# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	4	1.014916e-31	3.338819911e-28	3.532145	124	0.02439024	473	0.01694132503255814	1.556853	45	113	0.009369144	
GO Biological Process	regulation of DNA-templated transcription in response to stress	7	1.352468e-29	2.542446630285714e-26	3.248471	129	0.02537372	364	0.005009819285714285	1.609766	49	119	0.01020196	
GO Biological Process	regulation of cellular amino acid metabolic process	26	1.310745e-20	6.633882098076923e-18	4.501038	59	0.01160504	207	0.00025575927755072463	2.08503	32	60	0.006662503	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	35	8.564155e-19	3.2198775898571424e-16	3.258325	79	0.01553895	319	0.0027401996344200625	1.804353	36	78	0.007495315	
GO Biological Process	cellular response to insulin stimulus	36	9.347298e-19	3.416697066166667e-16	2.227397	152	0.02989772	164	0.00007201411992317074	1.71698	65	148	0.01353321	
GO Biological Process	response to insulin	38	4.021725e-18	1.3926810335526317e-15	2.008542	186	0.03658537	180	0.0001368680749	1.578809	84	208	0.01748907	
GO Biological Process	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	39	5.483064e-18	1.8500420301538464e-15	3.514006	68	0.0133753	226	0.00042550313562831856	1.954716	36	72	0.007495315	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	42	9.232162e-18	2.8925242799523807e-15	3.235446	75	0.01475216	421	0.011333077789311164	2.132417	18	33	0.003747658	
GO Biological Process	negative regulation of protein ubiquitination	44	1.929989e-17	5.771983011590909e-15	2.506098	111	0.0218332	149	0.000054171266712080535	1.756411	62	138	0.0129086	
GO Biological Process	anaphase-promoting complex-dependent catabolic process	45	2.943889e-17	8.608585633555555e-15	3.164408	75	0.01475216	153	0.0000648682795751634	2.003584	41	80	0.008536331	
GO Biological Process	regulation of ubiquitin protein ligase activity	47	5.786326e-17	1.620048166680851e-14	3.068052	77	0.01514555	234	0.0005151618034700855	1.827234	43	92	0.008952738	
GO Biological Process	negative regulation of ubiquitin protein ligase activity	54	2.574539e-16	6.273770129814815e-14	3.280233	67	0.0131786	219	0.00036789115020091325	1.92933	38	77	0.007911722	
GO Biological Process	negative regulation of ubiquitin-protein transferase activity	56	3.168798e-16	7.446109443214286e-14	3.105633	72	0.01416208	275	0.0013595304589090911	1.815093	39	84	0.008119925	
GO Biological Process	positive regulation of ubiquitin protein ligase activity	58	3.919483e-16	8.892495999482758e-14	3.063629	73	0.01435877	239	0.0005861761890794978	1.861634	40	84	0.008328128	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	59	4.032953e-16	8.994852292711865e-14	2.294513	121	0.02380016	567	0.03016544095238095	1.437662	57	155	0.01186758	
GO Biological Process	positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition	62	8.27453e-16	1.756202262419355e-13	3.104169	70	0.01376869	209	0.00025874768362200957	1.954716	38	76	0.007911722	
GO Biological Process	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	71	2.09558e-15	3.8839066507042256e-13	3.27501	63	0.01239182	254	0.0007523223070472441	1.927185	35	71	0.007287112	
GO Biological Process	cellular response to epidermal growth factor stimulus	76	3.55845e-15	6.161268888157895e-13	3.069597	68	0.0133753	169	0.00008875099229585799	2.469115	24	38	0.004996877	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	77	3.594188e-15	6.142327258701298e-13	4.415621	43	0.008457907	633	0.0411038931121643	2.443395	10	16	0.002082032	
GO Biological Process	regulation of mRNA stability	78	3.600578e-15	6.074359731025641e-13	2.189911	125	0.02458694	420	0.010566871251904761	1.501636	58	151	0.01207579	
GO Cellular Component	ribosomal subunit	33	2.321838e-15	1.2157988072727272e-13	2.385843	106	0.02084972	76	0.019024613810526315	1.415848	67	185	0.01394961	
GO Cellular Component	proteasome complex	35	1.173286e-13	5.792680594285713e-12	3.156204	58	0.01140834	39	0.0016829776246153844	1.897224	33	68	0.006870706	
GO Cellular Component	endopeptidase complex	36	1.200235e-13	5.7611280000000006e-12	3.154422	58	0.01140834	40	0.002377735344	1.869728	33	69	0.006870706	
GO Cellular Component	ribosome	38	3.738799e-13	1.700169650526316e-11	2.024809	128	0.02517703	61	0.010851392419672132	1.391493	84	236	0.01748907	
