# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	RNA catabolic process	5	3.949353e-34	1.03939072254e-30	2.486429	231	0.03503185	99	7.418232063737374e-11	1.745158	124	241	0.02239884	
GO Biological Process	mRNA catabolic process	7	1.202368e-33	2.260280073142857e-30	2.613702	208	0.03154383	101	1.5230252657425743e-10	1.783481	112	213	0.02023121	
GO Biological Process	nuclear-transcribed mRNA catabolic process	11	8.271028e-32	9.894405222909092e-29	2.654164	191	0.02896573	122	2.331806079590164e-9	1.764421	103	198	0.01860549	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	23	5.245258e-25	3.000971740086956e-22	3.150746	113	0.01713679	163	0.0000012745718596932515	1.83962	64	118	0.01156069	
GO Biological Process	rRNA processing	25	2.104779e-24	1.1078714744400001e-21	2.272674	194	0.02942069	179	0.0000026505342992178775	1.547845	115	252	0.02077312	
GO Biological Process	rRNA metabolic process	28	1.335563e-23	6.2766691132142855e-21	2.224209	196	0.02972399	184	0.000003929892440217391	1.532203	117	259	0.02113439	
GO Biological Process	cotranslational protein targeting to membrane	36	1.397148e-20	5.106964036666666e-18	3.119107	93	0.01410373	149	2.749672846442953e-7	1.972781	57	98	0.01029624	
GO Biological Process	RNA phosphodiester bond hydrolysis	38	5.608434e-20	1.9421416580526317e-17	2.573213	123	0.01865332	363	0.006739474289256199	1.504633	59	133	0.01065751	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	40	7.851043e-20	2.5827968709250004e-17	3.15135	88	0.01334547	165	0.000001388330326060606	1.953971	53	92	0.009573699	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	41	7.977829e-20	2.5604939466097556e-17	2.841951	103	0.01562026	474	0.01651971698670886	1.500796	50	113	0.009031792	
GO Biological Process	protein targeting to ER	44	1.242782e-19	3.716765531363636e-17	2.992323	94	0.01425538	182	0.000003198782266813187	1.880601	56	101	0.01011561	
GO Biological Process	viral gene expression	45	1.867803e-19	5.4618710393333337e-17	2.727263	108	0.01637853	142	1.252478253450704e-7	1.869496	70	127	0.01264451	
GO Biological Process	translational initiation	51	1.681845e-18	4.339489873529412e-16	2.470178	122	0.01850167	207	0.000018712587489371983	1.68404	71	143	0.01282514	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	52	2.565881e-18	6.493159245961538e-16	3.018534	86	0.01304216	315	0.003236753067428571	1.771835	35	67	0.006322254	
GO Biological Process	viral transcription	57	1.144468e-17	2.642114809122807e-15	2.697931	99	0.01501365	155	4.1133777527741934e-7	1.891003	63	113	0.01138006	
GO Biological Process	gene silencing	59	1.695744e-17	3.782083948474577e-15	2.20242	145	0.02198969	272	0.0006643456610294118	1.507466	80	180	0.01445087	
GO Biological Process	regulation of mRNA stability	60	2.095065e-17	4.594826722500001e-15	2.120668	157	0.02380952	185	0.000003926129198162162	1.707131	76	151	0.01372832	
GO Biological Process	multi-organism metabolic process	62	2.807254e-17	5.9581702235483866e-15	2.366855	123	0.01865332	176	0.000002413907147102273	1.73051	75	147	0.01354769	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	64	5.458102e-17	1.12223694090625e-14	2.678602	96	0.01455869	175	0.0000023055372578857145	1.873565	58	105	0.01047688	
GO Biological Process	protein localization to endoplasmic reticulum	67	1.495233e-16	2.936682245820896e-14	2.481899	107	0.01622687	211	0.00002986430684454976	1.723253	63	124	0.01138006	
GO Cellular Component	ribosomal subunit	25	3.169318e-19	2.1906326016e-17	2.37746	137	0.02077646	40	0.000006324415199999999	1.613396	88	185	0.01589595	
GO Cellular Component	large ribosomal subunit	29	4.784684e-16	2.8510117075862066e-14	2.646966	92	0.01395208	53	0.00014640235471698114	1.681153	57	115	0.01029624	
GO Cellular Component	chromosome, telomeric region	35	1.71264e-13	8.455548342857143e-12	2.130826	117	0.0177434	59	0.0002323893185084746	1.543573	76	167	0.01372832	
GO Cellular Component	methyltransferase complex	39	7.364838e-12	3.26318976e-10	2.280052	87	0.01319381	57	0.00022437801094736843	1.751808	47	91	0.008489884	
GO Cellular Component	nuclear chromosome, telomeric region	43	3.084448e-11	1.2395177079069766e-9	2.159915	92	0.01395208	70	0.0017570958171428573	1.541727	60	132	0.01083815	
GO Cellular Component	catalytic step 2 spliceosome	45	7.180584e-11	2.757344256e-9	2.235833	82	0.01243555	56	0.00022598737714285712	1.731231	49	96	0.008851156	
GO Cellular Component	ficolin-1-rich granule lumen	48	2.190996e-10	7.8875856e-9	2.040401	96	0.01455869	67	0.000877868360597015	1.586487	58	124	0.01047688	
GO Cellular Component	histone methyltransferase complex	50	2.745292e-10	9.487729152e-9	2.276113	74	0.01122232	66	0.0006007127563636364	1.818791	37	69	0.006683526	
GO Cellular Component	cytosolic ribosome	53	6.806995e-10	2.219337237735849e-8	2.037276	91	0.01380042	44	0.000023303085381818183	1.756467	58	112	0.01047688	
