# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 26 1.417686e-64 7.175126951538461e-62 2.372898 492 0.03634483 220 0.000043333179155 1.299942 164 248 0.01716918 GO Biological Process negative regulation of gene expression, epigenetic 32 6.188448e-56 2.544805851e-53 3.328587 244 0.01802467 519 0.011423992188631986 1.310511 76 114 0.007956449 GO Biological Process cellular response to topologically incorrect protein 68 1.04251e-37 2.017410160294118e-35 2.437371 269 0.01987146 264 0.0002125006037348485 1.371794 97 139 0.01015494 GO Biological Process gene silencing 74 2.876631e-36 5.1153496390540535e-34 2.249222 304 0.02245697 431 0.004664752534106729 1.266827 116 180 0.01214405 GO Biological Process endoplasmic reticulum unfolded protein response 76 9.757213e-36 1.6894100771973684e-33 2.578719 229 0.0169166 237 0.00007594869538818566 1.431216 83 114 0.00868928 GO Biological Process response to topologically incorrect protein 84 8.953163e-35 1.4025556180595237e-32 2.160071 318 0.02349117 272 0.0002884277669191177 1.321432 121 180 0.0126675 GO Biological Process regulation of DNA-templated transcription in response to stress 86 2.379676e-34 3.641180986511628e-32 2.392726 253 0.01868952 767 0.04823094325684485 1.255447 76 119 0.007956449 GO Biological Process regulation of intrinsic apoptotic signaling pathway 95 8.660729e-33 1.1996477148526316e-30 2.150776 302 0.02230923 570 0.016412999074736843 1.255554 99 155 0.01036432 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 102 2.918938e-32 3.765716190392157e-30 8.596519 55 0.004062939 550 0.014085754874363636 1.965766 11 11 0.001151591 GO Biological Process cellular response to unfolded protein 108 4.128842e-31 5.0306881368518523e-29 2.356798 235 0.01735983 246 0.00009893075278861789 1.413402 87 121 0.00910804 GO Biological Process viral gene expression 113 6.219064e-31 7.242182581946903e-29 2.521643 205 0.01514368 400 0.002789215524425 1.331149 86 127 0.00900335 GO Biological Process regulation of gene silencing 130 3.72186e-29 3.7673812107692304e-27 2.248419 242 0.01787693 416 0.0034854996146634616 1.320515 88 131 0.00921273 GO Biological Process viral transcription 133 8.484139e-29 8.39419436849624e-27 2.522178 190 0.01403561 334 0.0011457178836526947 1.374297 79 113 0.008270519 GO Biological Process response to unfolded protein 135 1.137396e-28 1.1086662195555554e-26 2.081743 283 0.02090567 260 0.0001577029726576923 1.351464 110 160 0.01151591 GO Biological Process cotranslational protein targeting to membrane 137 3.421589e-28 3.2864736971532845e-26 2.695614 165 0.01218882 652 0.027949594904907976 1.303825 65 98 0.006804858 GO Biological Process multi-organism metabolic process 146 3.458843e-27 3.1174599340410965e-25 2.202728 235 0.01735983 314 0.0007277635239171974 1.337256 100 147 0.01046901 GO Biological Process IRE1-mediated unfolded protein response 152 1.558665e-26 1.3493732062499999e-24 3.13162 122 0.009012337 564 0.015701815762234044 1.423486 42 58 0.004396985 GO Biological Process positive regulation of pri-miRNA transcription from RNA polymerase II promoter 154 3.154662e-26 2.6955972245454547e-24 3.674756 97 0.007165546 478 0.007279357836192468 1.76919 18 20 0.001884422 GO Biological Process regulation of posttranscriptional gene silencing 156 5.425111e-26 4.5762202339102565e-24 2.295751 205 0.01514368 523 0.011860644494646272 1.316522 73 109 0.007642379 GO Biological Process regulation of gene silencing by RNA 156 5.425111e-26 4.5762202339102565e-24 2.295751 205 0.01514368 523 0.011860644494646272 1.316522 73 109 0.007642379 GO Cellular Component nucleosome 33 2.048444e-38 1.0726397672727273e-36 3.39428 161 0.01189333 115 0.02193003297391304 1.291789 69 105 0.007223618 GO Cellular Component DNA packaging complex 39 1.161049e-32 5.144340184615385e-31 2.909901 170 0.01255817 129 0.037436128744186045 1.263707 72 112 0.007537688 GO Cellular Component ribosomal subunit 41 8.926612e-30 3.7622403746341467e-28 2.197822 260 0.01920662 135 0.040737472000000004 1.200711 113 185 0.01182998 GO Cellular Component chromosome, telomeric region 49 3.530625e-23 1.2450857142857142e-21 2.058148 232 0.01713821 85 0.0042143277176470584 1.271274 108 167 0.01130653 GO Cellular Component nuclear