# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	platelet-derived growth factor receptor-beta signaling pathway	2	3.804552e-147	2.5032049884e-143	23.26407	152	0.01284001	916	0.048132001838427946	2.584584	6	6	0.0008258775	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	18	8.992451e-99	6.573981261611112e-96	5.02076	271	0.02289238	679	0.02029654625184094	1.723056	22	33	0.003028217	
GO Biological Process	liver regeneration	19	1.510584e-96	1.0461986766315788e-93	6.333765	215	0.01816185	413	0.002765839868062954	1.846131	25	35	0.003441156	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	26	2.846129e-90	1.4404696734999999e-87	4.030971	312	0.0263558	881	0.044257032888762766	1.374779	50	94	0.006882312	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	28	1.614449e-89	7.587333711071429e-87	3.273847	402	0.03395844	431	0.0035771657638051044	1.384003	83	155	0.01142464	
GO Biological Process	cellular response to insulin stimulus	32	1.30007e-84	5.346131603125e-82	2.88235	458	0.03868897	305	0.0005488252173770492	1.449462	83	148	0.01142464	
GO Biological Process	acute-phase response	40	6.4253e-82	2.1137630675e-79	6.091056	188	0.01588106	894	0.0464813266868009	1.575966	25	41	0.003441156	
GO Biological Process	response to insulin	48	7.517463e-78	2.0608811586875e-75	2.495039	538	0.04544687	232	0.00009106731325862069	1.416551	114	208	0.01569167	
GO Biological Process	regulation of DNA-templated transcription in response to stress	49	1.855834e-77	4.983861144081633e-75	3.471535	321	0.02711607	925	0.04965155302594595	1.324871	61	119	0.008396421	
GO Biological Process	triglyceride homeostasis	74	7.067745e-67	1.2568169791216215e-64	6.596808	143	0.01207974	279	0.0002979096195519713	2.019206	25	32	0.003441156	
GO Biological Process	regulation of cellular response to insulin stimulus	89	1.277432e-62	1.8887334480898877e-60	3.388523	267	0.02255449	559	0.009226139773881932	1.543035	40	67	0.00550585	
GO Biological Process	positive regulation of cellular catabolic process	114	6.133462e-56	7.079844426140351e-54	2.03355	594	0.05017739	633	0.014351147192733019	1.242761	138	287	0.01899518	
GO Biological Process	placenta development	122	2.311177e-54	2.4928506674590165e-52	2.344658	422	0.03564791	349	0.0010310242401432663	1.433913	81	146	0.01114935	
GO Biological Process	mammary gland epithelium development	132	5.70102e-53	5.683312286363638e-51	2.779328	302	0.02551107	523	0.006512811798279159	1.62733	34	54	0.004679972	
GO Biological Process	negative regulation of cell-cell adhesion	134	1.026216e-52	1.0077594286567164e-50	2.341798	410	0.03463423	462	0.004337593764502164	1.390328	78	145	0.01073641	
GO Biological Process	negative regulation of apoptotic signaling pathway	143	5.422441e-51	4.989783295034965e-49	2.121015	490	0.04139213	212	0.00005006414793490565	1.428977	115	208	0.01582932	
GO Biological Process	phagocytosis	147	4.657769e-50	4.1694953925850337e-48	2.238405	427	0.03607028	299	0.0005096590725083612	1.4059	99	182	0.01362698	
GO Biological Process	embryonic placenta development	151	7.746727e-50	6.750939112119205e-48	2.550638	329	0.02779186	391	0.0017721827719693096	1.539134	53	89	0.007295251	
GO Biological Process	negative regulation of cell activation	163	3.676156e-48	2.96776299411043e-46	2.172622	438	0.03699949	587	0.010551305404940375	1.330525	87	169	0.01197522	
