# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process production of molecular mediator of immune response 2 4.315137e-15 2.83914438915e-11 5.70248 33 0.03219512 57 0.01910286258508772 3.050063 15 68 0.01104566 GO Biological Process regulation of receptor catabolic process 9 3.797577e-11 5.552479527e-8 13.49301 13 0.01268293 80 0.0318123101675 7.68164 5 9 0.003681885 GO Biological Process JAK-STAT cascade 138 0.0001370545 0.013068841778985506 2.996468 16 0.01560976 60 0.020756956157166665 3.530285 12 47 0.008836524 GO Biological Process positive regulation of growth hormone secretion 162 0.0002186673 0.01776199383148148 7.248031 6 0.005853659 80 0.0318123101675 7.68164 5 9 0.003681885 GO Biological Process negative regulation of endoplasmic reticulum unfolded protein response 238 0.0007975479 0.044096356370168066 7.106949 5 0.004878049 80 0.0318123101675 7.68164 5 9 0.003681885 GO Biological Process negative regulation of receptor catabolic process 249 0.0008630341 0.045609099284738955 9.703843 4 0.003902439 113 0.043961703651327434 13.82695 3 3 0.002209131 Mouse Phenotype Single KO cervical aortic arch 9 1.36841e-13 1.3922811522222222e-10 32.01837 11 0.01073171 93 0.037170665481720426 13.82695 3 3 0.002209131 Mouse Phenotype Single KO abnormal pancreas physiology 59 7.839492e-8 0.000012167157329491525 2.177486 57 0.05560976 58 0.005383891304655173 2.040042 36 244 0.02650957 Mouse Phenotype Single KO scoliosis 61 1.533204e-7 0.000023015654144262292 4.186764 20 0.0195122 75 0.015921190434666666 3.950558 10 35 0.00736377 Mouse Phenotype Single KO abnormal conotruncus septation 66 4.610117e-7 0.00006396188086212122 21.87972 6 0.005853659 93 0.037170665481720426 13.82695 3 3 0.002209131 Mouse Phenotype Single KO decreased insulin secretion 82 0.000002021471 0.00022573914569512196 2.627463 31 0.0302439 60 0.005529993186833334 2.794809 19 94 0.01399116 Mouse Phenotype Single KO pale yolk sac 104 0.00001354166 0.0011923171213461539 2.515035 28 0.02731707 88 0.031234901604545454 2.633705 16 84 0.01178203 Mouse Phenotype Single KO abnormal endocrine pancreas secretion 140 0.00008587724 0.0056169849048571426 2.042605 35 0.03414634 104 0.04696336502307692 2.106092 23 151 0.01693667 Mouse Phenotype Single KO abnormal erythropoiesis 144 0.0000963731 0.006128392199305555 2.241154 28 0.02731707 70 0.014377392618571428 2.513991 20 110 0.01472754 Mouse Phenotype Single KO increased body length 170 0.0001728244 0.009309135475294118 2.822373 17 0.01658537 77 0.021365183753246756 3.318468 12 50 0.008836524 Mouse Phenotype Single KO abnormal myocardium compact layer morphology 198 0.000359955 0.016647009772727275 2.357281 21 0.0204878 107 0.047255117839252334 2.962918 12 56 0.008836524 Mouse Phenotype Single KO decreased interleukin-2 secretion 229 0.0006734283 0.026928309795196507 2.584892 16 0.01560976 107 0.047255117839252334 2.962918 12 56 0.008836524 Mouse Phenotype Single KO increased susceptibility to parasitic infection 258 0.001127102 0.0400033837751938 2.381023 17 0.01658537 73 0.01537407615890411 2.733235 17 86 0.01251841 Mouse Phenotype Single KO abnormal vertebral transverse process morphology 266 0.001200942 0.041342202609022556 5.216913 6 0.005853659 79 0.022417564660759493 7.68164 5 9 0.003681885 Mouse Phenotype Single KO abnormal conotruncus morphology 