# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 71 3.277489e-8 0.000006074433486056338 5.154834 18 0.009873834 285 0.011231414273684211 4.117763 8 16 0.003508772 GO Biological Process positive regulation of mRNA catabolic process 77 5.721858e-8 0.000009778432392467533 4.471861 20 0.01097093 310 0.01678442760032258 3.294211 10 25 0.004385965 GO Biological Process regulation of Rho protein signal transduction 80 7.23093e-8 0.000011893975983750001 2.18005 58 0.03181569 122 0.00037804361667213116 2.217257 35 130 0.01535088 GO Biological Process negative regulation of sequence-specific DNA binding transcription factor activity 103 4.226338e-7 0.000053994545380582524 2.07794 57 0.03126714 166 0.001375756010361446 2.073694 35 139 0.01535088 GO Biological Process placenta development 108 5.810457e-7 0.00007079611450277777 2.056523 57 0.03126714 385 0.04325811047792208 1.748639 31 146 0.01359649 GO Biological Process negative regulation of cellular amide metabolic process 124 0.000001608035 0.00017064623036290322 2.098695 50 0.02742732 355 0.02822423127380282 1.764756 33 154 0.01447368 GO Biological Process smoothened signaling pathway involved in ventral spinal cord patterning 137 0.000003206778 0.00030801453797080295 6.84359 10 0.005485464 276 0.010340551981159421 8.235526 4 4 0.001754386 GO Biological Process Peyer's patch development 139 0.000003246127 0.00030730780714388487 7.875015 9 0.004936917 118 0.00035536950062711866 8.235526 6 6 0.002631579 GO Biological Process regulation of cellular response to transforming growth factor beta stimulus 173 0.00001146473 0.0008720484512716763 2.070336 43 0.02358749 313 0.017197619020447284 2.018511 25 102 0.01096491 GO Biological Process regulation of transforming growth factor beta receptor signaling pathway 188 0.00002137549 0.0014961706005851064 2.0345 42 0.02303895 350 0.027502012982571426 1.976526 24 100 0.01052632 GO Biological Process adherens junction assembly 192 0.00002247489 0.0015403493620312501 2.993349 20 0.01097093 233 0.005305747203948498 3.148878 13 34 0.005701754 GO Biological Process negative regulation of Notch signaling pathway 201 0.00002656806 0.0017393487638805972 3.310781 17 0.009325288 293 0.013584143487030716 2.994737 12 33 0.005263158 GO Biological Process entrainment of circadian clock 297 0.0001334395 0.005912223503367003 3.306295 14 0.007679649 390 0.045019267130769224 3.088322 9 24 0.003947368 GO Biological Process positive regulation of protein kinase C signaling 314 0.0001543962 0.006470380878343948 4.301718 10 0.005485464 117 0.0003105462141452991 7.206086 7 8 0.003070175 GO Biological Process regulation of Notch signaling pathway 316 0.0001550945 0.006458507992088607 2.033777 33 0.01810203 353 0.027761076329745043 2.173264 19 72 0.008333333 GO Biological Process positive regulation of sodium ion transport 321 0.0001610645 0.006602640982866044 2.659748 19 0.01042238 344 0.026160394197965117 2.922284 11 31 0.004824561 GO Biological Process negative regulation of protein binding 324 0.0001636298 0.006645693019135802 2.141914 29 0.01590784 359 0.028714088954317547 2.035748 22 89 0.009649123 GO Biological Process regulation of nitric oxide biosynthetic process 435 0.0005669118 0.01714940776137931 2.334885 20 0.01097093 395 0.04954390151139241 2.287646 15 54 0.006578947 GO Biological Process regulation of protein kinase C signaling 438 0.0005807932 0.017448990225570775 2.989258 13 0.007131103 155 0.0012065826687096774 4.941316 9 15 0.003947368 GO Biological Process regulation of sodium ion transmembrane transporter activity 468 0.0006889628 0.01937192625042735 2.112344 24 0.01316511 171 0.0014735286598245613 2.978807 17 47 0.00745614 GO Cellular Component actomyosin 23 1.714408e-8 0.000001288042184347826 2.928681 37 0.02029622 48 0.0159753312 2.316242 18 64 0.007894737 