# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 79 8.195036e-49 1.3650440344810127e-46 2.288295 397 0.035049 360 0.0011499708584444444 1.346071 121 248 0.01777843 GO Biological Process platelet activation 155 2.32915e-31 1.977373216129032e-29 2.068133 315 0.02780966 319 0.0005523347934796238 1.487061 76 141 0.01116662 GO Biological Process interleukin-12-mediated signaling pathway 174 1.574979e-29 1.1911004977586207e-27 3.079298 140 0.01235985 415 0.0030534647764096385 1.694055 35 57 0.005142521 GO Biological Process response to interleukin-12 201 1.043031e-26 6.828480064179105e-25 2.847993 142 0.01253642 384 0.00189847977140625 1.712414 36 58 0.00528945 GO Biological Process regulation of regulatory T cell differentiation 232 1.89919e-23 1.0772172935344826e-21 3.167895 105 0.009269886 615 0.026558135702439027 1.876045 17 25 0.002497796 GO Biological Process regulation of tumor necrosis factor superfamily cytokine production 237 4.485212e-23 2.490333531983122e-21 2.059624 230 0.02030546 740 0.04435397435405406 1.367237 56 113 0.008228034 GO Biological Process regulation of megakaryocyte differentiation 248 2.275127e-22 1.2071933948790323e-20 2.493325 148 0.01306613 533 0.013443071455534708 1.524649 42 76 0.006171026 GO Biological Process regulation of tumor necrosis factor production 251 2.675879e-22 1.4028642135856574e-20 2.043553 226 0.01995233 694 0.039991983342939484 1.379445 55 110 0.008081105 GO Biological Process T-helper cell lineage commitment 322 6.007868e-19 2.4552029506832297e-17 6.572397 38 0.003354816 669 0.035668738192825115 2.452346 8 9 0.001175433 GO Biological Process erythrocyte differentiation 324 8.246175e-19 3.349117803240741e-17 2.240898 152 0.01341926 350 0.0010114838296857143 1.679324 42 69 0.006171026 GO Biological Process negative regulation of stem cell differentiation 339 2.679604e-18 1.0401448093215339e-16 3.119736 82 0.00723934 690 0.03951481782173913 1.992531 13 18 0.001910079 GO Biological Process erythrocyte homeostasis 363 1.112654e-17 4.033447379063361e-16 2.130482 159 0.01403726 386 0.0020098146379015545 1.612338 45 77 0.006611813 GO Biological Process regulation of vascular endothelial growth factor receptor signaling pathway 366 1.286042e-17 4.623777780874316e-16 2.682519 100 0.008828463 728 0.042991808666208796 1.803889 17 26 0.002497796 GO Biological Process regulation of interleukin-8 production 376 2.601857e-17 9.105807516755318e-16 2.4577 115 0.01015273 471 0.006358688627388535 1.6203 37 63 0.00543638 GO Biological Process JAK-STAT cascade 404 1.714947e-16 5.585888013118811e-15 2.237034 132 0.01165357 736 0.04362383714945652 1.584894 27 47 0.003967088 GO Biological Process p38MAPK cascade 441 1.384407e-15 4.13093236122449e-14 5.010516 39 0.003443101 707 0.04214902149787836 2.758889 6 6 0.0008815751 GO Biological Process positive regulation of memory T cell differentiation 451 2.460711e-15 7.179710875609757e-14 5.512888 35 0.003089962 707 0.04214902149787836 2.758889 6 6 0.0008815751 GO Biological Process positive regulation of cell killing 529 1.013615e-13 2.5213912637051044e-12 2.19479 112 0.009887879 667 0.035040976809595205 1.642196 25 42 0.00367323 GO Biological Process cellular response to hydrogen peroxide 584 7.380782e-13 1.6630772318150684e-11 2.011104 128 0.01130043 584 0.020712358383390413 1.557437 35 62 0.005142521 GO Biological Process regulation of transforming growth factor beta production 657 5.776532e-12 1.156976934368341e-10 2.333915 84 0.007415909 723 0.04283709513831258 1.773572 18 28 0.002644725 GO Cellular Component cortical cytoskeleton 59 8.177219e-23 2.3949549884745764e-21 2.200229 195 0.0172155 48 0.00102189636 1.604005 50 86 0.007346459 GO Cellular Component platelet dense tubular network membrane 82 5.942238e-17 1.2522179590243903e-15 4.988412 43 0.003796239 76 0.04123073936842105 2.452346 8 9 0.001175433 GO Cellular Component cortical actin cytoskeleton 87 