# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	cellular response to insulin stimulus	78	2.028641e-107	3.4224213998717955e-105	2.194542	983	0.02945671	333	0.000034031102406006004	1.253809	127	148	0.009882499	
GO Biological Process	mitochondrial transport	103	1.126789e-97	1.4395549952427185e-95	2.046814	1050	0.03146445	310	0.00001191824637967742	1.210477	198	239	0.01540736	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	110	7.012595e-93	8.388976145909091e-91	2.273611	787	0.02358335	530	0.0011835430537547168	1.206612	128	155	0.009960314	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	138	9.145255e-82	8.720464532246376e-80	2.49529	575	0.01723053	400	0.00018413493972	1.267176	98	113	0.007625866	
GO Biological Process	mRNA catabolic process	141	3.421759e-81	3.193399055390071e-79	2.080734	838	0.02511162	270	0.0000026651405196666664	1.234759	180	213	0.01400669	
GO Biological Process	nuclear-transcribed mRNA catabolic process	144	1.636489e-79	1.4954554688194447e-77	2.130767	776	0.02325372	258	0.000001600356776899225	1.247127	169	198	0.01315073	
GO Biological Process	response to topologically incorrect protein	147	3.857021e-78	3.4526897509523806e-76	2.121704	770	0.02307393	1025	0.04471821044292683	1.136436	140	180	0.01089409	
GO Biological Process	regulation of mRNA stability	152	1.048579e-76	9.077796750657896e-75	2.089848	783	0.02346349	475	0.0005542615125052633	1.219222	126	151	0.009804684	
GO Biological Process	regulation of DNA-templated transcription in response to stress	168	1.046952e-70	8.200500814285714e-69	2.278831	594	0.01779989	382	0.00013623929516492147	1.264677	103	119	0.00801494	
GO Biological Process	regulation of mitochondrial membrane permeability	215	1.011147e-58	6.188689940930233e-57	2.402603	441	0.01321507	355	0.00006815168423098592	1.341038	67	73	0.005213602	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	219	2.766029e-57	1.6620171511872148e-55	2.391137	434	0.0130053	454	0.0004200361495374449	1.250629	101	118	0.007859311	
GO Biological Process	macroautophagy	220	2.812935e-57	1.682518712045455e-55	2.022405	630	0.01887867	385	0.00013736170829610389	1.237091	127	150	0.009882499	
GO Biological Process	regulation of membrane permeability	221	4.90162e-57	2.9185709312217193e-55	2.280611	476	0.01426388	331	0.000033376451820241696	1.334861	74	81	0.005758307	
GO Biological Process	multi-organism intracellular transport	236	1.232723e-53	6.873475405508474e-52	2.635674	338	0.01012855	470	0.0005393118157446809	1.326258	59	65	0.004591082	
GO Biological Process	multi-organism transport	242	7.205453e-53	3.918039505247934e-51	2.551644	353	0.01057805	546	0.001397988541282051	1.296497	63	71	0.004902342	
GO Biological Process	secondary alcohol metabolic process	243	9.144593e-53	4.9520040858847736e-51	2.024001	578	0.01732043	465	0.000516280206	1.24883	100	117	0.007781496	
GO Biological Process	intracellular transport of virus	251	3.599084e-51	1.886866388685259e-49	2.608238	328	0.009828893	493	0.0006855219752941176	1.32415	58	64	0.004513267	
GO Biological Process	regulation of type I interferon production	255	1.680967e-50	8.674448922745098e-49	2.063109	527	0.01579215	715	0.008212634963496503	1.199791	101	123	0.007859311	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	260	1.980664e-49	1.0024445221538462e-47	2.455164	354	0.01060801	863	0.023106090898030125	1.243052	57	67	0.004435452	
GO Biological Process	cellular response to epidermal growth factor stimulus	262	4.774254e-49	2.397878182671756e-47	2.44139	355	0.01063798	730	0.00980279164219178	1.345779	35	38	0.002723523	
GO Cellular Component	host cell	76	4.111429e-46	9.3480912e-45	2.426452	337	0.01009859	115	0.006263953419130434	1.267746	59	68	0.004591082	
GO Cellular Component	other organism cell	82	1.549712e-42	3.265734556097561e-41	2.307236	343	0.01027839	136	0.010498070117647059	1.243936	63	74	0.004902342	
GO Cellular Component	high-density lipoprotein particle	84	3.134536e-42	6.448188342857143e-41	4.023871	144	0.004315124	159	0.03405874958490566	1.352899	25	27	0.001945374	
GO Cellular Component	cleavage furrow	85	2.042842e-41	4.15297761882353e-40	2.329597	327	0.009798927	105	0.0030466384457142853	1.320638	47	52	0.003657303	
GO Cellular Component	cell division site part	106	1.833433e-33	2.9888417207547174e-32	2.056571	346	0.01036828	132	0.010014417163636363	1.269508	53	61	0.004124193	
GO Cellular Component	cytoplasmic stress granule	115	8.852655e-31	1.3302076382608697e-29	2.303657	245	0.007341704	121	0.008194891477685949	1.325212	39	43	0.003034783	