GO Cellular Component	peptidase complex	47	1.300397e-10	4.781034076595745e-9	2.512911	63	0.01239182	67	0.013878542901492538	1.643738	37	88	0.007703519	
GO Cellular Component	proteasome accessory complex	63	3.784477e-10	1.0380279771428572e-8	4.601626	26	0.005114083	38	0.0012375194778947367	2.606288	16	24	0.003331251	
GO Cellular Component	ficolin-1-rich granule lumen	65	1.071712e-9	2.8491051323076925e-8	2.150217	78	0.01534225	77	0.019306407646753246	1.513328	48	124	0.009993754	
GO Cellular Component	proteasome regulatory particle	83	4.92731e-7	0.000010258303228915661	3.74713	21	0.004130606	46	0.0033223448347826086	2.606288	14	21	0.002914845	
GO Cellular Component	Bcl-2 family protein complex	116	0.00002092457	0.0003117039393103448	4.550896	12	0.002360346	84	0.03142651885714286	3.350941	6	7	0.001249219	
GO Cellular Component	U1 snRNP	156	0.0002001138	0.0022166451692307693	2.906443	16	0.003147128	98	0.048940416	2.263355	11	19	0.002290235	
GO Molecular Function	cadherin binding	4	3.679634e-26	3.8838536870000003e-23	2.006735	275	0.05409127	3	0.0000011988528028666667	1.620357	126	304	0.0262336	
GO Molecular Function	14-3-3 protein binding	131	0.00009620235	0.003100506272519084	2.068544	34	0.006687648	47	0.02508577655319149	2.345659	15	25	0.003123048	
Human Phenotype	Decreased circulating low-density lipoprotein levels	32	4.369245e-7	0.000091112412140625	4.557588	17	0.003343824	18	0.04705725455555555	3.47505	8	9	0.001665626	
Mouse Phenotype Single KO	decreased circulating triglyceride level	20	1.601097e-19	7.3306226145e-17	2.120668	177	0.03481511	179	0.02473147115083799	1.397489	79	221	0.01644805	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	75	4.767385e-11	5.820659259333333e-9	2.293552	79	0.01553895	127	0.004714098586456693	1.991597	27	53	0.005621487	
Mouse Phenotype Single KO	decreased white adipose tissue amount	97	9.093331e-10	8.584291955360825e-8	2.050479	88	0.01730921	129	0.005589164478604651	1.843018	33	70	0.006870706	
Mouse Phenotype Single KO	increased muscle cell glucose uptake	98	9.593357e-10	8.963915311122448e-8	2.925446	44	0.008654603	178	0.024178199388202246	2.420124	13	21	0.002706642	
Mouse Phenotype Single KO	abnormal fourth pharyngeal arch artery morphology	184	4.749994e-7	0.000023638964705434785	2.456858	40	0.007867821	164	0.019681084264634146	2.687734	11	16	0.002290235	
Mouse Phenotype Single KO	increased circulating ammonia level	300	0.00001381429	0.0004216581784333333	3.349226	18	0.003540519	95	0.0013422041431578947	3.307981	11	13	0.002290235	
Mouse Phenotype Single KO	increased respiratory quotient	311	0.00001896587	0.0005584259536655948	2.117754	39	0.007671125	167	0.019434811316766467	1.914824	24	49	0.004996877	
Mouse Phenotype Single KO	decreased left ventricle systolic pressure	493	0.0004160946	0.007728556292494929	2.240149	23	0.004523997	176	0.024436713587500002	2.932074	9	12	0.001873829	
Mouse Phenotype Single KO	increased hepatocyte proliferation	683	0.002392566	0.032077198919472916	2.359683	15	0.002950433	176	0.024436713587500002	2.932074	9	12	0.001873829	
Mouse Phenotype	Meibomian gland atrophy	3	9.390669e-31	2.9928062103e-27	17.09033	35	0.006884343	362	0.04034842364088398	3.350941	6	7	0.001249219	
Mouse Phenotype	abnormal amino acid metabolism	25	1.594867e-18	6.0994093548e-16	13.47132	23	0.004523997	362	0.04034842364088398	3.350941	6	7	0.001249219	
Mouse Phenotype	abnormal sebaceous gland physiology	42	1.005946e-15	2.289964215714286e-13	4.924086	40	0.007867821	359	0.040432030855153206	2.389097	11	18	0.002290235	
Mouse Phenotype	dry eyes	54	8.701079e-14	1.5405743762777777e-11	4.181805	41	0.008064516	391	0.04834931677749361	2.443395	10	16	0.002082032	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	103	2.398707e-10	2.2266055948543685e-8	3.11258	43	0.008457907	297	0.02087508822020202	2.156928	16	29	0.003331251	
Mouse Phenotype	abnormal embryonic hematopoiesis	120	1.935515e-9	1.5421215762499998e-7	2.076102	82	0.01612903	215	0.007752356747441861	1.858582	29	61	0.006037893	
Mouse Phenotype	decreased transitional stage T2 B cell number	125	2.450462e-9	1.87430937456e-7	3.117045	38	0.00747443	387	0.04758685108527132	2.105079	14	26	0.002914845