# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process Bergmann glial cell differentiation 6 5.460825e-165 1.19764993625e-161 37.95564 140 0.0311943 284 0.019949544412676056 4.516597 6 8 0.00192431 GO Biological Process leukocyte mediated immunity 33 4.394777e-92 1.7524506225151515e-89 2.791058 505 0.1125223 167 0.0010202873988023951 1.39347 143 618 0.04586273 GO Biological Process regulation of cellular response to heat 52 1.402685e-78 3.549602291346154e-76 6.419877 171 0.0381016 177 0.0021898806338983053 2.16179 28 78 0.008980115 GO Biological Process immune effector process 59 8.824409e-76 1.9681423395084744e-73 2.239471 614 0.1368093 283 0.019724155295053003 1.25239 188 904 0.06029506 GO Biological Process positive regulation of telomere maintenance via telomere lengthening 67 1.699628e-70 3.3381201271641787e-68 7.711188 133 0.02963458 270 0.01589838700925926 2.509221 15 36 0.004810776 GO Biological Process positive regulation of telomere maintenance via telomerase 69 7.394096e-70 1.410129119768116e-67 7.693078 132 0.02941176 299 0.026093143937123746 2.4797 14 34 0.004490058 GO Biological Process positive regulation of telomere maintenance 78 1.407303e-64 2.3741923303846156e-62 6.600347 137 0.03052585 312 0.030535092566346157 2.167967 18 50 0.005772931 GO Biological Process positive regulation of chromosome organization 88 2.150354e-61 3.2155123052272726e-59 5.419753 154 0.03431373 225 0.006484322415111111 2.120468 25 71 0.00801796 GO Biological Process protein folding 91 2.544258e-60 3.679108903516484e-58 3.62284 232 0.0516934 271 0.01606147723099631 1.545502 58 226 0.01860167 GO Biological Process regulation of telomere maintenance via telomere lengthening 93 9.348245e-60 1.3227264081182796e-57 5.754146 142 0.03163993 340 0.044672715041176474 2.007377 20 60 0.006414368 GO Biological Process cellular response to reactive oxygen species 100 7.598374e-56 9.9987003466e-54 4.012848 190 0.04233512 325 0.03521187657753846 1.70627 34 120 0.01090443 GO Biological Process cellular response to oxidative stress 104 1.031693e-54 1.30538924875e-52 2.924038 282 0.06283422 321 0.03373422382866043 1.505532 56 224 0.01796023 GO Biological Process positive regulation of telomerase activity 106 3.826018e-54 4.749676496415095e-52 5.484095 134 0.0298574 342 0.0448040094502924 2.341939 14 36 0.004490058 GO Biological Process posttranscriptional regulation of gene expression 108 1.875131e-53 2.2847082249074074e-51 2.312826 412 0.09180036 38 4.746759497631578e-11 1.740687 161 557 0.05163566 GO Biological Process regulation of translation 112 8.961913e-52 1.0529447604196429e-49 2.457919 356 0.07932264 47 3.663795974893617e-10 1.819332 129 427 0.04137267 GO Biological Process regulation of telomere maintenance 113 1.232711e-51 1.4355083229203538e-49 4.699447 148 0.03297683 298 0.02562244087147651 1.93017 25 78 0.00801796 GO Biological Process Fc receptor signaling pathway 128 4.682231e-46 4.813552947578125e-44 3.055198 222 0.04946524 354 0.04759762706497176 1.538261 47 184 0.01507377 GO Biological Process regulation of cellular amide metabolic process 132 6.473951e-45 6.453842515833333e-43 2.266869 361 0.08043672 61 4.699937470819672e-9 1.737404 133 461 0.04265555 GO Biological