# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of catenin import into nucleus 13 7.281399e-224 7.370456110846154e-221 22.86679 232 0.05531712 430 0.02906521973116279 3.574334 7 11 0.002093928 GO Biological Process regulation of catenin import into nucleus 15 2.171077e-205 1.9046134828666668e-202 14.50497 264 0.06294707 347 0.012139097863400578 2.808406 12 24 0.00358959 GO Biological Process liver development 29 1.285428e-146 5.832740362758621e-144 5.579157 358 0.08536004 390 0.019842800258461538 1.68961 37 123 0.0110679 GO Biological Process hepaticobiliary system development 31 7.137105e-145 3.029585957903226e-142 5.469692 360 0.08583691 370 0.016811497395675674 1.693959 38 126 0.01136704 GO Biological Process positive regulation of cell-substrate adhesion 39 6.034386e-129 2.0360637275384616e-126 5.375882 326 0.07773009 402 0.022942192758706466 1.732288 33 107 0.009871373 GO Biological Process chordate embryonic development 41 9.962318e-127 3.197418111268293e-124 2.601946 756 0.1802575 68 0.000005803697608970588 1.518057 150 555 0.04486988 GO Biological Process embryo development ending in birth or egg hatching 42 5.593094e-126 1.7523696177619047e-123 2.59081 757 0.1804959 69 0.0000060511585215942025 1.514533 151 560 0.04516901 GO Biological Process regulation of cellular component size 44 4.903819e-125 1.4665762322954544e-122 3.444785 505 0.1204101 210 0.0016505302369047617 1.512887 87 323 0.02602453 GO Biological Process regeneration 55 1.31859e-114 3.1547865109090908e-112 4.498662 344 0.08202194 281 0.005474340682562278 1.699824 46 152 0.0137601 GO Biological Process regulation of organ morphogenesis 57 1.219602e-111 2.815568897894737e-109 3.31197 476 0.1134955 152 0.0004398207022236842 1.646696 73 249 0.02183667 GO Biological Process negative regulation of protein phosphorylation 58 2.537299e-111 5.756606472586208e-109 2.852251 583 0.1390081 338 0.010708112890828403 1.383654 101 410 0.03021238 GO Biological Process connective tissue development 64 1.598282e-106 3.2862176309375e-104 3.468812 429 0.102289 331 0.009818359257099698 1.576146 55 196 0.01645229 GO Biological Process positive regulation of cellular component movement 65 3.219117e-106 6.516978554307692e-104 2.685468 611 0.1456843 227 0.001917371224185022 1.422926 114 450 0.03410111 GO Biological Process negative regulation of phosphorylation 67 5.978832e-105 1.1742604520597016e-102 2.703188 598 0.1425846 359 0.01373941453286908 1.357082 108 447 0.03230631 GO Biological Process negative regulation of protein modification process 68 2.789983e-103 5.3990273966176475e-101 2.516022 661 0.1576061 439 0.030279368574031885 1.275714 139 612 0.04157942 GO Biological Process positive regulation of locomotion 69 1.047483e-102 1.9976563473913042e-100 2.616166 617 0.1471149 231 0.002115317794805195 1.410178 118 470 0.03529764 GO Biological Process actin filament organization 70 9.084193e-102 1.707698509814286e-99 4.162588 332 0.07916071 274 0.005084623192335767 1.608835 57 199 0.01705055 GO Biological Process positive regulation of cell migration 76 3.538086e-98 6.126009693947369e-96 2.653991 578 0.1378159 242 0.0029775315183471073 1.424168 107 422 0.03200718 GO Biological Process positive regulation of cell motility 77 4.680819e-97 7.999337301428571e-95 2.616322 585 0.139485 222 0.001841047238108108 1.429734 112 440 0.03350284 GO Biological Process positive regulation of cell death 80 4.594255e-96 7.556975193125e-94 2.412257 664 0.1583214 336 0.010533395695833333 1.301563 149 643 0.04457074 GO Cellular Component nuclear chromatin 13 3.595436e-58 