chromosome, telomeric region 55 5.524445e-21 1.7356801745454546e-19 2.149974 188 0.01388786 100 0.010690852607999998 1.280727 86 132 0.00900335 GO Cellular Component methyltransferase complex 82 2.854867e-15 6.016109970731708e-14 2.004249 157 0.01159784 72 0.00121956216 1.404119 65 91 0.006804858 GO Cellular Component uropod 86 5.288063e-15 1.062531728372093e-13 4.282821 44 0.003250351 121 0.02949200449586777 1.814554 12 13 0.001256281 GO Cellular Component PcG protein complex 88 6.036505e-15 1.1853500727272728e-13 2.198498 123 0.009086208 137 0.04058542248175183 1.410224 33 46 0.003454774 GO Cellular Component sex chromosome 137 3.723476e-9 4.696471918248175e-8 2.465992 55 0.004062939 92 0.0068193641739130425 1.663341 22 26 0.002303183 GO Cellular Component platelet dense tubular network membrane 153 1.44523e-8 1.6322597647058824e-7 3.20332 33 0.002437763 123 0.03199241678048781 1.965766 9 9 0.0009422111 GO Cellular Component U2 snRNP 247 0.000009573795 0.00006697780469635627 2.58364 28 0.002068405 127 0.03773611842519685 1.655382 16 19 0.001675042 GO Cellular Component precatalytic spliceosome 256 0.00002527288 0.00017059193999999998 2.222101 34 0.002511635 124 0.03424989367741936 1.544531 22 28 0.002303183 GO Molecular Function ubiquitin-protein transferase regulator activity 78 5.721868e-11 3.097144448205128e-9 2.550208 64 0.004727783 96 0.007795601952083334 1.850133 16 17 0.001675042 GO Molecular Function transcription factor activity, transcription factor recruiting 142 9.549043e-8 0.0000028391591229577465 2.356642 49 0.003619709 125 0.037989792432 1.825354 13 14 0.001360972 GO Molecular Function NF-kappaB binding 219 0.000005012382 0.00009663140093150686 2.039957 49 0.003619709 116 0.022623499648275862 1.614737 23 28 0.002407873 Mouse Phenotype Single KO extramedullary hematopoiesis 27 1.793161e-45 6.0814723248148155e-43 2.545873 301 0.02223535 335 0.012316031061791044 1.310511 76 114 0.007956449 Mouse Phenotype Single KO abnormal platelet aggregation 55 2.594321e-31 4.3193086176363634e-29 2.417386 225 0.01662111 378 0.018223113141269842 1.360915 54 78 0.005653266 Mouse Phenotype Single KO abnormal platelet activation 60 1.381651e-30 2.108629701166667e-28 2.366145 229 0.0169166 476 0.034817703422268906 1.31822 57 85 0.005967337 Mouse Phenotype Single KO abnormal platelet physiology 74 1.814063e-26 2.2447803906756757e-24 2.034426 275 0.02031469 314 0.010255705852866242 1.322425 74 110 0.007747069 Mouse Phenotype Single KO decreased circulating total protein level 105 5.364579e-22 4.678423800285715e-20 2.420674 154 0.01137623 204 0.001155089565735294 1.525164 45 58 0.004711055 Mouse Phenotype Single KO decreased circulating free fatty acid level 119 1.015149e-20 7.811528901680672e-19 2.040389 210 0.01551304 201 0.0011339313551741294 1.416197 67 93 0.007014238 Mouse Phenotype Single KO abnormal vascular branching morphogenesis 151 2.540157e-18 1.540411764834437e-16 2.31529 138 0.01019428 456 0.031224044644736843 1.559056 23 29 0.002407873 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 199 7.79716e-16 3.587869051256281e-14 2.512492 100 0.007387161 456 0.031224044644736843 1.559056 23 29 0.002407873 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 236 5.513183e-14 2.1391617258898304e-12 2.295287 104 0.007682648 432 0.027662936655092594 1.516448 27 35 0.002826633 Mouse Phenotype Single KO increased circulating tumor necrosis factor level 256 3.627443e-13 1.2975193574609374e-11 2.110662 117 0.008642979 518 0.04235508478378378 1.363354 43 62 0.004501675 Mouse Phenotype Single KO increased skin tumor incidence 268 8.234133e-13 2.8134311895895522e-11 2.345639 90 0.006648445 396 0.02129046666338384 1.474325 33 44 0.003454774 Mouse Phenotype Single KO increased interleukin-1 beta secretion 337 3.38368e-11 9.194171442136497e-10 2.289488 81 0.005983601 218 0.002051524618944954 1.667923 28 33 0.002931323 Mouse Phenotype Single KO decreased total retina thickness 338 3.646573e-11 9.879192000295858e-10 2.234866 85 0.006279087 235 0.0033999789032765956 1.603651 31 38 0.003245394 Mouse Phenotype Single KO skin fibrosis 343 4.861169e-11 1.297776225451895e-9 3.288245 43 0.003176479 504 0.041374341996031745 1.965766 9 9 0.0009422111 Mouse Phenotype Single