GO Biological Process	negative regulation of leukocyte cell-cell adhesion	167	6.471432e-48	5.099255909461078e-46	2.55508	315	0.02660922	613	0.012985088681076673	1.416551	57	104	0.007845836	
GO Cellular Component	cytoplasmic side of membrane	29	1.964738e-59	1.1707128496551724e-57	2.352132	459	0.03877344	127	0.04063102185826772	1.258462	93	191	0.0128011	
GO Cellular Component	nuclear transcription factor complex	34	1.89127e-48	9.612101647058823e-47	2.246146	410	0.03463423	112	0.023753874857142858	1.30886	79	156	0.01087405	
GO Cellular Component	RNA polymerase II transcription factor complex	36	2.195091e-42	1.05364368e-40	2.30724	338	0.02855212	121	0.035021618776859505	1.321886	67	131	0.009222299	
GO Cellular Component	ruffle membrane	41	2.355731e-40	9.928544312195122e-39	2.615788	253	0.02137185	97	0.01583870370309278	1.439143	49	88	0.006744666	
GO Cellular Component	ruffle	45	4.634921e-38	1.779809664e-36	2.062481	388	0.03277581	81	0.005183285333333333	1.356109	85	162	0.01169993	
GO Cellular Component	podosome	66	5.255915e-26	1.3760941090909092e-24	3.338338	109	0.009207636	128	0.04195314	1.693348	19	29	0.002615279	
GO Cellular Component	PcG protein complex	84	1.695678e-22	3.488251885714286e-21	2.677542	131	0.01106606	116	0.028155823448275864	1.573225	28	46	0.003854095	
GO Cellular Component	high-density lipoprotein particle	89	3.331527e-21	6.468402984269663e-20	4.647555	59	0.00498395	96	0.0152146836	1.818781	19	27	0.002615279	
GO Cellular Component	cortical actin cytoskeleton	91	6.351443e-21	1.2060762092307692e-19	2.377633	151	0.01275553	62	0.0009082223070967743	1.679979	39	60	0.005368204	
GO Cellular Component	cleavage furrow	93	8.952122e-20	1.6633620232258065e-18	2.530431	126	0.01064369	43	0.00008254599739534882	1.839031	37	52	0.005092911	
GO Cellular Component	cortical cytoskeleton	102	1.621238e-18	2.746567905882353e-17	2.02968	188	0.01588106	74	0.001968817816216216	1.532718	51	86	0.007019959	
GO Cellular Component	cell division site part	107	1.482528e-17	2.3942134429906544e-16	2.278753	136	0.01148843	50	0.00020482464384000002	1.737179	41	61	0.005643496	
GO Cellular Component	Bcl-2 family protein complex	125	5.371159e-15	7.425090201599999e-14	5.537602	34	0.002872107	105	0.02132310857142857	2.584584	7	7	0.0009635237	
GO Cellular Component	protein-lipid complex	161	1.88781e-10	2.0261712298136645e-9	2.22995	79	0.006673425	95	0.012486862686315789	1.661518	27	42	0.003716449	
GO Cellular Component	plasma lipoprotein particle	185	1.739695e-9	1.6249691675675675e-8	2.180475	74	0.006251056	94	0.012327908629787233	1.679979	26	40	0.003578802	
GO Cellular Component	ripoptosome	198	5.362953e-9	4.6803953454545456e-8	6.242883	17	0.001436053	105	0.02132310857142857	2.584584	7	7	0.0009635237	
GO Cellular Component	very-low-density lipoprotein particle	304	0.000046756	0.00026577094736842104	2.27878	30	0.002534212	98	0.018876830693877553	1.938438	15	20	0.002064694	
GO Cellular Component	death-inducing signaling complex	401	0.001979623	0.008530644748129675	2.409284	15	0.001267106	126	0.04058589257142857	2.297408	8	9	0.00110117	
GO Cellular Component	platelet dense tubular network membrane	409	0.002442157	0.010317964048899755	2.109036	19	0.001605001	78	0.0042915456	2.584584	9	9	0.001238816	
