# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 54 2.641175e-11 6.436152189814815e-9 2.197953 89 0.01517735 763 0.01238378658099607 1.432925 56 113 0.008623345 GO Biological Process regulation of DNA-templated transcription in response to stress 65 5.14273e-10 1.041125908769231e-7 2.03041 93 0.01585948 720 0.00945834377625 1.43357 59 119 0.00908531 GO Biological Process cytoplasmic translation 80 1.531483e-8 0.000002519098099625 3.191945 33 0.005627558 861 0.02016081067131243 1.681069 25 43 0.003849707 GO Biological Process glycolytic process through glucose-6-phosphate 85 1.947991e-8 0.0000030157192434117645 3.668285 27 0.004604366 857 0.020223325466744456 1.890556 17 26 0.002617801 GO Biological Process canonical glycolysis 99 5.412359e-8 0.000007194063846565656 3.587237 26 0.004433834 998 0.03348045161122244 1.85052 16 25 0.002463813 GO Biological Process histone H4 acetylation 146 6.103647e-7 0.00005501225402260274 2.269744 46 0.007844475 793 0.015177768155233293 1.644151 29 51 0.004465661 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 184 0.000002459479 0.00017589284870108695 2.670891 30 0.005115962 609 0.0038240205252873566 2.349294 13 16 0.002001848 GO Biological Process regulation of endoplasmic reticulum unfolded protein response 217 0.000005325991 0.00032297103948847924 2.399981 34 0.00579809 744 0.011666619061962365 2.011435 16 23 0.002463813 GO Biological Process ER-nucleus signaling pathway 218 0.000005453742 0.00032920087604587157 2.39721 34 0.00579809 928 0.026122032995689652 1.734863 21 35 0.003233754 GO Biological Process positive regulation of mRNA catabolic process 236 0.000007290664 0.0004065163032881356 2.36336 34 0.00579809 998 0.03348045161122244 1.85052 16 25 0.002463813 GO Biological Process negative regulation of G0 to G1 transition 271 0.00001834116 0.0008905952931365314 2.098771 40 0.006821282 1026 0.03503237460526316 1.673991 22 38 0.003387743 GO Biological Process regulation of G0 to G1 transition 272 0.00001838595 0.0008894879266544117 2.056224 42 0.007162347 976 0.030547607306352455 1.65225 24 42 0.003695719 GO Biological Process arterial endothelial cell differentiation 321 0.00004384274 0.0017972791765109035 3.326073 16 0.002728513 915 0.024573202888524593 2.891438 6 6 0.0009239298 GO Biological Process positive regulation of adherens junction organization 324 0.00004512661 0.001832781052438272 2.054656 38 0.006480218 857 0.020223325466744456 1.890556 17 26 0.002617801 GO Biological Process positive regulation of focal adhesion assembly 329 0.00004951547 0.001980468297051672 2.067887 37 0.006309686 868 0.020378712638248846 1.927626 16 24 0.002463813 GO Biological Process negative regulation of cyclin-dependent protein kinase activity 361 0.00009483254 0.0034567905647091414 2.256716 28 0.004774898 663 0.006561039689441931 2.001765 18 26 0.002771789 GO Biological Process negative regulation of Notch signaling pathway 370 0.0001056249 0.003756535294864865 2.058511 34 0.00579809 945 0.02766381061587302 1.752387 20 33 0.003079766 GO Biological Process negative regulation of circadian rhythm 395 0.0001609793 0.00536285217392405 3.096462 15 0.002557981 992 0.03354982558870968 2.120388 11 15 0.001693871 GO Biological Process negative regulation of cyclin-dependent protein serine/threonine kinase activity 417 0.000216457 0.006830593916067147 2.257002 25 0.004263302 868 0.020378712638248846 1.927626 16 24 0.002463813 GO Biological Process positive regulation of protein kinase C signaling 441 0.0002891269 0.008627258224716553 2.540904 19 0.003240109 621 0.004325081472785829 2.891438 8 8 0.001231906 GO Cellular Component methyltransferase complex 30 1.693669e-8 9.75553344e-7 2.092371 71 0.01210778 80 0.00596801088 1.525154 48 91 0.007391438 GO Cellular Component histone methyltransferase complex 35 5.646015e-7 0.00002787518262857143 2.040652 59 0.01006139 61 0.001658567260327869 1.676196 40 69 0.006159532 GO Cellular Component