# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	17	2.334197e-38	1.8068057837058823e-35	2.527157	256	0.01745058	271	0.00004615783886715867	1.446781	82	113	0.008706732	
GO Biological Process	mRNA catabolic process	21	1.964616e-34	1.231065806857143e-31	2.039007	361	0.02460804	177	3.768087084463277e-8	1.413399	151	213	0.01603313	
GO Biological Process	regulation of DNA-templated transcription in response to stress	22	2.423799e-34	1.4497623200454543e-31	2.330108	267	0.01820041	264	0.00003472189067613636	1.440851	86	119	0.00913145	
GO Biological Process	nuclear-transcribed mRNA catabolic process	23	4.981146e-34	2.8498652266956517e-31	2.092464	335	0.02283572	184	8.208012069565217e-8	1.419781	141	198	0.01497133	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	25	2.860491e-33	1.50564804276e-30	2.10953	321	0.02188139	246	0.000013164252901626015	1.402046	109	155	0.01157358	
GO Biological Process	endoplasmic reticulum unfolded protein response	26	3.182606e-33	1.610765859769231e-30	2.441905	235	0.01601909	303	0.0001907654149933993	1.416601	81	114	0.008600552	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	37	1.069683e-30	3.8043131343243243e-28	2.531659	202	0.0137696	217	9.418933253456222e-7	1.50375	89	118	0.009449989	
GO Biological Process	cellular response to unfolded protein	42	6.709584e-29	2.1021765680000001e-26	2.239558	242	0.01649625	311	0.0002280640026109325	1.400558	85	121	0.009025271	
GO Biological Process	cellular response to topologically incorrect protein	44	4.785344e-28	1.4311441294545454e-25	2.148794	257	0.01751875	370	0.000769652838864865	1.348281	94	139	0.009980888	
GO Biological Process	multi-organism metabolic process	45	4.873933e-28	1.4252463188222224e-25	2.170996	251	0.01710975	170	1.826439011705882e-8	1.505474	111	147	0.01178594	
GO Biological Process	IRE1-mediated unfolded protein response	46	5.338217e-28	1.5270782065869565e-25	3.102936	131	0.008929789	478	0.0045314035083682015	1.478114	43	58	0.004565725	
GO Biological Process	response to unfolded protein	47	7.838654e-28	2.1946563401276597e-25	2.015995	297	0.0202454	263	0.000028994145329657793	1.383154	111	160	0.01178594	
GO Biological Process	protein targeting to ER	52	4.052603e-27	1.0255423630192307e-24	2.532635	177	0.01206544	175	2.8659858353714286e-8	1.598936	81	101	0.008600552	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	56	2.948494e-26	6.928434383214286e-24	2.251941	216	0.01472393	473	0.003953478275475687	1.378647	65	94	0.006901678	
GO Biological Process	viral gene expression	58	6.364301e-26	1.4439282217068967e-23	2.304189	203	0.01383776	196	2.3351310163775512e-7	1.507076	96	127	0.01019325	
GO Biological Process	protein localization to endoplasmic reticulum	67	3.831197e-24	7.524585272089553e-22	2.189468	210	0.01431493	173	2.730364713179191e-8	1.543537	96	124	0.01019325	
GO Biological Process	cotranslational protein targeting to membrane	69	5.069457e-23	9.667968791739131e-21	2.427124	161	0.01097478	220	0.0000012811297350454546	1.546162	76	98	0.008069654	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	73	1.539586e-22	2.7752619416438355e-20	2.462772	153	0.01042945	221	0.0000015065655739819003	1.560315	72	92	0.007644935	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	76	2.429217e-22	4.206061381973685e-20	2.35845	165	0.01124744	384	0.0010359152030989583	1.45696	57	78	0.00605224	
GO Biological Process	viral transcription	78	2.740161e-22	4.622792128076923e-20	2.241638	183	0.01247444	215	7.881586110232557e-7	1.517356	86	113	0.00913145	
GO Cellular Component	PcG protein complex	43	4.293727e-18	1.7254791293023253e-16	2.292599	139	0.009475119	163	0.025401398576687117	1.430288	33	46	0.003503929	
GO Cellular Component	large ribosomal subunit	47	2.381801e-16	8.756919421276596e-15	2.056253	159	0.01083845	79	0.00016557179787341772	1.404283	81	115	0.008600552	
GO Cellular Component	peptidase complex	50	1.764033e-15	6.096498048e-14	2.059673	149	0.01015678	68	0.000012807554823529411	1.517958	67	88	0.007114037	
GO Cellular Component	outer mitochondrial membrane protein complex	52	2.45361e-15	8.153534769230769e-14	4.57614	42	0.002862986	129	0.006787242418604651	1.86082	14	15	0.001486515	
GO Cellular Component	endopeptidase complex	56	4.385151e-15	1.3531323085714285e-13	2.242922	119	0.008111793	90	0.00090980736	1.473631	51	69	0.005415162	
GO Cellular Component	mitochondrial ribosome	58	1.959186e-14	5.83702311724138e-13	2.303681	107	0.007293797	132	0.007177011054545455	1.360431	58	85	0.00615842	
