# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	viral gene expression	1	1.679566e-27	2.2101408994000002e-23	4.215558	86	0.02531646	86	6.710831410348837e-7	2.167654	53	127	0.01466113	
GO Biological Process	ncRNA metabolic process	2	4.842322e-26	3.1860057599e-22	2.170249	225	0.06623491	45	7.570501365777778e-9	1.600372	171	555	0.0473029	
GO Biological Process	multi-organism metabolic process	3	4.963638e-26	2.1772170813999997e-22	3.623194	97	0.02855461	66	8.053593111666665e-8	2.155413	61	147	0.01687414	
GO Biological Process	viral transcription	6	1.146924e-22	2.515395486e-19	3.967439	75	0.0220783	118	0.000012313913407627118	2.114449	46	113	0.01272476	
GO Biological Process	translation	9	1.317093e-21	1.9257363096666668e-18	2.265818	169	0.04974978	64	5.7161400660937506e-8	1.703471	122	372	0.03374827	
GO Biological Process	ncRNA processing	11	5.400405e-21	6.4603572177272724e-18	2.265342	164	0.04827789	91	0.000001383626914725275	1.613347	123	396	0.0340249	
GO Biological Process	viral life cycle	14	2.275943e-20	2.1392238526428572e-17	2.29961	154	0.04533412	102	0.000003590408638137255	1.690727	97	298	0.02683264	
GO Biological Process	peptide biosynthetic process	15	4.0095e-20	3.5174007e-17	2.135752	178	0.05239918	46	8.901073714347827e-9	1.722563	130	392	0.03596127	
GO Biological Process	ribonucleoprotein complex biogenesis	17	7.22978e-20	5.59627500117647e-17	2.036787	196	0.05769797	41	3.9127580407317074e-9	1.68182	147	454	0.0406639	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	21	8.021426e-19	5.026378320666667e-16	6.711352	37	0.01089196	329	0.027106872050759876	2.597095	12	24	0.003319502	
GO Biological Process	translational initiation	22	1.002493e-18	5.996275175909091e-16	3.183515	81	0.02384457	152	0.00010141468155263158	1.888797	52	143	0.01438451	
GO Biological Process	response to topologically incorrect protein	25	3.633562e-17	1.91256169432e-14	2.652734	98	0.02884898	361	0.040707931498614965	1.500544	52	180	0.01438451	
GO Biological Process	cellular response to topologically incorrect protein	27	1.0939e-16	5.3313444814814814e-14	2.9247	81	0.02384457	371	0.044005930547169815	1.569468	42	139	0.01161826	
GO Biological Process	nuclear-transcribed mRNA catabolic process	29	1.223253e-16	5.5506159403448274e-14	2.616493	97	0.02855461	173	0.0002828418279075144	1.705164	65	198	0.01798064	
GO Biological Process	protein targeting to ER	32	1.526448e-16	6.277040385e-14	3.645742	59	0.01736827	204	0.0008077445734313726	1.95425	38	101	0.01051176	
GO Biological Process	ribosome biogenesis	34	3.13697e-16	1.2140996538235294e-13	2.179681	135	0.03974095	111	0.000008207043055855857	1.640271	102	323	0.02821577	
GO Biological Process	response to endoplasmic reticulum stress	35	3.629721e-16	1.3646713896857142e-13	2.213494	130	0.03826906	256	0.006398209073828125	1.511424	71	244	0.01964039	
GO Biological Process	cotranslational protein targeting to membrane	40	8.835005e-16	2.9064957698749997e-13	3.645765	56	0.01648513	209	0.0009311113218660287	1.961072	37	98	0.01023513	
GO Biological Process	rRNA processing	43	2.479067e-15	7.586521547209302e-13	2.387691	105	0.03090963	197	0.0006867621982741117	1.587114	77	252	0.02130014	
GO Biological Process	rRNA metabolic process	44	3.063648e-15	9.16239637090909e-13	2.356984	107	0.03149838	192	0.0005848797864114584	1.584328	79	259	0.02185339	
GO Cellular Component	ribosomal subunit	25	2.5229e-19	1.74382848e-17	3.031716	90	0.02649397	45	0.0002392331136	1.712679	61	185	0.01687414	
GO Cellular Component	ribosome	26	1.931555e-16	1.283741169230769e-14	2.485841	105	0.03090963	37	0.000030434848345945942	1.694715	77	236	0.02130014	
GO Cellular Component	large ribosomal subunit	27	1.25313e-13	8.020032e-12	3.183383	57	0.01677951	90	0.025791513600000003	1.626008	36	115	0.009958506	
GO Cellular Component	mitochondrial ribosome	39	8.022571e-11	3.554616073846154e-9	3.533106	38	0.01118634	99	0.03328571345454546	1.711028	28	85	0.007745505	
GO Cellular Component	nuclear chromosome, telomeric region	41	1.910957e-9	8.053984624390244e-8	2.506484	55	0.01619076	55	0.0012285658996363635	1.770747	45	132	0.01244813	
GO Cellular Component	chromosome, telomeric region	45	4.739675e-9	1.8200352e-7	2.262536	64	0.01884015	85	0.011659090447058823	1.555147	50	167	0.01383126	
GO Cellular Component	cytosolic ribosome	46	9.339365e-9	3.5083527652173916e-7	2.390146	55	0.01619076	93	0.029858353548387093	1.623185	35	112	0.009681881	
