# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 18 9.577621e-46 7.001773041055555e-43 3.611776 177 0.02494012 433 0.0019938373965588917 1.522348 59 113 0.009161491 GO Biological Process regulation of DNA-templated transcription in response to stress 29 4.039759e-42 1.8330754717586208e-39 3.301195 183 0.02578554 342 0.000367501666254386 1.568099 64 119 0.009937888 GO Biological Process negative regulation of endoplasmic reticulum unfolded protein response 30 2.230937e-41 9.785633327666667e-39 11.90667 58 0.008172467 700 0.02246094671142857 2.591718 8 9 0.001242236 GO Biological Process platelet-derived growth factor receptor signaling pathway 116 9.454234e-24 1.0724850448793104e-21 3.213934 104 0.01465408 767 0.03036472705084746 1.767081 20 33 0.00310559 GO Biological Process regulation of endoplasmic reticulum unfolded protein response 123 4.467818e-23 4.779838785528455e-21 4.199336 72 0.01014513 606 0.012880513433828383 2.028301 16 23 0.002484472 GO Biological Process regulation of hematopoietic progenitor cell differentiation 136 3.336812e-22 3.22861096382353e-20 2.89689 113 0.01592222 787 0.034071961650571796 1.393335 54 113 0.008385093 GO Biological Process animal organ regeneration 152 3.659321e-21 3.167960857828947e-19 2.428024 146 0.02057207 769 0.03035738520416125 1.47584 41 81 0.00636646 GO Biological Process regulation of stem cell differentiation 160 1.811433e-20 1.4897904279375e-18 2.142867 183 0.02578554 280 0.00006125368811071429 1.571574 76 141 0.01180124 GO Biological Process regulation of hematopoietic stem cell differentiation 168 7.324089e-20 5.7367670923214295e-18 2.899866 100 0.01409046 778 0.03268719279434447 1.41538 50 103 0.007763975 GO Biological Process triglyceride homeostasis 174 1.93154e-19 1.4607548770114945e-17 4.386076 57 0.008031563 530 0.007239183015471698 1.913417 21 32 0.00326087 GO Biological Process regulation of cellular response to insulin stimulus 185 4.222466e-19 3.00342865372973e-17 2.540294 120 0.01690855 643 0.01698770007278383 1.566636 36 67 0.005590062 GO Biological Process negative regulation of gene expression, epigenetic 218 1.101037e-17 6.6461219646789e-16 2.654104 102 0.01437227 555 0.00909169773045045 1.457842 57 114 0.008850932 GO Biological Process chromatin silencing 238 1.024507e-16 5.664490593697479e-15 3.039175 77 0.01084965 852 0.04202765283333333 1.412754 47 97 0.007298137 GO Biological Process regulation of posttranscriptional gene silencing 245 1.467007e-16 7.879324535918368e-15 2.413776 113 0.01592222 720 0.02511528567638889 1.417718 53 109 0.008229814 GO Biological Process regulation of gene silencing by RNA 245 1.467007e-16 7.879324535918368e-15 2.413776 113 0.01592222 720 0.02511528567638889 1.417718 53 109 0.008229814 GO Biological Process negative regulation of cellular response to insulin stimulus 251 2.337824e-16 1.225634502629482e-14 2.918503 80 0.01127237 530 0.007239183015471698 1.913417 21 32 0.00326087 GO Biological Process protein-lipid complex subunit organization 255 3.85471e-16 1.989181525098039e-14 3.127167 71 0.01000423 831 0.039081580759326114 1.612931 26 47 0.004037267 GO Biological Process regulation of gene silencing by miRNA 267 1.020038e-15 