GO Cellular Component ruffle membrane 44 0.00001366833 0.0005367925963636363 2.28272 34 0.01865058 56 0.02051132605714286 2.058882 22 88 0.009649123 GO Molecular Function retinoic acid-responsive element binding 3 3.070046e-10 4.3205780706666663e-7 8.226877 16 0.008776742 37 0.02474835984864865 8.235526 4 4 0.001754386 GO Molecular Function Rho guanyl-nucleotide exchange factor activity 4 5.56896e-10 5.87803728e-7 2.88061 46 0.02523313 12 0.000025089414435000003 2.918921 28 79 0.0122807 GO Molecular Function transforming growth factor beta receptor, cytoplasmic mediator activity 9 1.074275e-7 0.00005039543388888889 6.265953 14 0.007679649 39 0.04680405273846154 4.941316 6 10 0.002631579 GO Molecular Function retinoic acid receptor binding 52 0.00006429343 0.005220131951153847 3.366351 15 0.008228195 38 0.04393189878421053 3.294211 10 25 0.004385965 Mouse Phenotype Single KO abnormal sublingual gland morphology 10 9.198246e-12 8.4228338622e-9 11.69355 15 0.008228195 214 0.04583027152336448 5.147204 5 8 0.002192982 Mouse Phenotype Single KO abnormal embryonic erythropoiesis 11 2.290161e-11 1.9064549342727273e-8 5.037373 27 0.01481075 49 0.0003551219151836735 3.975771 14 29 0.006140351 Mouse Phenotype Single KO abnormal embryonic erythrocyte morphology 15 3.763249e-10 2.2973380728666665e-7 4.424897 27 0.01481075 95 0.0026945571340000005 3.294211 14 35 0.006140351 Mouse Phenotype Single KO abnormal heart ventricle wall thickness 21 2.059838e-9 8.981874555238096e-7 2.359229 61 0.03346133 219 0.04840306574429224 1.795716 29 133 0.0127193 Mouse Phenotype Single KO abnormal placenta vasculature 49 3.221264e-7 0.00006019819275102041 2.266145 48 0.02633022 100 0.0030066862988000005 2.148398 30 115 0.01315789 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 61 7.339138e-7 0.00011017128961639343 2.671864 33 0.01810203 47 0.0003247613826808511 3.107746 20 53 0.00877193 Mouse Phenotype Single KO abnormal circulating lactate dehydrogenase level 72 0.000001652767 0.0002101998252638889 12.9513 7 0.003839824 214 0.04583027152336448 5.147204 5 8 0.002192982 Mouse Phenotype Single KO abnormal vertebral body morphology 125 0.00001471906 0.00107825945936 2.511777 28 0.0153593 173 0.025444714691907518 2.440156 16 54 0.007017544 Mouse Phenotype Single KO pale yolk sac 132 0.00001802969 0.001250741449469697 2.070652 41 0.0224904 127 0.008596029201574804 2.254966 23 84 0.01008772 Mouse Phenotype Single KO thin interventricular septum 140 0.00002317497 0.0015158085734999999 4.172547 13 0.007131103 212 0.04407842891509434 3.46759 8 19 0.003508772 Mouse Phenotype Single KO absent midbrain-hindbrain boundary 155 0.00003109475 0.0018369975854838712 10.4007 6 0.003291278 145 0.01369667432 8.235526 4 4 0.001754386 Mouse Phenotype Single KO rib fusion 163 0.00003891696 0.002186273636319018 2.294088 30 0.01645639 138 0.01147386698115942 2.353008 20 70 0.00877193 Mouse Phenotype Single KO abnormal vascular endothelial cell development 193 0.00008663803 0.004110592957046632 2.708499 20 0.01097093 98 0.00277416080377551 3.453608 13 31 0.005701754 Mouse Phenotype Single KO abnormal vascular branching morphogenesis 195 0.00009400758 0.00441449953876923 2.616263 21 0.01151947 161 0.02001330600931677 3.12382 11 29 0.004824561 Mouse Phenotype Single KO abnormal placental labyrinth vasculature morphology 205 0.0001203221 0.005374582779024389 2.217775 28 0.0153593 180 0.028918594519444445 2.167244 20 76 0.00877193 Mouse Phenotype Single KO abnormal neuromere morphology 209 0.0001324108 0.005801366964593301 3.148479 15 0.008228195 44 0.0002415860092954545 5.032822 11 18 0.004824561 Mouse Phenotype Single KO abnormal sympathetic neuron morphology 211 0.0001344381 0.005834358681042654 4.856317 9 0.004936917 200 0.039070982294500005 4.492105 6 11 0.002631579 Mouse Phenotype Single KO