# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 43 2.572514e-135 7.872491099069767e-133 2.921296 731 0.02017219 245 0.00004853679962734694 1.301405 98 113 0.007831855 GO Biological Process cellular response to insulin stimulus 54 2.100403e-128 5.1183709401851854e-126 2.263511 1101 0.03038247 614 0.012850580043811075 1.186285 117 148 0.009350276 GO Biological Process regulation of intrinsic apoptotic signaling pathway 65 9.473971e-123 1.9179689906e-120 2.428943 913 0.02519455 700 0.022543265655714285 1.171436 121 155 0.009669943 GO Biological Process regulation of DNA-templated transcription in response to stress 72 5.279142e-120 9.648365219166668e-118 2.663802 754 0.02080689 259 0.00009422900784555985 1.286228 102 119 0.008151522 GO Biological Process response to insulin 73 1.707936e-119 3.0787301128767124e-117 2.017964 1332 0.036757 382 0.001216822375340314 1.190379 165 208 0.01318629 GO Biological Process endoplasmic reticulum unfolded protein response 81 1.992966e-115 3.237708591851852e-113 2.801567 666 0.0183785 842 0.041708950813539196 1.184684 90 114 0.00719252 GO Biological Process liver regeneration 86 1.505328e-112 2.303326878139535e-110 3.916806 407 0.0112313 441 0.003350403739909297 1.414851 33 35 0.002637257 GO Biological Process cellular response to topologically incorrect protein 103 9.650151e-105 1.232877058339806e-102 2.497951 738 0.02036536 857 0.04392421993932322 1.165933 108 139 0.008631024 GO Biological Process cellular response to unfolded protein 116 2.30562e-101 2.6154873775862067e-99 2.558783 683 0.01884762 850 0.043724059509411765 1.178157 95 121 0.007592104 GO Biological Process response to topologically incorrect protein 128 7.693559e-95 7.909339287578125e-93 2.197439 866 0.02389757 623 0.014473991754414125 1.167133 140 180 0.01118836 GO Biological Process response to unfolded protein 148 4.673205e-87 4.1550476077702704e-85 2.192814 798 0.02202108 664 0.018808152754668676 1.172343 125 160 0.009989611 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 173 8.141681e-79 6.1928543513872835e-77 3.990657 277 0.00764391 737 0.026923331854816827 1.500599 16 16 0.00127867 GO Biological Process nuclear-transcribed mRNA catabolic process 204 8.088168e-71 5.217264838823529e-69 2.010233 795 0.0219383 695 0.022185127309352518 1.151975 152 198 0.01214737 GO Biological Process secondary alcohol metabolic process 264 4.609205e-60 2.297444264962121e-58 2.054127 637 0.01757823 274 0.00014899825241240878 1.282564 100 117 0.007991689 GO Biological Process cholesterol metabolic process 291 1.201175e-56 5.431705094501718e-55 2.040248 610 0.01683316 328 0.00043969073387195123 1.27283 95 112 0.007592104 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to hypoxia 297 4.874289e-56 2.1596218502020203e-54 2.41293 417 0.01150726 434 0.0029317130149769583 1.288976 67 78 0.005354431 GO Biological Process regulation of mitochondrial membrane permeability 309 1.167932e-54 4.973727245307444e-53 2.282758 455 0.01255588 443 0.0034404576803611733 1.295038 63 73 0.005034764 GO Biological Process regulation of type I interferon production 328 5.387749e-53 2.1615057649695125e-51 2.044089 567 0.01564656 674 0.01946937892626113 1.1956 98 123 0.007831855 GO Biological Process response to cadmium ion 334 3.004544e-52 1.1837363621556884e-50 2.663995 323 0.008913295 776 0.03179027867783505 1.267748 49 58 0.003915927 GO Biological Process multi-organism metabolic process 336 4.321928e-52 1.6926265045238097e-50 2.01685 576 0.01589492 477 0.004887964344654087 1.204563 118 147 0.009430193 GO Cellular Component cleavage furrow 51 2.274586e-64 7.706832564705883e-63 2.650449 404 0.01114852 69 0.000052256873739130434 1.414026 49 52 0.003915927 GO Cellular Component cell division site part 62 6.792207e-54 1.893053821935484e-52 2.337224 427 0.01178321 99 0.004897258472727273 1.303799 53 61 0.004235595 GO Cellular Component PcG protein complex 99 6.868214e-36 1.1988155345454543e-34 2.176691 326 0.008996081 132 0.020493124363636362 1.304869 40 46 0.003196675 GO Cellular Component U1 snRNP 292 1.673643e-10 9.904298301369864e-10 2.166218 85 0.002345604 169 0.04795907559763314 1.42162 18 19 0.001438504 GO Cellular Component platelet dense granule