Process response to oxygen radical 141 1.191503e-43 1.1119849629078015e-41 11.98685 61 0.0135918 222 0.005951371139189188 3.312171 11 20 0.003527903 GO Biological Process positive regulation of DNA biosynthetic process 147 5.306897e-42 4.7505753485034015e-40 4.011051 142 0.03163993 335 0.04342870662089552 1.976011 21 64 0.006735087 GO Cellular Component ficolin-1-rich granule lumen 17 3.767134e-67 3.829180912941176e-65 5.33994 171 0.0381016 58 0.0051249381517241375 1.796926 37 124 0.01186658 GO Cellular Component azurophil granule lumen 19 1.720477e-64 1.5647285557894736e-62 6.001438 148 0.03297683 80 0.0291077712 1.786786 27 91 0.008659397 GO Cellular Component azurophil granule 21 1.891078e-60 1.55608704e-58 4.314815 190 0.04233512 87 0.04031425986206896 1.564189 40 154 0.01282874 GO Cellular Component vacuolar lumen 26 1.245656e-47 8.278821415384616e-46 3.467637 193 0.04300357 55 0.0029811267490909093 1.700366 48 170 0.01539448 GO Cellular Component secretory granule lumen 40 1.878032e-34 8.113098240000001e-33 2.420239 243 0.05414439 54 0.00263284512 1.500842 80 321 0.02565747 GO Cellular Component cytoplasmic vesicle lumen 43 1.464193e-32 5.8840128e-31 2.338882 245 0.05459002 59 0.005181718454237288 1.46099 82 338 0.02629891 GO Cellular Component focal adhesion 44 3.690841e-32 1.4494939199999999e-30 2.034731 327 0.07286096 45 0.0002999814144 1.517025 99 393 0.03175112 GO Cellular Component vesicle lumen 45 5.080172e-32 1.950786048e-30 2.318744 245 0.05459002 63 0.005377083428571428 1.45668 82 339 0.02629891 GO Cellular Component cell-substrate adherens junction 47 6.5983e-32 2.425928170212766e-30 2.027914 327 0.07286096 46 0.00041258441739130437 1.505532 99 396 0.03175112 GO Cellular Component host cell 66 1.069532e-21 2.800229236363637e-20 3.908239 73 0.0162656 77 0.02361224477922078 1.948336 22 68 0.007055805 GO Cellular Component other organism cell 71 1.138385e-20 2.7706046197183097e-19 3.701229 74 0.01648841 83 0.03137812742168675 1.871743 23 74 0.007376523 GO Cellular Component nucleosome 107 1.347308e-11 2.175839461682243e-10 3.115928 49 0.010918 26 3.2236537846153845e-9 2.638266 46 105 0.01475305 GO Cellular Component DNA packaging complex 117 1.553728e-9 2.2947367384615385e-8 2.63311 51 0.01136364 28 1.12267296e-8 2.527144 47 112 0.01507377 GO Cellular Component nuclear chromosome, telomeric region 118 5.302882e-9 7.765576352542373e-8 2.242117 65 0.01448307 43 0.00019349099162790698 1.961754 43 132 0.01379089 GO Cellular Component nuclear nucleosome 130 4.10463e-8 5.456000492307691e-7 4.577405 20 0.004456328 68 0.009236518305882353 2.408852 16 40 0.005131495 GO Cellular Component catalytic step 2 spliceosome 136 1.299896e-7 0.0000016516325647058823 2.203354 55 0.0122549 82 0.03117143414634146 1.756454 28 96 0.008980115 GO Cellular Component cytoplasmic stress granule 149 0.000002564033 0.000029735899489932884 2.447012 35 0.007798574 66 0.007417788218181819 2.380842 17 43 0.005452213 GO Cellular Component granular component 156 0.00001500178 0.00016617356307692307 7.576917 8 0.001782531 76 0.014803980631578947 5.018441 5 6 0.001603592 GO Cellular Component mitochondrial nucleoid 163 0.00002954914 0.0003132571406134969 2.570634 25 0.00557041 88 