abnormal distal convoluted tubule morphology 237 0.0002041262 0.007886850689451476 3.169721 14 0.007679649 210 0.04449730777619048 3.843246 7 15 0.003070175 Mouse Phenotype Single KO abnormal rhombomere 3 morphology 322 0.0006291741 0.017892382713354037 5.927275 6 0.003291278 130 0.00999063214846154 6.862939 5 6 0.002192982 Mouse Phenotype Single KO abnormal rhombomere morphology 431 0.002041123 0.04336557612761021 2.716746 12 0.006582556 67 0.0008074209350895522 4.844427 10 17 0.004385965 Mouse Phenotype extramedullary hematopoiesis 11 7.997919e-14 6.951645778090909e-11 2.679818 75 0.04114098 164 0.0029833106681707317 1.882406 40 175 0.01754386 Mouse Phenotype increased lactate dehydrogenase level 21 4.451092e-11 2.0265186005714286e-8 5.537264 24 0.01316511 275 0.017212497940363638 3.019693 11 30 0.004824561 Mouse Phenotype abnormal sublingual gland morphology 23 2.804892e-10 1.1659814092173912e-7 7.60707 17 0.009325288 376 0.038947954053191486 4.117763 6 12 0.002631579 Mouse Phenotype abnormal circulating lactate dehydrogenase level 24 3.038769e-10 1.2105696003749999e-7 15.44657 11 0.00603401 315 0.02590143799904762 4.492105 6 11 0.002631579 Mouse Phenotype abnormal embryonic erythropoiesis 25 3.877311e-10 1.48283881884e-7 4.418678 27 0.01481075 113 0.0004337845160442478 3.71927 14 31 0.006140351 Mouse Phenotype abnormal embryonic erythrocyte morphology 26 5.06263e-10 1.8616848242307692e-7 4.089734 29 0.01590784 148 0.0016346835768243243 3.16751 15 39 0.006578947 Mouse Phenotype abnormal thymus involution 65 1.497423e-7 0.000022025940466153844 4.918253 17 0.009325288 325 0.027467417401846154 3.222597 9 23 0.003947368 Mouse Phenotype abnormal neuromere morphology 91 6.861363e-7 0.00007208955125604395 3.409353 23 0.01261657 84 0.00012596025628571427 4.117763 14 28 0.006140351 Mouse Phenotype abnormal rhombomere 5 morphology 95 9.241795e-7 0.00009301137052105265 5.217482 14 0.007679649 91 0.00017605446787912087 6.588421 8 10 0.003508772 Mouse Phenotype abnormal podocyte foot process morphology 120 0.000003551234 0.00028294456895 2.402142 35 0.01919912 355 0.03449560321690141 2.187562 17 64 0.00745614 Mouse Phenotype abnormal facial motor nucleus morphology 135 0.000004914698 0.0003480698339111111 4.222077 15 0.008228195 383 0.04056490154569191 3.603043 7 16 0.003070175 Mouse Phenotype abnormal embryonic hematopoiesis 136 0.000004917059 0.00034567647866911764 2.400671 34 0.01865058 114 0.0004306510908947369 2.835181 21 61 0.009210526 Mouse Phenotype abnormal podocyte morphology 148 0.000007466367 0.0004823373978851351 2.202237 39 0.02139331 306 0.023024872063725492 2.083687 21 83 0.009210526 Mouse Phenotype abnormal rhombomere morphology 168 0.00001231011 0.0007005771530357143 3.125492 20 0.01097093 110 0.00040181780020909094 3.965253 13 27 0.005701754 Mouse Phenotype increased bone trabecula number 175 0.00001561092 0.0008528914635428571 2.733974 24 0.01316511 225 0.009903797969333333 2.583695 16 51 0.007017544 Mouse Phenotype abnormal Mullerian duct morphology 193 0.00002834529 0.001404193355906736 2.516116 26 0.01426221 273 0.01683464457142857 2.620395 14 44 0.006140351 Mouse Phenotype abnormal vertebral body morphology 209 0.00003750813 0.0017158623489473685 2.168082 34 0.01865058 161 0.002554619623975155 2.573602 20 64 0.00877193 Mouse Phenotype decreased white fat cell number 217 0.00004531771 0.0019966941258525344 4.189843 12 0.006582556 334 0.029211688949101793 3.843246 7 15 0.003070175 Mouse Phenotype abnormal vascular endothelial cell development 272 0.0001102951 0.003876953864338235 2.405363 24 0.01316511 206 0.007924365656796117 2.745175 15 45 0.006578947 Mouse Phenotype decreased susceptibility to non-insulin-dependent diabetes 285 0.0001408648 0.004725643343157894 15.75957 4 0.002194185 396 0.04317494088636364 8.235526 3 3 0.001315789