# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	30	1.262366e-39	5.537158064666667e-37	2.076806	400	0.02506423	204	0.000026004841601960787	1.307603	151	213	0.01483301	
GO Biological Process	rRNA processing	31	7.020336e-39	2.9800194007741934e-36	2.023275	418	0.02619212	280	0.0002918250751571429	1.251624	171	252	0.01679764	
GO Biological Process	nuclear-transcribed mRNA catabolic process	34	2.325724e-38	9.001235916470588e-36	2.118674	369	0.02312175	196	0.000019647944595918367	1.322823	142	198	0.01394892	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	47	6.325177e-33	1.7709149817659573e-30	2.52303	219	0.01372266	324	0.0009292499965123457	1.344296	86	118	0.008447937	
GO Biological Process	regulation of DNA-templated transcription in response to stress	62	1.578988e-29	3.351274692258064e-27	2.15795	269	0.01685569	524	0.018567723177671757	1.270999	82	119	0.00805501	
GO Biological Process	liver regeneration	77	2.858222e-27	4.884590038701298e-25	2.971906	136	0.008521837	594	0.030624692584175085	1.475599	28	35	0.002750491	
GO Biological Process	regulation of mitochondrial membrane permeability	82	7.782729e-27	1.2489381818414634e-24	2.335398	205	0.01284542	406	0.005096953905418719	1.389691	55	73	0.00540275	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	83	1.21783e-26	1.930774092771084e-24	2.204223	230	0.01441193	651	0.044394362655913976	1.275451	65	94	0.006385069	
GO Biological Process	cotranslational protein targeting to membrane	86	5.184587e-26	7.933020968953489e-24	2.466667	178	0.01115358	226	0.00007785755252654867	1.430428	76	98	0.007465619	
GO Biological Process	protein targeting to ER	92	1.551534e-25	2.219199555e-23	2.406994	183	0.01146688	225	0.00007676135969333334	1.424465	78	101	0.007662083	
GO Biological Process	RNA phosphodiester bond hydrolysis	99	5.360343e-24	7.12492459969697e-22	2.065912	239	0.01497588	564	0.024559336980496452	1.248157	90	133	0.008840864	
GO Biological Process	regulation of membrane permeability	101	1.718883e-23	2.2394833066336633e-21	2.143984	214	0.01340936	414	0.005799965925603864	1.366296	60	81	0.00589391	
GO Biological Process	multi-organism metabolic process	102	1.742186e-23	2.2475907425490195e-21	2.003597	252	0.01579046	146	2.9015477830821915e-7	1.430428	114	147	0.01119843	
GO Biological Process	viral gene expression	104	3.903643e-23	4.939234445865385e-21	2.159816	207	0.01297074	157	0.000001795449162420382	1.437838	99	127	0.009724951	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	105	5.203499e-23	6.5212231753333336e-21	2.41182	163	0.01021367	264	0.00020353972349242423	1.423472	71	92	0.00697446	
GO Biological Process	protein-lipid complex subunit organization	129	2.288495e-21	2.3344423027131783e-19	2.585448	132	0.008271195	467	0.012035520083940042	1.452052	37	47	0.003634578	
GO Biological Process	viral transcription	131	2.783576e-21	2.796112716335878e-19	2.150662	191	0.01196817	205	0.000026553989012682926	1.420101	87	113	0.008546169	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	140	1.223622e-20	1.1501172784285714e-18	2.144338	186	0.01165487	283	0.00031545187233568905	1.387766	79	105	0.007760314	
GO Biological Process	positive regulation of mRNA metabolic process	149	3.616111e-20	3.1935842046308726e-18	2.333313	151	0.009461746	616	0.03500890000162338	1.383374	39	52	0.003831041	
GO Biological Process	mitochondrial translation	169	1.514428e-18	1.1791927841420117e-16	2.13053	168	0.01052698	186	0.0000099905179672043	1.448018	84	107	0.008251473	
GO Cellular Component	ribosomal subunit	39	2.352776e-26	1.0424607507692308e-24	2.014848	281	0.01760762	36	5.3255424000000006e-8	1.395837	140	185	0.01375246	
GO Cellular Component	large ribosomal subunit	40	5.449901e-26	2.354357232e-24	2.341909	197	0.01234413	34	2.4667616752941175e-8	1.507677	94	115	0.009233792	
GO Cellular Component	mitochondrial large ribosomal subunit	49	7.812274e-19	2.7550223412244897e-17	2.996724	90	0.005639451	49	0.000007231320293877551	1.627499	45	51	0.004420432	
GO Cellular Component	mitochondrial ribosome	53	2.744485e-17	8.948056754716982e-16	2.394684	121	0.007581929	62	0.0000553355489032258	1.453899	67	85	0.006581532	
GO Cellular Component	high-density lipoprotein particle	58	2.063062e-15	6.14650195862069e-14	3.447444	59	0.003696973	145	0.0358362412137931	1.502925	22	27	0.0021611	
GO Cellular Component	protein-lipid complex	66	4.713499e-14	1.2340797381818183e-12	2.261333	108	0.006767341	140	0.034147427657142855	1.405333	32	42	0.003143418	
GO Cellular Component	spliceosomal snRNP complex	70	1.446034e-13	3.5696382171428572e-12	2.279665	102	0.006391378	106	0.005982047456603774	1.398249	47	62	0.004616896	
