# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of intrinsic apoptotic signaling pathway 141 9.743766e-57 9.093490552765957e-55 2.176392 522 0.02257493 500 0.00105801807658 1.250525 118 155 0.01032281 GO Biological Process macroautophagy 146 9.324239e-55 8.403949383630138e-53 2.223791 480 0.02075855 643 0.0051300351267496115 1.226503 112 150 0.009797918 GO Biological Process nuclear-transcribed mRNA catabolic process 154 1.644058e-52 1.4048155338961039e-50 2.092344 528 0.02283441 660 0.00592475800469697 1.194646 144 198 0.01259732 GO Biological Process mRNA catabolic process 157 1.401839e-51 1.1749553758598726e-49 2.021048 564 0.0243913 659 0.00593124253201821 1.187635 154 213 0.01347214 GO Biological Process multi-organism transport 172 2.483023e-47 1.8996569568023254e-45 2.795794 268 0.01159019 433 0.00039661438732101613 1.388145 60 71 0.005248885 GO Biological Process transport of virus 179 6.747206e-47 4.960138757206704e-45 2.818182 262 0.01133071 436 0.0004260467699541284 1.397469 57 67 0.00498644 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 182 2.545171e-46 1.840214570824176e-44 2.51262 316 0.01366605 579 0.002982418032297064 1.26678 91 118 0.007960808 GO Biological Process intracellular transport of virus 184 1.242598e-45 8.886601675000001e-44 2.857575 249 0.0107685 499 0.0010303602482965933 1.385976 54 64 0.004723996 GO Biological Process multi-organism intracellular transport 188 3.666257e-45 2.566184886329787e-43 2.824709 251 0.01085499 473 0.0007761406326427062 1.389925 55 65 0.004811478 GO Biological Process mitochondrial membrane organization 194 2.071584e-44 1.4051532915463916e-42 2.093125 444 0.01920166 423 0.00036727608936170216 1.298214 98 124 0.008573178 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 201 2.341309e-43 1.5328002552736322e-41 2.267184 362 0.01565541 1017 0.04380261043559489 1.20654 83 113 0.007260957 GO Biological Process translational initiation 211 2.192318e-41 1.3672375621800948e-39 2.17678 377 0.01630411 909 0.028157133108910888 1.194646 104 143 0.009098067 GO Biological Process regulation of DNA-templated transcription in response to stress 218 2.48398e-40 1.4993895788990825e-38 2.131628 385 0.01665009 900 0.02698226632 1.214724 88 119 0.007698364 GO Biological Process negative regulation of type I interferon production 225 1.642969e-39 9.608812920444445e-38 3.296702 173 0.007481728 796 0.015667262448366834 1.36304 39 47 0.003411775 GO Biological Process multi-organism metabolic process 227 3.343576e-39 1.9382430213215857e-37 2.107184 384 0.01660684 527 0.0014705981528463 1.251534 112 147 0.009797918 GO Biological Process viral gene expression 233 1.06556e-38 6.0178987296137346e-37 2.282797 317 0.01370929 835 0.01969238834251497 1.215811 94 127 0.008223253 GO Biological Process negative regulation of intrinsic apoptotic signaling pathway 238 1.126086e-37 6.226120031092436e-36 2.202589 333 0.01440125 907 0.028033138546857773 1.240716 71 94 0.00621118 GO Biological Process positive regulation of viral process 297 2.581398e-32 1.143724453939394e-30 2.021605 347 0.0150067 784 0.013754528672193879 1.247773 79 104 0.006911031 GO Biological Process gene silencing by miRNA 306 1.126163e-31 4.842868927124183e-30 2.648831 193 0.008346668 512 0.0012124607505664064 1.455975 39 44 0.003411775 GO Biological Process positive regulation of viral life cycle 312 3.368788e-31 1.4208295285897435e-29 2.034807 329 0.01422826 876 0.023821485335616437 1.24036 74 98 0.006473624 GO Cellular Component host cell 62 2.285663e-44 6.370363974193548e-43 2.722502 262 0.01133071 90 0.0006800734079999999 1.376918 57 68 0.00498644 GO Cellular Component ruffle membrane 68 3.260216e-42 8.284784188235295e-41 2.133149 403 0.01742853 168 0.03819857142857143 1.231979 66 88 0.005773773 GO Cellular Component intrinsic component of mitochondrial membrane 70 1.517938e-41 3.7471383771428575e-40 2.726982 244 0.01055226 181 0.04422136256353591 1.263568 50 65 0.004374071 GO Cellular Component cytoplasmic stress granule 73 