# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process cellular response to insulin stimulus 34 3.777228e-64 1.4618983309411764e-61 2.168787 595 0.02911101 382 0.0008476342291884817 1.310293 104 148 0.01032771 GO Biological Process regulation of intrinsic apoptotic signaling pathway 56 3.161732e-56 7.429505605e-54 2.254649 478 0.02338666 643 0.015793051150855365 1.239088 103 155 0.0102284 GO Biological Process regulation of DNA-templated transcription in response to stress 82 2.844183e-51 4.564220011829268e-49 2.399021 383 0.01873869 859 0.047910524973224684 1.237875 79 119 0.007845084 GO Biological Process liver regeneration 92 4.356133e-48 6.2306906681521735e-46 3.429559 201 0.009834141 342 0.00043516120421052635 1.651545 31 35 0.003078451 GO Biological Process cellular response to topologically incorrect protein 116 3.658734e-43 4.150455233275862e-41 2.232416 372 0.0182005 745 0.030593473910067115 1.234155 92 139 0.009136048 GO Biological Process regulation of necrotic cell death 144 1.13746e-39 1.039433065277778e-37 4.991174 107 0.00523509 818 0.04030672481907091 1.519342 22 27 0.002184707 GO Biological Process response to epidermal growth factor 168 3.009914e-37 2.3575868051190478e-35 2.549169 245 0.01198689 787 0.03668347973570521 1.420684 32 42 0.003177756 GO Biological Process mitochondrial membrane organization 187 4.008088e-36 2.8204508017112297e-34 2.037324 382 0.01868976 439 0.001693122068838269 1.323298 88 124 0.008738828 GO Biological Process triglyceride homeostasis 197 5.421876e-35 3.6216480347208124e-33 3.607034 135 0.00660502 532 0.006496729395300751 1.573296 27 32 0.002681231 GO Biological Process regulation of mitochondrial membrane permeability 198 9.047779e-35 6.013117366717172e-33 2.357213 265 0.01296541 480 0.0029403346866666664 1.404871 55 73 0.005461768 GO Biological Process regulation of necroptotic process 232 1.170634e-31 6.639815864655173e-30 5.275998 80 0.003914086 608 0.01336847483125 1.678183 18 20 0.001787488 GO Biological Process regulation of membrane permeability 233 1.359495e-31 7.6779376416309e-30 2.190342 280 0.0136993 425 0.0014468196650588236 1.404241 61 81 0.006057597 GO Biological Process entry into host cell 244 3.236469e-31 1.7454383430737704e-29 2.034315 329 0.01609668 707 0.02642170855445545 1.27966 70 102 0.006951341 GO Biological Process regulation of type I interferon production 269 1.533638e-29 7.502283435687732e-28 2.0198 316 0.01546064 453 0.002195375519558499 1.318897 87 123 0.008639523 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to hypoxia 293 7.422114e-28 3.3333651237542666e-26 2.2878 223 0.01091051 549 0.007892387092349728 1.362627 57 78 0.005660377 GO Biological Process regulation of plasma lipoprotein particle levels 355 7.363526e-25 2.729482778422535e-23 2.181538 219 0.01071481 536 0.006887612092910447 1.379328 54 73 0.005362463 GO Biological Process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 375 5.179724e-24 1.8175996830933333e-22 2.6238 146 0.007143207 631 0.015166373125990491 1.502077 29 36 0.002879841 GO Biological Process apoptotic mitochondrial changes 391 2.201503e-23 7.40909922685422e-22 2.145433 213 0.01042125 535 0.006843872918691589 1.422189 45 59 0.004468719 GO Biological Process regulation of cholesterol metabolic process 393 3.135869e-23 1.049997459821883e-21 2.36814 171 0.008366358 323 0.0002785915519164087 1.548009 44 53 0.004369414 GO Biological Process protein-lipid complex subunit organization 398 8.518145e-23 2.8163384435929645e-21 2.431672 159 0.007779246 835 0.04282423985868264 1.388567 35 47 0.00347567 GO Cellular Component ficolin-1-rich granule lumen 52 2.688834e-34 8.935202215384616e-33 2.159952 315 