0.04223286981818182 2.150761 15 42 0.004810776 GO Cellular Component intrinsic component of mitochondrial membrane 177 0.0001246572 0.0012169923254237288 2.015356 35 0.007798574 81 0.029469888 1.945611 21 65 0.006735087 GO Molecular Function GTPase activity 27 6.01192e-46 9.40086157037037e-44 2.765866 258 0.05748663 49 0.008910453453061224 1.526737 72 284 0.02309173 GO Molecular Function nucleosome binding 66 1.232315e-16 7.883081712121213e-15 3.329674 67 0.0149287 11 0.00024677021949090906 2.554843 28 66 0.008980115 GO Molecular Function nucleosomal DNA binding 132 6.782864e-8 0.0000021694887733333333 2.877548 35 0.007798574 37 0.007121054557297298 2.487401 19 46 0.00609365 GO Molecular Function mismatch repair complex binding 267 0.002838637 0.044886612037453186 3.816753 7 0.001559715 57 0.03189126957192982 4.516597 6 8 0.00192431 Mouse Phenotype Single KO abnormal pre-B cell morphology 3 1.296625e-138 3.9577317083333333e-135 6.846903 287 0.06394831 37 0.0010862270987027029 2.249229 31 83 0.009942271 Mouse Phenotype Single KO embryonic lethality prior to organogenesis 66 3.346667e-53 4.643246927121212e-51 2.062419 521 0.1160873 12 0.000008758868901666666 1.486634 177 717 0.05676716 Mouse Phenotype Single KO abnormal B cell differentiation 68 7.844115e-53 1.0563023684558824e-50 2.595107 330 0.07352941 108 0.042592852842592586 1.499486 62 249 0.01988454 Mouse Phenotype Single KO embryonic lethality between implantation and placentation 73 8.365037e-51 1.0492964905342466e-48 2.32782 387 0.08622995 50 0.0025636468306 1.490772 101 408 0.03239256 Mouse Phenotype Single KO abnormal trophoblast layer morphology 80 1.567092e-48 1.7937326805e-46 3.289394 211 0.04701426 88 0.018253438931818182 1.738784 41 142 0.01314945 Mouse Phenotype Single KO abnormal placenta morphology 117 8.816446e-38 6.900187694188034e-36 2.187355 327 0.07286096 86 0.016603578876744185 1.481786 78 317 0.02501604 Mouse Phenotype Single KO abnormal trophectoderm morphology 125 7.102434e-36 5.202959051039999e-34 3.182546 162 0.03609626 104 0.03606638534134615 1.756454 35 120 0.01122514 Mouse Phenotype Single KO abnormal parietal yolk sac morphology 134 4.942811e-34 3.377710472164179e-32 2.966728 170 0.03787879 75 0.008960942525333332 1.802243 41 137 0.01314945 Mouse Phenotype Single KO decreased pre-B cell number 146 1.966206e-32 1.2331882426027397e-30 3.791501 116 0.0258467 98 0.03019328266122449 2.14347 21 59 0.006735087 Mouse Phenotype Single KO abnormal blastocyst morphology 151 3.077581e-31 1.8663184911920528e-29 2.485789 209 0.04656863 68 0.006761088456029412 1.672814 55 198 0.01763951 Mouse Phenotype Single KO embryonic lethality between somite formation and embryo turning, complete penetrance 159 8.874117e-30 5.110710023207547e-28 3.680321 110 0.0245098 94 0.022842798921276598 2.034503 25 74 0.00801796 Mouse Phenotype Single KO absent inner cell mass proliferation 409 9.350936e-9 2.0935579694865526e-7 2.959663 38 0.008467023 74 0.008279417868648649 2.625031 17 39 0.005452213 Mouse Phenotype Single KO increased cellular sensitivity to alkylating agents 650 0.0006926875 0.009758368365384615 3.296856 11 0.00245098 115 0.04873962150782609 3.832264 7 11 0.002245029 Mouse Phenotype decreased pre-B cell number 