# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 13 4.157866e-60 4.208719899538462e-57 2.479009 419 0.0379701 276 0.000454931899094203 1.302026 146 248 0.0171967 GO Biological Process negative regulation of gene expression, epigenetic 27 1.325419e-47 6.459699489259259e-45 3.380427 202 0.01830539 554 0.03152257452166065 1.319236 68 114 0.008009423 GO Biological Process gene silencing 45 9.671465e-37 2.828151287444444e-34 2.414295 266 0.02410512 550 0.030367024300000003 1.253274 102 180 0.01201413 GO Biological Process RNA catabolic process 49 8.426999e-36 2.2630791804285714e-33 2.14183 333 0.03017671 137 3.2025135140875915e-7 1.41326 154 241 0.01813899 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 51 1.840204e-35 4.7480871443137255e-33 2.716567 207 0.0187585 516 0.024318540953875967 1.330911 68 113 0.008009423 GO Biological Process regulation of DNA-templated transcription in response to stress 60 4.96711e-33 1.0893700081666667e-30 2.529176 218 0.01975532 526 0.026062049944866918 1.319562 71 119 0.00836278 GO Biological Process mRNA catabolic process 63 3.843507e-32 8.028048986190477e-30 2.170037 289 0.0261894 153 0.0000011308853200653593 1.422524 137 213 0.01613663 GO Biological Process nuclear-transcribed mRNA catabolic process 65 6.877387e-32 1.3923005466615386e-29 2.233692 269 0.02437698 149 9.617118261073826e-7 1.440931 129 198 0.01519435 GO Biological Process rRNA metabolic process 67 2.115301e-31 4.154514307313432e-29 2.088559 308 0.02791119 269 0.0003932886585947955 1.297963 152 259 0.01790342 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 68 2.139321e-31 4.139900741029412e-29 2.832439 170 0.01540553 209 0.00003642612047894737 1.499431 80 118 0.00942285 GO Biological Process response to topologically incorrect protein 69 4.741592e-31 9.042696975072463e-29 2.216525 266 0.02410512 212 0.00004255552942877358 1.400718 114 180 0.01342756 GO Biological Process rRNA processing 70 5.30329e-31 9.969427587142857e-29 2.100068 300 0.02718623 258 0.00028450349644961245 1.307688 149 252 0.01755006 GO Biological Process cellular response to topologically incorrect protein 71 5.650909e-31 1.0473283314225352e-28 2.434241 219 0.01984594 204 0.000029923940128431373 1.463833 92 139 0.01083628 GO Biological Process multi-organism metabolic process 72 6.64718e-31 1.2148644669444445e-28 2.46069 214 0.01939284 134 2.3877683090298505e-7 1.534622 102 147 0.01201413 GO Biological Process viral gene expression 84 5.272671e-28 8.259890201071428e-26 2.610513 173 0.01567739 184 0.000006482951558804348 1.515075 87 127 0.01024735 GO Biological Process endoplasmic reticulum unfolded protein response 92 3.876553e-27 5.544734883369565e-25 2.50033 181 0.01640236 229 0.00006763731746288209 1.493841 77 114 0.009069494 GO Biological Process regulation of megakaryocyte differentiation 96 8.207536e-27 1.1250308981666665e-24 2.697642 156 0.01413684 394 0.007837310028680202 1.45504 50 76 0.005889282 GO Biological Process viral transcription 97 8.672332e-27 1.1764867710103093e-24 2.638076 162 0.01468056 165 0.0000024531805315151517 1.565778 80 113 0.00942285 GO Biological Process cotranslational protein targeting to membrane 98 1.107543e-26 1.4871590139795918e-24 2.845851 142 0.01286815 171 0.000003064234751754386 1.602326 71 98 0.00836278 GO Biological Process nucleosome organization 100 1.395081e-26 1.8357870879000003e-24 2.129592 247 0.02238333 375 0.006262276864266666 1.306303 101 171 0.01189635 GO Cellular Component nucleosome 29 1.742094e-36 1.0380477351724137e-34 3.620762 140 0.01268691 98 0.007313097012244897 1.369123 65 105 0.007656066 GO Cellular Component ribosomal subunit 32 3.029885e-31 1.6361379000000002e-29 2.385048 230 0.02084277 41 0.000002142127843902439 1.434591 120 185 0.01413428 GO Cellular Component DNA packaging complex 34 1.540819e-30 7.830985976470589e-29 3.065718 146 0.01323063 104 0.011240492123076925 1.342794 68 112 0.008009423 GO Cellular Component melanosome 51 5.191405e-22 1.7589701647058822e-20 2.111432 206 0.01866787 121 0.022819968 1.326996 63 105 0.007420495 GO Cellular Component large ribosomal subunit 52 6.027044e-22 2.002833083076923e-20 2.492902 145 0.01314001 58 0.000059252971034482756 1.480851 77 115 0.009069494 GO Cellular Component