# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	7	1.370348e-34	2.576058476e-31	2.698224	204	0.01863184	518	0.016599461195559845	1.359838	66	113	0.008183509	
GO Biological Process	IRE1-mediated unfolded protein response	11	1.900462e-33	2.273470859818182e-30	3.808364	120	0.01095991	480	0.011900958478125	1.525378	38	58	0.004711717	
GO Biological Process	rRNA processing	14	1.465775e-32	1.3777238017857143e-29	2.137729	303	0.02767376	63	1.8537960566666668e-13	1.579856	171	252	0.02120273	
GO Biological Process	endoplasmic reticulum unfolded protein response	15	3.762306e-32	3.3005456436e-29	2.673116	192	0.01753585	262	0.0002210387043015267	1.49087	73	114	0.009051457	
GO Biological Process	rRNA metabolic process	16	5.799365e-32	4.7696152521875e-29	2.104964	308	0.02813042	66	4.3246993686363637e-13	1.564125	174	259	0.02157471	
GO Biological Process	regulation of DNA-templated transcription in response to stress	19	1.220069e-30	8.44994103736842e-28	2.467191	211	0.01927117	521	0.01670774740806142	1.34997	69	119	0.008555487	
GO Biological Process	cellular response to topologically incorrect protein	21	1.84133e-29	1.153812450952381e-26	2.397348	214	0.01954516	269	0.0002507830479628253	1.440474	86	139	0.01066336	
GO Biological Process	mRNA catabolic process	23	2.784746e-29	1.5932379397391306e-26	2.111404	279	0.02548178	197	0.0000022298079132994927	1.431903	131	213	0.01624303	
GO Biological Process	response to topologically incorrect protein	28	2.054352e-28	9.654720702857143e-26	2.15835	257	0.02347246	254	0.00014591455583464567	1.396925	108	180	0.0133912	
GO Biological Process	cellular response to unfolded protein	31	8.386085e-28	3.559757823064516e-25	2.430293	196	0.01790118	284	0.0003750363651232394	1.462346	76	121	0.009423435	
GO Biological Process	response to unfolded protein	37	1.387197e-26	4.933547384594595e-24	2.16454	238	0.02173714	265	0.000235172831309434	1.411476	97	160	0.01202728	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	38	4.135591e-26	1.432111630763158e-23	2.130844	242	0.02210248	418	0.006048103062200956	1.336842	89	155	0.01103534	
GO Biological Process	nuclear-transcribed mRNA catabolic process	39	7.347083e-26	2.478981158897436e-23	2.092228	250	0.02283314	224	0.000010667284604464287	1.422794	121	198	0.0150031	
GO Biological Process	activation of signaling protein activity involved in unfolded protein response	46	5.960028e-24	1.7049567054782606e-21	6.408875	50	0.004566627	569	0.02673469395782074	2.328208	8	8	0.0009919405	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	54	3.951777e-23	9.629895100555556e-21	2.642881	138	0.01260389	604	0.03325906749006623	1.402895	47	78	0.00582765	
GO Biological Process	liver regeneration	57	1.412551e-22	3.261010282280702e-20	3.185132	100	0.009133254	636	0.040382860594339626	1.596486	24	35	0.002975821	
GO Biological Process	mitochondrial translational termination	59	6.164765e-22	1.374951570084746e-19	2.831945	116	0.01059457	278	0.0003153950540035971	1.552139	58	87	0.007191569	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	61	1.965901e-21	4.2408674195081966e-19	2.304851	165	0.01506987	616	0.035808181079545455	1.36225	55	94	0.006819591	
GO Biological Process	translational elongation	62	2.70886e-21	5.749336893548386e-19	2.450352	145	0.01324322	247	0.00008841025984615383	1.517493	73	112	0.009051457	