GO Cellular Component	nuclear inner membrane	142	1.838093e-25	2.2367779605633804e-24	2.030971	267	0.008000959	154	0.02885562514285714	1.252398	48	56	0.003735118	
GO Cellular Component	protein-lipid complex	181	8.295492e-20	7.91967413038674e-19	2.032699	203	0.006083126	133	0.009947287867669172	1.321976	38	42	0.002956968	
GO Cellular Component	plasma lipoprotein particle	184	1.577351e-19	1.4813383304347826e-18	2.048729	196	0.005873363	140	0.0167128704	1.315018	36	40	0.002801338	
GO Cellular Component	very-low-density lipoprotein particle	218	7.920158e-17	6.2779968e-16	2.640684	98	0.002936682	118	0.007410506033898305	1.461131	20	20	0.001556299	
GO Cellular Component	Cul4-RING E3 ubiquitin ligase complex	233	1.51113e-15	1.1207007038626609e-14	2.168847	133	0.003985496	126	0.008856800914285715	1.369811	30	32	0.002334449	
GO Cellular Component	U5 snRNP	306	2.908881e-10	1.642662211764706e-9	2.278645	74	0.002217494	155	0.029464852645161292	1.394716	21	22	0.001634114	
GO Molecular Function	cadherin binding	8	1.024144e-187	5.4049199599999996e-185	2.098919	1888	0.05657607	24	8.023956738333333e-14	1.288103	268	304	0.02085441	
GO Molecular Function	protein transporter activity	40	1.326878e-53	1.4005197290000002e-51	2.21189	477	0.01429385	120	0.024833835665	1.21761	80	96	0.006225196	
GO Molecular Function	lysine-acetylated histone binding	52	2.400749e-39	1.949223515e-37	3.198303	180	0.005393905	121	0.025811378441322315	1.461131	19	19	0.001478484	
GO Molecular Function	RNA polymerase core enzyme binding	135	1.56799e-19	4.9037435407407406e-18	2.079534	189	0.0056636	138	0.041039828623188404	1.335892	32	35	0.002490079	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	32	4.258044e-78	1.218465903375e-75	2.376644	603	0.01806958	287	0.002474791239790941	1.256887	80	93	0.006225196	
Mouse Phenotype Single KO	abnormal cell adhesion	95	1.014941e-49	9.782962881052632e-48	2.161025	465	0.01393425	302	0.0032071452543046357	1.312542	53	59	0.004124193	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning	113	3.751528e-46	3.040065654513274e-44	2.010538	512	0.01534266	489	0.036313328777096116	1.204229	75	91	0.005836122	
Mouse Phenotype Single KO	decreased total retina thickness	257	1.291978e-26	4.603362858365759e-25	2.282441	214	0.006412754	219	0.0004212132193150685	1.422681	37	38	0.002879153	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	844	3.435191e-10	3.727019429739336e-9	2.011563	98	0.002936682	462	0.026542396954545456	1.400251	23	24	0.001789744	
Mouse Phenotype	decreased circulating free fatty acid level	49	2.648217e-87	5.167265864693877e-85	2.240136	763	0.02286416	244	0.00015497311265163935	1.264677	103	119	0.00801494	
Mouse Phenotype	decreased fatty acid level	66	2.836103e-77	4.1084819368181816e-75	2.006877	871	0.02610051	546	0.012817098362637364	1.170778	125	156	0.00972687	
Mouse Phenotype	abnormal cell adhesion	118	1.937167e-55	1.5695977700847456e-53	2.067616	577	0.01729046	238	0.000144574492197479	1.326554	69	76	0.005369232	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	198	2.514236e-42	1.2140712321212122e-40	2.734891	248	0.007431602	625	0.025645432056	1.360364	27	29	0.002101004	
Mouse Phenotype	abnormal cellular replicative senescence	237	1.189577e-37	4.798964429113924e-36	2.057806	391	0.01171676	263	0.00023649715157794676	1.304582	75	84	0.005836122	
Mouse Phenotype	early cellular replicative senescence	284	5.987636e-32	2.015767175915493e-30	2.028362	341	0.01021845	323	0.0010038256703405572	1.301007	65	73	0.005057972	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	285	6.03027e-32	2.0229968936842105e-30	2.325019	250	0.007491535	678	0.0323590775840708	1.356765	26	28	0.002023189	
Mouse Phenotype	abnormal transitional stage T1 B cell morphology	330	3.864747e-28	1.119722608090909e-26	2.429711	200	0.005993228	735	0.04076599667755102	1.352899	25	27	0.001945374	
Mouse Phenotype	abnormal sperm midpiece morphology	406	5.080723e-24	1.1964727242118226e-22	2.067431	240	0.007191873	662	0.02924741673716012	1.27849	42	48	0.003268228	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	420	1.209367e-23	2.753037592142857e-22	2.572558	149	0.004464955	594	0.01967219209090909	1.363723	28	30	0.002178819	
Mouse Phenotype	decreased liver cholesterol level	436	8.656765e-23	1.898333260665138e-21	2.171521	202	0.00605316	738	0.04200798950813008	1.32415	29	32	0.002256634	
Mouse Phenotype	decreased classified tumor incidence	549	2.05029e-18	3.5706416557377054e-17	2.148645	164	0.004914447	471	0.00686077872611465	1.408948	27	28	0.002101004