# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	36	6.784392e-49	2.4798837313333332e-46	2.610164	311	0.01802376	459	0.003678052308496732	1.329076	79	113	0.00799838	
GO Biological Process	regulation of DNA-templated transcription in response to stress	52	1.850686e-43	4.683303283461539e-41	2.396527	323	0.01871921	404	0.0014888792893316834	1.341941	84	119	0.008504607	
GO Biological Process	liver regeneration	78	8.210005e-37	1.3850699460897435e-34	3.274175	162	0.009388583	621	0.015663526406280194	1.520867	28	35	0.002834869	
GO Biological Process	endoplasmic reticulum unfolded protein response	111	9.008372e-32	1.0679384427747749e-29	2.27927	258	0.01495219	445	0.002810639089820225	1.334094	80	114	0.008099625	
GO Biological Process	multi-organism metabolic process	113	1.492573e-31	1.7381210714159293e-29	2.147253	292	0.01692263	240	0.00005241247245333333	1.370849	106	147	0.010732	
GO Biological Process	cellular response to topologically incorrect protein	138	1.393224e-29	1.3285097547826087e-27	2.082785	293	0.01698059	502	0.0057399505573705175	1.285625	94	139	0.00951706	
GO Biological Process	cotranslational protein targeting to membrane	141	5.383204e-29	5.023941945815603e-27	2.499285	195	0.01130107	301	0.0002993876661229236	1.416113	73	98	0.007390908	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	156	9.405894e-28	7.93411276576923e-26	2.312218	217	0.01257606	771	0.03391154516990921	1.256648	78	118	0.007897135	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	160	1.838651e-27	1.5121755318125e-25	2.406152	198	0.01147493	646	0.019235088807120743	1.340507	55	78	0.005568492	
GO Biological Process	cellular response to unfolded protein	163	2.687173e-27	2.1693564114723926e-25	2.092877	266	0.01541582	455	0.0034024720184615384	1.31976	84	121	0.008504607	
GO Biological Process	viral gene expression	168	5.22426e-27	4.092026032142857e-25	2.219551	230	0.01332947	272	0.00017194526649264708	1.377163	92	127	0.009314569	
GO Biological Process	regulation of necrotic cell death	172	9.074817e-27	6.942762610639535e-25	4.420319	80	0.004636337	753	0.03154219290172643	1.549031	22	27	0.002227397	
GO Biological Process	cellular response to epidermal growth factor stimulus	176	1.92428e-26	1.438727302272727e-24	2.447264	184	0.01066358	490	0.0052493265132653065	1.550884	31	38	0.003138605	
GO Biological Process	protein targeting to ER	178	2.307288e-26	1.7057080220224716e-24	2.372188	195	0.01130107	344	0.000620270886627907	1.392873	74	101	0.007492153	
GO Biological Process	response to epidermal growth factor	190	1.74487e-25	1.2084602278947368e-23	2.354023	191	0.01106926	458	0.00366828673580786	1.538972	34	42	0.003442341	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	197	1.217245e-24	8.130825865482233e-23	2.408578	176	0.01019994	358	0.0008028338981284917	1.405149	68	92	0.006884682	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	205	2.479573e-24	1.5916439564390242e-22	2.203736	209	0.01211243	660	0.02150545463181818	1.278605	76	113	0.007694644	
GO Biological Process	mitochondrial transmembrane transport	213	6.147544e-24	3.797912276807512e-22	2.313894	185	0.01072153	484	0.005149742024380166	1.374277	60	83	0.006074719	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	215	7.616517e-24	4.661662660604651e-22	2.196535	206	0.01193857	276	0.00019077956342028986	1.412233	78	105	0.007897135	
GO Biological Process	viral transcription	224	2.269597e-23	1.3332869162053572e-21	2.166172	208	0.01205448	367	0.0009121029977111716	1.362723	81	113	0.008200871	
GO Cellular Component	mitochondrial ribosome	75	1.779557e-17	4.100099328e-16	2.342953	128	0.00741814	84	0.0048244608	1.364307	61	85	0.006175964	