5.027220989513109e-14 2.387133 109 0.0153586 696 0.022319819353448275 1.430335 52 106 0.008074534 GO Biological Process plasma lipoprotein particle organization 283 3.627124e-15 1.6865485765371022e-13 3.168338 65 0.009158799 771 0.030776904108949416 1.656638 25 44 0.003881988 GO Biological Process negative regulation of insulin receptor signaling pathway 285 3.934426e-15 1.8166004117192984e-13 2.83105 77 0.01084965 683 0.02092808901317716 1.846599 19 30 0.002950311 GO Cellular Component cytoplasmic side of membrane 41 4.490802e-22 1.8927087453658534e-20 2.000177 234 0.03297168 53 0.001596199245283019 1.404413 92 191 0.01428571 GO Cellular Component nucleosome 52 1.141338e-15 3.79275396923077e-14 2.975782 74 0.01042694 83 0.018684759903614456 1.443957 52 105 0.008074534 GO Cellular Component ruffle membrane 68 1.050119e-11 2.668537694117647e-10 2.000523 116 0.01634493 73 0.009164372252054794 1.524107 46 88 0.007142857 GO Cellular Component podosome 86 2.274673e-9 4.570505748837209e-8 2.605419 51 0.007186135 79 0.012822910541772151 1.910275 19 29 0.002950311 GO Cellular Component TOR complex 137 0.000001163939 0.00001468092402919708 3.040782 26 0.00366352 100 0.04047579072 2.138168 11 15 0.001708075 GO Cellular Component uropod 227 0.0004822459 0.0036710172475770925 2.784942 15 0.002113569 96 0.037864656000000003 2.242833 10 13 0.001552795 GO Molecular Function cadherin binding 7 2.05769e-37 1.2410810257142857e-34 2.03347 389 0.05481189 21 5.807499722857143e-8 1.505797 157 304 0.02437888 GO Molecular Function nuclear hormone receptor binding 13 4.471386e-23 1.4521685916923077e-20 2.100016 218 0.0307172 60 0.0025707807256666665 1.489765 70 137 0.01086957 GO Molecular Function hormone receptor binding 16 1.911886e-22 5.0449891825e-20 2.004167 237 0.03339439 48 0.00019284178508333335 1.521226 84 161 0.01304348 GO Molecular Function protein N-terminus binding 20 3.671879e-20 7.751336568999999e-18 2.380589 144 0.02029026 63 0.0030819105546031744 1.555031 56 105 0.008695652 GO Molecular Function steroid hormone receptor binding 26 1.689829e-16 2.7440223223076925e-14 2.091946 153 0.0215584 101 0.03451722853267327 1.490974 45 88 0.006987578 GO Molecular Function SH2 domain binding 61 3.658063e-10 2.531859341967213e-8 2.490595 61 0.008595181 95 0.025205771088421054 1.881086 20 31 0.00310559 GO Molecular Function apolipoprotein binding 149 0.000001908738 0.00005408518010738255 2.761989 29 0.004086234 108 0.04125163738888889 2.186762 12 16 0.001863354 GO Molecular Function insulin-like growth factor I binding 444 0.004236374 0.04028371853153153 2.000988 19 0.002677188 98 0.03026966346530612 2.429736 10 12 0.001552795 Human Phenotype Irregular hyperpigmentation 139 3.413702e-8 0.0000016388225500719427 2.263074 57 0.008031563 17 0.013891580554705883 2.032143 23 33 0.003571429 Mouse Phenotype Single KO decreased circulating free fatty acid level 14 2.335599e-38 1.5276485744999998e-35 3.206176 173 0.0243765 228 0.007949946750877193 1.53622 49 93 0.007608696 Mouse Phenotype Single KO decreased circulating triglyceride level 18 7.323774e-36 3.725766584333333e-33 2.343111 273 0.03846696 399 0.04208251966666667 1.279734 97 221 0.01506211 Mouse Phenotype Single KO decreased