4.77916416e-56 2.792849 321 0.07653791 25 0.0041203966464 1.493076 84 316 0.02512713 GO Cellular Component chromatin 19 9.82866e-51 8.938907621052631e-49 2.315732 389 0.09275155 53 0.027576056513207547 1.317524 114 486 0.03410111 GO Molecular Function transcription factor binding 8 2.391641e-72 1.2621885377499998e-69 2.266454 571 0.1361469 10 0.00001905572257 1.523203 144 531 0.04307508 GO Molecular Function transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 31 6.783546e-30 9.238752003870969e-28 2.423554 209 0.04983309 15 0.00010434200135999999 2.02712 48 133 0.01435836 Mouse Phenotype Single KO decreased embryo size 29 3.054514e-97 9.644891275172414e-95 2.530388 619 0.1475918 27 0.00004362649161111111 1.518661 136 503 0.04068202 Mouse Phenotype Single KO abnormal thoracic cage morphology 30 1.04378e-95 3.185964486666666e-93 2.643004 568 0.1354316 64 0.000706713365953125 1.482943 113 428 0.03380197 Mouse Phenotype Single KO embryonic lethality during organogenesis, incomplete penetrance 32 1.088383e-94 3.1144759784375e-92 3.171168 430 0.1025274 207 0.033190833788405795 1.468295 63 241 0.01884535 Mouse Phenotype Single KO embryonic lethality during organogenesis 33 1.396191e-92 3.874218480909091e-90 2.156878 790 0.1883643 57 0.0005328198048421052 1.364621 181 745 0.05414299 Mouse Phenotype Single KO abnormal embryo size 35 1.542046e-90 4.0344329205714286e-88 2.346804 660 0.1573677 21 0.000028963028498571433 1.477625 161 612 0.04816034 Mouse Phenotype Single KO abnormal prenatal body size 47 1.049232e-81 2.0442164731914895e-79 2.122956 728 0.1735813 15 0.0000071353236446666665 1.455093 193 745 0.05773258 Mouse Phenotype Single KO abnormal joint morphology 53 3.429857e-75 5.925886896037735e-73 2.759164 421 0.1003815 175 0.023108934852000003 1.454714 72 278 0.02153754 Mouse Phenotype Single KO abnormal female reproductive system physiology 74 1.65653e-63 2.0498439472972973e-61 2.051624 620 0.1478302 233 0.039823832300429185 1.270892 143 632 0.04277595 Mouse Phenotype Single KO abnormal Paneth cell morphology 162 1.911793e-32 1.080635092654321e-30 6.881068 65 0.01549833 238 0.04157066388655462 3.209606 8 14 0.00239306 Mouse Phenotype Single KO decreased rib number 192 6.273676e-27 2.992085996458333e-25 3.058565 127 0.03028135 167 0.018348484055688622 1.815535 32 99 0.009572241 Mouse Phenotype Single KO abnormal intestinal goblet cell morphology 203 1.525333e-25 6.880529202463054e-24 3.982294 85 0.02026705 226 0.0391805826300885 2.106304 18 48 0.005384385 Mouse Phenotype Single KO abnormal placenta labyrinth morphology 259 9.015332e-21 3.1873897731274133e-19 2.300021 158 0.03767287 267 0.04858018282397004 1.558212 43 155 0.0128627 Mouse Phenotype Single KO common ventricle 268 2.694037e-20 9.204961495895523e-19 8.058967 35 0.008345255 224 0.03882615420178571 3.574334 7 11 0.002093928 Mouse Phenotype Single KO kinked tail 269 4.440106e-20 1.5114516967286247e-18 2.382424 142 0.03385789 182 0.02506350897967033 1.779584 32 101 0.009572241 Mouse Phenotype Single KO abnormal B cell activation 312 7.261177e-18 2.1311089034935897e-16 2.32844 131 0.0312351 129 0.00829810179379845 1.699824 46 152 0.0137601 Mouse Phenotype Single KO abnormal B cell proliferation 320 1.790403e-17 5.1233500846875e-16 2.354965 125 0.02980448 213 0.0352131790140845 1.628061 40 138 0.0119653 Mouse Phenotype Single KO decreased susceptibility to diet-induced obesity 333 8.353381e-17 2.2970543488588588e-15 2.460602 110 0.02622794 191 0.026908707463350782 1.736105 34 110 0.01017051 Mouse Phenotype Single KO abnormal mammary gland duct morphology 