# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA processing	21	3.35687e-44	2.1034786823809524e-41	2.042051	462	0.04351922	39	6.2129374974358966e-30	1.634106	296	396	0.03446268	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	22	7.350457e-44	4.3965756210454546e-41	3.001125	220	0.02072344	387	0.0002536895047829457	1.450997	75	113	0.008732099	
GO Biological Process	rRNA processing	26	9.273523e-42	4.6934726598846156e-39	2.343038	322	0.03033157	71	5.657919628591549e-24	1.709028	197	252	0.02293631	
GO Biological Process	rRNA metabolic process	28	4.869219e-41	2.2883590293214286e-38	2.304917	327	0.03080256	73	9.412273982054793e-24	1.696602	201	259	0.02340203	
GO Biological Process	regulation of DNA-templated transcription in response to stress	31	8.436431e-39	3.5811288880322586e-36	2.725476	226	0.02128862	351	0.00006511500586324786	1.469693	80	119	0.009314239	
GO Biological Process	ribosome biogenesis	33	2.792118e-36	1.113378204909091e-33	2.014923	390	0.036737	61	2.2056878506557378e-26	1.658239	245	323	0.02852486	
GO Biological Process	mRNA catabolic process	38	8.610149e-34	2.981603965552632e-31	2.23227	286	0.02694047	139	2.427395288848921e-13	1.58061	154	213	0.01792991	
GO Biological Process	mitochondrial translational elongation	42	2.864178e-33	8.973742452857142e-31	3.455535	135	0.01271665	143	1.2842595065734265e-12	1.877533	73	85	0.008499243	
GO Biological Process	nuclear-transcribed mRNA catabolic process	43	1.237109e-32	3.785841239767442e-30	2.278696	264	0.02486812	154	7.729838417987014e-12	1.567858	142	198	0.01653277	
GO Biological Process	mitochondrial translational termination	44	1.396898e-32	4.1776774504545454e-30	3.39918	135	0.01271665	158	1.4533848988607596e-11	1.834371	73	87	0.008499243	
GO Biological Process	translational termination	45	4.538509e-32	1.3271608873555557e-29	3.130794	149	0.01403542	141	7.341754206879432e-13	1.840984	80	95	0.009314239	
GO Biological Process	translational elongation	46	1.037458e-31	2.967806483043478e-29	2.893224	166	0.01563677	125	3.40839996576e-14	1.815301	93	112	0.0108278	
GO Biological Process	mitochondrial translation	47	1.275054e-31	3.569879911914894e-29	2.993111	157	0.014789	133	1.1298178884210526e-13	1.818402	89	107	0.01036209	
GO Biological Process	RNA catabolic process	50	4.53319e-31	1.1930449442e-28	2.072592	310	0.02920121	142	1.1017456152112675e-12	1.533039	169	241	0.01967633	
GO Biological Process	endoplasmic reticulum unfolded protein response	55	2.69181e-30	6.44027778e-28	2.642092	184	0.01733233	243	2.0716733561728393e-7	1.591684	83	114	0.009663523	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	57	5.043029e-30	1.1642319054561402e-27	2.822998	163	0.01535418	190	8.242569048947369e-10	1.667417	90	118	0.01047852	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	59	2.318968e-29	5.172084730847458e-27	2.943054	149	0.01403542	436	0.0006882594627293579	1.513501	54	78	0.006287111	
GO Biological Process	cellular response to topologically incorrect protein	61	1.97354e-28	4.257346370491803e-26	2.39167	207	0.01949887	232	5.261186571336207e-8	1.557055	99	139	0.01152637	
GO Biological Process	IRE1-mediated unfolded protein response	64	2.854975e-28	5.870096253906251e-26	3.567774	109	0.01026752	512	0.0026779181828125	1.545395	41	58	0.004773548	
GO Biological Process	response to topologically incorrect protein	65	3.137913e-28	6.352584179538461e-26	2.174083	251	0.02364356	223	1.491720762511211e-8	1.506027	124	180	0.01443707	
GO Cellular Component	ribosomal subunit	26	7.275323e-43	4.835291593846154e-41	2.716322	252	0.02373775	43	2.1155582511627908e-16	1.678032	142	185	0.01653277	
