# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mitochondrial transport	96	7.190758e-118	9.856581721041667e-116	2.180959	1093	0.03352658	294	0.000014630162772448978	1.224984	192	239	0.01559201	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	153	7.680839e-81	6.606023555620916e-79	2.505362	564	0.01730008	419	0.0002770652888639618	1.281953	95	113	0.007714796	
GO Biological Process	mitochondrial membrane organization	154	2.053667e-80	1.7548184450000003e-78	2.273707	680	0.02085826	306	0.000020743039138562092	1.303501	106	124	0.008608088	
GO Biological Process	regulation of DNA-templated transcription in response to stress	160	2.54866e-78	2.09611355875e-76	2.375852	605	0.01855771	448	0.0004281010420535714	1.268572	99	119	0.00803963	
GO Biological Process	negative regulation of translation	169	1.714264e-74	1.3347928979881657e-72	2.03334	812	0.02490721	156	2.847715571282051e-9	1.3649	128	143	0.01039467	
GO Biological Process	nuclear-transcribed mRNA catabolic process	179	1.930102e-71	1.4188945373184358e-69	2.077098	739	0.02266802	236	9.7621491220339e-7	1.270708	165	198	0.01339938	
GO Biological Process	mRNA catabolic process	187	5.638162e-70	3.9675173132620325e-68	2.005339	789	0.02420171	199	7.39293780201005e-8	1.281447	179	213	0.0145363	
GO Biological Process	macroautophagy	215	3.417037e-63	2.0913855759534886e-61	2.09646	638	0.01956995	324	0.00003796678949475309	1.270708	125	150	0.01015105	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	222	1.09813e-60	6.509140842342342e-59	2.458892	436	0.01337382	407	0.00022297747675675673	1.279323	99	118	0.00803963	
GO Biological Process	translational initiation	225	1.782237e-60	1.0423314081333334e-58	2.211466	540	0.01656391	437	0.0003789728764530893	1.247604	117	143	0.009501381	
GO Biological Process	regulation of type I interferon production	228	4.411928e-60	2.5463403750877192e-58	2.191984	547	0.01677863	995	0.044507401359799	1.177729	95	123	0.007714796	
GO Biological Process	negative regulation of type I interferon production	234	3.33174e-59	1.8736054128205127e-57	3.406021	252	0.007729824	773	0.01240819308240621	1.330188	41	47	0.003329544	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	239	4.139585e-58	2.2791966115062764e-56	2.534184	394	0.01208552	940	0.03359701284148936	1.231609	63	78	0.005116128	
GO Biological Process	gene silencing by miRNA	245	7.204462e-57	3.869531243183673e-55	2.930061	301	0.009232846	360	0.00008843001521666668	1.455538	42	44	0.003410752	
GO Biological Process	posttranscriptional gene silencing	265	4.227083e-53	2.099025856490566e-51	2.669897	327	0.01003037	328	0.00004161622011585366	1.436878	49	52	0.003979211	
GO Biological Process	posttranscriptional gene silencing by RNA	268	5.915665e-53	2.904635661753732e-51	2.679722	324	0.009938345	342	0.00005755573455263158	1.435153	48	51	0.003898002	
GO Biological Process	multi-organism metabolic process	283	2.04976e-51	9.531021851590106e-50	2.0706	532	0.01631852	292	0.000011730531965410959	1.286268	124	147	0.01006984	
GO Biological Process	viral gene expression	293	3.327265e-50	1.4943167281569965e-48	2.232044	437	0.0134045	446	0.0004169314082511211	1.260703	105	127	0.00852688	
GO Biological Process	regulation of mitochondrial membrane permeability	299	1.296855e-49	5.707463192307693e-48	2.286471	410	0.0125763	537	0.0013844667215828677	1.315966	63	73	0.005116128	
GO Biological Process	positive regulation of viral process	300	1.883046e-49	8.259667437999999e-48	2.082622	504	0.01545965	430	0.0003378766044651163	1.290257	88	104	0.007146338	