6.579218e-41 1.5573820142465754e-39 2.917529 215 0.009298101 162 0.035552 1.337031 35 43 0.003061849 GO Cellular Component other organism cell 77 1.570171e-39 3.523708425974026e-38 2.543456 262 0.01133071 152 0.027589191157894735 1.265276 57 74 0.00498644 GO Cellular Component PML body 83 1.549053e-35 3.22501636626506e-34 2.069196 362 0.01565541 104 0.0031129105846153847 1.287016 76 97 0.006648587 GO Cellular Component cleavage furrow 111 8.432794e-26 1.3127809037837839e-24 2.231094 217 0.009384595 94 0.0008734874553191489 1.421514 45 52 0.003936663 GO Cellular Component cytoplasmic microtubule 124 2.187292e-22 3.048097238709677e-21 2.170664 198 0.008562903 111 0.0055181547243243236 1.379816 42 50 0.003674219 GO Cellular Component PcG protein complex 132 6.844581e-21 8.960178763636364e-20 2.092807 200 0.008649397 170 0.038532519529411766 1.321253 37 46 0.003236812 GO Cellular Component axon cytoplasm 148 3.318799e-18 3.874922075675676e-17 2.242548 147 0.006357307 157 0.03142694889171974 1.355177 33 40 0.002886887 GO Cellular Component AP-type membrane coat adaptor complex 165 2.187899e-16 2.2913269527272727e-15 2.093454 153 0.006616788 170 0.038532519529411766 1.321253 37 46 0.003236812 GO Cellular Component Cul4-RING E3 ubiquitin ligase complex 196 4.074637e-14 3.5923330285714284e-13 2.353436 100 0.004324698 169 0.038287234650887576 1.385976 27 32 0.002361998 GO Molecular Function ligand-dependent nuclear receptor transcription coactivator activity 59 1.759812e-31 1.2593095362711863e-29 2.3615 238 0.01029278 140 0.024879172405714287 1.352761 42 51 0.003674219 GO Molecular Function mitogen-activated protein kinase binding 71 3.973214e-26 2.3626633109859155e-24 2.875833 137 0.005924837 151 0.039550046344370864 1.460123 24 27 0.002099554 GO Molecular Function thyroid hormone receptor binding 80 1.759042e-23 9.283344155e-22 2.923498 119 0.005146391 141 0.028645707066666665 1.466641 25 28 0.002187035 GO Molecular Function signal sequence binding 83 3.066266e-23 1.5597319339759034e-21 2.200206 200 0.008649397 155 0.04881065095483871 1.350614 37 45 0.003236812 GO Molecular Function telomeric DNA binding 213 2.728874e-11 5.409063862910798e-10 2.10336 99 0.004281451 132 0.014504498686363637 1.449387 30 34 0.002624442 GO Molecular Function four-way junction DNA binding 214 3.011205e-11 5.940797901869159e-10 2.296813 81 0.003503006 127 0.011783053472440946 1.642638 16 16 0.001399703 Human Phenotype Laryngomalacia 14 5.166332e-31 2.4624952454285713e-28 3.928219 107 0.004627427 245 0.02607437163306122 1.642638 14 14 0.00122474 Human Phenotype Leukemia 21 2.446556e-28 7.774222946666667e-26 2.400684 206 0.008908879 274 0.04298938996715329 1.326746 42 52 0.003674219 Human Phenotype Cafe-au-lait spot 31 3.472997e-25 7.475906122903227e-23 2.21899 214 0.009254854 187 0.009050985997860963 1.38497 43 51 0.003761701 Human Phenotype Foot dorsiflexor weakness 40 7.23489e-24 1.20696052425e-21 2.324296 183 0.007914198 117 0.002491785462307692 1.478375 36 40 0.003149331 Human Phenotype Abnormality of the foot musculature 47 2.2255e-23 3.1597364893617025e-21 2.299541 183 0.007914198 204 0.013888639200980393 1.407976 36 42 0.003149331 Mouse Phenotype Single KO extramedullary hematopoiesis 60 8.582302e-42 1.3098023235666666e-39 2.084638 421 0.01820698 666 0.03794780418468468 1.210365 84 114 0.007348438 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 65 2.407755e-38 3.391971159230769e-36 2.766783 219 0.009471089 503 0.011722456432206759 1.42066 32 37 0.002799405 Mouse Phenotype Single KO embryonic lethality between somite formation and embryo turning, complete penetrance 90 1.379375e-31 1.4034374305555556e-29 2.071535 319 0.01379579 642 0.03461441563707165 1.265276 57 74 0.00498644 Mouse Phenotype Single KO small superior cervical ganglion 98 4.749945e-30 4.438290445408163e-28 2.934636 154 0.006660035 538 0.016417297654460965 1.437309 28 32 0.002449479 Mouse Phenotype Single KO abnormal thymus development 270 2.241789e-17 7.602985878888889e-16 2.693983 98 0.004238204 