GO Cellular Component	proteasome complex	59	2.155501e-14	6.313060555932203e-13	2.206472	117	0.00797546	91	0.0013407992545054945	1.465982	50	68	0.005308983	
GO Cellular Component	nuclear ubiquitin ligase complex	71	3.402644e-12	8.281364552112676e-11	2.577382	71	0.004839809	143	0.014178034573426571	1.495302	30	40	0.00318539	
GO Cellular Component	mitochondrial large ribosomal subunit	83	6.318581e-11	1.3154828877108434e-9	2.463138	68	0.00463531	165	0.025525995054545454	1.407343	36	51	0.003822468	
GO Cellular Component	spliceosomal snRNP complex	99	2.897643e-9	5.0577041454545454e-8	2.042329	84	0.005725971	110	0.004188731694545454	1.447066	45	62	0.004778085	
GO Cellular Component	spliceosomal tri-snRNP complex	170	0.000003317452	0.00003372092385882353	2.216405	42	0.002862986	179	0.040986905027932966	1.512489	22	29	0.002335952	
GO Cellular Component	trans-Golgi network transport vesicle	184	0.000008577275	0.0000805518	2.0311	47	0.003203817	127	0.006521567244094488	1.637711	23	28	0.002442132	
GO Cellular Component	Seh1-associated complex	185	0.000008767971	0.0000818975885837838	2.457001	31	0.002113156	170	0.038770282164705884	1.727904	13	15	0.001380336	
GO Cellular Component	zonula adherens	189	0.00001165198	0.00010653238857142858	2.794514	24	0.001635992	174	0.039720115862068965	1.993735	8	8	0.0008494372	
GO Cellular Component	platelet dense tubular network	195	0.00001419745	0.00012581124923076925	2.435697	30	0.00204499	128	0.0068034033	1.993735	11	11	0.001167976	
GO Cellular Component	U5 snRNP	198	0.00001545429	0.00013487380363636365	2.311522	33	0.002249489	160	0.024420819599999997	1.631238	18	22	0.001911234	
GO Cellular Component	mRNA cleavage factor complex	213	0.00003762834	0.0003052665329577465	2.149112	35	0.002385821	148	0.015657828324324326	1.694675	17	20	0.001805054	
GO Cellular Component	Swr1 complex	241	0.00009983521	0.000715830883319502	3.23987	15	0.001022495	154	0.02250025433766234	1.993735	9	9	0.0009556169	
GO Cellular Component	mRNA cleavage and polyadenylation specificity factor complex	253	0.0001641842	0.001121384575494071	2.182774	28	0.001908657	129	0.006787242418604651	1.86082	14	15	0.001486515	
GO Cellular Component	prespliceosome	271	0.0002813411	0.0017939388221402213	2.078139	29	0.001976823	169	0.038220936710059175	1.613976	17	21	0.001805054	
GO Molecular Function	unfolded protein binding	8	1.091033e-31	5.7579266575e-29	2.669448	190	0.0129516	48	0.0000209189545	1.485897	79	106	0.008388193	
GO Molecular Function	ribonucleoprotein complex binding	11	5.644658e-20	2.1665223705454544e-17	2.069842	195	0.01329243	53	0.00009452651732075472	1.438957	83	115	0.008812911	
GO Molecular Function	telomeric DNA binding	83	8.278608e-8	0.000004211118430843373	2.10976	63	0.004294479	81	0.00538879921728395	1.6419	28	34	0.00297303	
Human Phenotype	Increased serum lactate	6	2.095743e-16	2.3308155065e-13	2.048955	161	0.01097478	35	0.0000057788313460000005	1.535176	77	100	0.008175834	
Human Phenotype	Abnormality of mitochondrial metabolism	12	8.215906e-14	4.568728394833333e-11	2.079814	128	0.00872529	46	0.00005473816929782609	1.589209	55	69	0.005839881	
Human Phenotype	Abnormality of the mitochondrion	13	8.953066e-14	4.5956776475384616e-11	2.063937	130	0.008861622	39	0.00002491027477948718	1.600604	57	71	0.00605224	
Human Phenotype	Exercise intolerance	23	2.696387e-11	7.823039326521739e-9	2.093631	100	0.006816633	114	0.01387210166140351	1.424097	50	70	0.005308983	
Human Phenotype	Abnormal CSF metabolite level	40	2.711164e-9	4.522899343e-7	2.016896	87	0.00593047	133	0.024133988235338348	1.424097	45	63	0.004778085	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	42	5.216852e-13	1.1373979467619049e-10	2.106406	116	0.007907294	86	0.0006994433900697674	1.561759	47	60	0.004990444	
Mouse Phenotype Single KO	early cellular replicative senescence	61	1.446837e-11	2.1719158047540985e-9	2.100419	102	0.006952965	131	0.004778756599923665	1.533643	40	52	0.004247186	
Mouse Phenotype	dry eyes	11	1.969222e-20	1.711611958363636e-17	3.18125	90	0.006134969	420	0.049277325707142855	1.744518	14	16	0.001486515	
Mouse Phenotype	abnormal cellular replicative senescence	12	3.017458e-20	2.4041596615e-17	2.154961	180	0.01226994	93	0.000026730654080645162	1.542771	65	84	0.006901678	
Mouse Phenotype	early cellular replicative senescence	16	2.164269e-19	1.2932859943125e-16	2.205555	163	0.01111111	121	0.00022655800911570246	1.529441	56	73	0.005946061	
Mouse Phenotype	small sebaceous gland	138	8.296428e-9	5.747981746956521e-7	4.411059	23	0.001567825	351	0.027383330504273506	1.993735	10	10	0.001061797