# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process mitochondrial transport 132 2.204334e-72 2.197487205e-70 2.036526 782 0.0313063 177 0.0000026120986723163844 1.26241 188 239 0.01606838 GO Biological Process RNA catabolic process 135 2.481834e-70 2.4191447115555558e-68 2.071408 729 0.02918451 213 0.000030926318867605634 1.238615 186 241 0.01589744 GO Biological Process mRNA catabolic process 142 7.683482e-68 7.120207016760564e-66 2.146204 647 0.02590176 284 0.00028610608241197183 1.228141 163 213 0.01393162 GO Biological Process nuclear-transcribed mRNA catabolic process 145 1.388955e-66 1.26050061e-64 2.200998 600 0.02402018 330 0.0007425404383333334 1.223917 151 198 0.01290598 GO Biological Process regulation of intrinsic apoptotic signaling pathway 159 6.765736e-63 5.5993911964779876e-61 2.196079 569 0.02277913 560 0.014545963299642858 1.201065 116 155 0.00991453 GO Biological Process macroautophagy 173 1.877988e-58 1.428464976416185e-56 2.217238 517 0.02069739 311 0.0005070865077491961 1.262499 118 150 0.01008547 GO Biological Process regulation of signal transduction by p53 class mediator 180 2.553813e-57 1.8669791815e-55 2.01844 631 0.02526122 441 0.004422957724716553 1.210532 132 175 0.01128205 GO Biological Process multi-organism transport 181 2.93935e-56 2.1369561685082873e-54 2.906739 301 0.01205012 587 0.019420738171720613 1.288418 57 71 0.004871795 GO Biological Process transport of virus 188 3.006712e-53 2.1045384685106386e-51 2.877629 289 0.01156972 721 0.044668563144244104 1.269525 53 67 0.004529915 GO Biological Process cytoskeleton-dependent intracellular transport 189 5.483123e-53 3.817588124708995e-51 2.02307 579 0.02317947 356 0.0012531944079213482 1.24943 116 149 0.00991453 GO Biological Process mitochondrial membrane organization 210 6.511444e-50 4.080194837904762e-48 2.120888 486 0.01945634 154 2.3296420166233763e-7 1.384849 107 124 0.009145299 GO Biological Process multi-organism metabolic process 213 2.149796e-49 1.3281298386854457e-47 2.214761 436 0.01745466 472 0.006408979433050847 1.222759 112 147 0.00957265 GO Biological Process negative regulation of type I interferon production 220 1.768193e-48 1.0576205312272728e-46 3.492753 198 0.007926658 666 0.035311089795795794 1.331702 39 47 0.003333333 GO Biological Process transport along microtubule 223 4.616564e-48 2.7241868016143496e-46 2.060005 501 0.02005685 513 0.01046873094619883 1.22873 98 128 0.008376068 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 237 9.420087e-46 5.230334381139241e-44 2.436334 331 0.01325113 659 0.03392745632776935 1.210454 89 118 0.007606838 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 243 7.165363e-45 3.880206243497943e-43 2.237869 386 0.01545298 384 0.0018522512448958335 1.278216 90 113 0.007692308 GO Biological Process organelle transport along microtubule 248 2.567288e-44 1.3622154351612903e-42 2.417922 325 0.01301093 444 0.004941643133333334 1.337393 55 66 0.004700855 GO Biological Process regulation of DNA-templated transcription in response to stress 255 1.909371e-43 9.853103132941176e-42 2.132127 416 0.01665399 349 0.00106747052260745 1.2812 95 119 0.008119658 GO Biological Process regulation of mitochondrial membrane permeability 269 9.582838e-42 4.68775335472119e-40 2.350932 323 0.01293086 235 0.00007325749689787234 1.407011 64 73 0.005470085 GO Biological Process regulation of membrane permeability 276 3.230988e-40 1.540455474347826e-38 2.2275 348 0.0139317 237 0.00007773948537552743 1.386926 70 81 0.005982906 GO Cellular Component ribonucleoprotein granule 53 8.019721e-72 2.614731676981132e-70 2.076809 740 0.02962488 59 0.00002521482663050848 1.259207 153 195 0.01307692 GO Cellular Component cytoplasmic ribonucleoprotein granule 61 9.925921e-62 2.8118018832786886e-60 2.018972 680 0.02722287 74 0.00012003537989189188 1.247264 143 184 0.01222222 GO Cellular Component chromosome, telomeric region 76 4.229739e-49 9.61709077894737e-48 2.173074 