306 0.001671705 0.05002549897058823 3.13897 10 0.009756098 97 0.0378352796484536 5.530781 6 15 0.004418262 Mouse Phenotype abnormal platelet physiology 31 1.188842e-11 3.666618826451613e-9 3.524077 41 0.04 153 0.03179465557058824 2.199742 21 132 0.01546392 Mouse Phenotype decreased insulin secretion 58 2.351157e-8 0.000003875760702931035 2.589904 44 0.04292683 15 0.000013024166298 3.095586 30 134 0.02209131 Mouse Phenotype abnormal third pharyngeal arch artery morphology 59 2.607591e-8 0.0000042256233137288126 5.557335 17 0.01658537 93 0.006536609992580645 5.26741 8 21 0.005891016 Mouse Phenotype abnormal third pharyngeal arch morphology 86 8.179002e-7 0.00009092957921162792 4.329458 17 0.01658537 165 0.035675921194545455 3.950558 8 28 0.005891016 Mouse Phenotype abnormal conotruncus septation 96 0.000001852847 0.00018453198090625 10.10885 8 0.007804878 176 0.04336505630113636 7.901115 4 7 0.002945508 Mouse Phenotype increased circulating interferon-gamma level 102 0.000002853358 0.00026746035135294117 4.71683 14 0.01365854 125 0.0204201007944 3.190835 12 52 0.008836524 Mouse Phenotype abnormal insulin secretion 114 0.000006410452 0.0005376344874736842 2.033213 47 0.04585366 69 0.0018183331504347826 2.246002 32 197 0.02356406 Mouse Phenotype increased circulating interleukin-13 level 118 0.000006915344 0.0005603186778305085 34.38522 4 0.003902439 141 0.025598485782978724 13.82695 3 3 0.002209131 Mouse Phenotype scoliosis 119 0.000006917524 0.000555785268605042 3.246136 20 0.0195122 172 0.036523653694186045 3.292131 10 42 0.00736377 Mouse Phenotype abnormal endocrine pancreas secretion 121 0.000007632627 0.0006031036921239669 2.019189 47 0.04585366 74 0.0023223901564864867 2.212312 32 200 0.02356406 Mouse Phenotype decreased T cell proliferation 141 0.00001602386 0.0010865540812765957 2.012183 44 0.04292683 81 0.0031106347585185185 2.142204 33 213 0.02430044 Mouse Phenotype abnormal oxygen consumption 151 0.00002315911 0.0014663857662913908 2.08201 39 0.03804878 131 0.0235581361351145 2.005983 28 193 0.02061856 Mouse Phenotype abnormal prostate gland epithelium morphology 162 0.0000346121 0.0020427548648148147 4.002817 13 0.01268293 191 0.04460219014397906 4.208203 7 23 0.005154639 Mouse Phenotype pale yolk sac 168 0.00004503181 0.0025627924726785716 2.267416 30 0.02926829 136 0.024536485691911768 2.44005 18 102 0.01325479 Mouse Phenotype abnormal erythropoiesis 184 0.00006734402 0.00349932703923913 2.122103 33 0.03219512 94 0.006612097718617021 2.319958 25 149 0.01840943 Mouse Phenotype prostate gland epithelial hyperplasia 210 0.0001378025 0.006273950964285714 4.83368 9 0.008780488 138 0.025200953082608696 6.913476 5 10 0.003681885 Mouse Phenotype abnormal circulating interleukin-13 level 212 0.000145666 0.006569399179245283 10.35192 5 0.004878049 176 0.04336505630113636 7.901115 4 7 0.002945508 Mouse Phenotype abnormal paranode morphology 238 0.0003214443 0.012913146858403361 4.830065 8 0.007804878 168 0.03569279511785714 6.284978 5 11 0.003681885 Mouse Phenotype abnormal erythrocyte osmotic lysis 241 0.0003419715 0.013566761458506224 4.265171 9 0.008780488 155 0.03258163653870968 3.660075 9 34 0.006627393 Mouse Phenotype increased body length 268 0.0005768697 0.02058004179738806 2.326288 20 0.0195122 96 0.008944365296875 3.173399 14 61 0.01030928