# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process DNA replication-dependent nucleosome assembly 1 2.154029e-19 2.8344867611e-15 16.11132 22 0.006436513 442 0.02461736001606335 2.260909 15 32 0.00385307 GO Biological Process viral gene expression 2 5.751341e-19 3.78409481095e-15 3.507621 72 0.02106495 330 0.007406268007272727 1.671055 44 127 0.01130234 GO Biological Process multi-organism metabolic process 4 5.820609e-15 1.914834845775e-11 2.82135 76 0.02223523 457 0.0258732258 1.542135 47 147 0.01207295 GO Biological Process viral transcription 6 4.241927e-14 9.303252898833334e-11 3.154451 60 0.01755413 464 0.02676182130689655 1.621985 38 113 0.00976111 GO Biological Process RNA catabolic process 17 2.997392e-12 2.3201577251764708e-9 2.13884 103 0.03013458 258 0.002523919151744186 1.521032 76 241 0.01952222 GO Biological Process chromatin silencing 18 5.205413e-12 3.805446092611111e-9 3.524002 43 0.01258046 429 0.023014348697435898 1.690632 34 97 0.008733624 GO Biological Process negative regulation of viral life cycle 28 3.993022e-11 1.8765777320714288e-8 3.013387 49 0.01433587 462 0.026224776175324677 1.718637 31 87 0.007963011 GO Biological Process mRNA catabolic process 35 1.261994e-10 4.7447368702857146e-8 2.133302 88 0.02574605 494 0.035902999617408914 1.426602 63 213 0.01618289 GO Biological Process negative regulation of gene expression, epigenetic 41 3.384353e-10 1.0862122226097562e-7 2.755438 51 0.01492101 346 0.010024275190173411 1.692376 40 114 0.01027485 GO Biological Process gene silencing 42 3.607779e-10 1.1303515205000001e-7 2.227013 76 0.02223523 359 0.01324443819805014 1.52737 57 180 0.01464166 GO Biological Process negative regulation of viral process 48 6.224307e-10 1.7063678294375003e-7 2.737082 50 0.01462844 410 0.02061235067585366 1.73421 32 89 0.008219882 GO Biological Process regulation of megakaryocyte differentiation 51 9.330403e-10 2.4074269230784316e-7 2.735622 49 0.01433587 225 0.0011299504634222225 2.030852 32 76 0.008219882 GO Biological Process negative regulation of multi-organism process 73 5.578336e-8 0.00001005552375671233 2.156716 61 0.01784669 533 0.043779993 1.544954 41 128 0.01053172 GO Biological Process protein heterotetramerization 79 7.478877e-8 0.000012457537018101265 3.523113 26 0.007606788 544 0.044644737652573534 1.973157 18 44 0.004623684 GO Biological Process apoptotic cell clearance 84 2.057171e-7 0.0000322265633202381 3.437904 25 0.007314219 493 0.035838069395537527 2.322316 13 27 0.003339327 GO Biological Process beta-catenin-TCF complex assembly 90 2.863944e-7 0.000041874043439999996 2.505168 40 0.01170275 204 0.0006061184406323529 2.467721 22 43 0.005651169 GO Biological Process negative regulation of viral transcription 138 0.000007452597 0.0007106429269782608 3.243574 20 0.005851375 498 0.035823025791164656 2.411636 12 24 0.003082456 GO Biological Process vesicle docking 147 0.00001101993 0.0009864711487755102 2.169393 39 0.01141018 469 0.028553178200426438 1.880259 23 59 0.00590804 GO Biological Process inhibition of neuroepithelial cell differentiation 161 0.00001796701 0.0014684961775776398 5.600236 10 0.002925688 538 0.04513803604275093 4.823273 4 4 0.001027485 GO Biological Process presynaptic dense core vesicle exocytosis 255 0.0001380629 0.007124587063137256 4.842627 9 0.002633119 538 0.04513803604275093 4.823273 4 4 0.001027485 GO Cellular Component nucleosome 13 2.897814e-12 3.851863532307692e-10 3.590382 43 0.01258046 22 0.000001962905890909091 2.158989 47 105 0.01207295 GO Cellular Component DNA packaging complex 20 1.664668e-10 1.438273152e-8 3.050649 45 0.01316559 25 0.000006516645350399999 2.067117 48 112 0.01232982 GO Cellular Component SNARE complex 41 0.000001914103 0.00008067243863414634 2.407815 37 0.01082504 64 0.0060906924 2.054357 23 54 0.00590804 GO Cellular Component postsynaptic density membrane 55 0.00004037965 0.0012686551854545454 2.968948 19 0.005558806 38 0.00015436465010526315 4.823273 8 8 0.00205497 GO Cellular Component postsynaptic specialization membrane 60 0.00005354175 0.0015420024 2.905224 19 0.005558806 49 0.0008791693714285716 4.287353 8 9 0.00205497 GO Cellular Component euchromatin 67 0.0001702584 0.004391142017910448 2.292288 25 0.007314219 55 0.00273449088 2.484716 17 33 0.004366812 Mouse Phenotype Single KO decreased neurotransmitter release 3 2.843442e-8 0.00008679132798 3.495139 28 0.008191925 80 0.00023895099930000002 3.288595 15 22 0.00385307 Mouse Phenotype Single KO lordosis 8 0.000001293818 0.00148093642825 2.81488 29 0.008484494 249 0.019953073579919677 2.333842 15 31 0.00385307 Mouse Phenotype Single KO oral atresia 26 0.00005778446 0.020351242316153848 9.294605 6 0.001755413 338 0.049996380156804736 4.823273 4 4 0.001027485 Mouse Phenotype Single KO abnormal gustatory papillae morphology 27 0.00005985355 0.020299220642592593 3.235354 16 0.0046811 237 0.017614273833755273 4.134234 6 7 0.001541228 Mouse Phenotype decreased neurotransmitter release 2 2.795856e-11 1.3365589608e-7 3.133177 47 0.01375073 85 0.000005779859588117648 2.99825 23 37 0.00590804 Mouse Phenotype abnormal neurotransmitter secretion 5 1.562655e-9 0.000002988108891 2.022243 88 0.02574605 45 8.058000176666666e-8 2.467721 44 86 0.01130234 Mouse Phenotype abnormal central nervous system regeneration 16 0.00000143885 0.000859802803125 5.02698 14 0.004095963 591 0.03953984714213198 3.069355 7 11 0.001798099 Mouse Phenotype lordosis 18 0.00000323751 0.001719657395 2.494855 33 0.009654769 293 0.004604881072013652 2.346457 18 37 0.004623684 Mouse Phenotype abnormal gustatory papillae morphology 27 0.00002636942 0.009337704615555555 3.183641 18 0.005266238 270 0.0036041322655555558 3.858618 8 10 0.00205497 Mouse Phenotype premature neuronal precursor differentiation 41 0.00008771667 0.02045509955780488 2.131817 32 0.0093622 438 0.018727872878082193 2.411636 13 26 0.003339327 Mouse Phenotype decreased synaptic glutamate release 46 0.0001056985 0.02196920344565217 2.954779 17 0.004973669 462 0.022408355759740258 3.376291 7 10 0.001798099 Mouse Phenotype abnormal Purkinje cell innervation 53 0.0001792701 0.032339649549056604 2.43578 22 0.006436513 317 0.006665389320189273 3.339189 9 13 0.002311842 Mouse Phenotype abnormal esophageal epithelium morphology 71 0.0003536279 0.04762023030845071 2.14221 26 0.007606788 351 0.009150636976923077 2.500956 14 27 0.003596198