# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process vesicle cytoskeletal trafficking 108 0.000001482849 0.00018067416658333333 2.854859 28 0.01002506 430 0.03335151610232558 2.061594 18 44 0.004830918 GO Biological Process bone marrow development 113 0.000002229982 0.0002596843640530974 9.874416 8 0.002864304 466 0.04342376813948498 4.199544 5 6 0.001341922 GO Biological Process regulation of hydrogen peroxide-mediated programmed cell death 124 0.000004876909 0.0005175423026693548 3.99316 16 0.005728607 402 0.02681478825721393 3.527617 7 10 0.00187869 GO Biological Process signal transduction involved in regulation of gene expression 213 0.00009670787 0.005974548644741784 2.546326 22 0.007876835 264 0.00463300377280303 3.023671 12 20 0.003220612 GO Biological Process regulation of the force of heart contraction by chemical signal 229 0.0001508126 0.008666126652401747 4.783844 9 0.003222342 466 0.04342376813948498 4.199544 5 6 0.001341922 GO Biological Process regulation of insulin receptor signaling pathway 250 0.0002474569 0.0130251413884 2.007587 32 0.01145721 373 0.02147105345227882 2.056919 20 49 0.005367687 GO Biological Process neural crest cell fate commitment 262 0.000322964 0.016220928534351146 3.618386 11 0.003938417 478 0.0426285805 5.039452 4 4 0.001073537 GO Biological Process positive regulation of ryanodine-sensitive calcium-release channel activity 319 0.0006214879 0.025636862934482755 3.596113 10 0.00358038 436 0.035470084500000006 3.779589 6 8 0.001610306 GO Biological Process D-amino acid transport 346 0.0008765829 0.03333801844248555 4.707777 7 0.002506266 466 0.04342376813948498 4.199544 5 6 0.001341922 GO Biological Process lung vasculature development 358 0.0009823065 0.03610662355726257 4.067094 8 0.002864304 466 0.04342376813948498 4.199544 5 6 0.001341922 GO Biological Process protein K63-linked ubiquitination 375 0.001147985 0.040283558973333335 2.25595 19 0.006802721 488 0.043042711487704916 2.159765 15 35 0.004025765 GO Biological Process osteoblast development 389 0.001281926 0.043364689547557844 2.233891 19 0.006802721 348 0.017334108695402296 2.964384 10 17 0.002683843 GO Biological Process positive regulation of cell maturation 399 0.001442962 0.0475888144310777 4.311996 7 0.002506266 466 0.04342376813948498 4.199544 5 6 0.001341922 GO Biological Process negative regulation of receptor activity 404 0.001522615 0.04959428412128713 2.062617 22 0.007876835 409 0.028680848057212712 2.141767 17 40 0.004562534 Mouse Phenotype Single KO meteorism 17 1.281011e-7 0.00006900128074705883 3.24119 28 0.01002506 151 0.0008299741065562915 3.275644 13 20 0.003488996 Mouse Phenotype Single KO distended abdomen 23 3.29179e-7 0.00013105617839130436 2.270062 48 0.01718582 126 0.0002500266524285714 2.283502 29 64 0.007783145 Mouse Phenotype Single KO xiphoid process foramen 39 0.000005595148 0.0013137120573333333 5.732365 11 0.003938417 283 0.009933795104946998 5.039452 5 5 0.001341922 Mouse Phenotype Single KO decreased anterior commissure size 44 0.000007846216 0.0016329045434545454 3.654258 17 0.006086645 279 0.009743783185663083 3.919574 7 9 0.00187869 Mouse Phenotype Single KO decreased vascular endothelial cell number 49 0.00001009654 0.0018868166689795917 4.223815 14 0.005012531 292 0.011089544082534245 4.319531 6 7 0.001610306 Mouse Phenotype Single KO absent outer hair cell stereocilia 68 0.00003681381 0.004957412620147059 3.746323 14 0.005012531 279 0.009743783185663083 3.919574 7 9 0.00187869 Mouse Phenotype Single KO impaired lipolysis 69 0.00003683388 0.004888229553043478 4.286157 12 0.004296455 403 0.026685679320099256 3.101202 8 13 0.002147075 Mouse Phenotype Single KO abnormal white fat cell number 88 0.00006982051 0.007265300114431819 3.059458 17 0.006086645 371 0.020937895156603773 2.799696 10 18 0.002683843 Mouse Phenotype Single KO absent primordial germ cells 111 0.0001223442 0.010092845399999998 3.337441 14 0.005012531 292 0.011089544082534245 4.319531 6 7 0.001610306 Mouse Phenotype Single KO abnormal heart apex morphology 155 0.0003586661 0.021189067598064514 4.757842 8 0.002864304 189 