lumen 293 1.681411e-10 9.916307877133105e-10 2.213078 81 0.002235223 152 0.03863129305263158 1.500599 14 14 0.001118836 GO Cellular Component prespliceosome 312 3.433229e-9 1.901480676923077e-8 2.146714 74 0.002042055 143 0.0275436433006993 1.429142 20 21 0.001598338 GO Molecular Function cadherin binding 3 6.692754e-200 9.418935796e-197 2.087449 2039 0.0562669 32 3.47318344125e-10 1.263663 256 304 0.02045872 GO Molecular Function thyroid hormone receptor binding 102 6.420639e-28 2.6576409664705885e-26 2.649247 169 0.004663613 118 0.04527611974576271 1.393414 26 28 0.002077839 GO Molecular Function RNA polymerase II core binding 196 6.185385e-17 1.3323824219387753e-15 2.01343 175 0.004829185 118 0.04527611974576271 1.393414 26 28 0.002077839 GO Molecular Function monosaccharide transmembrane transporter activity 260 3.368448e-14 5.46984132923077e-13 2.076631 133 0.00367018 104 0.030909570530769235 1.438074 23 24 0.001838088 Human Phenotype Aplasia/hypoplasia of the femur 19 4.007799e-44 1.4075811961578947e-41 2.821212 246 0.006788454 260 0.032407501496153845 1.364181 30 33 0.002397507 Human Phenotype External ophthalmoplegia 209 3.35862e-21 1.0723479071770334e-19 2.186173 184 0.005077543 282 0.041060223145390075 1.359918 29 32 0.00231759 Human Phenotype Ectropion 228 3.38904e-20 9.918887684210527e-19 2.295114 157 0.004332469 176 0.013790349761931818 1.442884 25 26 0.001997922 Human Phenotype Abnormality of cells of the monocyte/macrophage lineage 339 8.358897e-16 1.64539586079646e-14 2.48681 102 0.002814725 176 0.013790349761931818 1.442884 25 26 0.001997922 Mouse Phenotype Single KO decreased circulating free fatty acid level 45 1.000803e-111 2.0365229046666666e-109 2.62053 722 0.01992384 492 0.038044468784552844 1.210161 75 93 0.005993766 Mouse Phenotype Single KO cortical renal glomerulopathies 59 5.11256e-103 7.934866427118644e-101 2.150215 988 0.0272642 213 0.0008662414523474179 1.243034 111 134 0.008870774 Mouse Phenotype Single KO glomerulonephritis 97 9.849636e-84 9.298259469278351e-82 2.438362 616 0.01699873 450 0.030071140324444443 1.229407 68 83 0.005434348 Mouse Phenotype Single KO abnormal mesangial matrix morphology 110 2.889121e-80 2.405061908818182e-78 2.866314 444 0.01225233 335 0.009447949324477612 1.378929 34 37 0.002717174 Mouse Phenotype Single KO pale yolk sac 123 1.769088e-74 1.317035676097561e-72 2.042686 804 0.02218665 153 0.00008433315706535948 1.339821 75 84 0.005993766 Mouse Phenotype Single KO expanded mesangial matrix 124 7.478431e-74 5.522580053790323e-72 2.822975 418 0.01153485 277 0.0037118147433213 1.414851 33 35 0.002637257 Mouse Phenotype Single KO abnormal brain vasculature morphology 162 2.16439e-64 1.2234147672839507e-62 2.11897 635 0.01752304 379 0.017234097352506597 1.273236 56 66 0.004475346 Mouse Phenotype Single KO abnormal cranial blood vasculature morphology 189 4.848262e-58 2.348970112910053e-56 2.022681 639 0.01763342 344 0.011419234188081395 1.279923 58 68 0.004635179 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 208 1.339192e-53 5.895664011538461e-52 2.126148 522 0.01440477 243 0.0018823573860905348 1.359033 48 53 0.003836011 Mouse Phenotype Single KO decreased sensitivity to induced cell death 213 6.333991e-53 2.723021389061033e-51 2.130124 513 0.01415641 272 0.0032551620055147057 1.288976 67 78 0.005354431 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 227 6.219841e-51 2.50903453907489e-49 2.638225 320 0.008830509 530 0.04969353586981132 1.329102 31 35 0.002477423 Mouse Phenotype Single KO absent segment of posterior cerebral artery 234 1.103164e-49 4.316954165811966e-48 3.523672 201 0.005546664 283 0.004260541780212014 1.500599 22 22 0.001758172 Mouse Phenotype Single KO persistence of hyaloid vascular system 324 2.303318e-40 6.509716952469136e-39 2.053286 423 0.01167283 526 0.04714340439163498 1.295972 38 44 0.003036842 Mouse Phenotype Single KO absent incisors 360 3.751183e-37 9.541550758611112e-36 2.260758 311 0.008582151 507 0.0411679213964497 1.429142 20 21 0.001598338 Mouse Phenotype Single KO decreased circulating total protein level 372 2.476665e-36 6.096457366935484e-35 2.102116 358 0.009879132 480 0.035763922587500004 1.267748 49 58 0.003915927 