GO Cellular Component	cytosolic large ribosomal subunit	87	2.832776e-11	5.626479227586207e-10	2.02724	108	0.006767341	99	0.0032633646545454547	1.421171	47	61	0.004616896	
GO Cellular Component	prespliceosome	119	1.333026e-9	1.935688174789916e-8	2.898369	44	0.002757065	107	0.007058902609345794	1.668832	19	21	0.001866405	
GO Cellular Component	mitochondrial nucleoid	123	1.73072e-9	2.431450536585366e-8	2.168746	75	0.004699543	82	0.0014967676799999999	1.537083	35	42	0.003438114	
GO Cellular Component	ESCRT complex	156	3.158129e-8	3.4982352000000006e-7	2.398014	51	0.003195689	132	0.02565260509090909	1.515124	23	28	0.002259332	
GO Cellular Component	U1 snRNP	184	3.433951e-7	0.0000032249278956521738	2.430474	42	0.002631744	121	0.017542541752066113	1.650341	17	19	0.001669941	
GO Cellular Component	fibrinogen complex	190	5.916206e-7	0.00000538063366736842	2.47098	39	0.002443762	151	0.04623357838410597	1.844499	9	9	0.0008840864	
GO Molecular Function	structural constituent of ribosome	10	6.230272e-26	2.6304208384e-23	2.055033	263	0.01647973	22	0.0000015248605076363636	1.400453	123	162	0.01208251	
GO Molecular Function	rRNA binding	11	2.207354e-24	8.472225989090909e-22	3.288111	104	0.006516699	99	0.03120200012727273	1.383374	45	60	0.004420432	
GO Molecular Function	ribonuclease activity	13	1.163952e-21	3.780157956923077e-19	2.153964	194	0.01215615	108	0.04566976492592593	1.28556	69	99	0.006777996	
Human Phenotype	Abnormal CSF metabolite level	11	2.04425e-16	1.2401163863636363e-13	2.408059	113	0.007080644	93	0.01851762522688172	1.405333	48	63	0.004715128	
Human Phenotype	Increased serum lactate	12	2.127327e-16	1.18297108925e-13	2.000447	171	0.01071496	49	0.001913153185510204	1.383374	75	100	0.007367387	
Human Phenotype	Abnormality of mitochondrial metabolism	14	8.826782e-16	4.2072225918571427e-13	2.120935	142	0.008897801	35	0.00012565499228	1.523717	57	69	0.005599214	
Human Phenotype	Increased CSF lactate	15	1.127211e-15	5.014586002000001e-13	2.447261	104	0.006516699	115	0.0317664103173913	1.399275	44	58	0.0043222	
Human Phenotype	Abnormality of the mitochondrion	16	1.13136e-15	4.7184783e-13	2.101551	144	0.009023122	30	0.00006172011179	1.532753	59	71	0.005795678	
Human Phenotype	Exercise intolerance	24	2.963445e-14	8.239611868750001e-12	2.213209	115	0.007205965	112	0.025690335035714284	1.370199	52	70	0.005108055	
Human Phenotype	Dysphonia	46	1.781968e-11	2.585015753043478e-9	2.539676	68	0.004260919	141	0.045740584890780145	1.603912	20	23	0.001964637	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	271	0.00001387583	0.0003416731128782288	2.32447	33	0.002067799	73	0.009349092386301371	1.844499	15	15	0.001473477	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	294	0.0000215	0.00048799149659863945	2.211109	35	0.00219312	63	0.005869214906666666	1.844499	16	16	0.001571709	
Mouse Phenotype Single KO	absent hypoglossal nerve	93	1.080195e-13	1.0635855500000002e-11	3.533281	50	0.003133028	271	0.04729310045756458	1.721532	14	15	0.001375246	
Mouse Phenotype Single KO	abnormal DNA replication	313	6.092374e-8	0.0000017823600229392972	2.282503	54	0.003383671	166	0.008434854708433734	1.684108	21	23	0.002062868	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	99	1.042817e-16	1.0071084178787878e-14	2.490438	108	0.006767341	403	0.030098502491315137	1.526482	24	29	0.002357564	
Mouse Phenotype	increased liver adenoma incidence	134	3.273687e-14	2.335800105e-12	2.718567	77	0.004824864	458	0.040907176886462886	1.515124	23	28	0.002259332	
Mouse Phenotype	absent hypoglossal nerve	149	1.080195e-13	6.931372077181208e-12	3.533281	50	0.003133028	416	0.0321679845	1.721532	14	15	0.001375246	
Mouse Phenotype	increased follicular B cell number	224	4.54354e-11	1.9393208008928572e-9	2.017485	107	0.006704681	409	0.03144823288753056	1.498655	26	32	0.002554028	
Mouse Phenotype	absent segment of posterior cerebral artery	322	2.41622e-9	7.17437249068323e-8	2.388412	60	0.003759634	431	0.03471370612064965	1.592976	19	22	0.001866405	
Mouse Phenotype	decreased liver cholesterol level	325	2.624128e-9	7.719780864e-8	2.000628	89	0.005576791	409	0.03144823288753056	1.498655	26	32	0.002554028	
Mouse Phenotype	abnormal lipoprotein lipase activity	956	0.0002387382	0.0023876317261506273	2.099765	29	0.001817156	467	0.04482526419057816	1.844499	10	10	0.0009823183	
Mouse Phenotype	decreased brain cholesterol level	1068	0.0005804858	0.0051966523724719105	2.0113	28	0.001754496	467	0.04482526419057816	1.844499	10	10	0.0009823183