GO Cellular Component	ribosome	29	2.692464e-39	1.6043371696551723e-37	2.325718	307	0.02891861	39	5.4867411692307696e-18	1.630363	176	236	0.02049133	
GO Cellular Component	mitochondrial ribosome	30	1.502322e-38	8.65337472e-37	3.956939	133	0.01252826	46	5.242661843478261e-13	1.877533	73	85	0.008499243	
GO Cellular Component	large ribosomal subunit	36	1.964213e-32	9.4282224e-31	2.948713	165	0.01554258	53	1.827386083018868e-9	1.653884	87	115	0.01012924	
GO Cellular Component	spliceosomal complex	39	1.086923e-28	4.8159049846153846e-27	2.124697	269	0.02533911	33	9.45707170909091e-25	1.821807	155	186	0.01804634	
GO Cellular Component	mitochondrial large ribosomal subunit	40	6.472694e-28	2.796203808e-26	4.304746	86	0.00810098	67	3.446307725373135e-7	1.84324	43	51	0.005006404	
GO Cellular Component	catalytic step 2 spliceosome	44	1.38122e-22	5.4244276363636365e-21	2.506543	148	0.01394122	44	3.4946086254545453e-15	1.890125	83	96	0.009663523	
GO Cellular Component	endopeptidase complex	52	1.530091e-18	5.084610092307692e-17	2.708755	104	0.009796534	105	0.00009868022125714284	1.58418	50	69	0.005821399	
GO Cellular Component	spliceosomal snRNP complex	53	1.180083e-17	3.8475158943396227e-16	2.923041	87	0.008195177	59	1.6867801708474575e-8	1.833561	52	62	0.006054255	
GO Cellular Component	chromosome, telomeric region	54	2.566601e-17	8.213123199999999e-16	2.013586	178	0.01676714	95	0.000023541253389473683	1.400719	107	167	0.01245779	
GO Cellular Component	nuclear chromosome, telomeric region	56	4.998228e-17	1.5423103542857142e-15	2.158234	148	0.01394122	104	0.000085834296	1.424322	86	132	0.01001281	
GO Cellular Component	proteasome complex	57	7.858443e-17	2.3823490357894738e-15	2.606044	100	0.009419744	109	0.00015217792117431194	1.575327	49	68	0.005704971	
GO Cellular Component	peptidase complex	58	7.239006e-16	2.1567245462068965e-14	2.292253	120	0.01130369	115	0.00025770775930434784	1.490569	60	88	0.006985679	
GO Cellular Component	small nuclear ribonucleoprotein complex	59	9.872839e-16	2.891570473220339e-14	2.602453	93	0.008760362	58	8.365733627586207e-9	1.805965	57	69	0.006636395	
GO Cellular Component	spliceosomal tri-snRNP complex	63	8.943386e-15	2.453043017142857e-13	3.719112	51	0.004804069	92	0.00001745919923478261	1.960013	26	29	0.003027128	
GO Cellular Component	nuclear ubiquitin ligase complex	65	3.534961e-14	9.397557858461538e-13	3.11015	62	0.005840241	140	0.0019886033828571425	1.639626	30	40	0.00349284	
GO Cellular Component	small ribosomal subunit	66	5.019356e-14	1.3141586618181818e-12	2.442208	92	0.008666164	62	1.7390374606451612e-7	1.730717	57	72	0.006636395	
GO Cellular Component	MLL1 complex	84	3.103573e-11	6.384493028571429e-10	3.088283	48	0.004521477	127	0.0006304058305511811	1.809243	24	29	0.002794272	
GO Cellular Component	preribosome	85	1.035909e-10	2.105942061176471e-9	2.131102	90	0.008477769	66	3.413828945454545e-7	1.697157	59	76	0.006869251	
GO Cellular Component	U5 snRNP	86	1.047221e-10	2.1041835906976745e-9	3.581418	37	0.003485305	136	0.0012391823435294116	1.888054	19	22	0.002212132	
GO Molecular Function	structural constituent of ribosome	7	1.905602e-35	1.1493502348571429e-32	2.607719	222	0.02091183	10	4.1504430108e-13	1.673363	124	162	0.01443707	
GO Molecular Function	unfolded protein binding	9	8.999216e-27	4.221632216888889e-24	2.815173	145	0.01365863	41	0.0000016935430565853657	1.588066	77	106	0.008964955	
GO Molecular Function	rRNA binding	11	5.319327e-24	2.041654417636364e-21	3.897371	82	0.00772419	39	0.000001173216937948718	1.785371	49	60	0.005704971	