0.01541171 105 0.008083911497142857 1.278186 85 124 0.008440914 GO Cellular Component high-density lipoprotein particle 80 1.216694e-24 2.62805904e-23 3.878021 85 0.004158716 140 0.030925991314285715 1.519342 22 27 0.002184707 GO Cellular Component cleavage furrow 100 1.176211e-19 2.0324926080000002e-18 2.116967 182 0.008904545 73 0.00005736699616438356 1.577779 44 52 0.004369414 GO Cellular Component mitochondrial nucleoid 142 1.466127e-14 1.7841320112676057e-13 2.348155 104 0.005088312 134 0.028291847641791042 1.420684 32 42 0.003177756 GO Cellular Component death-inducing signaling complex 198 1.075289e-9 9.384340363636364e-9 3.349022 36 0.001761339 147 0.04306609763265306 1.864647 9 9 0.0008937438 GO Cellular Component very-low-density lipoprotein particle 249 5.23407e-7 0.0000036323184578313254 2.199732 50 0.002446304 146 0.040966110246575344 1.58495 17 20 0.001688183 GO Molecular Function cadherin binding 4 2.222125e-116 2.3454529374999998e-113 2.101899 1158 0.05665639 9 1.431436262222222e-12 1.404619 229 304 0.02274081 GO Molecular Function ribonuclease activity 41 3.741986e-23 3.853332900487805e-21 2.045949 236 0.01154655 123 0.027136215063414633 1.299603 69 99 0.006852036 GO Molecular Function signal sequence binding 54 3.920108e-20 3.0649436992592594e-18 2.17799 175 0.008562063 99 0.009148267981818182 1.491718 36 45 0.003574975 GO Molecular Function ligand-dependent nuclear receptor binding 104 5.204689e-15 2.1129035536538461e-13 2.043634 147 0.007192133 112 0.013709109183928569 1.687062 19 21 0.001886792 GO Molecular Function RNA polymerase core enzyme binding 121 1.068607e-13 3.7286435983471076e-12 2.137769 119 0.005822203 78 0.0034475953471794873 1.598269 30 35 0.002979146 GO Molecular Function aldo-keto reductase (NADP) activity 134 1.100686e-12 3.467982307462686e-11 2.41579 84 0.00410979 143 0.04439704625174826 1.566304 21 25 0.002085402 GO Molecular Function RNA polymerase II core binding 142 2.516837e-12 7.483159023943662e-11 2.141867 105 0.005137238 113 0.013619159467256637 1.598269 24 28 0.002383317 Human Phenotype Increased serum ferritin 21 5.333598e-25 1.6948142597142855e-22 4.556916 72 0.003522677 110 0.004268245530272727 1.771415 19 20 0.001886792 Human Phenotype Abnormality of transition element cation homeostasis 26 6.457711e-23 1.6573963655e-20 3.709772 83 0.004060864 99 0.0025496360169696966 1.671753 26 29 0.002581927 Human Phenotype Abnormality of iron homeostasis 30 3.857453e-21 8.580261289666666e-19 3.711876 76 0.003718382 111 0.004355779107837838 1.70926 22 24 0.002184707 Human Phenotype Papillary thyroid carcinoma 164 3.997256e-11 1.626444468780488e-9 2.369367 75 0.003669455 181 0.0208046812320442 1.864647 12 12 0.001191658 Mouse Phenotype Single KO decreased circulating free fatty acid level 11 1.969468e-69 1.6394925887272727e-66 2.702749 420 0.02054895 274 0.006908702510218978 1.343348 67 93 0.006653426 Mouse Phenotype Single KO decreased fatty acid level 18 7.836139e-61 3.986418045722223e-58 2.391903 459 0.02245707 344 0.018986174376453488 1.274176 82 120 0.008142999 Mouse Phenotype Single KO renal glomerulus hypertrophy 167 1.481507e-28 8.123448861676647e-27 2.907047 148 0.007241059 329 0.017191741459574465 1.678183 18 20 0.001787488 Mouse Phenotype Single KO decreased bone ossification 273 2.918402e-20 9.788940334798536e-19 2.296789 157 0.007681393 468 0.04902473877350427 1.519342 22 27 0.002184707 Mouse Phenotype Single KO increased hepatocyte proliferation 301 5.804338e-19 1.765791463986711e-17 3.208648 82 0.004011938 323 0.015998129495356037 1.864647 12 12 0.001191658 Mouse Phenotype Single KO increased liver adenoma incidence 323 1.352764e-17 3.835064999380805e-16 2.963636 