3 5.084474e-219 1.6204218637999997e-215 7.601333 417 0.09291444 31 0.00007359900506129033 2.258299 39 104 0.01250802 Mouse Phenotype abnormal pre-B cell morphology 5 5.969088e-198 1.14140900736e-194 6.394281 430 0.09581105 19 0.000021074939924210524 2.1734 48 133 0.01539448 Mouse Phenotype decreased immature B cell number 23 1.475058e-108 6.131751973043478e-106 4.854023 303 0.06751337 121 0.013827750332231405 1.765888 39 133 0.01250802 Mouse Phenotype abnormal B cell differentiation 31 1.085259e-98 3.3471488061290323e-96 2.983662 489 0.1089572 53 0.0009204885221320754 1.56645 90 346 0.02886466 Mouse Phenotype abnormal immature B cell number 41 8.87377e-87 2.069319877317073e-84 3.831555 312 0.06951872 125 0.0147092848992 1.664942 47 170 0.01507377 Mouse Phenotype abnormal immature B cell morphology 45 3.553208e-86 7.549382597333334e-84 3.798629 313 0.06974153 142 0.0210351561 1.623945 48 178 0.01539448 Mouse Phenotype decreased B cell number 56 2.22789e-76 3.8037243375e-74 2.402254 542 0.1207665 45 0.0003977900792666667 1.496181 120 483 0.03848621 Mouse Phenotype abnormal lymphopoiesis 78 4.637114e-66 5.684031660769231e-64 2.118546 604 0.1345811 16 0.00001629355741875 1.498594 162 651 0.05195638 Mouse Phenotype abnormal B cell number 100 1.032464e-56 9.871388304e-55 2.017703 582 0.1296791 107 0.008657593619719626 1.337226 145 653 0.04650417 Mouse Phenotype abnormal mature B cell morphology 103 2.334596e-56 2.1670944034951457e-54 2.012472 582 0.1296791 113 0.010267422523008848 1.331111 145 656 0.04650417 Mouse Phenotype embryonic lethality between implantation and placentation 147 3.326559e-44 2.1636211291836737e-42 2.137206 402 0.08957219 54 0.0009192226918333333 1.488915 112 453 0.03592046 Mouse Phenotype abnormal trophoblast layer morphology 149 5.826957e-44 3.739029253489933e-42 2.986136 219 0.04879679 96 0.006912462572812501 1.742251 46 159 0.01475305 Mouse Phenotype decreased thymocyte number 182 1.006703e-36 5.2885095510989e-35 2.536257 238 0.0530303 57 0.001419214208368421 1.771215 55 187 0.01763951 Mouse Phenotype abnormal fibroblast physiology 193 2.243183e-35 1.111247288238342e-33 2.37896 258 0.05748663 118 0.011772329659322033 1.547187 65 253 0.0208467 Mouse Phenotype decreased double-positive T cell number 197 4.723359e-35 2.2923875837055838e-33 2.505253 232 0.0516934 20 0.000021794519403000002 1.936765 64 199 0.02052598 Mouse Phenotype abnormal trophectoderm morphology 202 1.289757e-33 6.10463696881188e-32 2.930728 171 0.0381016 88 0.005510896297840909 1.828943 41 135 0.01314945 Mouse Phenotype embryonic lethality between implantation and somite formation, complete penetrance 206 1.289737e-32 5.986007503398058e-31 2.251827 265 0.05904635 167 0.036999667338323355 1.461894 67 276 0.02148813 Mouse Phenotype abnormal parietal yolk sac morphology 218 1.850057e-31 8.11394265e-30 2.727729 179 0.03988414 63 0.001959857790952381 1.837923 47 154 0.01507377 Mouse Phenotype abnormal cell cycle 227 1.300758e-29 5.478655170925109e-28 2.111169 276 0.06149733 148 0.02305746910337838 1.452958 76 315 0.0243746 Mouse Phenotype abnormal blastocyst morphology 235 2.706308e-29 1.1010642888510638e-27 2.348004 218 0.04857398 65 0.001991293004769231 1.692857 61 217 0.01956382