fatty acid level 24 3.862075e-33 1.4735425322916667e-30 2.776435 185 0.02606735 401 0.04236982720199501 1.38495 57 120 0.008850932 Mouse Phenotype Single KO abnormal branching of the mammary ductal tree 83 7.203693e-24 7.947496000120483e-22 3.029304 114 0.01606313 196 0.0034042679895918363 1.918213 25 38 0.003881988 Mouse Phenotype Single KO abnormal mammary gland duct morphology 133 9.374068e-19 6.454010577142856e-17 2.428714 128 0.01803579 204 0.004079463699264706 1.760413 32 53 0.004968944 Mouse Phenotype Single KO abnormal mammary gland epithelium morphology 168 7.344882e-17 4.0033978853571425e-15 2.227077 136 0.01916303 207 0.004309138661207729 1.685629 37 64 0.005745342 Mouse Phenotype Single KO decreased percent body fat/body weight 193 4.478559e-15 2.1248790032642487e-13 2.203185 123 0.01733127 347 0.031323774763688764 1.516155 39 75 0.006055901 Mouse Phenotype Single KO abnormal iridocorneal angle 208 2.841649e-14 1.2510086487019232e-12 3.194697 60 0.008454276 286 0.016925670730069932 2.148398 14 19 0.002173913 Mouse Phenotype Single KO abnormal basal metabolism 220 1.122125e-13 4.6705902840909096e-12 2.505187 85 0.01197689 335 0.02633367873253731 1.800863 21 34 0.00326087 Mouse Phenotype Single KO abnormal aqueous drainage system morphology 229 2.7195e-13 1.0874437336244542e-11 3.024503 60 0.008454276 349 0.03162331905157593 2.040978 14 20 0.002173913 Mouse Phenotype Single KO increased respiratory quotient 254 2.956616e-12 1.0658949886614174e-10 2.645152 68 0.009581513 425 0.04774996292470588 1.606601 27 49 0.004192547 Mouse Phenotype Single KO decreased circulating total protein level 408 1.932152e-8 4.3364499666666663e-7 2.098752 70 0.009863323 416 0.045793078411057696 1.558382 31 58 0.004813665 Mouse Phenotype Single KO abnormal B cell apoptosis 462 1.618696e-7 0.000003208311530735931 2.027155 66 0.009299704 367 0.03440080302179837 1.719505 23 39 0.003571429 Mouse Phenotype Single KO increased CD4-positive NK T cell number 508 4.753062e-7 0.000008567674947637796 4.530847 17 0.002395378 220 0.007067147837272727 2.650621 10 11 0.001552795 Mouse Phenotype Single KO small visceral yolk sac 521 7.11388e-7 0.00001250322440690979 3.530177 22 0.003099901 292 0.017468561159246578 2.915683 7 7 0.001086957 Mouse Phenotype Single KO increased urine potassium level 544 0.000001174605 0.00001977179776654412 3.039234 26 0.00366352 418 0.04608275584688995 2.242833 10 13 0.001552795 Mouse Phenotype Single KO abnormal atrium myocardium morphology 617 0.000003766082 0.000055893051659643436 2.994854 24 0.003381711 348 0.03143961222413793 2.591718 8 9 0.001242236 Mouse Phenotype Single KO abnormal pharynx morphology 816 0.00007376914 0.0008278235477696079 2.126401 33 0.004649852 355 0.031545013785915496 1.987966 15 22 0.002329193 Mouse Phenotype Single KO decreased small intestinal villus size 953 0.000297905 0.00286245129590766 2.70146 17 0.002395378 382 0.03895677851570681 2.915683 6 6 0.000931677 Mouse Phenotype Single KO abnormal CD4-positive NK T cell number 1119 0.001112332 0.009102434427167114 2.118523 22 0.003099901 273 0.015668794265934066 2.22964 13 17 0.002018634 Mouse Phenotype extramedullary hematopoiesis 13 4.027303e-43 2.961926460230769e-40 