452 0.0180952 90 0.0010007303040000001 1.230081 128 167 0.01094017 GO Cellular Component methyltransferase complex 83 2.078515e-42 4.3273179759036144e-41 2.324548 336 0.0134513 108 0.0068937472 1.269789 72 91 0.006153846 GO Cellular Component nuclear chromosome, telomeric region 88 2.754259e-40 5.408363127272727e-39 2.206342 356 0.01425197 112 0.010717940057142857 1.215812 100 132 0.008547009 GO Cellular Component PML body 90 3.231299e-38 6.20409408e-37 2.068897 391 0.01565315 86 0.0007019310809302325 1.307061 79 97 0.006752137 GO Cellular Component ficolin-1-rich granule lumen 91 3.669649e-38 6.968300518681318e-37 2.104018 375 0.01501261 109 0.007575223838532111 1.229539 95 124 0.008119658 GO Cellular Component P-body 102 6.641297e-35 1.1251138447058825e-33 2.121526 335 0.01341127 121 0.019111437223140498 1.256827 65 83 0.005555556 GO Cellular Component histone methyltransferase complex 107 5.370824e-33 8.673629786915888e-32 2.249136 277 0.01108932 110 0.009000347694545455 1.302505 56 69 0.004786325 GO Cellular Component cytoplasmic stress granule 115 9.978502e-31 1.4993783874782608e-29 2.537449 202 0.008086793 111 0.008933492237837837 1.380936 37 43 0.003162393 GO Cellular Component Cul4-RING E3 ubiquitin ligase complex 166 6.568168e-20 6.8372254843373485e-19 2.614284 120 0.004804035 104 0.005704805907692308 1.454415 29 32 0.002478632 GO Molecular Function ribonucleoprotein complex binding 49 2.335903e-38 2.0126902991836736e-36 2.17562 349 0.01397174 71 0.00028196930270422537 1.311808 94 115 0.008034188 GO Molecular Function histone methyltransferase activity 65 1.034221e-30 6.717663172307692e-29 2.090952 303 0.01213019 100 0.005911619067999999 1.360061 50 59 0.004273504 GO Molecular Function RNA polymerase core enzyme binding 89 4.472689e-23 2.121763253707865e-21 2.410695 164 0.006565515 98 0.004637892848979592 1.467311 32 35 0.002735043 GO Molecular Function RNA polymerase II core binding 135 9.853245e-18 3.08151114e-16 2.286695 137 0.005484607 140 0.04670958432857143 1.432921 25 28 0.002136752 GO Molecular Function exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 201 7.513403e-14 1.5781884311442785e-12 2.016074 139 0.005564674 104 0.008424996940384616 1.38019 43 50 0.003675214 Human Phenotype Leukemia 56 5.533113e-23 6.5932969730357135e-21 2.179156 202 0.008086793 19 0.00891770588526316 1.419694 46 52 0.003931624 Human Phenotype Foot dorsiflexor weakness 73 4.132249e-21 3.77732843520548e-19 2.17511 185 0.007406221 71 0.03828845218309859 1.404263 35 40 0.002991453 Mouse Phenotype Single KO extramedullary hematopoiesis 36 7.822454e-63 1.9897280910555554e-60 2.31936 506 0.02025702 76 0.00009044041175789474 1.337393 95 114 0.008119658 Mouse Phenotype Single KO increased sensitivity to induced cell death 65 2.097408e-47 2.954763854769231e-45 2.026953 514 0.02057728 114 0.00047380559055263153 1.275104 116 146 0.00991453 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 68 2.794136e-47 3.762632845882353e-45 2.295555 386 0.01545298 236 0.015072425880084747 1.253328 82 105 0.007008547 Mouse Phenotype Single KO increased circulating tumor necrosis factor level 84 6.17047e-43 6.726546879761904e-41 2.629859 269 0.01076905 133 0.0009669069078947368 1.397792 54 62 0.004615385 Mouse Phenotype Single KO decreased total retina thickness 141 9.350381e-30 6.07244246929078e-28 2.62179 184 0.007366188 104 0.00037990588014423076 1.520405 36 38 0.003076923 Mouse Phenotype Single KO decreased circulating total protein level 148 1.016534e-28 6.289460701351352e-27 2.180735 256 0.01024861 131 0.0009379032784732824 1.41118 51 58 0.004358974 Mouse Phenotype Single KO prenatal lethality prior to heart atrial septation 239 2.954225e-21 1.1318760805439331e-19 2.014329 224 0.008967533 267 0.020627456032209737 1.32817 48 58 0.004102564 Mouse Phenotype Single KO abnormal sperm midpiece morphology 268 5.09684e-20 1.741483726865672e-18 2.207034 169 0.006765683 335 0.03929164829552238 1.349551 