MLL1 complex 53 0.00001145339 0.0003734237343396227 2.795465 24 0.004092769 109 0.03610013944954128 1.794686 18 29 0.002771789 GO Molecular Function chromatin DNA binding 10 2.081103e-10 8.786416866000001e-8 2.041555 96 0.01637108 103 0.0082892247592233 1.501324 54 104 0.008315368 Mouse Phenotype Single KO increased body temperature 8 5.831744e-8 0.00006675159976 2.598965 42 0.007162347 605 0.009340934615702479 1.840006 21 33 0.003233754 Mouse Phenotype Single KO increased core body temperature 25 8.552618e-7 0.000313265292104 4.117311 18 0.003069577 707 0.01648405061386139 2.570167 8 9 0.001231906 Mouse Phenotype Single KO increased cellular sensitivity to ultraviolet irradiation 31 0.000003668959 0.0010837631471935483 2.920269 25 0.004263302 725 0.01697808842758621 1.927626 16 24 0.002463813 Mouse Phenotype Single KO abnormal stapedial artery morphology 36 0.000007786836 0.001980668257 2.942475 23 0.003922237 583 0.00805325323018868 2.2111 13 17 0.002001848 Mouse Phenotype Single KO absent stapedial artery 52 0.00004639673 0.008170285704038462 2.760662 21 0.003581173 688 0.01528938167587209 2.168579 12 16 0.00184786 Mouse Phenotype Single KO cervical vertebral transformation 60 0.00007295692 0.011134441940666666 2.100085 34 0.00579809 399 0.001955019270501253 1.902262 25 38 0.003849707 Mouse Phenotype Single KO increased squamous cell carcinoma incidence 82 0.0002228322 0.02488383482195122 2.252526 25 0.004263302 928 0.04435058752586207 1.779347 16 26 0.002463813 Mouse Phenotype Single KO increased pheochromocytoma incidence 104 0.0003254891 0.02865868931442308 3.617351 11 0.001875853 707 0.01648405061386139 2.570167 8 9 0.001231906 Mouse Phenotype Single KO abnormal spinal cord ventral horn morphology 117 0.0005134353 0.040183991812820515 2.889664 14 0.002387449 521 0.0053981411366602694 2.446602 11 13 0.001693871 Mouse Phenotype increased body temperature 4 1.405782e-10 3.3601704254999996e-7 2.768593 53 0.009038199 700 0.0022953365871428576 1.900088 23 35 0.003541731 Mouse Phenotype increased core body temperature 23 1.003358e-7 0.0000417091558173913 3.579432 25 0.004263302 849 0.005472999063250883 2.602294 9 10 0.001385895 Mouse Phenotype abnormal stapedial artery morphology 36 4.939888e-7 0.00013119519213333333 2.896968 30 0.005115962 532 0.0007519250247180452 2.313151 16 20 0.002463813 Mouse Phenotype increased cellular sensitivity to ultraviolet irradiation 43 0.000001044426 0.0002322269066511628 2.849391 29 0.00494543 806 0.003997575095285359 1.927626 20 30 0.003079766 Mouse Phenotype abnormal uterine fat pad morphology 50 0.000002082523 0.00039822004805999996 5.750612 12 0.002046385 1334 0.035427482777361324 2.891438 5 5 0.0007699415 Mouse Phenotype absent stapedial artery 56 0.00000286677 0.0004894497851785714 2.759714 28 0.004774898 620 0.001506576733935484 2.282714 15 19 0.002309824 Mouse Phenotype fusion of atlas and occipital bones 69 0.000008483181 0.0011754738194347826 3.476751 18 0.003069577 1378 0.037872016042815676 2.065313 10 14 0.001539883 Mouse Phenotype absent maxillary shelf 76 0.0000165546 0.002082612244736842 2.456187 29 0.00494543 648 0.0018144446768518518 2.478376 12 14 0.00184786 Mouse Phenotype cardiac ischemia 85 0.0000318627 0.003583991467058824 4.738136 11 0.001875853 1334 0.035427482777361324 2.891438 5 5 0.0007699415 Mouse Phenotype athymia 92 0.00004110308 0.004271592911739131 2.137449 35 0.005968622 1309 0.03282901188082506 1.779347 16 26 0.002463813 Mouse Phenotype delayed hepatic development 134 0.0001094047 0.007806106990298507 2.412668 24 0.004092769 648 0.0018144446768518518 2.478376 12 14 0.00184786 Mouse Phenotype decreased cervical vertebrae number 186 0.0004187649 0.02152586671451613 2.823678 15 0.002557981 1378 0.037872016042815676 2.065313 10 14 0.001539883 Mouse Phenotype abnormal peritoneum morphology 223 0.0008019099 0.03438143746143498 2.646097 15 0.002557981 1013 0.012012240307996053 2.570167 8 9 0.001231906