GO Biological Process	protein targeting to ER	64	1.191216e-20	2.4492517725e-18	2.530632	132	0.0120559	176	5.397645349772727e-7	1.659713	72	101	0.008927464	
GO Cellular Component	ribosomal subunit	33	4.224423e-26	2.212061498181818e-24	2.247013	215	0.0196365	52	4.471226584615385e-8	1.510189	120	185	0.01487911	
GO Cellular Component	large ribosomal subunit	36	9.644849e-25	4.62952752e-23	2.616447	151	0.01379121	56	6.271131085714287e-7	1.599378	79	115	0.009795412	
GO Cellular Component	mitochondrial large ribosomal subunit	40	1.364057e-21	5.89272624e-20	3.737027	77	0.007032606	90	0.000336843072	1.689092	37	51	0.004587725	
GO Cellular Component	mitochondrial ribosome	41	4.3843e-21	1.847822048780488e-19	2.971196	103	0.009407252	101	0.0007178828863366337	1.506488	55	85	0.006819591	
GO Cellular Component	endopeptidase complex	43	2.744468e-20	1.1028931869767444e-18	2.777893	110	0.01004658	185	0.03964460730810811	1.383428	41	69	0.005083695	
GO Cellular Component	peptidase complex	45	1.143325e-18	4.390368e-17	2.407748	130	0.01187323	141	0.009822689770212766	1.402216	53	88	0.006571606	
GO Cellular Component	catalytic step 2 spliceosome	49	3.478065e-16	1.2265502693877552e-14	2.200416	134	0.01223856	69	0.000020329496765217393	1.576391	65	96	0.008059516	
GO Cellular Component	PcG protein complex	54	2.106736e-14	6.7415552e-13	2.320375	105	0.009589917	93	0.00037192004129032254	1.72085	34	46	0.004215747	
GO Cellular Component	methyltransferase complex	55	6.052246e-14	1.9015056523636366e-12	2.067622	131	0.01196456	129	0.003551991069767442	1.432744	56	91	0.006943583	
GO Cellular Component	nuclear ubiquitin ligase complex	62	1.02725e-11	2.8630451612903225e-10	2.821006	58	0.005297287	184	0.03797421808695652	1.513335	26	40	0.003223807	
GO Cellular Component	cytoplasmic exosome (RNase complex)	67	2.446343e-11	6.309374185074628e-10	6.017464	23	0.002100648	168	0.027067217142857144	1.970022	11	13	0.001363918	
GO Cellular Component	cytosolic large ribosomal subunit	95	7.498704e-9	1.363974790736842e-7	2.079343	76	0.006941273	117	0.0016416103384615385	1.564861	41	61	0.005083695	
GO Cellular Component	ESCRT complex	99	1.084907e-8	1.8936558545454541e-7	2.809937	41	0.003744634	96	0.00044970966	1.912457	23	28	0.002851829	
GO Cellular Component	Bcl-2 family protein complex	135	6.134782e-7	0.000007852520960000001	3.697993	21	0.001917983	172	0.027053105860465117	2.328208	7	7	0.0008679479	
GO Cellular Component	pre-autophagosomal structure	136	7.324619e-7	0.000009306574729411766	2.135209	52	0.004749292	102	0.0009170926305882353	1.818913	25	32	0.003099814	
GO Cellular Component	ATP-binding cassette (ABC) transporter complex	146	0.00000148846	0.000017616841643835614	6.60827	11	0.001004658	148	0.013497291243243243	2.328208	8	8	0.0009919405	
GO Cellular Component	exosome (RNase complex)	158	0.000003452506	0.00003775905296202532	2.533418	32	0.002922641	138	0.007707067826086956	1.822076	18	23	0.002231866	
GO Cellular Component	pre-autophagosomal structure membrane	175	0.00001069364	0.00010559205668571428	2.620121	27	0.002465979	163	0.021907562797546014	1.891669	13	16	0.001611903	