0.002948417856243386 5.039452 6 6 0.001610306 Mouse Phenotype Single KO abnormal glomerular capillary morphology 198 0.0006511877 0.03011578671161616 2.052586 26 0.009308987 462 0.033857115584415585 2.039778 17 42 0.004562534 Mouse Phenotype Single KO abnormal kidney capillary morphology 203 0.0006975299 0.03146443987339902 2.042649 26 0.009308987 489 0.04324482198364008 1.992342 17 43 0.004562534 Mouse Phenotype Single KO increased skin papilloma incidence 204 0.0007083077 0.03179398827892157 2.926502 13 0.004654493 437 0.03093521672997712 2.519726 11 22 0.002952228 Mouse Phenotype Single KO translucent skin 210 0.0007800809 0.03401524191095238 2.471911 17 0.006086645 403 0.026685679320099256 3.101202 8 13 0.002147075 Mouse Phenotype Single KO absent allantois 255 0.001312433 0.04712921169019608 2.2292 19 0.006802721 321 0.014859089573831776 2.771699 11 20 0.002952228 Mouse Phenotype extramedullary hematopoiesis 15 3.340246e-11 2.1290728004000002e-8 2.145595 92 0.03293949 438 0.007356704901369864 1.555031 54 175 0.01449275 Mouse Phenotype meteorism 42 1.309876e-7 0.000029818391514285718 2.897686 33 0.01181525 166 0.00010451100301807229 3.22525 16 25 0.004294149 Mouse Phenotype abnormal hair follicle outer root sheath morphology 54 9.102876e-7 0.00016117147673333336 3.000188 27 0.009667025 325 0.002216166548030769 2.699707 15 28 0.004025765 Mouse Phenotype pale placenta 71 0.000002585718 0.0003481978844788733 4.462209 15 0.005370569 814 0.047134156076167076 2.687708 8 15 0.002147075 Mouse Phenotype increased hematopoietic stem cell number 83 0.000004760824 0.0005484125092048192 2.175949 42 0.01503759 512 0.012671299740820314 1.880393 25 67 0.006709608 Mouse Phenotype xiphoid process foramen 86 0.000005595148 0.0006220373259069767 5.732365 11 0.003938417 430 0.00682626717 5.039452 5 5 0.001341922 Mouse Phenotype abnormal adaptive thermogenesis 94 0.000008119715 0.0008258786714361703 2.105399 43 0.01539563 382 0.004860529574607329 1.932941 28 73 0.007514761 Mouse Phenotype enlarged liver sinusoidal spaces 97 0.000008366751 0.0008246856320721649 2.546879 29 0.0103831 591 0.02012825076142132 2.089529 17 41 0.004562534 Mouse Phenotype decreased vascular endothelial cell number 99 0.00001032518 0.0009971620806060605 3.754886 16 0.005728607 320 0.0021821877009375002 4.031562 8 10 0.002147075 Mouse Phenotype abnormal epidermis stratum granulosum morphology 104 0.00001191886 0.0010957328890384614 2.071137 43 0.01539563 302 0.0017232151211920529 1.977507 31 79 0.008319914 Mouse Phenotype absent outer hair cell stereocilia 130 0.00003681381 0.0027075141339230765 3.746323 14 0.005012531 425 0.006678716193882353 3.919574 7 9 0.00187869 Mouse Phenotype abnormal liver glycogen level 134 0.00004188717 0.0029886808385820897 2.106001 36 0.01288937 740 0.037697046198648644 1.788193 22 62 0.005904455 Mouse Phenotype delayed hair appearance 157 0.0000915315 0.005574093449044586 2.494869 23 0.008234873 212 0.00034718376740094334 2.986342 16 27 0.004294149 Mouse Phenotype increased keratinocyte proliferation 163 0.00009684783 0.00568074909588957 2.332805 26 0.009308987 644 0.025424762631987577 1.954073 19 49 0.005099302 Mouse Phenotype parakeratosis 169 0.0001072807 0.006069294513017751 2.593806 21 0.007518797 526 0.013839558406083651 2.29066 15 33 0.004025765 Mouse Phenotype increased lung adenoma incidence 171 0.0001192784 0.006669127382456141 2.260282 27 0.009667025 824 0.04724252544174757 1.799804 20 56 0.005367687 Mouse Phenotype decreased embryonic neuroepithelium thickness 211 0.0002917799 0.013221363146445498 2.208447 25 0.008950949 600 0.021262277654999998 2.339746 13 28 0.003488996 Mouse Phenotype abnormal hippocampal fornix morphology 212 0.0002928459 0.013207073820283018 4.907137 8 0.002864304 631 0.023462800064976228 5.039452 4 4 0.001073537 Mouse Phenotype abnormal mesangial cell morphology 231 0.0003669075 0.015186158474025973 2.13592 26 0.009308987 539 0.01467178909090909 2.015781 20 50 0.005367687 Mouse Phenotype decreased lung tumor incidence 238 0.0004075784 0.016373349085714285 3.109417 13 0.004654493 791 0.04488068776991151 2.939681 7 12 0.00187869