intrinsic component of endoplasmic reticulum membrane 57 1.504542e-19 4.561137852631579e-18 2.018805 202 0.01830539 97 0.007285123298969072 1.317585 84 141 0.009893993 GO Cellular Component integral component of endoplasmic reticulum membrane 61 7.142005e-19 2.0231778098360655e-17 2.008188 197 0.01785229 94 0.007108519557446808 1.323768 82 137 0.009658422 GO Cellular Component cytosolic ribosome 63 1.218333e-18 3.3417133714285716e-17 2.167205 162 0.01468056 40 0.0000021001636799999998 1.560011 79 112 0.009305065 GO Cellular Component cytosolic large ribosomal subunit 68 5.993666e-18 1.5230963011764706e-16 2.714656 100 0.009062075 49 0.000013734704718367347 1.704067 47 61 0.005535925 GO Cellular Component ficolin-1-rich granule lumen 78 2.008839e-15 4.450351015384615e-14 2.006679 158 0.01431808 86 0.004462983962790698 1.355534 76 124 0.008951708 GO Cellular Component vesicle coat 97 4.878947e-12 8.691567439175258e-11 2.169277 99 0.008971454 122 0.022943789114754098 1.474441 34 51 0.004004711 GO Cellular Component pronucleus 104 1.245337e-11 2.069175323076923e-10 3.786316 38 0.003443589 115 0.017508877356521742 1.916773 13 15 0.001531213 GO Cellular Component small ribosomal subunit 109 2.837541e-11 4.4984136220183483e-10 2.221788 87 0.007884005 127 0.0316185085984252 1.382288 45 72 0.005300353 GO Cellular Component nuclear euchromatin 159 3.332011e-7 0.00000362120440754717 2.023011 63 0.005709107 76 0.0017273133473684214 1.857795 21 25 0.002473498 GO Molecular Function structural constituent of ribosome 8 5.946471e-24 3.1382500702499997e-21 2.237493 198 0.01794291 40 0.0001882581356 1.406179 103 162 0.01213192 GO Molecular Function eukaryotic initiation factor 4E binding 431 0.002013628 0.019725144816705335 2.099537 20 0.001812415 88 0.017083963170454547 2.211661 10 10 0.001177856 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 44 1.896088e-23 3.9460176854545454e-21 3.032297 112 0.01014952 149 0.001660959960067114 1.769329 28 35 0.003297998 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 49 4.304414e-22 8.043983468979592e-20 3.112978 101 0.009152696 292 0.024611936859246578 1.677812 22 29 0.002591284 Mouse Phenotype Single KO abnormal iron level 57 9.14268e-19 1.4687635221052633e-16 2.041057 188 0.0170367 269 0.018752048413011153 1.338148 72 119 0.008480565 Mouse Phenotype Single KO decreased mean corpuscular hemoglobin 62 7.563221e-18 1.1170389467258065e-15 2.289998 137 0.01241504 340 0.038932278252941176 1.410334 44 69 0.005182568 Mouse Phenotype Single KO decreased erythroid progenitor cell number 64 1.086962e-17 1.5552048490625002e-15 2.136677 158 0.01431808 178 0.0035564285840449434 1.604538 37 51 0.004358068 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 83 2.420194e-15 2.670086320240964e-13 2.033098 152 0.01377435 225 0.010315405267555554 1.54399 37 53 0.004358068 Mouse Phenotype Single KO microcytosis 88 1.770667e-14 1.8424997407954546e-12 3.710454 50 0.004531038 305 0.026853553998032784 1.790392 17 21 0.002002356 Mouse Phenotype Single KO abnormal spleen iron level 95 4.27717e-14 4.122741651578947e-12 3.000628 65 0.005890349 292 0.024611936859246578 1.677812 22 29 0.002591284 Mouse Phenotype Single KO abnormal erythrocyte physiology 139 2.127504e-11 1.4015506566906475e-9 2.339776 79 0.007159039 244 0.014616669853688525 1.572737 32 45 0.00376914 Mouse Phenotype Single KO abnormal erythrocyte osmotic lysis 168 1.494834e-10 8.147735082142858e-9 2.6789 56 0.005074762 292 0.024611936859246578 1.677812 22 29 0.002591284 Mouse Phenotype Single KO spherocytosis 171 1.981723e-10 1.0612068719883041e-8 4.038931 31 0.002809243 270 0.018685078946296296 2.041533 12 13 0.001413428 Mouse Phenotype Single KO hemolysis 199 1.679035e-9 7.726092208542714e-8 2.476733 57 0.005165383 313 0.029619208795527156 1.64091 23 31 0.002709069 Mouse Phenotype Single KO abnormal hemoglobin concentration distribution width 224 4.740809e-9 1.9380173220089285e-7 3.818397 28 0.002537381 360 0.04435243822222223 2.211661 8 8 0.000942285 Mouse Phenotype Single KO pancytopenia 225 5.027258e-9 2.0459822891555555e-7 2.80649 43 0.003896692 274 0.01995294258540146 1.935203 14 16 0.001648999 Mouse Phenotype Single KO increased spleen iron level 242 1.235192e-8 4.67382361322314e-7 