Mouse Phenotype Single KO abnormal B cell apoptosis 421 4.193368e-33 9.120824412351545e-32 2.057215 342 0.009437607 389 0.020296177420051412 1.346692 35 39 0.002797091 Mouse Phenotype Single KO prenatal lethality prior to heart atrial septation 425 7.536883e-33 1.6238879442588236e-31 2.070331 334 0.009216844 365 0.01586277145068493 1.29362 50 58 0.003995844 Mouse Phenotype Single KO increased liver adenoma incidence 556 8.314406e-26 1.3693348155035972e-24 2.792477 142 0.003918539 325 0.008363206436615384 1.500599 20 20 0.001598338 Mouse Phenotype Single KO ruffled hair 654 4.19277e-22 5.870519096330275e-21 2.416299 156 0.004304873 356 0.013545484533426968 1.440575 24 25 0.001918005 Mouse Phenotype Single KO lordosis 696 1.462252e-20 1.92382781091954e-19 2.004998 219 0.00604338 514 0.04236646386575875 1.35538 28 31 0.002237673 Mouse Phenotype decreased circulating free fatty acid level 61 1.614858e-117 2.531091366885246e-115 2.406273 890 0.02455985 350 0.0010758911348571429 1.248398 99 119 0.007911772 Mouse Phenotype decreased fatty acid level 76 1.343255e-108 1.6898501388157896e-106 2.168495 1022 0.02820244 589 0.01642211320033956 1.173546 122 156 0.00974986 Mouse Phenotype shiny skin 89 2.933664e-103 3.151546236404494e-101 4.435043 324 0.008940891 577 0.015186944266897746 1.368194 31 34 0.002477423 Mouse Phenotype thick epidermis 100 6.768533e-99 6.471394401299999e-97 2.211212 891 0.02458745 739 0.03889751181596752 1.179958 92 117 0.007352354 Mouse Phenotype abnormal keratinocyte physiology 122 1.268001e-88 9.937178328688525e-87 2.193438 812 0.02240742 654 0.023619397912844037 1.195168 90 113 0.00719252 Mouse Phenotype abnormal vitelline vein morphology 160 5.096799e-77 3.0456559524375e-75 3.170761 365 0.0100723 774 0.04275703905426357 1.380551 23 25 0.001838088 Mouse Phenotype abnormal mesangial matrix morphology 166 3.447669e-75 1.9857327294578314e-73 2.527166 516 0.0142392 800 0.04606046408625 1.265211 43 51 0.003436426 Mouse Phenotype abnormal brain vasculature morphology 168 4.22193e-74 2.4027305196428573e-72 2.044627 798 0.02202108 455 0.006387101021538461 1.250499 75 90 0.005993766 Mouse Phenotype decreased white adipose tissue amount 180 1.854337e-70 9.849620031666668e-69 2.018268 783 0.02160715 455 0.006387101021538461 1.250499 75 90 0.005993766 Mouse Phenotype expanded mesangial matrix 187 3.370581e-69 1.7233221893582887e-67 2.482907 490 0.01352172 690 0.030766854591304345 1.286228 42 49 0.003356509 Mouse Phenotype renal glomerulus hypertrophy 222 7.267416e-63 3.1298992962162164e-61 2.599915 408 0.0112589 802 0.04600459932418952 1.324058 30 34 0.002397507 Mouse Phenotype absent segment of posterior cerebral artery 326 1.103164e-49 3.2353837435582825e-48 3.523672 201 0.005546664 399 0.003155211472180451 1.500599 22 22 0.001758172 Mouse Phenotype abnormal transitional stage T1 B cell morphology 398 4.305121e-41 1.0342025598241205e-39 2.718541 243 0.006705668 662 0.02562322003323263 1.389444 25 27 0.001997922 Mouse Phenotype abnormal embryonic erythrocyte morphology 411 5.902311e-40 1.3730412523357663e-38 2.298606 324 0.008940891 762 0.04094017690551181 1.308215 34 39 0.002717174 Mouse Phenotype decreased circulating total protein level 464 3.875336e-36 7.985363684482758e-35 2.092263 360 0.009934323 634 0.02201067367665615 1.271694 50 59 0.003995844 Mouse Phenotype increased liver adenoma incidence 465 4.880726e-36 1.0035402427096775e-34 2.923133 188 0.005187924 421 0.003925351442280285 1.447007 27 28 0.002157756 Mouse Phenotype abnormal renal glomerulus basement membrane thickness 488 1.134389e-34 2.2225191043032786e-33 2.08142 349 0.009630774 620 0.021399322253225807 1.321957 37 42 0.002956925 Mouse Phenotype abnormal Paneth cell morphology 490 1.714479e-34 3.345333412040816e-33 2.048208 361 0.009961918 602 0.018581755853820596 1.342642 34 38 0.002717174 Mouse Phenotype prenatal lethality prior to heart atrial septation 508 7.536883e-33 1.4185066606889764e-31 2.070331 334 0.009216844 521 0.011603374574856046 1.29362 50 58 0.003995844 Mouse Phenotype increased renal glomerulus basement membrane thickness 524 1.243527e-31 2.2689621463740456e-30 2.070175 321 0.008858105 568 0.014513281544366197 1.346692 35 39 0.002797091