85 0.004158716 329 0.017191741459574465 1.678183 18 20 0.001787488 Mouse Phenotype Single KO abnormal hepatic vein morphology 832 2.840572e-8 3.126336274519231e-7 2.674081 42 0.002054895 373 0.02584520288203753 1.864647 11 11 0.001092354 Mouse Phenotype Single KO abnormal osteocyte morphology 1041 0.000001270314 0.000011174126126801152 2.07861 53 0.002593082 392 0.028389853558673468 1.740338 14 15 0.001390268 Mouse Phenotype decreased circulating free fatty acid level 18 4.414398e-80 2.344781071e-77 2.559768 534 0.02612652 245 0.00037536052828163267 1.36323 87 119 0.008639523 Mouse Phenotype decreased fatty acid level 27 2.154027e-69 7.627648943333334e-67 2.24588 597 0.02920887 324 0.0014166589767592593 1.29091 108 156 0.01072493 Mouse Phenotype extramedullary hematopoiesis 36 1.994456e-61 5.296942726666667e-59 2.055563 645 0.03155732 591 0.02053073488832487 1.214685 114 175 0.01132075 Mouse Phenotype dry eyes 105 5.114647e-43 4.657251425428572e-41 3.881658 153 0.007485689 520 0.012718124939423078 1.748107 15 16 0.001489573 Mouse Phenotype embryo tumor 217 6.932584e-29 3.0544901209216588e-27 5.663709 68 0.003326973 746 0.046954109449061664 1.864647 9 9 0.0008937438 Mouse Phenotype early cellular replicative senescence 223 2.111919e-28 9.054734331390135e-27 2.262855 233 0.01139977 620 0.024280406235483873 1.328242 52 73 0.005163853 Mouse Phenotype abnormal cellular replicative senescence 226 2.974488e-28 1.2583663614159293e-26 2.173992 253 0.0123783 702 0.03858596237606838 1.287495 58 84 0.005759682 Mouse Phenotype abnormal epidermis stratum spinosum morphology 255 3.856936e-26 1.4461241214117647e-24 2.054594 266 0.01301434 695 0.03721419088057554 1.298172 55 79 0.005461768 Mouse Phenotype increased liver adenoma incidence 284 5.407142e-24 1.8203410092253522e-22 3.087545 112 0.00547972 460 0.007576279815 1.598269 24 28 0.002383317 Mouse Phenotype increased pancreatic beta cell mass 341 2.065642e-21 5.791672481524927e-20 2.301535 166 0.008121728 678 0.03359798857964602 1.553873 20 24 0.001986097 Mouse Phenotype renal glomerulus hypertrophy 344 4.596958e-21 1.2776603324999998e-19 2.14663 190 0.009295954 483 0.00897989310931677 1.535592 28 34 0.002780536 Mouse Phenotype abnormal bile salt homeostasis 437 1.140712e-16 2.495731677803204e-15 2.035058 167 0.008170654 448 0.0068572537734375005 1.467914 37 47 0.00367428 Mouse Phenotype increased cellular sensitivity to oxidative stress 446 2.587821e-16 5.547568740134529e-15 2.220134 133 0.006507168 646 0.02832887299226006 1.398486 36 48 0.003574975 Mouse Phenotype decreased red blood cell distribution width 481 1.863399e-15 3.703941338669439e-14 3.332416 62 0.003033417 753 0.047061057701195216 1.721213 12 13 0.001191658 Mouse Phenotype pancytopenia 489 3.130948e-15 6.121675629447853e-14 2.273594 117 0.005724351 425 0.005058167187529412 1.607455 25 29 0.002482622 Mouse Phenotype increased hepatocyte proliferation 564 1.67761e-13 2.8439058882978724e-12 2.004006 137 0.006702872 439 0.0063307867482915725 1.544994 29 35 0.002879841 Mouse Phenotype increased cellular sensitivity to ultraviolet irradiation 616 1.227855e-12 1.905766502435065e-11 2.396113 85 0.004158716 689 0.035231743811320756 1.491718 24 30 0.002383317 Mouse Phenotype abnormal hepatic vein morphology 927 2.840572e-8 2.9297420595469254e-7 2.674081 42 0.002054895 565 0.017815188982300886 1.864647 11 11 0.001092354 Mouse Phenotype absent tongue 965 5.639814e-8 5.587799135129533e-7 2.042457 70 0.003424825 520 0.012718124939423078 1.748107 15 16 0.001489573 Mouse Phenotype abnormal nucleotide metabolism 977 6.809134e-8 6.663472893961105e-7 2.587687 42 0.002054895 663 0.0306740962760181 1.731458 13 14 0.001290963