# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	15	2.163671e-49	1.8981164459333334e-46	2.306491	397	0.02783621	154	2.078921197077922e-9	1.439681	155	213	0.01633126	
GO Biological Process	nuclear-transcribed mRNA catabolic process	16	3.607578e-48	2.967007431375e-45	2.364345	368	0.02580283	179	2.5489879870391062e-8	1.428845	143	198	0.01506691	
GO Biological Process	RNA catabolic process	18	2.762219e-47	2.0193355456111114e-44	2.164821	435	0.03050063	141	4.2524895046099285e-10	1.428389	174	241	0.01833316	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	44	2.180837e-33	6.522189564318182e-31	2.426833	239	0.01675782	389	0.0007339856788431875	1.38313	79	113	0.008323675	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	47	8.320469e-33	2.3295542887446807e-30	2.856135	176	0.01234049	642	0.017831746552180686	1.387833	47	67	0.00495206	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	49	3.134439e-32	8.41756791857143e-30	2.604083	202	0.01416351	183	5.126453738087431e-8	1.542482	92	118	0.009693394	
GO Biological Process	multi-organism metabolic process	58	4.188359e-30	9.502520013965516e-28	2.242	252	0.01766933	161	3.4329599691304352e-9	1.520811	113	147	0.01190602	
GO Biological Process	endoplasmic reticulum unfolded protein response	64	4.378642e-29	9.0028984496875e-27	2.351437	220	0.01542561	310	0.00010852312196774193	1.42306	82	114	0.008639764	
GO Biological Process	regulation of DNA-templated transcription in response to stress	65	7.153564e-29	1.4482115180923076e-26	2.217233	247	0.01731875	375	0.0005477161797333334	1.379893	83	119	0.008745127	
GO Biological Process	viral gene expression	69	3.905878e-28	7.448905594492754e-26	2.393457	205	0.01437386	192	1.2617493442708333e-7	1.511062	97	127	0.01022021	
GO Biological Process	IRE1-mediated unfolded protein response	74	1.343033e-26	2.3882393577027024e-24	3.069883	126	0.008834666	695	0.027326187671942448	1.398525	41	58	0.004319882	
GO Biological Process	cellular response to topologically incorrect protein	80	2.292622e-25	3.7710766122500003e-23	2.098462	244	0.0171084	269	0.000025517159892193306	1.409077	99	139	0.01043093	
GO Biological Process	cellular response to unfolded protein	81	2.906032e-25	4.7210463071604935e-23	2.160839	227	0.01591642	292	0.00005912573038356164	1.422486	87	121	0.009166579	
GO Biological Process	mitochondrial translation	82	3.939843e-25	6.322487077682927e-23	2.45499	173	0.01213014	221	0.0000014882614645248868	1.516157	82	107	0.008639764	
GO Biological Process	mitochondrial translational elongation	83	4.533516e-25	7.187534583614458e-23	2.724571	143	0.01002664	284	0.000037175375063732394	1.512895	65	85	0.006848593	
GO Biological Process	protein targeting to ER	85	9.129063e-25	1.4132863531411764e-22	2.472626	168	0.01177955	196	1.5963934842857144e-7	1.56705	80	101	0.008429038	
GO Biological Process	response to epidermal growth factor	87	1.546952e-24	2.3398093526436784e-22	2.475255	166	0.01163932	507	0.004534080093688363	1.554458	33	42	0.003476978	
GO Biological Process	liver regeneration	90	2.648593e-24	3.8725372541111107e-22	2.95874	121	0.008484084	547	0.0076356192078610614	1.58272	28	35	0.002950163	
GO Biological Process	cotranslational protein targeting to membrane	92	3.285628e-24	4.699519440434783e-22	2.496558	161	0.01128874	197	1.6597520176649747e-7	1.574645	78	98	0.008218312	
GO Biological Process	mitochondrial translational termination	95	5.480507e-24	7.591367538210526e-22	2.661394	142	0.009956528	323	0.00013580617619195047	1.478115	65	87	0.006848593	
GO Cellular Component	ribosomal subunit	31	8.893569e-34	4.957447494193548e-32	2.254589	281	0.01970271	48	4.473054e-9	1.454392	136	185	0.01432936	
