12	2.5994328192e-10	2.256917	89	0.01005423	107	0.021739725757009346	1.408154	46	74	0.005549523	
GO Cellular Component	protein phosphatase type 2A complex	51	8.373911e-12	2.8372780800000004e-10	2.723204	62	0.007004067	97	0.011357182020618556	1.833807	17	21	0.002050911	
GO Cellular Component	host cell	53	4.026981e-11	1.3129477675471697e-9	2.252931	83	0.009376412	105	0.019122837942857143	1.432464	43	68	0.005187598	
GO Cellular Component	small ribosomal subunit	56	6.479255e-11	1.9993129714285715e-9	2.355841	74	0.008359693	76	0.002146792850526316	1.510194	48	72	0.005790807	
GO Cellular Component	mitochondrial large ribosomal subunit	57	9.7691e-11	2.961579789473684e-9	2.941471	49	0.005535472	80	0.0025774524	1.599029	36	51	0.004343105	
GO Cellular Component	protein serine/threonine phosphatase complex	58	1.735755e-10	5.1713528275862075e-9	2.034726	98	0.01107094	78	0.002230781538461538	1.618065	35	49	0.004222464	
GO Cellular Component	cytosolic small ribosomal subunit	75	3.453484e-8	7.956827136000001e-7	2.389244	51	0.00576141	79	0.0024994535696202533	1.647485	32	44	0.003860538	
GO Cellular Component	spliceosomal snRNP complex	112	0.000002647455	0.00004084644857142857	2.054969	51	0.00576141	117	0.032976132923076926	1.424941	39	62	0.004705031	
GO Cellular Component	ESCRT complex	119	0.00000632658	0.00009186832134453781	2.543121	30	0.003389065	124	0.04494500129032258	1.618065	20	28	0.002412836	
GO Cellular Component	chromatin silencing complex	171	0.0001121741	0.0011335488	3.806957	12	0.001355626	108	0.023030736	2.265291	8	8	0.0009651345	
GO Molecular Function	structural constituent of ribosome	7	1.073757e-25	6.476288648571428e-23	2.465275	175	0.01976954	16	2.9687705462500003e-9	1.594094	114	162	0.01375317	
GO Molecular Function	rRNA binding	13	3.559403e-17	1.1559845743076923e-14	3.591021	63	0.007117036	86	0.04408283476744186	1.472439	39	60	0.004705031	
GO Molecular Function	unfolded protein binding	16	4.85353e-15	1.2807252287499999e-12	2.398246	103	0.01163579	61	0.001754759406229508	1.453206	68	106	0.008203643	
GO Molecular Function	snRNA binding	27	4.708244e-10	7.36229858074074e-8	3.20028	40	0.004518753	69	0.013000810718840579	1.669162	28	38	0.003377971	
GO Molecular Function	mitogen-activated protein kinase binding	34	3.421827e-8	0.000004249103998235295	2.52234	46	0.005196566	75	0.022003251354666666	1.761893	21	27	0.002533478	
GO Molecular Function	protein transmembrane transporter activity	82	0.000005357227	0.0002758318584634146	2.66795	28	0.003163127	84	0.03894836717380953	1.887743	15	18	0.001809627	
GO Molecular Function	macromolecule transmembrane transporter activity	122	0.00007331867	0.002537306760163934	2.187169	31	0.003502033	81	0.03323011103703704	1.833807	17	21	0.002050911	
Human Phenotype	Abnormality of bladder morphology	48	0.000001534255	0.00021329340864583335	2.994775	26	0.002937189	74	0.03982074876216216	1.98213	14	16	0.001688985	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	155	0.00003356473	0.0019829176297419355	2.321436	30	0.003389065	94	0.04920692219255319	1.793356	19	24	0.002292194	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	132	0.000001986792	0.0001439069569090909	2.408288	37	0.004179846	114	0.00547676389	1.812233	24	30	0.002895404