441 0.007359663624716553 1.642638 16 16 0.001399703 Mouse Phenotype Single KO abnormal synaptic vesicle recycling 278 3.888225e-17 1.2807365584532372e-15 3.189196 74 0.003200277 441 0.007359663624716553 1.642638 16 16 0.001399703 Mouse Phenotype Single KO increased fibroblast apoptosis 318 1.597017e-15 4.5987058707547175e-14 2.166176 133 0.005751849 570 0.02117904858596491 1.407976 30 35 0.002624442 Mouse Phenotype Single KO abnormal transitional stage T1 B cell morphology 447 1.621822e-12 3.322376745861297e-11 2.562618 74 0.003200277 652 0.03616423727453987 1.546013 16 17 0.001399703 Mouse Phenotype Single KO decreased thoracic vertebrae number 486 6.170941e-12 1.1627017847119342e-10 2.584225 69 0.002984042 654 0.03619846109174312 1.642638 12 12 0.001049777 Mouse Phenotype Single KO abnormal internal carotid artery morphology 857 3.648414e-8 3.898311201633606e-7 2.176856 62 0.002681313 654 0.03619846109174312 1.642638 12 12 0.001049777 Mouse Phenotype enlarged liver sinusoidal spaces 82 3.272599e-43 3.8157706145121954e-41 2.715671 256 0.01107123 558 0.002523353512903226 1.442317 36 41 0.003149331 Mouse Phenotype decreased classified tumor incidence 186 4.811702e-26 2.4733700441935486e-24 2.76057 146 0.00631406 777 0.01177179605945946 1.466641 25 28 0.002187035 Mouse Phenotype increased acute lymphoblastic leukemia incidence 229 1.862702e-23 7.776984201746725e-22 3.987579 78 0.003373265 1013 0.03778778079269497 1.539974 15 16 0.001312221 Mouse Phenotype abnormal central nervous system regeneration 268 2.232725e-21 7.965329748134329e-20 3.874627 73 0.00315703 1030 0.03943541199029126 1.642638 11 11 0.0009622955 Mouse Phenotype increased fibroblast apoptosis 304 8.758267e-20 2.7545325916776317e-18 2.193942 169 0.00730874 736 0.008902093812228262 1.368865 40 48 0.003499256 Mouse Phenotype abnormal ceramide level 317 2.668081e-19 8.047167962460569e-18 2.785091 104 0.004497686 1052 0.0408659951891635 1.478375 18 20 0.001574665 Mouse Phenotype abnormal double-strand DNA break repair 384 3.707739e-17 9.23169077578125e-16 2.211095 142 0.006141072 987 0.033966929756838904 1.301713 42 53 0.003674219 Mouse Phenotype straub tail 568 3.137142e-13 5.280671595422535e-12 2.027671 130 0.005622108 781 0.011808181448527529 1.437309 28 32 0.002449479 Mouse Phenotype abnormal transitional stage T2 B cell morphology 581 7.148642e-13 1.176388402099828e-11 2.021237 127 0.005492367 726 0.008490136393388428 1.47271 26 29 0.002274517 Mouse Phenotype abnormal transitional stage T1 B cell morphology 592 1.071801e-12 1.730994824493243e-11 2.068862 118 0.005103144 605 0.0038785958568595042 1.520962 25 27 0.002187035 Mouse Phenotype abnormal thymus corticomedullary boundary morphology 611 2.491818e-12 3.899226169885433e-11 2.00103 124 0.005362626 1089 0.046130762666666665 1.377697 26 31 0.002274517 Mouse Phenotype abnormal fetal derived definitive erythrocyte cell number 657 1.444168e-11 2.1016271305936074e-10 2.458632 73 0.00315703 1030 0.03943541199029126 1.642638 11 11 0.0009622955 Mouse Phenotype decreased transitional stage T2 B cell number 687 3.222354e-11 4.4845599117903935e-10 2.001907 111 0.004800415 896 0.022231459151785714 1.453103 23 26 0.002012072 Mouse Phenotype impaired muscle regeneration 704 5.780279e-11 7.850177204403408e-10 2.109567 95 0.004108463 885 0.021533046525423725 1.493308 20 22 0.001749628 Mouse Phenotype testis degeneration 808 9.175448e-10 1.0857234941584157e-8 2.020678 92 0.003978722 854 0.018486607735363 1.551381 17 18 0.001487184 Mouse Phenotype impaired skeletal muscle regeneration 838 1.711355e-9 1.952537607995227e-8 2.011369 90 0.003892229 957 0.02996967881818182 1.486197 19 21 0.001662147 Mouse Phenotype abnormal internal carotid artery morphology 876 3.090756e-9 3.373369647945205e-8 2.265853 66 0.002854301 844 0.017821941892180095 1.642638 13 13 0.001137258 Mouse Phenotype increased plasmacytoid dendritic cell number 974 2.152612e-8 2.1130516767967143e-7 2.428964 51 0.002205596 778 0.01176474536722365 1.642638 14 14 0.00122474