GO Molecular Function	ribonucleoprotein complex binding	13	1.497121e-16	4.8621883553846153e-14	2.141532	146	0.01375283	44	0.000002229984595909091	1.558833	82	115	0.009547095	
GO Molecular Function	ribonuclease activity	17	2.318664e-12	5.75847024e-10	2.019607	121	0.01139789	125	0.035504858336	1.347033	61	99	0.007102107	
GO Molecular Function	snRNA binding	21	9.314935e-12	1.8727455033333335e-9	3.202209	48	0.004521477	104	0.017883896726923077	1.610861	28	38	0.003259984	
GO Molecular Function	SUMO transferase activity	30	1.250922e-10	1.7604642279999998e-8	3.239002	42	0.003956292	112	0.02479827511607143	1.840984	16	19	0.001862848	
GO Molecular Function	translation initiation factor activity	53	6.514239e-8	0.000005189267369433962	2.082361	66	0.006217031	59	0.000028750102576271188	1.757508	41	51	0.004773548	
GO Molecular Function	thyroid hormone receptor binding	55	6.863475e-8	0.000005268652990909091	2.461483	46	0.004333082	140	0.048353631128571425	1.639626	21	28	0.002444988	
GO Molecular Function	sequence-specific single stranded DNA binding	57	9.633071e-8	0.000007135232589824561	3.139373	30	0.002825923	100	0.012993893186000001	2.030013	13	14	0.001513564	
GO Molecular Function	telomeric DNA binding	60	1.210353e-7	0.000008516850609999999	2.313831	50	0.004709872	86	0.0030454896251162792	1.736075	27	34	0.003143556	
GO Molecular Function	RNA polymerase III activity	70	2.826935e-7	0.000017050456528571427	3.883884	21	0.001978146	113	0.025798908364601768	1.912897	14	16	0.001629992	
GO Molecular Function	mannosyltransferase activity	118	0.000007326453	0.00026213800479661013	2.479689	31	0.002920121	120	0.030669160378333334	1.730717	19	24	0.002212132	
GO Molecular Function	NADH dehydrogenase activity	127	0.0000111213	0.00036971754803149604	2.103964	42	0.003956292	143	0.048409363426573426	1.488455	32	47	0.003725696	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	131	0.00001306239	0.0004209878670229008	2.030784	45	0.004238885	96	0.010165274216666667	1.733858	23	29	0.002677844	
GO Molecular Function	protein binding involved in protein folding	140	0.00002428733	0.0007324364804285714	2.226245	34	0.003202713	114	0.026104251945614033	1.700353	21	27	0.002444988	
GO Molecular Function	single-stranded telomeric DNA binding	185	0.00009409098	0.0021473087435675674	2.555519	22	0.002072344	130	0.04138988984615385	2.003988	11	12	0.001280708	
GO Molecular Function	RNA polymerase I activity	382	0.002789541	0.03083100026701571	2.404334	14	0.001318764	130	0.04138988984615385	2.003988	11	12	0.001280708	
Human Phenotype	Increased serum lactate	1	8.555886e-21	5.709342727799999e-17	2.462089	140	0.01318764	26	1.0152073778076922e-10	1.770796	81	100	0.009430667	
Human Phenotype	Abnormal CSF metabolite level	3	6.307398e-17	1.4029755618000001e-13	2.819137	88	0.008289375	71	0.000018987795933802817	1.700353	49	63	0.005704971	
Human Phenotype	Increased CSF lactate	4	1.492779e-16	2.4903285667499997e-13	2.900718	82	0.00772419	82	0.00005895840447926829	1.696165	45	58	0.00523926	
Human Phenotype	Abnormality of mitochondrial metabolism	5	2.224093e-16	2.9682745178e-13	2.44743	109	0.01026752	40	4.68435090975e-8	1.805965	57	69	0.006636395	
Human Phenotype	Abnormality of the mitochondrion	6	4.093954e-16	4.553159173666666e-13	2.41332	110	0.01036172	41	7.573763856585366e-8	1.785884	58	71	0.006752823	
Human Phenotype	Exercise intolerance	13	3.102961e-13	1.5927737502307695e-10	2.459169	85	0.008006782	103	0.00024142466973786406	1.59278	51	70	0.005937827	
Human Phenotype	Mitochondrial inheritance	17	1.098407e-11	4.3115705358823526e-9	2.705678	62	0.005840241	255	0.02694314031764706	1.470695	37	55	0.004307836	