1.32933e-16 2.6403244137931034e-15 2.221595 135 0.01191843 81 0.04896245333333333 1.517389 33 60 0.004848663 GO Cellular Component endoplasmic reticulum subcompartment 140 5.199415e-10 6.4175636571428575e-9 2.830379 48 0.004237662 68 0.013875911152941177 2.006465 16 22 0.002350867 GO Cellular Component endoplasmic reticulum tubular network 163 9.095468e-9 9.642312088343558e-8 2.747933 43 0.003796239 80 0.0447548328 1.992531 13 18 0.001910079 GO Molecular Function organic cation transmembrane transporter activity 148 1.442807e-8 4.115899428378378e-7 3.522141 29 0.002560254 84 0.03465210520952381 2.207111 12 15 0.00176315 GO Molecular Function clathrin adaptor activity 243 0.000001547987 0.000026895477835390944 2.793758 29 0.002560254 68 0.017857377408823528 2.508081 10 11 0.001469292 GO Molecular Function AP-2 adaptor complex binding 267 0.000003542124 0.0000560106648988764 2.622637 30 0.002648539 69 0.018182575339130435 2.758889 8 8 0.001175433 GO Molecular Function C-C chemokine binding 345 0.0000313675 0.0003838654637681159 3.030282 19 0.001677408 58 0.007834597975862069 2.758889 9 9 0.001322363 Mouse Phenotype Single KO abnormal T cell physiology 16 1.397791e-113 7.999732616875e-111 2.11752 1082 0.09552397 41 1.853073502292683e-10 1.413602 269 525 0.03952395 Mouse Phenotype Single KO abnormal T cell activation 33 1.077274e-76 2.989272126666667e-74 2.254655 645 0.05694359 97 7.750910553298968e-7 1.451042 152 289 0.02233324 Mouse Phenotype Single KO abnormal T cell proliferation 43 2.225039e-66 4.738298168139535e-64 2.211133 582 0.05138165 118 0.000003996003829576271 1.448153 137 261 0.0201293 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 46 1.430522e-64 2.847671729130435e-62 2.718707 383 0.03381301 272 0.001371211935110294 1.444251 78 149 0.01146048 Mouse Phenotype Single KO increased granulocyte number 55 1.773346e-57 2.9524598767272727e-55 2.135142 544 0.04802684 83 1.2342367259036143e-7 1.508768 140 256 0.02057009 Mouse Phenotype Single KO abnormal platelet morphology 60 9.69948e-55 1.480302306e-52 2.059533 563 0.04970425 177 0.00007593082695480226 1.389816 134 266 0.01968851 Mouse Phenotype Single KO abnormal erythropoiesis 64 3.061718e-53 4.3806487071875003e-51 2.54956 352 0.03107619 130 0.000008355621623076924 1.680414 67 110 0.009844255 Mouse Phenotype Single KO abnormal neutrophil cell number 66 1.377469e-51 1.9111338837878787e-49 2.117671 497 0.04387746 528 0.027291033732954547 1.245618 121 268 0.01777843 Mouse Phenotype Single KO decreased T cell proliferation 72 3.634432e-48 4.622290808888889e-46 2.331341 377 0.03328331 143 0.000016518030546153846 1.563371 85 150 0.01248898 Mouse Phenotype Single KO decreased erythrocyte cell number 80 2.18675e-45 2.50300871875e-43 2.116376 437 0.03858038 393 0.007080607144529263 1.355797 86 175 0.01263591 Mouse Phenotype Single KO abnormal platelet cell number 81 2.472032e-45 2.79461691654321e-43 2.058141 466 0.04114064 182 0.00009806789776373626 1.431013 111 214 0.01630914 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 83 4.20085e-45 4.6346004156626504e-43 2.062974 461 0.04069921 295 0.002113238802101695 1.321307 125 261 0.01836615 Mouse Phenotype Single KO abnormal circulating cytokine level 85 2.280495e-44 2.4567638488235298e-42 2.125067 423 0.0373444 278 0.0016638575331294964 1.326794 126 262 0.01851308 Mouse Phenotype Single KO abnormal granulocyte physiology 87 4.141279e-43 4.358815149770115e-41 2.077388 433 0.03822724 525 0.026918074177142856 1.265984 106 231 0.01557449 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 91 5.184604e-42 5.217078992087912e-40 2.219905 363 0.03204732 343 0.004566756080758017 1.371562 87 175 0.01278284 Mouse Phenotype Single KO extramedullary hematopoiesis 93 6.192955e-41 6.097729993010753e-39 2.607939 258 0.02277743 282 0.0018376063028723406 1.500449 62 114 0.009109609 Mouse Phenotype Single KO abnormal T-helper 2 physiology 95 1.968514e-40 