3.373497 31 0.002809243 373 0.04827135872117962 1.821368 14 17 0.001648999 Mouse Phenotype Single KO enlarged liver sinusoidal spaces 265 2.790404e-8 9.642162048301886e-7 2.011947 76 0.006887177 365 0.045358584852054795 1.55414 26 37 0.003062426 Mouse Phenotype Single KO renal glomerulus hypertrophy 308 1.177016e-7 0.0000034993297116883117 2.146494 59 0.005346624 355 0.041818264983098596 1.769329 16 20 0.00188457 Mouse Phenotype Single KO increased mortality induced by gamma-irradiation 387 0.000001772036 0.000041929027524547804 2.086027 51 0.004621658 255 0.016404169397254902 1.695607 23 30 0.002709069 Mouse Phenotype Single KO increased cellular sensitivity to ultraviolet irradiation 404 0.000002354131 0.00005335836031435643 2.358784 38 0.003443589 287 0.02329952067351916 1.750898 19 24 0.002237927 Mouse Phenotype Single KO absent segment of posterior cerebral artery 440 0.000005391682 0.00011220825471363638 2.245205 39 0.003534209 182 0.004040740584175824 1.910071 19 22 0.002237927 Mouse Phenotype abnormal platelet physiology 39 1.07683e-29 2.6398901615384617e-27 2.155643 270 0.0244676 474 0.03265926660126582 1.290135 77 132 0.009069494 Mouse Phenotype decreased erythroid progenitor cell number 59 1.203872e-22 1.9508847783050847e-20 2.121706 210 0.01903036 210 0.0005948203141428572 1.542342 53 76 0.006242638 Mouse Phenotype abnormal embryonic erythrocyte morphology 64 2.052705e-20 3.06654882890625e-18 2.702523 116 0.01051201 249 0.0021063412886746986 1.701278 30 39 0.003533569 Mouse Phenotype abnormal iron level 68 4.143293e-20 5.825591819558823e-18 2.008453 211 0.01912098 386 0.01722355941839378 1.310614 80 135 0.00942285 Mouse Phenotype microcytosis 87 5.798091e-18 6.371902074827586e-16 3.944815 59 0.005346624 288 0.00472606205625 1.843051 20 24 0.002355713 Mouse Phenotype microcytic anemia 96 9.67375e-17 9.634450390625e-15 3.220175 71 0.006434073 401 0.01871261037830424 1.677812 22 29 0.002591284 Mouse Phenotype decreased mean corpuscular hemoglobin 105 7.366752e-16 6.707953892571429e-14 2.063848 152 0.01377435 411 0.01980926142919708 1.40742 49 77 0.005771496 Mouse Phenotype poikilocytosis 135 1.95191e-13 1.3823860377777778e-11 2.843439 67 0.00607159 388 0.017297327505154638 1.587859 28 39 0.003297998 Mouse Phenotype hypochromic anemia 139 4.483278e-13 3.083785680431655e-11 2.815658 66 0.00598097 340 0.009308333702647059 1.737733 22 28 0.002591284 Mouse Phenotype abnormal spleen iron level 158 4.595875e-12 2.7810861313291136e-10 2.642912 67 0.00607159 524 0.03762019948854962 1.589631 23 32 0.002709069 Mouse Phenotype abnormal erythrocyte physiology 180 4.831534e-11 2.5663498096666666e-9 2.186341 88 0.007974626 512 0.0365323569140625 1.447633 36 55 0.004240283 Mouse Phenotype tumor regression 191 7.94676e-11 3.977956668062827e-9 5.954701 22 0.001993657 494 0.0337476204048583 2.211661 8 8 0.000942285 Mouse Phenotype increased incidence of tumors by ionizing radiation induction 217 1.996749e-10 8.79765769078341e-9 3.361714 39 0.003534209 571 0.048693101364273204 1.746048 15 19 0.001766784 Mouse Phenotype pancytopenia 260 2.790744e-9 1.0262424378461538e-7 2.303532 64 0.005799728 237 0.0014789806011392406 1.83034 24 29 0.002826855 Mouse Phenotype abnormal hemoglobin concentration distribution width 277 4.740809e-9 1.636349272527076e-7 3.818397 28 0.002537381 494 0.0337476204048583 2.211661 8 8 0.000942285 Mouse Phenotype abnormal cellular hemoglobin content 284 6.246737e-9 2.1029948048239436e-7 3.768481 28 0.002537381 546 0.040414259445054945 2.010601 10 11 0.001177856 Mouse Phenotype increased cellular sensitivity to ultraviolet irradiation 328 5.450937e-8 0.0000015889148980792685 2.453994 47 0.004259175 362 0.0120652398339779 1.695607 23 30 0.002709069 Mouse Phenotype decreased spongiotrophoblast size 346 1.073599e-7 0.00000296667053150289 2.611546 40 0.00362483 571 0.048693101364273204 1.746048 15 19 0.001766784 Mouse Phenotype increased mortality induced by gamma-irradiation 364 1.863177e-7 0.000004893910795879121 2.116103 59 0.005346624 244 0.0018915141495491803 1.756319 27 34 0.003180212 Mouse Phenotype increased cerebral infarction size 497 0.000003421231 0.00006581567322132796 2.069654 49 0.004440417 482 0.03346088163485477 1.621885 22 30 0.002591284