GO Cellular Component	mitochondrial ribosome	39	8.672297e-29	3.84249467076923e-27	3.056098	138	0.009676062	72	0.000019255821599999997	1.512895	65	85	0.006848593	
GO Cellular Component	large ribosomal subunit	44	4.355443e-26	1.710501250909091e-24	2.434334	183	0.0128313	57	8.054853726315791e-8	1.53111	89	115	0.009377305	
GO Cellular Component	mitochondrial large ribosomal subunit	49	2.405591e-21	8.483390302040817e-20	3.316038	89	0.006240359	100	0.0006649480512	1.551687	40	51	0.004214519	
GO Cellular Component	catalytic step 2 spliceosome	52	2.469602e-19	8.206677415384615e-18	2.155709	171	0.0119899	66	0.0000020403784145454543	1.525017	74	96	0.00779686	
GO Cellular Component	nuclear ubiquitin ligase complex	54	7.43003e-17	2.3776096e-15	2.987171	80	0.005609311	169	0.039998793088757395	1.43434	29	40	0.003055526	
GO Cellular Component	endopeptidase complex	61	3.491082e-15	9.889491304918033e-14	2.268312	117	0.008203618	181	0.04676515040883977	1.318934	46	69	0.004846697	
GO Cellular Component	peptidase complex	62	1.654449e-14	4.611109470967742e-13	2.033283	143	0.01002664	140	0.015459403885714283	1.326428	59	88	0.006216416	
GO Cellular Component	spliceosomal snRNP complex	69	9.705336e-14	2.4305537113043477e-12	2.375854	95	0.006661057	103	0.0006733638524271845	1.499755	47	62	0.00495206	
GO Cellular Component	small nuclear ribonucleoprotein complex	79	1.619417e-12	3.542218450632912e-11	2.166276	104	0.007292105	87	0.00013122531310344828	1.519641	53	69	0.005584238	
GO Cellular Component	spliceosomal tri-snRNP complex	103	1.140549e-10	1.9134647300970873e-9	2.822623	52	0.003646052	143	0.01680125941258741	1.569076	23	29	0.002423348	
GO Cellular Component	ESCRT complex	104	1.161381e-10	1.9296792e-9	2.788577	53	0.003716169	158	0.024186017620253165	1.554458	22	28	0.002317985	
GO Cellular Component	small ribosomal subunit	105	1.313707e-10	2.161986377142857e-9	2.015466	102	0.007151872	156	0.02153225353846154	1.346412	49	72	0.005162786	
GO Cellular Component	cytoplasmic exosome (RNase complex)	131	1.675111e-8	2.2096120671755726e-7	4.41878	22	0.001542561	154	0.02157795116883117	1.826216	12	13	0.001264356	
GO Cellular Component	MKS complex	159	3.273823e-7	0.000003557966128301887	2.897656	31	0.002173608	154	0.02157795116883117	1.826216	12	13	0.001264356	
GO Cellular Component	U12-type spliceosomal complex	177	0.000001111829	0.000010854466169491526	2.375182	40	0.002804656	145	0.01765581020689655	1.597939	21	26	0.002212622	
GO Cellular Component	U2 snRNP	192	0.000003430022	0.000030870197999999996	2.627467	30	0.002103492	160	0.0275052132	1.666022	16	19	0.001685808	
GO Cellular Component	BLOC-1 complex	202	0.000004670106	0.0000399502137029703	2.538895	31	0.002173608	174	0.04265614675862069	1.648667	15	18	0.001580445	
GO Cellular Component	methylosome	242	0.00004017679	0.0002868822029752066	3.083496	18	0.001262095	165	0.03702163549090909	1.813534	11	12	0.001158993	
GO Cellular Component	DNA-directed RNA polymerase I complex	268	0.0001753859	0.0011308464	2.44297	22	0.001542561	136	0.013223494588235294	1.837086	13	14	0.001369719	
GO Molecular Function	unfolded protein binding	9	1.502475e-30	7.048277166666666e-28	2.659104	184	0.01290142	31	0.0000052026684548387095	1.511797	81	106	0.008534401	
GO Molecular Function	structural constituent of ribosome	11	2.388931e-28	9.169151529090908e-26	2.18589	250	0.0175291	12	2.4010109391666666e-7	1.465482	120	162	0.01264356	
GO Molecular Function	ribonuclease activity	17	7.500813e-16	1.862848969764706e-13	2.012691	162	0.01135886	96	0.0177613998625	1.338918	67	99	0.007059319	