GO Cellular Component	platelet dense tubular network	419	0.003219712	0.013278430396181385	2.012258	20	0.001689475	90	0.01025861376	2.349621	10	11	0.001376462	
GO Molecular Function	cadherin binding	4	1.8145e-92	1.9152047499999998e-89	2.312815	738	0.06234161	9	3.384581311555555e-8	1.470832	173	304	0.0238128	
GO Molecular Function	nuclear hormone receptor binding	13	5.865759e-52	1.905018038307692e-49	2.338932	405	0.03421186	98	0.028260676463265307	1.358321	72	137	0.00991053	
GO Molecular Function	phosphatase binding	24	6.634127e-40	1.1670535080833334e-37	2.061154	408	0.03446528	69	0.0006262780185507246	1.439515	88	158	0.01211287	
GO Molecular Function	RNA polymerase II core promoter sequence-specific DNA binding	30	2.221821e-35	3.1268427539999995e-33	2.537621	233	0.01968238	100	0.028458618988	1.559663	35	58	0.004817619	
GO Molecular Function	phosphoprotein binding	73	5.236262e-22	3.028424406027397e-20	2.107621	207	0.01748606	51	0.00007334426114117647	1.711867	51	77	0.007019959	
GO Molecular Function	BH domain binding	79	7.269229e-21	3.8848968149367087e-19	6.42463	43	0.00363237	70	0.00067501336	2.584584	12	12	0.001651755	
GO Molecular Function	phosphotyrosine binding	89	6.628381e-18	3.144384784494382e-16	2.440607	121	0.01022132	62	0.0002788055582258064	1.993822	27	35	0.003716449	
GO Molecular Function	apolipoprotein binding	90	9.183758e-18	4.3082029195555553e-16	3.654268	64	0.005406319	94	0.028811071727659576	2.099974	13	16	0.001789401	
GO Molecular Function	protein phosphorylated amino acid binding	126	9.071766e-15	3.0397615914285713e-13	2.146541	128	0.01081264	53	0.00008390962120754718	1.938438	33	44	0.004542326	
GO Molecular Function	clathrin heavy chain binding	280	1.318506e-7	0.0000019881186900000003	4.073407	21	0.001773948	113	0.048410087168141595	2.584584	7	7	0.0009635237	
GO Molecular Function	death domain binding	292	2.542278e-7	0.0000036758553821917805	2.63491	37	0.003125528	110	0.04848065027272728	2.326125	9	10	0.001238816	
GO Molecular Function	cadherin binding involved in cell-cell adhesion	344	0.000003042164	0.000037337257	2.029215	52	0.004392634	84	0.006898828419047619	2.15382	15	18	0.002064694	
Human Phenotype	Abnormality of peripheral nerve conduction	84	1.675722e-20	1.3312015364285714e-18	2.234812	168	0.01419159	66	0.037756673180303034	1.528909	42	71	0.005781142	
Human Phenotype	Elevated hepatic transaminases	110	4.804794e-18	2.914762760181818e-16	2.065824	175	0.0147829	51	0.026382255041176472	1.45229	59	105	0.008121129	
Human Phenotype	Abnormality of peripheral nerves	118	1.964984e-17	1.1112151044067798e-15	2.063257	169	0.01427606	63	0.03850346420952381	1.522426	43	73	0.005918789	
Human Phenotype	Abnormality of peripheral nervous system electrophysiology	132	4.164515e-17	2.1052885299242423e-15	2.008236	177	0.01495185	53	0.027848808616981132	1.524242	46	78	0.006331727	
Human Phenotype	Gait imbalance	596	9.758019e-7	0.000010925379326677853	3.349667	23	0.001942896	49	0.02638090201632653	2.584584	9	9	0.001238816	
Human Phenotype	Poor coordination	944	0.0002230318	0.0015765796625	2.024084	32	0.002703159	71	0.03967268614507042	2.215357	12	14	0.001651755	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	10	1.423897e-105	1.3038624829e-102	4.044261	364	0.03074844	203	0.0009387318848768473	1.556308	56	93	0.00770819	