GO Cellular Component	membrane coat	58	1.379869e-7	0.0000041110579862068964	2.196801	55	0.01619076	44	0.00012070991127272728	2.056034	38	96	0.01051176	
GO Cellular Component	small ribosomal subunit	62	4.602235e-7	0.000012826874322580646	2.737626	33	0.009714454	91	0.027109737494505494	1.803538	25	72	0.006915629	
GO Cellular Component	spliceosomal snRNP complex	68	0.000002586976	0.00006573962541176471	2.834946	27	0.00794819	87	0.015465586096551723	1.926877	23	62	0.006362379	
GO Cellular Component	protein phosphatase type 2A complex	72	0.000005089935	0.00012215844	2.861372	25	0.007359435	108	0.04837416	2.473424	10	21	0.002766252	
GO Cellular Component	cytosolic small ribosomal subunit	73	0.00000529427	0.00012532189808219177	2.929863	24	0.007065057	104	0.036549343384615386	2.006846	17	44	0.004702628	
GO Cellular Component	respiratory chain complex	78	0.00001146494	0.0002539925169230769	2.21769	37	0.01089196	52	0.0006102711138461539	2.006846	34	88	0.009405256	
GO Cellular Component	respiratory chain	82	0.00001579451	0.00033284040585365856	2.110516	40	0.0117751	58	0.001227690968275862	1.884167	37	102	0.01023513	
GO Cellular Component	mitochondrial respiratory chain	86	0.00002106996	0.0004233591962790698	2.105354	39	0.01148072	51	0.00044996713411764707	1.989265	36	94	0.009958506	
GO Cellular Component	integrator complex	88	0.0000231504	0.00045458967272727274	3.695202	15	0.004415661	68	0.0020319290258823527	3.462794	10	15	0.002766252	
GO Cellular Component	small nuclear ribonucleoprotein complex	89	0.00002373225	0.0004607789662921348	2.448631	28	0.008242567	95	0.031178631410526316	1.806675	24	69	0.006639004	
GO Cellular Component	vesicle coat	96	0.00006114007	0.0011005212600000002	2.206573	31	0.009125699	100	0.03532764672	1.935091	19	51	0.005255878	
GO Cellular Component	nucleosome	105	0.0001135389	0.0018685258971428574	2.268362	27	0.00794819	70	0.002070916416	1.830334	37	105	0.01023513	
GO Cellular Component	AP-type membrane coat adaptor complex	108	0.0001348843	0.0021581488	2.328417	25	0.007359435	76	0.0032966033684210527	2.258344	20	46	0.005532503	
GO Molecular Function	structural constituent of ribosome	7	3.516624e-15	2.1210266468571426e-12	2.826597	77	0.02266706	43	0.003065009011162791	1.699334	53	162	0.01466113	
GO Molecular Function	ribonucleoprotein complex binding	27	7.931898e-7	0.0001240313828	2.200282	48	0.01413011	49	0.012142988979591837	1.761508	39	115	0.01078838	
GO Molecular Function	mitogen-activated protein kinase binding	38	0.000004370315	0.0004855649981578947	3.143506	22	0.006476303	50	0.012469643224	2.693284	14	27	0.003872752	
GO Molecular Function	very long-chain fatty acid-CoA ligase activity	126	0.001000846	0.03353628422222222	4.055686	8	0.002355019	61	0.046732002950819675	3.635934	7	10	0.001936376	
Mouse Phenotype Single KO	abnormal induced cell death	1	3.255348e-18	2.9809221636e-14	2.35697	130	0.03826906	8	0.00000340609952975	1.89551	77	211	0.02130014	
Mouse Phenotype Single KO	increased sensitivity to induced cell death	3	5.372572e-13	1.6398880601333333e-9	2.435787	84	0.0247277	50	0.0053126478238	1.743256	49	146	0.01355463	
Mouse Phenotype Single KO	decreased sensitivity to induced cell death	24	3.940417e-7	0.00015034332695416667	2.214757	50	0.01471887	34	0.0020154457350294117	2.13095	32	78	0.008852006	
Mouse Phenotype Single KO	aneuploidy	50	0.000006580854	0.00120521760156	2.40886	33	0.009714454	64	0.0207448258046875	2.258344	20	46	0.005532503	
Mouse Phenotype	abnormal induced cell death	1	8.936942e-17	8.5446102462e-13	2.145104	145	0.04268472	20	0.0000050123542499999995	1.771662	88	258	0.02434302	
Mouse Phenotype	increased sensitivity to induced cell death	4	5.115566e-12	1.2227481631500001e-8	2.206834	94	0.02767147	105	0.013566895097142857	1.589479	56	183	0.01549101	
Mouse Phenotype	abnormal uterine fat pad morphology	7	5.179968e-11	7.075096292571429e-8	11.58135	14	0.004121283	121	0.020852485688429755	5.194191	5	5	0.001383126	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	13	1.717921e-8	0.000012634648216153844	4.07065	24	0.007065057	103	0.013567578821359222	2.597095	15	30	0.004149378	
Mouse Phenotype	increased leukemia incidence	19	3.469314e-8	0.00001745795323894737	2.203494	60	0.01766264	110	0.01481046705	1.8431	33	93	0.009128631	
Mouse Phenotype	absent hypoglossal nerve	38	6.906213e-7	0.00017376395392894737	4.979773	15	0.004415661	144	0.03860077137083333	3.116515	9	15	0.002489627