350 3.594146e-16 9.403312834857144e-15 2.761285 86 0.02050548 259 0.0469642023976834 2.013574 19 53 0.005683518 Mouse Phenotype Single KO pale yolk sac 358 7.163324e-16 1.8322502197765364e-14 2.392808 109 0.02598951 141 0.011495405555319147 1.939137 29 84 0.008674843 Mouse Phenotype Single KO abnormal mammary gland development 367 2.32476e-15 5.800497907356948e-14 2.086632 141 0.03361946 159 0.01721239562264151 1.758306 36 115 0.01076877 Mouse Phenotype split vertebrae 1 2.073625e-267 1.9825928625e-263 32.6387 240 0.05722461 374 0.02331376480828877 4.680676 5 6 0.001495663 Mouse Phenotype caudal vertebral fusion 11 1.833849e-187 1.593948208090909e-184 16.04341 229 0.05460181 400 0.0259596686625 2.973606 9 17 0.002692193 Mouse Phenotype kinked tail 19 6.366272e-165 3.2035750837894736e-162 5.558311 403 0.09608965 204 0.003909037815147059 1.79738 40 125 0.0119653 Mouse Phenotype decreased bone volume 32 8.180524e-127 2.444187186375e-124 5.585825 310 0.07391512 325 0.014654803673538462 1.779584 32 101 0.009572241 Mouse Phenotype abnormal neurocranium morphology 36 1.2695e-117 3.3715804166666667e-115 3.027975 564 0.1344778 240 0.00603979922875 1.495122 74 278 0.02213581 Mouse Phenotype decreased embryo size 47 2.737639e-105 5.569056697659574e-103 2.411496 723 0.1723891 49 0.000008306585092653061 1.48096 164 622 0.04905773 Mouse Phenotype abnormal bone volume 48 1.155734e-104 2.30207766125e-102 4.057036 351 0.08369099 335 0.016732075359402986 1.576649 48 171 0.01435836 Mouse Phenotype small liver 52 8.150735e-102 1.498638025673077e-99 3.542659 400 0.09537434 241 0.006273527510788382 1.554653 62 224 0.01854622 Mouse Phenotype abnormal embryo size 56 5.821342e-98 9.938901939642857e-96 2.260602 760 0.1812113 51 0.00000899329219117647 1.438827 187 730 0.05593778 Mouse Phenotype prenatal lethality, incomplete penetrance 58 1.423172e-95 2.3460254296551722e-93 2.612308 578 0.1378159 319 0.014147528589968653 1.353141 106 440 0.03170805 Mouse Phenotype embryonic lethality during organogenesis, incomplete penetrance 60 2.168093e-94 3.4548561955e-92 2.838393 502 0.1196948 315 0.013733502351428572 1.417165 82 325 0.02452887 Mouse Phenotype abnormal craniofacial bone morphology 61 5.078309e-93 7.959624975245902e-91 2.033688 894 0.2131617 19 2.870722958684211e-7 1.498826 198 742 0.05922824 Mouse Phenotype vertebral fusion 62 2.282461e-92 3.519775745322581e-90 3.803018 334 0.07963758 263 0.008287180335741445 1.656239 46 156 0.0137601 Mouse Phenotype abnormal mandible morphology 63 2.559717e-92 3.884675275714286e-90 3.015036 450 0.1072961 254 0.007692987629527559 1.566226 58 208 0.01734969 Mouse Phenotype abnormal autonomic nervous system morphology 66 7.121417e-90 1.031634362681818e-87 3.804063 325 0.07749165 231 0.005523253114285714 1.807148 37 115 0.0110679 Mouse Phenotype abnormal prenatal body size 69 3.181318e-89 4.408200202608695e-87 2.068008 832 0.1983786 26 6.098630942307693e-7 1.43907 227 886 0.06790308 Mouse Phenotype fused joints 70 4.391833e-89 5.998616473285714e-87 3.567206 348 0.08297568 178 0.00252372156 1.705103 51 168 0.01525576 Mouse Phenotype abnormal sphenoid bone morphology 71 1.646411e-88 2.2170895170422534e-86 3.836278 317 0.07558417 236 0.005752047497033898 1.87227 33 99 0.009871373 Mouse Phenotype abnormal pectoral girdle bone morphology 77 5.081958e-85 6.3102078490909094e-83 2.719327 485 0.1156414 260 0.008142941898461539 1.486803 72 272 0.02153754 Mouse Phenotype abnormal joint morphology 89 6.80986e-81 7.315626006741573e-79 2.56021 510 0.1216023 101 0.00027085271702970295 1.560225 95 342 0.02841759