Mouse Phenotype Single KO	decreased fatty acid level	18	3.667565e-99	1.8657718169444446e-96	3.571928	397	0.03353607	420	0.01680447291047619	1.378445	64	120	0.00880936	
Mouse Phenotype Single KO	decreased circulating triglyceride level	25	5.231153e-90	1.91606672084e-87	2.732255	531	0.04485555	349	0.007882324609742121	1.298139	111	221	0.01527873	
Mouse Phenotype Single KO	abnormal circulating triglyceride level	27	2.285361e-87	7.75075951e-85	2.218634	760	0.06420003	152	0.00011867508146052631	1.31432	179	352	0.02463868	
Mouse Phenotype Single KO	decreased triglyceride level	37	1.242766e-79	3.075677908648649e-77	2.326646	629	0.05313398	241	0.0018245307301659752	1.301656	139	276	0.01913283	
Mouse Phenotype Single KO	renal glomerulus hypertrophy	43	1.044158e-74	2.2235708851162792e-72	5.934849	175	0.0147829	314	0.005823921989808917	2.067667	16	20	0.00220234	
Mouse Phenotype Single KO	abnormal liver physiology	46	5.606151e-74	1.1159896675434784e-71	2.179171	670	0.0565974	54	2.0434778157407408e-8	1.455873	178	316	0.02450103	
Mouse Phenotype Single KO	abnormal circulating free fatty acids level	53	3.996552e-71	6.904986163018868e-69	2.581744	462	0.03902686	213	0.0010573970516431924	1.409773	90	165	0.01238816	
Mouse Phenotype Single KO	abnormal free fatty acids level	54	8.99818e-71	1.5258580418518519e-68	2.571344	463	0.03911134	253	0.0020823104864822134	1.383512	91	170	0.01252581	
Mouse Phenotype Single KO	cortical renal glomerulopathies	58	5.388804e-70	8.507806591034483e-68	2.738121	411	0.0347187	293	0.004536109027986348	1.408019	73	134	0.01004818	
Mouse Phenotype Single KO	abnormal mesangial matrix morphology	74	2.355249e-66	2.914461499054054e-64	4.248789	215	0.01816185	459	0.022416375899782136	1.676487	24	37	0.00330351	
Mouse Phenotype Single KO	abnormal fatty acid level	81	6.127263e-65	6.926832998888889e-63	2.295815	527	0.04451766	196	0.0007445458589285714	1.363427	115	218	0.01582932	
Mouse Phenotype Single KO	expanded mesangial matrix	84	8.444432e-64	9.205436169523808e-62	4.258766	206	0.01740159	452	0.02209813025	1.698441	23	35	0.003165864	
Mouse Phenotype Single KO	abnormal hepatobiliary system physiology	86	1.539277e-63	1.6389720336046515e-61	2.00531	698	0.05896266	57	3.028962098947368e-8	1.430885	191	345	0.02629043	
Mouse Phenotype Single KO	abnormal body temperature	88	3.972304e-63	4.1334531509090904e-61	2.891303	339	0.02863659	403	0.014440843487344913	1.418987	56	102	0.00770819	
Mouse Phenotype Single KO	abnormal white adipose tissue morphology	110	4.710794e-57	3.921521878e-55	2.038963	602	0.05085318	172	0.00028677477340697676	1.360307	130	247	0.01789401	
Mouse Phenotype Single KO	abnormal tumor necrosis factor level	116	7.259042e-55	5.73026272362069e-53	2.603089	350	0.02956581	520	0.03416113941923077	1.320183	71	139	0.009772884	
Mouse Phenotype Single KO	abnormal adipose tissue physiology	122	3.542091e-53	2.6586005972950818e-51	2.67649	323	0.02728501	299	0.005051203327759197	1.480751	55	96	0.007570544	
Mouse Phenotype Single KO	abnormal glomerular mesangium morphology	130	2.670929e-52	1.8813612963846153e-50	3.039903	259	0.0218787	401	0.01405403800523691	1.527254	39	66	0.005368204	
Mouse Phenotype Single KO	abnormal white adipose tissue amount	132	3.881937e-52	2.6929467506818183e-50	2.126879	498	0.04206792	384	0.01206368218671875	1.298658	102	203	0.01403992	