GO Cellular Component	fibrinogen complex	113	2.551098e-12	3.901148092035398e-11	3.105784	53	0.003071573	128	0.041550165	1.901083	9	9	0.0009112079	
GO Cellular Component	plasma lipoprotein particle	116	4.141887e-12	6.169983393103449e-11	2.122619	105	0.006085193	130	0.041130600369230774	1.425812	30	40	0.00303736	
GO Cellular Component	protein-lipid complex	120	4.877162e-12	7.02311328e-11	2.091487	108	0.006259055	110	0.022662028799999998	1.448444	32	42	0.00323985	
GO Cellular Component	mitochondrial nucleoid	126	1.632911e-11	2.2394208e-10	2.273301	85	0.004926108	94	0.00842015979574468	1.493708	33	42	0.003341095	
GO Cellular Component	very-low-density lipoprotein particle	153	1.247974e-9	1.4094765176470589e-8	2.657754	51	0.002955665	123	0.037062832390243904	1.615921	17	20	0.00172117	
GO Cellular Component	platelet dense tubular network membrane	249	0.000002918803	0.000020255789493975906	2.513088	33	0.001912489	128	0.041550165	1.901083	9	9	0.0009112079	
GO Molecular Function	unfolded protein binding	11	9.102816e-34	3.4938262865454546e-31	2.580101	216	0.01251811	106	0.037675893264150946	1.291302	72	106	0.007289663	
GO Molecular Function	drug transporter activity	43	4.732589e-15	4.646742036744186e-13	2.922169	73	0.004230658	95	0.015348574359999999	1.663448	21	24	0.002126152	
Human Phenotype	Increased serum lactate	12	8.252534e-21	4.589096615166666e-18	2.109873	195	0.01130107	12	0.0049600714845833335	1.406802	74	100	0.007492153	
Human Phenotype	Abnormal CSF metabolite level	20	4.0684e-19	1.3574216599999999e-16	2.483419	126	0.007302231	43	0.015259985552790697	1.448444	48	63	0.004859775	
Mouse Phenotype Single KO	decreased sensitivity to induced cell death	53	1.361235e-30	2.351854508490566e-28	2.241145	257	0.01489423	148	0.00401621936472973	1.413626	58	78	0.005872228	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	82	1.189687e-26	1.3285321779268292e-24	2.058093	270	0.01564764	217	0.021086912612442395	1.328714	65	93	0.006580946	
Mouse Phenotype Single KO	abnormal rostral-caudal body axis extension	305	6.240226e-13	1.8734999830163933e-11	2.523086	79	0.004578383	193	0.011157173473575132	1.901083	13	13	0.001316189	
Mouse Phenotype	decreased sensitivity to induced cell death	85	9.311249e-31	1.0473511963411762e-28	2.101082	299	0.01732831	217	0.0017426997721658986	1.390039	68	93	0.006884682	
Mouse Phenotype	spontaneous skin ulceration	135	3.016363e-24	2.136255306888889e-22	2.659126	144	0.008345407	440	0.022612221320454543	1.47334	31	40	0.003138605	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	147	1.473501e-23	9.583770789795917e-22	2.772592	130	0.007534048	564	0.046924862484042554	1.507756	23	29	0.002328642	
Mouse Phenotype	early cellular replicative senescence	273	1.129692e-16	3.95640483956044e-15	2.00168	174	0.01008403	233	0.002200057499742489	1.432323	55	73	0.005568492	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	289	7.975669e-16	2.6385941629411764e-14	2.248282	125	0.007244277	455	0.023998173039560443	1.561604	23	28	0.002328642	
Mouse Phenotype	increased liver adenoma incidence	338	3.001794e-14	8.491169359171598e-13	2.644996	81	0.004694292	455	0.023998173039560443	1.561604	23	28	0.002328642	
Mouse Phenotype	increased urine uric acid level	851	3.155321e-7	0.000003545008705170388	2.381535	44	0.002549986	418	0.019461104424401916	1.901083	11	11	0.001113698	
Mouse Phenotype	decreased macrophage nitric oxide production	1508	0.0003373417	0.00213880901438992	2.026374	30	0.001738626	495	0.031257072296969696	1.901083	10	10	0.001012453