# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process mesodermal cell differentiation 95 0.000001864919 0.0002583207275894737 3.426772 21 0.014862 107 0.0005022327890280374 4.396909 12 26 0.00608828 GO Biological Process mesoderm formation 158 0.00004076561 0.0033951560885443037 2.216157 32 0.02264685 47 0.0000407570907212766 3.270338 23 67 0.0116692 GO Biological Process mesoderm morphogenesis 162 0.00004541264 0.0036887958627160496 2.172442 33 0.02335456 42 0.000018396272600714284 3.313613 24 69 0.01217656 GO Biological Process establishment of epithelial cell polarity 189 0.00008768603 0.006105081845343916 2.99568 17 0.01203114 278 0.016631612765467627 3.40237 10 28 0.005073567 GO Biological Process regulation of axon extension 195 0.00009982823 0.00673661373625641 2.055599 34 0.02406228 122 0.0007410844632950819 2.75771 22 76 0.01116185 GO Biological Process regulation of alpha-beta T cell differentiation 266 0.0003424213 0.016939555965037593 2.265761 23 0.01627742 162 0.0023831769406790124 2.944597 17 55 0.008625063 GO Biological Process regulation of T-helper cell differentiation 294 0.0004734395 0.021190443471088432 2.907688 14 0.009907997 358 0.0429252093547486 2.977074 10 32 0.005073567 GO Biological Process regulation of alpha-beta T cell activation 344 0.0008585016 0.032840181844186044 2.040811 25 0.01769285 319 0.02964008648934169 2.256309 18 76 0.00913242 GO Biological Process cell-substrate junction assembly 349 0.0008955268 0.03376572252492837 2.719169 14 0.009907997 323 0.0304524070622291 2.788284 12 41 0.00608828 GO Biological Process myofibril assembly 387 0.001149369 0.03908151594573643 2.379451 17 0.01203114 321 0.030192919661682242 2.463785 15 58 0.00761035 GO Biological Process response to low-density lipoprotein particle 399 0.001213735 0.04002891946115288 3.282965 10 0.007077141 165 0.0024347762743636365 4.763318 9 18 0.00456621 GO Biological Process regulation of CD4-positive, alpha-beta T cell differentiation 408 0.001321657 0.04262667760539216 2.422437 16 0.01132343 308 0.02494406368311688 2.857991 12 40 0.00608828 GO Biological Process positive regulation of axon extension 424 0.00146516 0.045471793490566036 2.152718 20 0.01415428 166 0.002468641876084337 3.334323 14 40 0.007102993 GO Biological Process response to epinephrine 439 0.001603972 0.04807896935763098 2.797043 12 0.008492569 315 0.028174066506349207 4.167903 7 16 0.003551497 GO Molecular Function collagen binding 23 0.00000199752 0.0003666751930434783 2.86584 27 0.01910828 5 0.001327126592 3.077836 21 65 0.01065449 Mouse Phenotype Single KO increased Purkinje cell number 122 0.0001208304 0.009069212891803279 8.103886 6 0.004246285 216 0.048965361759259265 9.526636 3 3 0.00152207 Mouse Phenotype Single KO absent outer hair cell stereocilia 131 0.0001551121 0.010842454196183206 4.760455 9 0.006369427 214 0.04754177472897197 5.292576 5 9 0.002536783 Mouse Phenotype Single KO decreased susceptibility to diet-induced obesity 143 0.0001931597 0.012368974635664337 2.058243 31 0.02193914 142 0.0247729157443662 2.078539 24 110 0.01217656 Mouse Phenotype Single KO abnormal circadian rhythm 165 0.000338955 0.01881097536363636 2.044591 29 0.02052371 131 0.02044501564198473 2.295575 20 83 0.01014713 Mouse Phenotype Single KO head bobbing 202 0.0005878664 0.026648973390099008 2.135242 24 0.01698514 168 0.03182284244761905 