Mouse Phenotype	decreased circulating free fatty acid level	34	5.474465e-98	1.5394517607352942e-95	3.426424	414	0.03497212	233	0.00004657983786695279	1.563782	72	119	0.00991053	
Mouse Phenotype	decreased fatty acid level	38	3.296893e-95	8.295156308684212e-93	3.059246	471	0.03978713	339	0.0006120664523893806	1.424835	86	156	0.01183758	
Mouse Phenotype	dry eyes	49	1.569615e-82	3.0626712275510204e-80	7.227549	165	0.01393817	624	0.009828511876923077	2.099974	13	16	0.001789401	
Mouse Phenotype	decreased circulating triglyceride level	50	1.893604e-82	3.6209495688e-80	2.464154	583	0.04924818	343	0.0006233052834402332	1.32749	132	257	0.0181693	
Mouse Phenotype	abnormal circulating triglyceride level	58	3.162881e-78	5.213845731206896e-76	2.025995	836	0.07062004	135	5.432074359555556e-7	1.355024	216	412	0.02973159	
Mouse Phenotype	decreased triglyceride level	59	4.746259e-78	7.691352932033899e-76	2.191479	698	0.05896266	240	0.000063032087625	1.332425	166	322	0.02284928	
Mouse Phenotype	abnormal circulating free fatty acids level	79	5.105887e-70	6.179415899620253e-68	2.382249	528	0.04460213	182	0.0000074029824873626375	1.462496	116	205	0.01596696	
Mouse Phenotype	abnormal free fatty acids level	80	7.03128e-70	8.40325851e-68	2.375208	530	0.04477108	206	0.00001690284548737864	1.438589	118	212	0.01624226	
Mouse Phenotype	abnormal bone marrow cell number	82	8.262141e-70	9.633454890365853e-68	2.183056	630	0.05321845	662	0.01359091672794562	1.27426	106	215	0.0145905	
Mouse Phenotype	abnormal fatty acid level	89	4.434191e-67	4.763516870898876e-65	2.14706	628	0.0530495	169	0.000004567330998994083	1.404665	150	276	0.02064694	
Mouse Phenotype	abnormal circulating cytokine level	102	1.157555e-64	1.0850375838235295e-62	2.116904	625	0.05279608	933	0.0493620595755627	1.181086	154	337	0.02119752	
Mouse Phenotype	cortical renal glomerulopathies	103	4.036951e-64	3.7473095641747577e-62	2.368017	489	0.04130765	448	0.002377852712276786	1.346704	99	190	0.01362698	
Mouse Phenotype	abnormal mesangial matrix morphology	109	4.655726e-62	4.0837978244036697e-60	3.628151	242	0.02044264	581	0.0070346513865748705	1.6217	32	51	0.00440468	
Mouse Phenotype	parakeratosis	110	1.067573e-61	9.279150411818182e-60	4.954043	170	0.01436053	854	0.036064226346604215	1.644735	21	33	0.002890571	
Mouse Phenotype	altered tumor pathology	112	3.297769e-61	2.815175840089285e-59	2.001113	676	0.05710424	181	0.000006909597359668508	1.384285	158	295	0.02174811	
Mouse Phenotype	enlarged lymph nodes	113	8.054474e-61	6.814940346371682e-59	2.197516	541	0.04570029	402	0.00147034100119403	1.333224	114	221	0.01569167	
Mouse Phenotype	abnormal keratinocyte physiology	117	1.360794e-60	1.112012943076923e-58	2.811474	340	0.02872107	631	0.01020073999540412	1.395218	61	113	0.008396421	
Mouse Phenotype	thick epidermis	121	2.082652e-60	1.64563932e-58	2.719704	358	0.03024159	365	0.0009030951257260274	1.480061	67	117	0.009222299	
Mouse Phenotype	abnormal lymph node size	126	1.062793e-59	8.064574502380952e-58	2.005304	656	0.05541477	524	0.004662753730534351	1.26499	139	284	0.01913283	
Mouse Phenotype	expanded mesangial matrix	127	1.618373e-59	1.218367264015748e-57	3.614151	233	0.01968238	578	0.007024074665916954	1.635145	31	49	0.004267034