# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process lymph vessel development 80 0.00002777991 0.004569447946125 2.949688 20 0.008669267 264 0.003931264209621212 3.163064 12 22 0.003705991 Mouse Phenotype Single KO absent cochlear hair cells 30 1.187686e-7 0.00003625213567333333 3.251294 28 0.01213697 679 0.04850921424300442 2.609527 9 20 0.002779494 Mouse Phenotype Single KO abnormal cochlear inner hair cell number 45 0.000001985506 0.00040402840982222223 2.643092 31 0.01343736 528 0.023221926543560607 2.485264 12 28 0.003705991 Mouse Phenotype Single KO abnormal juxtaglomerular cell morphology 85 0.00003094342 0.003333516434588235 4.364194 12 0.00520156 334 0.004170127957784431 5.79895 5 5 0.001544163 Mouse Phenotype Single KO abnormal juxtaglomerular apparatus morphology 92 0.00004846831 0.004824177333369565 4.161973 12 0.00520156 597 0.035968297202680063 4.142107 5 7 0.001544163 Mouse Phenotype Single KO decreased corpus callosum size 120 0.0001430034 0.010912351115 2.273469 26 0.01127005 289 0.0020157487873702423 2.805944 15 31 0.004632489 Mouse Phenotype Single KO abnormal cortical plate morphology 158 0.0003639178 0.02109110945949367 2.564543 18 0.007802341 400 0.009812970852 2.899475 11 22 0.003397159 Mouse Phenotype Single KO decreased circulating total protein level 161 0.0003662518 0.020830855481987577 2.213613 24 0.01040312 654 0.04179020974464832 1.899656 19 58 0.00586782 Mouse Phenotype Single KO abnormal head fold morphology 183 0.0005748441 0.028764193572131145 3.163675 12 0.00520156 650 0.041259089355384616 3.122512 7 13 0.002161828 Mouse Phenotype Single KO abnormal fourth pharyngeal arch artery morphology 191 0.0006524969 0.031282272844502614 2.436411 18 0.007802341 411 0.010565894683211677 3.261909 9 16 0.002779494 Mouse Phenotype absent cochlear outer hair cells 40 0.000001276081 0.000305015261025 3.2869 23 0.009969658 740 0.020371377214864865 3.092773 8 15 0.002470661 Mouse Phenotype decreased long bone epiphyseal plate size 51 0.000005110621 0.000958091125117647 2.270311 38 0.01647161 306 0.0005075869285294119 2.537041 21 48 0.006485485 Mouse Phenotype abnormal head fold morphology 84 0.00002895578 0.0032957882450000003 3.157832 18 0.007802341 353 0.0010310750326912182 3.543803 11 18 0.003397159 Mouse Phenotype abnormal cochlear inner hair cell number 85 0.00002943091 0.0033104580060000005 2.26066 32 0.01387083 870 0.032300299948275865 2.217246 13 34 0.004014824 Mouse Phenotype abnormal juxtaglomerular cell morphology 88 0.00003094342 0.003361932257045455 4.364194 12 0.00520156 461 0.003154605285683297 5.79895 5 5 0.001544163 Mouse Phenotype absent cochlear hair cells 93 0.00003808718 0.0039156078277419355 2.263053 31 0.01343736 601 0.009488013457737105 2.676438 12 26 0.003705991 Mouse Phenotype abnormal cortical plate morphology 99 0.00004342677 0.004193973211818182 2.12645 35 0.01517122 383 0.0015077854269712795 2.416229 20 48 0.006176652 Mouse Phenotype decreased brain cholesterol level 103 0.00004832076 0.004485386275339806 4.969091 10 0.004334634 858 0.03248782112237763 3.47937 6 10 0.001852996 Mouse Phenotype abnormal juxtaglomerular apparatus morphology 104 0.00004846831 0.004455822229903846 4.161973 12 0.00520156 809 0.0277137816934487 4.142107 5 7 0.001544163 Mouse Phenotype increased embryonic neuroepithelial cell proliferation 118 0.00006113544 0.004953524930847456 9.196167 6 0.00260078 1007 0.04865110577457795 5.79895 3 3 0.0009264978 Mouse Phenotype decreased corpus callosum size 121 0.00006431019 0.005081567988347107 2.08362 35 0.01517122 235 0.0000919419121787234 2.667517 23 50 0.00710315 Mouse Phenotype decreased lymphatic vessel endothelial cell number 145 0.0001104311 0.00728159825586207 3.808667 12 0.00520156 921 0.0395139520228013 4.63916 4 5 0.00123533 Mouse Phenotype interparietal bone hypoplasia 172 0.0001816374 0.010096716170930232 3.874715 11 0.004768097 464 0.003220870117241379 4.970529 6 7 0.001852996 Mouse Phenotype delayed intramembranous bone ossification 173 0.0001820129 0.010059105993641617 2.279848 25 0.01083658 356 0.0010486480628932584 2.899475 15 30 0.004632489 Mouse Phenotype chylous ascites 194 0.0002757862 0.013591710609278352 3.076679 14 0.006068487 508 0.004610564517519685 3.47937 9 15 0.002779494 Mouse Phenotype hematuria 199 0.0002879313 0.013833724418592964 2.925437 15 0.006501951 911 0.037750763647639955 2.609527 9 20 0.002779494 Mouse Phenotype decreased circulating total protein level 213 0.0004223113 0.018956424128169017 2.190997 24 0.01040312 915 0.038692050403278694 1.867458 19 59 0.00586782 Mouse Phenotype small interparietal bone 231 0.0006080944 0.025168790296103898 2.061522 26 0.01127005 277 0.00023856106714440436 3.382721 14 24 0.004323657 Mouse Phenotype short fibula 232 0.0006121679 0.025228177982327585 2.132352 24 0.01040312 476 0.003654246337815126 2.706177 14 30 0.004323657 Mouse Phenotype abnormal lymphatic vessel endothelial cell morphology 254 0.0008635595 0.032505875509842526 2.447659 17 0.007368877 269 0.00018663256822304834 4.744595 9 11 0.002779494