GO Cellular Component	ESCRT III complex	189	0.00002059003	0.00018825170285714283	3.020947	20	0.001826651	192	0.04721045399999999	1.940174	10	12	0.001239926	
GO Cellular Component	SMN-Sm protein complex	199	0.00003520712	0.0003057181073366834	2.396563	28	0.002557311	193	0.047639733388601044	1.780395	13	17	0.001611903	
GO Molecular Function	structural constituent of ribosome	5	1.555847e-26	1.3137572067999999e-23	2.323403	204	0.01863184	30	4.3793243860000004e-8	1.566511	109	162	0.01351519	
GO Molecular Function	ribonucleoprotein complex binding	10	1.546929e-18	6.531134237999999e-16	2.204398	155	0.01415654	60	0.001146743753	1.457661	72	115	0.008927464	
GO Molecular Function	5'-3' RNA polymerase activity	51	2.631492e-8	0.0000021784625929411762	2.411401	51	0.00465796	79	0.006546558379746835	1.655615	32	45	0.003967762	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	64	1.473569e-7	0.000009720950496875	2.344365	48	0.004383962	91	0.015862207105494505	1.624331	30	43	0.003719777	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	79	6.001248e-7	0.00003207249247594937	2.187801	50	0.004566627	90	0.015372907153333334	1.766227	22	29	0.002727836	
Human Phenotype	Abnormality of mitochondrial metabolism	14	1.203716e-13	5.7374263342857145e-11	2.264141	104	0.009498584	57	0.0008147323254385964	1.619623	48	69	0.005951643	
Human Phenotype	Abnormality of the mitochondrion	15	2.065852e-13	9.190286930666667e-11	2.233562	105	0.009589917	59	0.0008996143875084745	1.606792	49	71	0.006075635	
Human Phenotype	Abnormality of coagulation	40	1.906241e-9	3.1800865482500005e-7	2.041172	86	0.007854599	144	0.03519636777777777	1.488527	39	61	0.00483571	
Human Phenotype	3-Methylglutaconic aciduria	47	1.365983e-8	0.0000019394052253191487	3.210523	33	0.003013974	142	0.03127336224788732	2.134191	11	12	0.001363918	
Human Phenotype	Abnormal glycosylation	83	1.211506e-7	0.000009740216310843373	3.037272	31	0.002831309	112	0.013355509025	1.904898	18	22	0.002231866	
Human Phenotype	Abnormal protein N-linked glycosylation	103	3.48116e-7	0.000022553185126213593	2.949698	30	0.002739976	127	0.02266846473385827	1.88474	17	21	0.002107874	
Human Phenotype	Abnormal isoelectric focusing of serum transferrin	120	9.61548e-7	0.000053470081700000004	2.863615	29	0.002648644	148	0.03708039564527027	1.862567	16	20	0.001983881	
Mouse Phenotype Single KO	absent hypoglossal nerve	180	0.00001066848	0.0005427292853333333	2.678013	26	0.002374646	184	0.03190970147445652	2.017781	13	15	0.001611903	
Mouse Phenotype Single KO	abnormal DNA replication	274	0.0001663555	0.005559552239051095	2.033119	33	0.003013974	181	0.031138606160220992	1.822076	18	23	0.002231866	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	57	1.141274e-10	1.914336967368421e-8	2.789006	53	0.004840625	297	0.02350256691111111	1.707353	22	30	0.002727836	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	70	6.339946e-10	8.659460529428571e-8	2.597315	55	0.00502329	224	0.0074812434750000005	1.862567	20	25	0.002479851	
Mouse Phenotype	increased neural tube apoptosis	101	2.496059e-8	0.0000023628534751485147	2.086334	70	0.006393278	313	0.03125329004472843	1.570187	29	43	0.003595784	
Mouse Phenotype	absent hypoglossal nerve	229	0.00001066848	0.000445420686812227	2.678013	26	0.002374646	287	0.02136037001707317	2.017781	13	15	0.001611903