2.560709 279 0.03931239 328 0.0018681704290243902 1.416189 85 175 0.01319876 Mouse Phenotype decreased circulating free fatty acid level 33 9.139819e-37 2.648054832090909e-34 2.802466 203 0.02860364 244 0.00037426224943032794 1.568099 64 119 0.009937888 Mouse Phenotype decreased circulating triglyceride level 47 1.840925e-32 3.744911473404255e-30 2.129168 302 0.04255319 582 0.01922884663917526 1.270648 112 257 0.0173913 Mouse Phenotype decreased fatty acid level 54 2.85245e-31 5.050421194444444e-29 2.416027 223 0.03142173 376 0.003423944126329787 1.420461 76 156 0.01180124 Mouse Phenotype abnormal keratinocyte physiology 71 5.141567e-28 6.923735505211268e-26 2.524119 183 0.02578554 670 0.029078868210447764 1.393335 54 113 0.008385093 Mouse Phenotype abnormal free fatty acids level 75 4.309323e-27 5.4935249604e-25 2.048235 274 0.03860786 365 0.00307889870630137 1.361569 99 212 0.01537267 Mouse Phenotype abnormal circulating free fatty acids level 83 6.585562e-26 7.586091359277109e-24 2.024459 269 0.03790334 374 0.0033236541288770055 1.365393 96 205 0.01490683 Mouse Phenotype abnormal respiratory quotient 127 1.270953e-22 9.568174514173229e-21 2.195336 193 0.02719459 683 0.029928869692532948 1.3457 66 143 0.01024845 Mouse Phenotype renal glomerulus hypertrophy 142 9.910977e-22 6.673158527957746e-20 3.156168 97 0.01366775 736 0.037958027372282606 1.715108 20 34 0.00310559 Mouse Phenotype abnormal keratinocyte proliferation 143 9.983724e-22 6.675131829650349e-20 2.67359 126 0.01775398 672 0.029355485455357138 1.498337 37 72 0.005745342 Mouse Phenotype increased bone resorption 153 1.506418e-20 9.413635619607841e-19 2.844454 107 0.01507679 578 0.01903621566435986 1.695165 25 43 0.003881988 Mouse Phenotype abnormal bone resorption 173 6.390572e-19 3.5318068723699423e-17 2.308676 143 0.02014936 774 0.04397640007751938 1.439844 40 81 0.00621118 Mouse Phenotype increased oxygen consumption 186 4.677312e-18 2.4042892490322584e-16 2.112931 165 0.02324926 338 0.0020724777187278104 1.52351 58 111 0.009006211 Mouse Phenotype decreased susceptibility to diet-induced obesity 191 6.029524e-18 3.018234500732984e-16 2.0753 171 0.02409469 458 0.00794293852860262 1.434701 62 126 0.009627329 Mouse Phenotype abnormal branching of the mammary ductal tree 195 9.460954e-18 4.638778522769231e-16 2.337692 130 0.0183176 579 0.019050350295336787 1.577337 33 61 0.005124224 Mouse Phenotype decreased white adipose tissue amount 200 1.979885e-17 9.4648402425e-16 2.105845 160 0.02254474 388 0.003843541713402062 1.555031 48 90 0.007453416 Mouse Phenotype abnormal brown fat cell morphology 205 3.261672e-17 1.521211999609756e-15 2.334806 126 0.01775398 379 0.003483695404749341 1.71817 33 56 0.005124224 Mouse Phenotype abnormal osteoblast differentiation 227 5.198762e-16 2.1896635895154182e-14 2.098026 147 0.02071298 655 0.027325294209160304 1.523118 35 67 0.005434783 Mouse Phenotype abnormal cell adhesion 269 5.857373e-14 2.081871496394052e-12 2.106194 125 0.01761308 440 0.007245323627045454 1.572934 41 76 0.00636646 Mouse Phenotype increased respiratory quotient 361 2.64818e-11 7.013642376731302e-10 2.419864 73 0.01028604 695 0.032019665188489206 1.561973 30 56 0.004658385