1.897440284e-38 3.153466 188 0.01659751 420 0.009241861407380952 1.61728 34 58 0.004995592 Mouse Phenotype Single KO abnormal platelet physiology 96 5.16316e-40 4.924901679166666e-38 2.466726 279 0.02463141 164 0.000048313225365853654 1.630253 65 110 0.009550397 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 98 1.125355e-39 1.051517932142857e-37 3.798163 144 0.01271299 410 0.008326837547073172 1.812984 23 35 0.003379371 Mouse Phenotype Single KO increased neutrophil cell number 99 2.043844e-39 1.8904524755555555e-37 2.222699 339 0.02992849 289 0.001970284440795848 1.423943 80 155 0.01175433 Mouse Phenotype abnormal T cell activation 40 2.677691e-79 6.40035091275e-77 2.030517 841 0.07424737 90 7.983167291999999e-10 1.450272 215 409 0.03158977 Mouse Phenotype decreased inflammatory response 41 3.670017e-79 8.558300618780488e-77 2.434366 572 0.05049881 483 0.0034875222229813663 1.278955 140 302 0.02057009 Mouse Phenotype abnormal T cell proliferation 43 2.059508e-76 4.579292090232558e-74 2.088935 759 0.06700803 122 3.4666830218852456e-8 1.431923 191 368 0.02806347 Mouse Phenotype abnormal erythropoiesis 57 1.624448e-63 2.7247977768421053e-61 2.513884 432 0.03813896 134 1.1234203540298507e-7 1.666443 90 149 0.01322363 Mouse Phenotype abnormal platelet physiology 64 4.144927e-60 6.1921323510937496e-58 2.737872 352 0.03107619 205 0.00000865112860097561 1.609352 77 132 0.01131355 Mouse Phenotype abnormal CD4-positive, alpha-beta T cell physiology 67 8.416984e-59 1.2011161794626865e-56 2.37506 445 0.03928666 308 0.0002481578969123377 1.440753 94 180 0.01381134 Mouse Phenotype decreased T cell proliferation 75 7.554143e-52 9.630021496399999e-50 2.102265 508 0.04484859 127 5.062643604330708e-8 1.567256 121 213 0.01777843 Mouse Phenotype extramedullary hematopoiesis 81 2.528356e-49 2.984396508148148e-47 2.294504 399 0.03522557 330 0.00039999196790909086 1.434622 91 175 0.01337056 Mouse Phenotype decreased erythrocyte cell number 82 3.386817e-48 3.948946016707317e-46 2.007311 527 0.046526 361 0.0007429172441551247 1.36153 114 231 0.01674993 Mouse Phenotype abnormal granulocyte physiology 85 1.155842e-47 1.3001182778823531e-45 2.044905 498 0.04396575 378 0.0010442602610317461 1.323863 131 273 0.01924772 Mouse Phenotype abnormal platelet activation 100 1.506997e-43 1.4408398317e-41 2.798326 244 0.02154145 503 0.004025585869383699 1.4898 54 100 0.007934176 Mouse Phenotype abnormal mean corpuscular hemoglobin 102 2.102419e-42 1.970708633235294e-40 2.167998 386 0.03407787 384 0.00117742370484375 1.394439 93 184 0.01366441 Mouse Phenotype abnormal megakaryocyte progenitor cell morphology 106 9.969215e-42 8.992043831603774e-40 2.350718 320 0.02825108 450 0.0025423867566666666 1.45795 65 123 0.009550397 Mouse Phenotype abnormal platelet aggregation 107 1.184811e-41 1.0586895299999999e-39 2.769625 237 0.02092346 518 0.004967028096138996 1.496844 51 94 0.007493388 Mouse Phenotype abnormal erythroid progenitor cell morphology 116 3.899637e-40 3.214174944568966e-38 2.23595 341 0.03010506 271 0.00009269336579335793 1.576508 68 119 0.009991184 Mouse Phenotype decreased erythroid progenitor cell number 117 6.442818e-40 5.26493870923077e-38 2.559156 260 0.022954 509 0.004416892728094302 1.56095 43 76 0.006317955 Mouse Phenotype abnormal embryonic erythrocyte morphology 128 1.042283e-37 7.78536543984375e-36 3.472644 153 0.01350755 441 0.0023510694122448983 1.839259 26 39 0.003820159 Mouse Phenotype abnormal embryonic erythropoiesis 132 1.014439e-36 7.347766120454546e-35 3.66113 139 0.01227156 696 0.017441173452586205 1.779929 20 31 0.002938584 Mouse Phenotype abnormal tumor necrosis factor level 134 1.287617e-36 9.187243385820896e-35 2.075305 367 0.03240046 411 0.0018452178672262772 1.372297 96 193 0.0141052 Mouse Phenotype decreased platelet aggregation 135 1.36224e-36 9.6476864e-35 3.015756 181 0.01597952 825 0.034633975003636366 1.45608 38 72 0.005583309