GO Cellular Component	ribonucleoprotein granule	47	3.176891e-91	1.1680143931914893e-89	2.064335	960	0.02944695	46	6.946571269565218e-9	1.305897	167	195	0.0135618	
GO Cellular Component	cytoplasmic ribonucleoprotein granule	53	5.599525e-82	1.825656452830189e-80	2.033776	894	0.02742247	50	4.0367324159999995e-8	1.301095	157	184	0.01274972	
GO Cellular Component	cytoplasmic stress granule	57	4.001511e-75	1.2130896505263157e-73	3.272419	340	0.01042913	97	0.00047656939546391746	1.418465	40	43	0.003248335	
GO Cellular Component	ruffle membrane	63	8.835721e-65	2.4235120457142858e-63	2.200022	586	0.01797491	147	0.006879279673469388	1.247604	72	88	0.005847003	
GO Cellular Component	cleavage furrow	68	6.464348e-58	1.642704903529412e-56	2.647147	363	0.01113463	104	0.0006169254092307693	1.37823	47	52	0.003816794	
GO Cellular Component	P-body	83	1.040149e-51	2.165515026506024e-50	2.217501	457	0.01401797	81	0.00006514944	1.341133	73	83	0.005928212	
GO Cellular Component	cell division site part	94	2.550129e-45	4.687896714893617e-44	2.281587	375	0.01150271	143	0.0059761659524475525	1.299872	52	61	0.004222836	
GO Cellular Component	ficolin-1-rich granule lumen	95	3.286894e-45	5.978687191578947e-44	2.050598	477	0.01463145	197	0.045260749644670056	1.168232	95	124	0.007714796	
GO Cellular Component	host cell	98	4.445116e-43	7.837918824489796e-42	2.38795	324	0.009938345	128	0.00305594775	1.300607	58	68	0.004710086	
GO Cellular Component	methyltransferase complex	100	1.450114e-40	2.5057969919999998e-39	2.109728	398	0.01220821	164	0.016867102829268295	1.223231	73	91	0.005928212	
GO Cellular Component	other organism cell	105	4.972537e-39	8.183375177142857e-38	2.258447	328	0.01006104	175	0.025105114697142855	1.236365	60	74	0.004872503	
GO Cellular Component	PcG protein complex	122	4.852472e-32	6.873009521311475e-31	2.167181	292	0.00895678	131	0.0033706948396946567	1.359105	41	46	0.003329544	
GO Cellular Component	axon cytoplasm	130	3.00092e-29	3.9889152e-28	2.369637	219	0.006717585	200	0.04625640864	1.296122	34	40	0.002761085	
GO Cellular Component	AP-type membrane coat adaptor complex	144	1.594368e-26	1.9132416e-25	2.212688	228	0.006993651	181	0.03006640760220995	1.292807	39	46	0.003167127	
GO Cellular Component	spliceosomal snRNP complex	168	1.227106e-23	1.2621661714285715e-22	2.210024	202	0.006196129	118	0.0016556290169491526	1.328095	54	62	0.004385253	
GO Cellular Component	endoribonuclease complex	192	5.544229e-21	4.989806099999999e-20	2.582366	130	0.003987608	182	0.030100354813186812	1.367107	26	29	0.002111418	
GO Cellular Component	small nuclear ribonucleoprotein complex	193	5.891422e-21	5.274806847668394e-20	2.013827	221	0.006778933	145	0.0060993323255172415	1.281758	58	69	0.004710086	
GO Cellular Component	ESC/E(Z) complex	220	2.511147e-17	1.9723918254545454e-16	2.20907	144	0.004417042	199	0.04552933531658292	1.440136	17	18	0.001380542	
GO Cellular Component	spliceosomal tri-snRNP complex	256	2.461755e-14	1.661684625e-13	2.374647	100	0.003067391	182	0.030100354813186812	1.367107	26	29	0.002111418	
GO Cellular Component	Cul4-RING E3 ubiquitin ligase complex	271	2.922265e-13	1.8633483099630996e-12	2.069842	124	0.003803564	160	0.0128000736	1.381895	29	32	0.002355043	
GO Molecular Function	ribonucleoprotein complex binding	52	2.280711e-51	1.8517618926923077e-49	2.201926	461	0.01414067	75	0.00010000758357333334	1.299437	98	115	0.007958421	
GO Molecular Function	protein transporter activity	53	5.032811e-51	4.0091562343396224e-49	2.192933	462	0.01417134	143	0.035781863342657344	1.223057	77	96	0.006253045	