KO decreased T cell apoptosis 362 1.182297e-10 2.9906888477900552e-9 2.096947 93 0.00687006 402 0.022237198201243782 1.572613 24 30 0.002512563 Mouse Phenotype Single KO subcutaneous edema 449 2.458442e-9 5.013798083296214e-8 2.216991 70 0.005171013 402 0.022237198201243782 1.572613 24 30 0.002512563 Mouse Phenotype Single KO increased skin papilloma incidence 454 2.928895e-9 5.907465091409692e-8 2.508117 54 0.003989067 354 0.014560367216101693 1.697707 19 22 0.001989112 Mouse Phenotype Single KO abnormal transitional stage T2 B cell morphology 533 3.247377e-8 5.57903024183865e-7 2.558789 45 0.003324223 528 0.044627697410984844 1.720046 14 16 0.001465662 Mouse Phenotype Single KO abnormal keratohyalin granule morphology 539 4.020136e-8 6.829756094990723e-7 2.453523 48 0.003545837 484 0.0390709324607438 1.814554 12 13 0.001256281 Mouse Phenotype Single KO multiple persisting craniopharyngeal ducts 573 1.147327e-7 0.0000018335206525305408 2.318726 50 0.003693581 363 0.015384027394490357 1.834715 14 15 0.001465662 Mouse Phenotype extramedullary hematopoiesis 25 6.355052e-48 2.4304260868800003e-45 2.150878 447 0.03302061 298 0.0015255996816442951 1.291789 115 175 0.01203936 Mouse Phenotype abnormal platelet aggregation 55 3.635617e-34 6.320024388545455e-32 2.41525 247 0.01824629 544 0.019158345860294117 1.317482 63 94 0.006595477 Mouse Phenotype abnormal platelet activation 57 9.602744e-34 1.6107339541052634e-31 2.389463 249 0.01839403 712 0.03971697141994382 1.277748 65 100 0.006804858 Mouse Phenotype abnormal platelet physiology 69 1.307982e-31 1.8124081017391306e-29 2.069617 318 0.02349117 336 0.0023372740925 1.325403 89 132 0.00931742 Mouse Phenotype abnormal spleen secondary B follicle morphology 80 2.817254e-29 3.3669706867499996e-27 2.00069 319 0.02356504 599 0.025394095808013356 1.249666 89 140 0.00931742 Mouse Phenotype decreased circulating total protein level 137 1.368164e-21 9.548186864233578e-20 2.395942 154 0.01137623 304 0.0017294933785855263 1.499313 45 59 0.004711055 Mouse Phenotype abnormal T-helper 2 physiology 179 4.253155e-18 2.2717550254189946e-16 2.055163 178 0.01314915 618 0.02651738708737864 1.358691 47 68 0.004920436 Mouse Phenotype abnormal embryonic erythropoiesis 316 3.191574e-13 9.656531333544305e-12 2.247983 102 0.007534904 662 0.03230510252719033 1.521884 24 31 0.002512563 Mouse Phenotype increased respiratory quotient 317 3.953452e-13 1.1923960432807569e-11 2.085459 120 0.008864593 577 0.02310663374350087 1.404119 40 56 0.004187605 Mouse Phenotype increased body temperature 326 8.497555e-13 2.492181698006135e-11 2.240216 99 0.00731329 568 0.021967659955985916 1.516448 27 35 0.002826633 Mouse Phenotype abnormal embryonic erythrocyte morphology 347 3.258506e-12 8.978263938328531e-11 2.089075 110 0.008125877 501 0.014590799735329342 1.512128 30 39 0.003140704 Mouse Phenotype macrocytosis 390 1.625499e-11 3.9849733176923083e-10 2.354333 79 0.005835857 607 0.025922627466227345 1.587734 21 26 0.002198492 Mouse Phenotype increased circulating iron level 391 1.676095e-11 4.098502377237852e-10 2.069347 105 0.007756519 357 0.003483332080672269 1.554327 34 43 0.003559464 Mouse Phenotype tight skin 415 4.190041e-11 9.65324867493976e-10 2.507194 67 0.004949398 268 0.0009685639051119402 1.867478 19 20 0.001989112 Mouse Phenotype dry eyes 436 1.061374e-10 2.3274763334862386e-9 2.489868 65 0.004801655 682 0.03607481658211144 1.720046 14 16 0.001465662 Mouse Phenotype polychromatophilia 516 1.358447e-9 2.5170759238372095e-8 2.098368 82 0.006057472 637 0.030129712883830456 1.503233 26 34 0.002721943 Mouse Phenotype abnormal transitional stage T2 B cell morphology 531 2.155711e-9 3.881497715819209e-8 2.120459 78 0.005761986 431 0.008387756601856148 1.626841 24 29 0.002512563 Mouse Phenotype subcutaneous edema 535 2.458442e-9 4.393488591028037e-8 2.216991 70 0.005171013 529 0.017644142313232514 1.572613 24 30 0.002512563 Mouse Phenotype interstitial pneumonia 582 1.48695e-8 2.4427369329896907e-7 2.28515 59 0.004358425 697 0.038016497582496415 1.608354 18 22 0.001884422 Mouse Phenotype abnormal keratohyalin granule morphology 585 1.51548e-8 2.4768383384615387e-7 2.481377 50 0.003693581 478 0.012198287838075313 1.834715 14 15 0.001465662