2.857991 12 40 0.00608828 Mouse Phenotype Single KO nonconvulsive seizures 208 0.0006959278 0.030637552233653848 2.352831 19 0.01344657 189 0.0400751792973545 2.910917 11 36 0.005580923 Mouse Phenotype Single KO abnormal vascular branching morphogenesis 211 0.000718839 0.031196249872037913 2.571738 16 0.01132343 86 0.010130781999186047 3.613552 11 29 0.005580923 Mouse Phenotype Single KO chondrodystrophy 265 0.001367472 0.04725260793962264 3.498085 9 0.006369427 149 0.025630080407382547 4.445764 7 15 0.003551497 Mouse Phenotype increased energy expenditure 30 1.563907e-7 0.000049841716090000007 2.296696 49 0.03467799 105 0.008876795718 1.977226 33 159 0.01674277 Mouse Phenotype abnormal colon morphology 39 3.815734e-7 0.0000935441866 2.147197 53 0.03750885 125 0.0129558892848 1.968838 31 150 0.01572806 Mouse Phenotype decreased susceptibility to diet-induced obesity 43 4.955336e-7 0.00011018131975813953 2.438245 40 0.02830856 149 0.015039093660402684 2.041422 27 126 0.01369863 Mouse Phenotype abnormal transitional stage T2 B cell morphology 46 6.189331e-7 0.00012864389932826088 4.427559 17 0.01203114 200 0.023243488953 3.285047 10 29 0.005073567 Mouse Phenotype decreased B cell proliferation 60 0.000003346911 0.00053333026785 2.30725 38 0.02689314 172 0.01988973718255814 2.053154 25 116 0.01268392 Mouse Phenotype head bobbing 75 0.0000109445 0.00139520486 2.414962 31 0.02193914 98 0.007241620424693878 2.977074 15 48 0.00761035 Mouse Phenotype atelectasis 77 0.00001194234 0.0014828663992207793 2.006636 46 0.03255485 172 0.01988973718255814 2.053154 25 116 0.01268392 Mouse Phenotype increased CD8-positive, alpha-beta memory T cell number 78 0.00001220836 0.0014964632046153847 3.696086 16 0.01132343 336 0.04666712717857143 3.062133 9 28 0.00456621 Mouse Phenotype decreased susceptibility to weight gain 84 0.00001517863 0.0017276533503571428 2.062091 42 0.02972399 258 0.031545370697674414 1.841816 29 150 0.01471334 Mouse Phenotype abnormal circadian rhythm 92 0.00002481219 0.002578579875978261 2.182367 35 0.02476999 95 0.006972461904947369 2.35605 23 93 0.0116692 Mouse Phenotype increased Purkinje cell number 122 0.00006101906 0.004781993710327869 7.348841 7 0.004953999 111 0.010428889008108108 9.526636 4 4 0.002029427 Mouse Phenotype abnormal carbon dioxide production 134 0.0000918871 0.006556213157462687 2.693909 20 0.01415428 328 0.045513624731707315 2.381659 14 56 0.007102993 Mouse Phenotype absent outer hair cell stereocilia 154 0.0001551121 0.00963004407857143 4.760455 9 0.006369427 280 0.037938594342857145 5.292576 5 9 0.002536783 Mouse Phenotype abnormal mesangial cell morphology 170 0.0002261348 0.012718087192941175 2.76051 17 0.01203114 196 0.022433579179591837 2.667458 14 50 0.007102993 Mouse Phenotype enhanced wound healing 185 0.0003018011 0.01559740711945946 3.402744 12 0.008492569 336 0.04666712717857143 3.062133 9 28 0.00456621 Mouse Phenotype abnormal Mullerian duct morphology 230 0.0006325596 0.026295227546086958 2.372223 19 0.01344657 73 0.003066327955890411 3.247717 15 44 0.00761035 Mouse Phenotype blistering 281 0.001253876 0.04266301934519572 2.62231 14 0.009907997 319 0.04555145131974922 2.886859 10 33 0.005073567 Mouse Phenotype abnormal vascular branching morphogenesis 286 0.001312606 0.04388051037062937 2.12645 21 0.014862 90 0.006157932023333333 3.175545 14 42 0.007102993