37 44 0.003162393 Mouse Phenotype Single KO blood in lymph vessels 384 1.234033e-15 2.9427187971354165e-14 2.065666 150 0.006005044 279 0.024085263250537635 1.444385 27 30 0.002307692 Mouse Phenotype Single KO subcutaneous edema 452 9.81087e-14 1.9875693935840708e-12 2.111146 123 0.004924136 199 0.005580740552261307 1.49788 28 30 0.002393162 Mouse Phenotype Single KO increased cellular sensitivity to ultraviolet irradiation 509 4.907037e-12 8.82784632789784e-11 2.330884 85 0.003402858 331 0.0376104824712991 1.471132 22 24 0.001880342 Mouse Phenotype abnormal circulating tumor necrosis factor level 70 1.141687e-54 1.5593813438571427e-52 2.148364 518 0.02073742 262 0.00246364928610687 1.242127 113 146 0.00965812 Mouse Phenotype increased circulating tumor necrosis factor level 78 4.927949e-52 6.040528254999999e-50 2.413662 385 0.01541295 157 0.00018767780174522292 1.342852 82 98 0.007008547 Mouse Phenotype abnormal DNA repair 105 3.837617e-45 3.4944243939999996e-43 2.272087 376 0.01505264 309 0.005192981342718447 1.249695 95 122 0.008119658 Mouse Phenotype decreased classified tumor incidence 160 3.830069e-34 2.2887056068125e-32 2.993031 171 0.00684575 497 0.029796327470824953 1.432921 25 28 0.002136752 Mouse Phenotype decreased circulating total protein level 208 1.947983e-28 8.95416608798077e-27 2.166886 257 0.01028864 187 0.0004820428678877005 1.414463 52 59 0.004444444 Mouse Phenotype increased cellular sensitivity to ionizing radiation 227 1.792457e-27 7.549639373127753e-26 2.063346 278 0.01112935 540 0.038205879938888895 1.248234 63 81 0.005384615 Mouse Phenotype abnormal cellular replicative senescence 246 2.925058e-26 1.1368487617073171e-24 2.003857 285 0.01140958 461 0.021760358986984817 1.260971 66 84 0.005641026 Mouse Phenotype enlarged liver sinusoidal spaces 247 3.769893e-26 1.4592691082186235e-24 2.209473 225 0.009007566 467 0.022735484749464668 1.370013 35 41 0.002991453 Mouse Phenotype increased circulating interferon-gamma level 283 1.619676e-23 5.471986655830388e-22 2.377932 172 0.006885784 285 0.0035646460810526315 1.388831 45 52 0.003846154 Mouse Phenotype prenatal lethality prior to heart atrial septation 322 2.954225e-21 8.771846343167702e-20 2.014329 224 0.008967533 406 0.01416383966453202 1.32817 48 58 0.004102564 Mouse Phenotype increased circulating interleukin-1 beta level 327 4.511618e-21 1.319130877614679e-19 2.360505 155 0.006205212 507 0.03025187146745562 1.381973 31 36 0.002649573 Mouse Phenotype decreased total retina thickness 372 3.920312e-19 1.0075834148387097e-17 2.009222 201 0.008046759 168 0.0002526786201964286 1.492904 40 43 0.003418803 Mouse Phenotype abnormal sperm midpiece morphology 392 3.190057e-18 7.780646677806123e-17 2.059998 179 0.007166019 371 0.010326300065498653 1.370828 41 48 0.003504274 Mouse Phenotype abnormal thymus corticomedullary boundary morphology 396 3.733146e-18 9.013285077272727e-17 2.225806 149 0.005965011 550 0.0398791743709091 1.397792 27 31 0.002307692 Mouse Phenotype increased cellular sensitivity to ultraviolet irradiation 402 6.410702e-18 1.5246945726865672e-16 2.56033 111 0.004443733 425 0.01650884822047059 1.444385 27 30 0.002307692 Mouse Phenotype blood in lymph vessels 485 1.234033e-15 2.4326988686597936e-14 2.065666 150 0.006005044 425 0.01650884822047059 1.444385 27 30 0.002307692 Mouse Phenotype subcutaneous edema 556 9.81087e-14 1.6870814401079138e-12 2.111146 123 0.004924136 290 0.003998499216206897 1.49788 28 30 0.002393162 Mouse Phenotype impaired muscle regeneration 563 1.502487e-13 2.5515591841918293e-12 2.22005 108 0.004323632 577 0.04927412967244367 1.458974 20 22 0.001709402 Mouse Phenotype empty decidua capsularis 624 1.735282e-12 2.6588191028846155e-11 2.894156 60 0.002402018 483 0.02624928011180124 1.604872 14 14 0.001196581 Mouse Phenotype increased number of Howell-Jolly bodies 859 3.563606e-9 3.966430380209546e-8 2.144219 74 0.002962488 434 0.01819443099331797 1.604872 15 15 0.001282051