# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process pyruvate metabolic process 182 8.313981e-19 6.011190987857144e-17 2.264111 149 0.009176007 549 0.002587828806010929 1.392337 53 67 0.004968129 GO Biological Process mammary gland epithelial cell differentiation 392 1.739378e-10 5.838896709693877e-9 2.045659 97 0.005973642 729 0.016756293339231825 1.656587 16 17 0.001499813 GO Biological Process glucose 6-phosphate metabolic process 747 6.368857e-7 0.000011219248897322624 2.128909 53 0.003263949 855 0.03249705085263158 1.530542 20 23 0.001874766 GO Biological Process regulation of hydrogen peroxide-mediated programmed cell death 836 0.000002252292 0.00003545204596650717 2.103445 49 0.003017613 931 0.049436723425349084 1.760124 10 10 0.0009373828 GO Biological Process endoplasmic reticulum tubular network organization 989 0.00001090294 0.00014506753029322548 2.353304 33 0.00203227 762 0.019479982637795275 1.760124 12 12 0.001124859 GO Cellular Component ficolin-1-rich granule lumen 40 5.052575e-22 2.1827124000000003e-20 2.011021 233 0.01434906 111 0.023372258594594596 1.234926 87 124 0.008155231 GO Molecular Function carbohydrate kinase activity 130 1.001533e-7 0.0000032526710199999997 2.142392 60 0.003695036 110 0.03683665829818182 1.592493 19 21 0.001781027 Mouse Phenotype Single KO increased squamous cell carcinoma incidence 116 6.52139e-13 5.1479627784482755e-11 2.537966 78 0.004803547 683 0.034913348398243046 1.489335 22 26 0.002062242 Mouse Phenotype Single KO increased hemangiosarcoma incidence 119 8.843724e-13 6.805208459495798e-11 2.504722 79 0.004865131 423 0.004913120159574468 1.613447 22 24 0.002062242 Mouse Phenotype Single KO increased embryonic neuroepithelium apoptosis 153 9.585592e-11 5.736945486535948e-9 2.561396 62 0.003818204 532 0.015978064791165415 1.656587 16 17 0.001499813 Mouse Phenotype Single KO increased neural tube apoptosis 232 1.78516e-8 7.045995741379311e-7 2.046865 75 0.004618795 377 0.0020730646458885942 1.62473 24 26 0.002249719 Mouse Phenotype Single KO absent segment of posterior cerebral artery 264 5.726333e-8 0.000001986213306098485 2.230006 57 0.003510285 726 0.04118484356887052 1.520107 19 22 0.001781027 Mouse Phenotype Single KO abnormal cervical rib 434 0.000002927847 0.0000617748732235023 2.279593 40 0.002463358 639 0.028464899920187792 1.760124 11 11 0.001031121 Mouse Phenotype Single KO short rostral-caudal axis 440 0.000003423439 0.00007124643391590909 2.106782 47 0.002894445 774 0.05015430868992248 1.634401 13 14 0.001218598 Mouse Phenotype increased skin tumor incidence 80 1.076948e-21 1.2870874785e-19 2.06369 215 0.01324055 871 0.012380539997703789 1.285484 65 89 0.006092988 Mouse Phenotype pale kidney 138 1.827209e-15 1.2659380615217392e-13 2.011344 158 0.009730262 840 0.010809756518928572 1.408099 36 45 0.003374578 Mouse Phenotype abnormal hair follicle outer root sheath morphology 149 9.117496e-15 5.850495252080536e-13 2.236192 117 0.007205321 650 0.0032641754113846154 1.571539 25 28 0.002343457 Mouse Phenotype increased embryonic neuroepithelium apoptosis 175 2.790103e-13 1.5243528447428573e-11 2.547381 80 0.004926715 590 0.002258795973050848 1.619314 23 25 0.002155981 Mouse Phenotype increased neural tube apoptosis 237 2.59068e-11 1.04512622278481e-9 2.069975 103 0.006343146 495 0.0007704435362424242 1.514525 37 43 0.003468316 Mouse Phenotype abnormal pulmonary valve cusp morphology 245 4.685535e-11 1.8285061279591836e-9 2.031607 105 0.006466314 693 0.0048456775991341985 1.564554 24 27 0.002249719 Mouse Phenotype absent segment of posterior cerebral artery 412 5.726333e-8 0.0000013288706265291263 2.230006 57 0.003510285 1088 0.028694274598345587 1.520107 19 22 0.001781027 Mouse Phenotype decreased molar number 505 4.642064e-7 0.00000878866809980198 2.152184 53 0.003263949 1234 0.047716239209076174 1.760124 9 9 0.0008436445 Mouse Phenotype absent uterus 875 0.0000456324 0.0004986187158857142 2.128009 35 0.002155438 1234 0.047716239209076174 1.760124 9 9 0.0008436445 Mouse Phenotype increased kidney tumor incidence 919 0.00006048867 0.0006293059563329706 2.097067 35 0.002155438 921 0.01604453106514658 1.650116 15 16 0.001406074 Mouse Phenotype increased leiomyosarcoma incidence 940 0.0000675932 0.0006875091331914894 2.957692 18 0.001108511 1234 0.047716239209076174 1.760124 9 9 0.0008436445 Mouse Phenotype abnormal aorta tunica adventitia morphology 1223 0.0003311097 0.0025885035500408833 2.329972 22 0.001354847 1234 0.047716239209076174 1.760124 9 9 0.0008436445 Mouse Phenotype double outlet right ventricle, Taussig bing type 1359 0.0006880854 0.004840901037086093 2.082024 25 0.001539598 1234 0.047716239209076174 1.760124 9 9 0.0008436445