GO Molecular Function	mitogen-activated protein kinase binding	62	1.081971e-43	7.367873487096775e-42	3.111735	209	0.006410846	144	0.03681701277777778	1.411898	25	27	0.00203021	
GO Molecular Function	signal sequence binding	98	1.201379e-27	5.175736875510203e-26	2.098934	269	0.008251281	146	0.0378345565479452	1.321536	39	45	0.003167127	
GO Molecular Function	protein phosphatase 2A binding	121	1.49935e-23	5.231616280991736e-22	2.216004	200	0.006134781	144	0.03681701277777778	1.411898	25	27	0.00203021	
Human Phenotype	Foot dorsiflexor weakness	53	5.181001e-34	6.523173523207548e-32	2.351224	261	0.008005889	257	0.04198018054474708	1.334244	35	40	0.002842293	
Human Phenotype	Hypoalbuminemia	134	4.563949e-25	2.272778483358209e-23	2.775585	139	0.004263673	191	0.01287139947015707	1.463856	24	25	0.001949001	
Human Phenotype	Abnormality of reticulocytes	289	1.638285e-17	3.7827943961937714e-16	2.272615	137	0.004202325	153	0.006353010023529411	1.432435	31	33	0.00251746	
Human Phenotype	Reticulocytosis	310	8.850296e-17	1.9050975873548387e-15	2.807524	88	0.002699304	234	0.03315237654700855	1.455538	21	22	0.001705376	
Mouse Phenotype Single KO	enlarged liver sinusoidal spaces	53	1.877154e-57	3.2432262600000003e-55	2.849518	318	0.009754302	465	0.020561088415053767	1.360001	33	37	0.002679877	
Mouse Phenotype Single KO	small superior cervical ganglion	73	7.736545e-48	9.704594871917809e-46	3.10867	230	0.007054998	231	0.0009553922255411255	1.477198	31	32	0.00251746	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	149	6.672551e-31	4.1007080206040266e-29	2.206211	270	0.008281955	163	0.00014402382400613496	1.397779	55	60	0.004466461	
Mouse Phenotype Single KO	abnormal superior cervical ganglion morphology	163	1.36407e-29	7.66306073006135e-28	2.105604	287	0.008803411	249	0.0014018344652208835	1.415932	39	42	0.003167127	
Mouse Phenotype Single KO	abnormal sperm midpiece morphology	234	1.080206e-24	4.227113821367521e-23	2.181338	218	0.006686911	525	0.03044180987047619	1.316916	38	44	0.003085918	
Mouse Phenotype Single KO	early cellular replicative senescence	253	1.037876e-23	3.7564547557312254e-22	2.103444	227	0.006962977	189	0.00033906839988359785	1.407554	48	52	0.003898002	
Mouse Phenotype Single KO	increased fibroblast apoptosis	285	5.057815e-22	1.6250670861403507e-20	2.194871	190	0.005828042	538	0.0333075832936803	1.350581	31	35	0.00251746	
Mouse Phenotype	enlarged liver sinusoidal spaces	72	4.775283e-65	6.341177883749999e-63	2.798938	372	0.01141069	537	0.005123697169273743	1.376084	37	41	0.00300471	
Mouse Phenotype	decreased susceptibility to hepatic steatosis	129	6.12806e-42	4.541890051162791e-40	2.056776	438	0.01343517	708	0.017263668402542374	1.247604	63	77	0.005116128	
Mouse Phenotype	decreased classified tumor incidence	178	1.038126e-34	5.576136340449439e-33	2.722421	203	0.006226803	935	0.04472091794438503	1.361473	25	28	0.00203021	
Mouse Phenotype	increased fibroblast apoptosis	199	1.956649e-32	9.400764366331659e-31	2.329551	253	0.007760498	597	0.00867739704321608	1.334244	42	48	0.003410752	
Mouse Phenotype	small superior cervical ganglion	261	3.167119e-28	1.1601848566666667e-26	2.086327	279	0.00855802	862	0.03242037493503481	1.324212	33	38	0.002679877	
Mouse Phenotype	testis degeneration	773	1.699357e-13	2.1018825714100905e-12	2.040769	131	0.004018282	585	0.00819222109025641	1.52485	18	18	0.001461751	
Mouse Phenotype	hypermyelination	1185	1.1375e-8	9.177753164556961e-8	2.060324	76	0.002331217	751	0.022655941657789613	1.52485	15	15	0.001218126