# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process mitochondrial transport 9 1.667126e-16 2.437523448222222e-13 3.081616 73 0.04737184 11 0.013146558763636363 1.977921 43 239 0.02517564 GO Biological Process mitochondrial membrane organization 32 1.114319e-11 4.5822886628124994e-9 3.253956 46 0.02985075 26 0.021580375352307692 2.305101 26 124 0.01522248 GO Biological Process protein-DNA complex subunit organization 48 1.059174e-9 2.90368138875e-7 2.340079 64 0.04153147 13 0.015658673517692307 1.934867 44 250 0.02576112 GO Biological Process protein-DNA complex assembly 75 3.256496e-8 0.000005713630781866667 2.287418 55 0.03569111 24 0.019232152645833334 1.957757 39 219 0.02283372 GO Biological Process post-embryonic camera-type eye development 85 5.374034e-8 0.000008319636871294118 7.303194 13 0.00843608 37 0.03953994981081081 7.852543 5 7 0.0029274 GO Biological Process negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding 120 3.959847e-7 0.0000434230222275 16.08816 7 0.004542505 22 0.020549722443181817 9.1613 5 6 0.0029274 GO Biological Process JAK-STAT cascade 199 0.00001119064 0.0007399880992964824 2.865093 23 0.01492537 10 0.013564599856999999 3.508583 15 47 0.008782201 GO Cellular Component ficolin-1-rich granule lumen 28 1.296569e-10 8.00168297142857e-9 3.456003 38 0.02465931 35 0.03663624137142857 2.039128 23 124 0.01346604 GO Cellular Component transcription factor AP-1 complex 156 0.001580553 0.017507664 8.224142 4 0.002595717 27 0.0202520448 8.794848 4 5 0.00234192 Mouse Phenotype Single KO abnormal platelet aggregation 5 1.014444e-23 1.8578527416e-20 5.3797 57 0.03698897 31 0.004535157851290323 2.818861 20 78 0.0117096 Mouse Phenotype Single KO abnormal platelet activation 6 6.292782e-23 9.603834128999999e-20 5.173692 57 0.03698897 43 0.012492460674883722 2.58672 20 85 0.0117096 Mouse Phenotype Single KO abnormal platelet physiology 13 1.726279e-19 1.2159643694615384e-16 4.029216 62 0.04023361 38 0.010180964656842106 2.398595 24 110 0.01405152 Mouse Phenotype Single KO decreased circulating alanine transaminase level 43 3.238025e-12 6.895487191860465e-10 3.558405 43 0.02790396 37 0.007399145559189189 2.785035 19 75 0.01112412 Mouse Phenotype Single KO abnormal blood coagulation 46 4.258904e-12 8.477996506086956e-10 2.406797 78 0.05061648 59 0.023902532620338986 1.865879 37 218 0.02166276 Mouse Phenotype Single KO abnormal hemostasis 50 5.097187e-12 9.334988271800001e-10 2.397646 78 0.05061648 63 0.027060155933333337 1.848917 37 220 0.02166276 Mouse Phenotype Single KO abnormal body temperature 292 0.0002432963 0.007629671983219177 2.0311 31 0.02011681 67 0.03999666895970149 2.26338 21 102 0.01229508 Mouse Phenotype abnormal platelet aggregation 5 1.026414e-24 1.9627088508e-21 5.239801 61 0.03958469 48 0.005557968650000001 2.572961 22 94 0.01288056 Mouse Phenotype abnormal platelet activation 7 2.620107e-24 3.578691861e-21 5.142218 61 0.03958469 63 0.011551087244761905 2.418583 22 100 0.01288056 Mouse Phenotype decreased pre-B cell number 8 2.943011e-24 3.517266021375e-21 4.087847 77 0.04996755 79 0.01700082558607595 2.325561 22 104 0.01288056 Mouse Phenotype abnormal pre-B cell morphology 12 2.035197e-21 1.6215432097500002e-18 3.507991 81 0.05256327 80 0.01735987184625 2.149117 26 133 0.01522248 Mouse Phenotype abnormal platelet physiology 14 1.924674e-20 1.3144148652857144e-17 3.88769 68 0.04412719 56 0.008269911584464286 2.248683 27 132 0.01580796 Mouse Phenotype abnormal pro-B cell morphology 28 1.179679e-16 4.0281824710714286e-14 3.132855 72 0.04672291 113 0.0359809113 2.159449 22 112 0.01288056 Mouse Phenotype cortical renal glomerulopathies 52 6.437605e-13 1.183652719326923e-10 2.641253 71 0.04607398 119 0.03836423560084034 1.851547 32 190 0.01873536 Mouse Phenotype decreased circulating alanine transaminase level 60 8.434038e-12 1.3439639553000001e-9 3.391729 44 0.02855289 62 0.010792626430645162 2.556642 20 86 0.0117096 Mouse Phenotype increased myeloid cell number 73 1.619025e-10 2.1204791815068495e-8 2.094186 89 0.0577547 73 0.014273263273972603 1.762034 46 287 0.02693208 Mouse Phenotype abnormal circulating alanine transaminase level 81 2.699846e-10 3.186818222962963e-8 2.367714 67 0.04347826 125 0.046643499124799995 1.773155 35 217 0.0204918 Mouse Phenotype decreased platelet aggregation 110 1.073409e-8 9.329875862727272e-7 3.551631 29 0.01881895 126 0.047008500407142856 2.443013 16 72 0.009367681 Mouse Phenotype increased circulating interleukin-18 level 182 0.000005440314 0.000285795836010989 8.722754 8 0.005191434 123 0.04267830629512195 5.073951 6 13 0.003512881 Mouse Phenotype thymus hyperplasia 184 0.000006633655 0.0003446976926902174 3.388472 19 0.01232966 110 0.03536189739272727 3.182346 11 38 0.006440281 Mouse Phenotype increased B cell derived lymphoma incidence 242 0.00005343623 0.002111172706735537 2.468052 25 0.01622323 122 0.042234886790163934 2.396032 17 78 0.009953162 Mouse Phenotype abnormal ear position 277 0.000151662 0.005234802823104693 2.52326 21 0.01362751 128 0.04817657183203125 3.2334 10 34 0.005854801