Human Phenotype	Progressive external ophthalmoplegia	26	8.217997e-11	2.109180537730769e-8	3.869731	34	0.003202713	274	0.032446537047445254	1.894679	13	15	0.001513564	
Human Phenotype	11 pairs of ribs	34	4.847732e-9	9.514386951764706e-7	2.771032	44	0.004144687	233	0.01798395838798283	2.018002	12	13	0.001397136	
Human Phenotype	Abnormal mitochondria in muscle tissue	45	8.178957e-8	0.000012128484458	2.911305	34	0.003202713	166	0.0020475003072891566	1.901016	20	23	0.00232856	
Human Phenotype	Progressive macrocephaly	58	4.569597e-7	0.000052574001346551724	2.744035	33	0.003108515	249	0.023360744602811248	1.730717	19	24	0.002212132	
Human Phenotype	Acute necrotizing encephalopathy	60	5.143793e-7	0.00005720755114833333	2.834404	31	0.002920121	164	0.0018958379545731706	1.967552	18	20	0.002095704	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	66	7.000423e-7	0.00007077851921060606	2.849103	30	0.002825923	238	0.019360016015966385	1.912897	14	16	0.001629992	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	71	7.580328e-7	0.00007124440668169014	2.964919	28	0.002637528	274	0.032446537047445254	1.894679	13	15	0.001513564	
Human Phenotype	Acute encephalopathy	78	0.000001992188	0.0001704342374871795	2.376149	38	0.003579503	99	0.0001958041538989899	2.003988	22	24	0.002561416	
Human Phenotype	3-Methylglutaconic aciduria	80	0.000002084856	0.00017390305110000004	2.809529	28	0.002637528	270	0.03149754859259259	2.003988	11	12	0.001280708	
Human Phenotype	Type I transferrin isoform profile	82	0.000002512102	0.00020442995909756098	3.645101	19	0.001789751	212	0.009687379810849056	2.030013	13	14	0.001513564	
Human Phenotype	Abnormal glycosylation	102	0.000005274813	0.00034508654067647054	2.728345	27	0.002543331	231	0.016807319764935064	1.788683	18	22	0.002095704	
Human Phenotype	CNS hypomyelination	114	0.000008617676	0.0005044364205964913	2.281432	36	0.003391108	106	0.0002465074818584906	1.894679	26	30	0.003027128	
Human Phenotype	Abnormal protein N-linked glycosylation	127	0.00001384984	0.0007277163962204724	2.636593	26	0.002449133	256	0.02743684755859375	1.769755	17	21	0.001979276	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	51	5.71387e-12	1.0259197566666667e-9	2.258374	90	0.008477769	37	0.000013378713581621623	1.748935	48	60	0.005588543	
Mouse Phenotype Single KO	early cellular replicative senescence	101	7.064363e-9	6.404789306039604e-7	2.10575	74	0.00697061	54	0.00017932526162962962	1.72371	41	52	0.004773548	
Mouse Phenotype Single KO	increased metastatic potential	143	1.319632e-7	0.000008450258897902098	2.154801	58	0.005463451	138	0.029291584123188406	1.656188	25	33	0.0029107	
Mouse Phenotype Single KO	reduced sympathetic cervical ganglion size	289	0.00002981275	0.0009446205942906574	2.697282	23	0.002166541	146	0.039384056298630135	2.018002	12	13	0.001397136	
Mouse Phenotype Single KO	abnormal hypoglossal nerve topology	321	0.00005823018	0.001661102050654206	2.250154	30	0.002825923	78	0.0020011132552564103	2.064715	17	18	0.001979276	
Mouse Phenotype	abnormal cellular replicative senescence	28	9.910654e-16	3.3841343890714285e-13	2.183786	132	0.01243406	33	8.739431961818182e-7	1.691678	65	84	0.007567819	
Mouse Phenotype	early cellular replicative senescence	30	1.35654e-15	4.32329298e-13	2.26248	121	0.01139789	34	0.000001002849353117647	1.736956	58	73	0.006752823	
Mouse Phenotype	reduced sympathetic cervical ganglion size	330	0.00002981275	0.000863756675	2.697282	23	0.002166541	171	0.03510971409824561	2.018002	12	13	0.001397136	
Mouse Phenotype	abnormal hypoglossal nerve topology	367	0.00005823018	0.0015169993214713897	2.250154	30	0.002825923	84	0.0019401579575000002	2.064715	17	18	0.001979276