GO Molecular Function	endoribonuclease activity	54	1.363354e-10	1.0659408496296296e-8	2.091121	93	0.006520825	102	0.0186641954	1.448472	41	56	0.004319882	
GO Molecular Function	NF-kappaB binding	64	5.150919e-10	3.3979968778125004e-8	2.449958	62	0.004347216	110	0.021209393556363636	1.625115	23	28	0.002423348	
Human Phenotype	Increased serum lactate	8	3.580792e-20	2.9868281270000003e-17	2.212294	169	0.01184967	61	0.000016354954154098362	1.503584	76	100	0.008007586	
Human Phenotype	Abnormal CSF metabolite level	18	3.010315e-15	1.115990666388889e-12	2.432283	102	0.007151872	179	0.00849410270726257	1.444546	46	63	0.004846697	
Human Phenotype	Increased CSF lactate	23	3.281923e-14	9.521857469130435e-12	2.44881	93	0.006520825	224	0.016894817581696427	1.432635	42	58	0.004425245	
Human Phenotype	Exercise intolerance	26	2.363464e-13	6.065921258461539e-11	2.239666	104	0.007292105	234	0.020948414869658122	1.38488	49	70	0.005162786	
Human Phenotype	Abnormal glycosylation	129	1.95218e-7	0.000010098369875968992	2.707812	36	0.00252419	221	0.015315274766968326	1.708619	19	22	0.002001897	
Human Phenotype	Abnormality of monocarboxylic acid metabolism	140	2.238761e-7	0.000010670894395	2.503152	41	0.002874772	291	0.044097637646048106	1.826216	12	13	0.001264356	
Human Phenotype	Abnormal protein N-linked glycosylation	160	4.966141e-7	0.000020711911808125	2.641912	35	0.002454074	249	0.023437401025301206	1.695772	18	21	0.001896534	
Human Phenotype	Abnormal isoelectric focusing of serum transferrin	181	0.000001218024	0.000044905382055248615	2.577446	34	0.002383957	278	0.035954868111510795	1.681641	17	20	0.001791171	
Mouse Phenotype Single KO	decreased creatinine clearance	66	9.275547e-14	1.2869118769545454e-11	3.443485	52	0.003646052	173	0.00851721681849711	1.862024	16	17	0.001685808	
Mouse Phenotype Single KO	spleen atrophy	124	7.76555e-11	5.734608173387096e-9	2.303232	77	0.005398962	241	0.03322950293651452	1.695772	18	21	0.001896534	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	145	3.386987e-10	2.138940686827586e-8	2.052756	93	0.006520825	214	0.023351227189252335	1.661856	21	25	0.002212622	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	250	1.585782e-7	0.0000058084023096	2.271713	51	0.003575936	209	0.022223009385167466	1.708619	19	22	0.002001897	
Mouse Phenotype	abnormal transitional stage T2 B cell morphology	42	2.991571e-18	6.810097697857143e-16	2.683555	104	0.007292105	386	0.03443896969430051	1.569076	23	29	0.002423348	
Mouse Phenotype	early cellular replicative senescence	59	2.289992e-16	3.7109514427118644e-14	2.101633	151	0.01058758	111	0.00009883076497297297	1.544779	57	73	0.00600569	
Mouse Phenotype	abnormal cellular replicative senescence	65	7.6737e-16	1.1287422415384617e-13	2.007262	163	0.01142897	132	0.00027341852454545453	1.4838	63	84	0.006637867	
Mouse Phenotype	pale kidney	66	8.830106e-16	1.2791612646363635e-13	2.101597	145	0.01016688	405	0.0363773859037037	1.450827	33	45	0.003476978	
Mouse Phenotype	decreased creatinine clearance	106	9.275547e-14	8.366368383679245e-12	3.443485	52	0.003646052	251	0.006129431397609562	1.862024	16	17	0.001685808	
Mouse Phenotype	spleen atrophy	168	5.060913e-11	2.8802017376785717e-9	2.269867	81	0.005679428	397	0.035679990264483624	1.597939	21	26	0.002212622	
Mouse Phenotype	abnormal vitelline vein morphology	192	3.386987e-10	1.6866136826562497e-8	2.052756	93	0.006520825	311	0.016776957236334405	1.661856	21	25	0.002212622	
Mouse Phenotype	absent segment of posterior cerebral artery	329	1.585782e-7	0.000004608407812158054	2.271713	51	0.003575936	304	0.015952386972039476	1.708619	19	22	0.002001897