GO Cellular Component	cytosolic large ribosomal subunit	54	8.88866e-10	2.8443712e-8	2.544053	56	0.008492569	65	0.0004382423335384615	1.890511	34	61	0.006141618	
GO Cellular Component	PcG protein complex	64	1.693282e-8	4.5718613999999995e-7	2.238331	61	0.009250834	98	0.018139521306122453	1.769634	24	46	0.00433526	
GO Cellular Component	CCR4-NOT complex	87	0.000001596737	0.0000317145004137931	3.249131	23	0.003488019	103	0.022307255300970875	2.331862	11	16	0.001986994	
GO Cellular Component	cytosolic small ribosomal subunit	119	0.00005216562	0.0007574974063865546	2.138266	34	0.005156203	102	0.02132435011764706	1.772986	23	44	0.004154624	
GO Cellular Component	proteasome accessory complex	154	0.000226538	0.002541932883116883	2.592676	19	0.002881407	115	0.04541452966956522	1.978549	14	24	0.002528902	
GO Molecular Function	rRNA binding	8	3.424386e-16	1.8072197115e-13	3.978993	52	0.007885957	57	0.0007530477712280702	1.92202	34	60	0.006141618	
GO Molecular Function	ribonucleoprotein complex binding	9	1.149475e-14	5.392314944444445e-12	2.385092	101	0.01531695	53	0.00035770297547169815	1.681153	57	115	0.01029624	
GO Molecular Function	structural constituent of ribosome	11	3.400494e-14	1.3051714243636363e-11	2.193703	116	0.01759175	56	0.0006646687814642856	1.54934	74	162	0.01336705	
GO Molecular Function	unfolded protein binding	13	2.428545e-13	7.887166915384615e-11	2.531827	81	0.01228389	83	0.02036083916385542	1.535909	48	106	0.00867052	
GO Molecular Function	mRNA 5'-UTR binding	36	2.403411e-7	0.00002818667011666667	3.145184	28	0.004246285	75	0.011068614744	2.31259	15	22	0.002709538	
GO Molecular Function	disordered domain specific binding	37	2.585146e-7	0.000029498611924324327	2.396884	44	0.006672733	95	0.03776219018947369	1.969432	18	31	0.003251445	
GO Molecular Function	histone methyltransferase binding	39	2.920062e-7	0.000031611542984615386	8.984666	10	0.00151653	90	0.030751396728888894	3.391799	6	6	0.001083815	
GO Molecular Function	cyclohydrolase activity	90	0.00001805745	0.0008470950433333334	3.779939	15	0.002274795	90	0.030751396728888894	3.391799	6	6	0.001083815	
GO Molecular Function	phosphatidylethanolamine binding	148	0.0002466872	0.007037252421621622	3.488277	12	0.001819836	82	0.019459352463414636	3.014933	8	9	0.001445087	
Human Phenotype	Dysphonia	8	7.170658e-9	0.00000598122510425	3.163692	35	0.005307856	62	0.044249201145161295	2.212043	15	23	0.002709538	
Mouse Phenotype Single KO	kinked neural tube	4	4.934784e-12	1.1296954272e-8	2.324409	85	0.01289051	90	0.004202070991666667	1.92867	29	51	0.005238439	
Mouse Phenotype Single KO	pale liver	27	1.652503e-8	0.000005604433322592592	2.015347	78	0.01182894	127	0.03587543159448819	1.611105	38	80	0.006864162	
Mouse Phenotype Single KO	increased susceptibility to endotoxin shock	40	1.941097e-7	0.0000444365630725	2.233272	52	0.007885957	148	0.04938649141013513	1.6959	29	58	0.005238439	
Mouse Phenotype Single KO	abnormal DNA replication	61	0.000001440461	0.00021623444880327868	2.864391	28	0.004246285	96	0.0078428016678125	2.359512	16	23	0.002890173	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	77	0.000005119267	0.0006087938690779221	2.019925	50	0.007582651	98	0.008639420197142858	1.80896	32	60	0.005780347	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	111	0.00002533044	0.0020896471989189187	2.596976	25	0.003791325	86	0.003599873308953488	2.402524	17	24	0.003070809	
Mouse Phenotype Single KO	increased incidence of tumors by ionizing radiation induction	151	0.0001084847	0.006578770847019867	3.072164	16	0.002426448	94	0.007341142546276596	2.713439	12	15	0.00216763	
Mouse Phenotype Single KO	gastrointestinal tract polyps	228	0.0006648915	0.026703559059210527	2.696917	15	0.002274795	133	0.038284246556390976	2.609076	10	13	0.001806358	
Mouse Phenotype	early cellular replicative senescence	16	6.794689e-10	4.0602513455625e-7	2.22763	74	0.01122232	234	0.026893017364102562	1.626205	35	73	0.006322254	
Mouse Phenotype	abnormal cellular replicative senescence	23	2.222332e-9	9.238137500869566e-7	2.104142	79	0.01198059	196	0.016384875944387756	1.615142	40	84	0.007225434	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	31	5.103594e-9	0.0000015740471688387097	3.145586	36	0.005459509	118	0.0022238027130508475	2.261199	20	30	0.003612717	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	96	0.000003831813	0.00038162462596875004	3.173527	22	0.003336366	84	0.00013403725249999998	2.856252	16	19	0.002890173	
Mouse Phenotype	abnormal DNA replication	156	0.00007354302	0.004507338552692307	2.254308	29	0.004397938	192	0.01564227405	2.135577	17	27	0.003070809	
Mouse Phenotype	increased liver adenoma incidence	254	0.0004774503	0.017972056371259846	2.13622	25	0.003791325	121	0.002369316150991736	2.301578	19	28	0.003432081